This document discusses challenges facing scientific disciplines and institutions in the 21st century. It notes that while traditional disciplines have advanced knowledge, they have also led to overspecialization and ignorance of relations between fields. The complexity of modern problems requires integrated, multi-disciplinary approaches. However, established institutions often resist new ideas and paradigms that do not fit traditional models. To promote innovation while maintaining established strengths, universities need flexible structures like centers and programs that support collaboration across disciplines without needing to establish new departments. This balances the needs of normal science with allowing new ideas to develop.