The focus on obesity may be somewhat misleading.
Impact of physical fitness and body composition on injury risk among active young adults: A study of Army trainees, Jones et al, https://doi.org/10.1016/j.jsams.2017.09.015
"Conclusions: While the most aerobically fit Army trainees experience lower risk of training-related injury, at any given aerobic fitness level those with the lowest BMIs are at highest risk."
The realties are that entry poor bone status, entry nutrient deficiencies, post-entry malnutrition, and treatment protocols are significant issues re injuries, re-injuries, attrition, and readiness rates.
Personalised Lifestyle Modification using Epigenetics (EPLIMO)
You are unique; not just because of your physical appearance or your thought process, but due to your genetic and metabolic profiles. Genetic profile is the genetic data stored in your DNA and Metabolic profile shows how food gets converted into energy and building blocks for cells inside your body. No two persons have the same geno-metabolic profiles. Hence nutrition for someone could be toxin for someone else. Also, while cardio exercise strengthens someone’s hearts, the same can damage the heart muscles of someone else. Jumping into some diet plans or enrolling for some fitness programs without knowing your geno-metabolic profile can cause more damages than expected benefits.
The focus on obesity may be somewhat misleading.
Impact of physical fitness and body composition on injury risk among active young adults: A study of Army trainees, Jones et al, https://doi.org/10.1016/j.jsams.2017.09.015
"Conclusions: While the most aerobically fit Army trainees experience lower risk of training-related injury, at any given aerobic fitness level those with the lowest BMIs are at highest risk."
The realties are that entry poor bone status, entry nutrient deficiencies, post-entry malnutrition, and treatment protocols are significant issues re injuries, re-injuries, attrition, and readiness rates.
Personalised Lifestyle Modification using Epigenetics (EPLIMO)
You are unique; not just because of your physical appearance or your thought process, but due to your genetic and metabolic profiles. Genetic profile is the genetic data stored in your DNA and Metabolic profile shows how food gets converted into energy and building blocks for cells inside your body. No two persons have the same geno-metabolic profiles. Hence nutrition for someone could be toxin for someone else. Also, while cardio exercise strengthens someone’s hearts, the same can damage the heart muscles of someone else. Jumping into some diet plans or enrolling for some fitness programs without knowing your geno-metabolic profile can cause more damages than expected benefits.
The orientation for Pelican Athletic Club's healthy lifestyle and fitness program designed to promote long term habits for effective weight management and mental and physical well being.
No one likes feeling sleepy. But the consequences may be much worse than you thought. Here are some surprising things about sleep and a few small habits that can make a huge difference.
Creating Health and Balance in Today's Classroom is a three credit graduate course for teachers available from the Regional Training Center in partnership with The College of New Jersey and Gratz College in PA and MD. This PPT represents just a few highlights from the course.
For more info go to www.theRTC.net or call 800-433-4740
Protecting kids from a most deadly disease!Ernie Medina
Lecture given by Ernie Medina, Jr., DrPH, on Aug. 17, 2011, for a grad class at Loma Linda Univ. School of Public Health. Professor: Serena Tonstadt, MD. Topic: getting kids to be more physically active.
The Fundamentals of Good Ergonomics and Health ImprovementTony Fahkry
This presentation addresses the key factors to improve workplace ergonomics and overall health and wellbeing. It is not enough to focus on ergonomics without addressing health and wellbeing. We must focus on the entire process in an integrated manner. I outline how to setup your work area for optimal posture and reduce injury, while looking at the mechanisms of health and wellbeing that support it.
Brain Power for Peace: Building Global Relations through NeuroplasticityRotary International
Building neuroplasticity, or the brain's ability to change, reform, and reorganize information, can improve cognitive, emotional, and prosocial functions at any age. We will provide an overview of this cutting-edge neuroscience and facilitate discussions on how Rotarians can enhance negotiating skills and increase prosocial behaviors in their community. Let us inspire you to build peaceful global relations through driving neuroplasticity in a positive direction.
Power Foods for the Brain, a new book by noted nutrition researcher and New York Times best-selling author Neal Barnard, M.D., reveals how simple diet changes can shield the brain from memory loss, stroke, and Alzheimer’s.
For more information: http://nealbarnard.org/books/
Doctor Is In: A Stress-Free Holiday SeasonAngela Holland
During the holidays, you should feel festive, not frenzied! Hectic schedules, lack of sleep, and overall holiday anxiety can easily dampen your spirit. Springfield Clinic’s panel of experts discuss how to keep your blood pressure in check, get a restful night’s sleep, recognize your emotional triggers and manage the holidays with ease!
How you feel when you wake up says a lot about the night you had and the day to come. Sleep plays an important role in our physical and mental health. Some of the benefits of sleep revealed by recent researches is mentioned here.
Do you know getting sufficient sleep is the key to a healthy lifestyle? Read on to find why sleep is so essential for your health and how much sleep you should be getting each night.
The orientation for Pelican Athletic Club's healthy lifestyle and fitness program designed to promote long term habits for effective weight management and mental and physical well being.
No one likes feeling sleepy. But the consequences may be much worse than you thought. Here are some surprising things about sleep and a few small habits that can make a huge difference.
Creating Health and Balance in Today's Classroom is a three credit graduate course for teachers available from the Regional Training Center in partnership with The College of New Jersey and Gratz College in PA and MD. This PPT represents just a few highlights from the course.
For more info go to www.theRTC.net or call 800-433-4740
Protecting kids from a most deadly disease!Ernie Medina
Lecture given by Ernie Medina, Jr., DrPH, on Aug. 17, 2011, for a grad class at Loma Linda Univ. School of Public Health. Professor: Serena Tonstadt, MD. Topic: getting kids to be more physically active.
The Fundamentals of Good Ergonomics and Health ImprovementTony Fahkry
This presentation addresses the key factors to improve workplace ergonomics and overall health and wellbeing. It is not enough to focus on ergonomics without addressing health and wellbeing. We must focus on the entire process in an integrated manner. I outline how to setup your work area for optimal posture and reduce injury, while looking at the mechanisms of health and wellbeing that support it.
Brain Power for Peace: Building Global Relations through NeuroplasticityRotary International
Building neuroplasticity, or the brain's ability to change, reform, and reorganize information, can improve cognitive, emotional, and prosocial functions at any age. We will provide an overview of this cutting-edge neuroscience and facilitate discussions on how Rotarians can enhance negotiating skills and increase prosocial behaviors in their community. Let us inspire you to build peaceful global relations through driving neuroplasticity in a positive direction.
Power Foods for the Brain, a new book by noted nutrition researcher and New York Times best-selling author Neal Barnard, M.D., reveals how simple diet changes can shield the brain from memory loss, stroke, and Alzheimer’s.
For more information: http://nealbarnard.org/books/
Doctor Is In: A Stress-Free Holiday SeasonAngela Holland
During the holidays, you should feel festive, not frenzied! Hectic schedules, lack of sleep, and overall holiday anxiety can easily dampen your spirit. Springfield Clinic’s panel of experts discuss how to keep your blood pressure in check, get a restful night’s sleep, recognize your emotional triggers and manage the holidays with ease!
How you feel when you wake up says a lot about the night you had and the day to come. Sleep plays an important role in our physical and mental health. Some of the benefits of sleep revealed by recent researches is mentioned here.
Do you know getting sufficient sleep is the key to a healthy lifestyle? Read on to find why sleep is so essential for your health and how much sleep you should be getting each night.
Gun violence reframed as a public health issueWayne Caswell
Public Health officials have a legitimate interest in preventing gun violence, even if the NRA, Congress, and the health insurance and medical industries do not, because they profit more from gun sales and treating gun injuries and long-term disabilities than from preventing them.
At Modern Health Talk, we see the future of mHealth as less about Mobile health and more about MODERN healthcare that includes all sorts of solutions for addressing demographic shift of retiring baby boomers and the resulting doctor shortage.
These solutions include mobile technologies (smartphones & tablets) and big broadband support of high-def video calls with medical imaging, as well as new delivery options such as retail clinics and insurance-funded home care (and home modifications), remote sensor monitoring, healthcare robots, Watson-like cloud services, new laws & regulations, support of family caregivers, and more.
Affiliated with Boy Scouts of America, The Vigil Honor is the highest honor that the Order of the Arrow can bestow upon its members for service to lodge, council, and Scouting.
Chipping away at healthcare special interests yetWayne Caswell
In this article about public interests versus private interests, I reflect on the healthcare progress that consumers are making despite politicians working against them.
PURPOSE -- Choosing Why you live, not just HowWayne Caswell
Slides supporting a talk given to Austin's LaunchPad Job Club about finding Purpose in your life, or your job search, using my own journey as examples.
This is the complete technical spec of HomeRF V2.01 adopted 2001/05/07.
HomeRF is a frequency-hopping spread-spectrum wireless home networking technology that once dominated the market with over 90% share, but that was when Wi-Fi was still new and expensive. The market eventually decided on a single standard for work, home and public hotspots, and it was an improved and more affordable Wi-Fi. Still, the hopping design of HomeRF has some significant technical advantages.
A history of HomeRF and collection of presentations, whitepapers, and related materials is available in the HomeRF Archives. Just Google it.
It's risky to say that something can't or won't be done, especially when technology is concerned. Here are some past quotations that still haunt their speakers today:
For Wild Flower is a community park in the Dallas suburb of Flower Mound with an interesting funding model. You'll see from the slides that individuals and businesses alike can sponsor the various park equipment and even the brick pavers and fence pickets.
The commemorative plaque credits the various politicians and business leaders that helped make the park a success, and could be a model for others trying to fund their own land purchases and park development.
I created this handout for the Democratic National Convention. Homeowners of Texas, a nonprofit consumer advocacy, was urging Congress to adopt a Homeowners' Bill of Rights that includes financial, legal, and disclosure reforms.
XPS™ One™ Sales Aid (2007 2-page flyer)Wayne Caswell
I created this for Dell as Messaging Manager for consumer desktop PCs. I did the layout and graphics and wrote all of the copy. Before leaving Dell, I got permission to use documents shown here as samples of my work.
As Dell Messaging Manager for consumer desktop PCs, I created this brochure with help from Linksys for Dell's CES product launch. The images and messaging were a collaborative effort between the two companies.
I often took the initiative to suggest improvements to Dell's products, including features, design, messaging, and branding. Here I made an example of Apple, which has a consistent design language across products that reinforces its brand.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pharynx and Clinical Correlations BY Dr.Rabia Inam Gandapore.pptx
Sleep Statistics
1. INTELLIGENT SLEEP
Wayne Caswell
Founding Editor, Modern Health Talk
waynecaswell@mHealthTalk.com
Sleep Statistics from “Sleepless in America,” a National Geographic channel
documentary. (Watch at www.mhealthtalk.com/sleepless-in-america/)
How much sleep do we Need?
Every species studied to date (plant or animal) needs sleep.
Human Infants need 16 hours/day
Children ages 5-12 need 10-11 hours/night
Teens need 8-10 hours
Adults need 7-9 hours
Seniors need 6-8 hours
How much sleep do we Get?
2 hours — Americans sleep this much less than we did 150 years ago.
40% of all adults sleep less than 7 hours. (Actually most sleep less than 7 hrs Mon-Fri.)
>40% of night shift workers sleep less than 6 hours.
30% of all adult workers get less than 6 hours. (CDC, 2012)
70% of adolescents are sleep deprived.
Short Sleep is a KILLER
20% more likely to Die in 20 years
27% higher risk of Obesity
Hungrier: high-calorie, high-carb
Increased appetite for fatty foods 33%
500 more calories/day consumed (like adding 1 cheese burger/day to your diet)
30-40% reduced Glucose Metabolism
62% higher risk of Breast Cancer
48% higher risk of Heart Disease
5 times higher risk of Diabetes
>29M Americans have diabetes.
>79M more have pre-diabetes.
3 times higher risk of catching a Cold due to Impaired Immunity
4 times higher risk of Stroke
5 times higher risk of developing Depression
Brain Tissue loss and failure to clear out amyloid plaques & toxins associated with
Alzheimer’s
2. Drowsy Driving is a KILLER
20% of Car Accidents (>100,000/year)
1,500 Deaths
71,000 Injuries
$12.5 billion Monetary Loss
32% reduced Alertness with 1.5 less sleep
Like driving Drunk (<5 hours sleep as bad as 5% blood-alcohol)
Benefits of Good Sleep (messages for women)
Look Better: We all need our Beauty Sleep
Overall Appearance: less attractive, sad looking
Weight: Lose 14.3 lbs/yr with 1 hour more sleep
Health: Live longer & better
School: Develop higher IQ, get better grades
Family: Improved relationships & sex
Benefits of Good Sleep (messages for men)
Improved: attention, creativity, decision-making, focus, mood, reaction & recovery
times, working memory, and more
Resulting in: more raises & promotions, earning capacity, net worth
11% quicker recovery from Exhaustion (better workouts)
17% improved Reaction Times off the block (swimming)
3% improved Reaction Times (basketball)
0.1 second faster 40-yard dash (football)
42% boost in Hitting Accuracy (tennis)
3x fewer lapses in attention (baseball)
Naps among military pilots improved performance of 34% and alertness 100% (NASA)
Other Sleep Stats
Corporate productivity: $63 billion/year lost from sleep deprivation (Harvard Health
News, 2011)
Disasters: Experts now believe sleep deprivation played a role in:
the Exxon Valdez oil spill,
Staten Island Ferry crash, and
Three Mile Island nuclear meltdown, among others.
among other disasters.
Mood & Emotion: 60% more reactive
Medical errors: increase dramatically with long hours.
Students: later start times result in higher test scores, less depression, and 70% fewer
car crashes.
Only about 50% of people who try a CPAP machine for apnea continue to use it
regularly.
60M sleep medications were prescribed by US physicians in 2011.