The MRC Diarrhoeal Pathogens Research Unit (DPRU) was established in 1996 at MEDUNSA to address diarrhoeal diseases in South Africa and Africa. Diarrhoeal diseases are a leading cause of death in children under 5 in Africa. The DPRU studies microbial agents associated with childhood diarrhoea, investigates rotavirus epidemiology and pathogenesis, supports vaccine development, and promotes training and collaboration. It has grown to become a premier research center conducting groundbreaking rotavirus research, training, and vaccine trials to help introduce vaccines in Africa. The DPRU works to reduce childhood mortality from diarrhoea and monitors the impact of the rotavirus vaccine in South Africa as the WHO Regional Rotavirus