Electronic Laboratory Notebook (ELN) Presentation by Farid Said of CSols, Inc. (the Premier Laboratory Informatics Experts). For more information and any questions visit: http://www.csolsinc.com

1. Premier Laboratory Informatics Experts
Strategic Planning  Implementation  Validation
Multiple Research Platforms:
One Single Data Sharing Portal
Farid A. Said
ELN Consultant

2. © 2017 CSols, Inc.
Speaker Introduction
Farid A. Said
 ELN Consultant
 Biopharmaceutical Experience:
 20 years interdisciplinary experience in medical sciences, scientific
research, scientific informatics computing with good understanding of
scientists' requirements
 Laboratory Informatics Experience:
 Leader and project manager for R&D Enterprise Electronic Laboratory
Notebook (ELN) implementations
 Specialization in strategic planning for laboratory informatics projects

3. © 2017 CSols, Inc.
Agenda
 High Level Architecture & Science Intelligence
 Strategic Role of Unified Platform in R&D
 Example of Collaborative Science Data Platform
 What do the Scientists Want?
 Use Case: ELN Template Design that Provides a “Hub”
application for user workflows
 Summary
 Q&A

4. © 2017 CSols, Inc.
High Level Architecture
& Science Intelligence
What Scientists Are Looking For…
• Creating Data
• Processing Data
• Analyzing Data
• Finding & Visualizing data
• Validating Data
• Sharing Data
Unified Corporate Portals
and Third Party Integration Technologies
ERP/SAP
MRP/MES
P
L
M
Integration&
Connections

5. © 2017 CSols, Inc.
Strategic Role of Unified Platform in R&D
Chemistry
Informatics
Chemical
Structure Drawing
Tools
3 D Modeling
SAR
Compound
Registration (IP)
Biology
Informatics
Cell Biology
Efficacy Assays
Bioanalytical
DMPK
Biochemistry
HTS
In Vivo
Clinical
Informatics
PK / PD Studies
Patient Samples
Management
Pre-clinical Tox
studies
Enterprise Scientific Search
Instruments &
Equipment
Systems:
SAP, ERP,LIMS, ELN, CDS etc..

6. © 2017 CSols, Inc.
Experiment
Results
Chemical
Registration
QC/Analytical
Synthesis of
Product
Track Product
Suppliers
Decide what to
make
Chemical DB
Explore Libraries
Literature
& References
Inventory
Manager
Procurement
Order Reagents
Instruments
Systems
Methods & SOPs
Instruments
(NMR/HPLC)
Systems
(LIMS/EDMS)
CoA etc.…
Compound
Registration (IP)
Container Inventory
Structure Search
Reports
Level 1:
Simple Capture of Experiment Results
Example of Collaborative Science Data Platform
ELN
EDMS
SDMS

7. © 2017 CSols, Inc.
Experiment
Results
Chemical
Registration
QC/Analytical
Synthesis of
Product
Track Product
Suppliers
Decide what to
make
Chemical DB
Explore Libraries
Literature
& References
Inventory
Manager
Procurement
Order Reagents
Instruments
Systems
Methods & SOPs
Instruments
(NMR/HPLC)
Systems
(LIMS/EDMS)
CoA etc.…
Compound
Registration (IP)
Container Inventory
Structure Search
Reports
Level 2:
 Capture of Experiment Results
 Compound Registration System Integration for IP Protection
 Inventory Manager Integration
 Chemical structure (including sub-structure) Search
ELN
EDMS
SDMS
Example of Collaborative Science Data Platform. Cont.

8. © 2017 CSols, Inc.
Experiment
Results
Chemical
Registration
QC/Analytical
Synthesis of
Product
Track Product
Suppliers
Decide what to
make
Chemical DB
Explore Libraries
Literature
& References
Inventory
Manager
Procurement
Order Reagents
Instruments
Systems
Methods & SOPs
Instruments
(NMR/HPLC)
Systems
(LIMS/EDMS)
CoA etc.…
Compound
Registration (IP)
Container Inventory
Structure Search
Reports
Level 3:
 Capture of Experiment Results
 Compound Registration System Integration for IP Protection
 Chemical structure (including sub-structure) Search
 Instruments & Systems Integration
 Document Manager (QA/QC)
ELN
EDMS
SDMS
Example of Collaborative Science Data Platform. Cont.

9. © 2017 CSols, Inc.
Experiment
Results
Chemical
Registration
QC/Analytical
Synthesis of
Product
Track Product
Suppliers
Decide what to
make
Chemical DB
Explore Libraries
Literature
& References
Inventory
Manager
Procurement
Order Reagents
Instruments
Systems
Methods & SOPs
Instruments
(NMR/HPLC)
Systems
(LIMS/EDMS)
CoA etc.…
Compound
Registration (IP)
Container Inventory
Structure Search
Reports
Level 4:
Full Capture Of Data Workflow and Decision Across Project
ELN, EDMS and SDMS
Example of Collaborative Science Data Platform. Cont.

10. © 2017 CSols, Inc.
What do the Scientists want?
 Workflow Support
 Complex experimental design and setup
 Sample materials tracking
 Data sharing
 Data Support
 Import instrument data
 Capture subjective data and observations
 Statistical analysis
 Data Searching and Reporting
 Example Departments
 ADME
 DMPK
 Toxicology

11. © 2017 CSols, Inc.
Use Case: Collaborative Template Design that
Provides a “Hub” application for user workflows
Phase I: Strategy
 The Evaluation
 Results of detailed requirements review from different contributing groups:
 Chemistry
 Formulation
 In vivo
 Bio-analytical
 Requirements Gathering
 As-Is Workflow
 Stakeholders Interview process
 Each group uses a single specific ELN interface
 To-Be Workflow
 Create/Design a common template that can be used by all groups
 Benefits Analysis
 Qualitative: Workflow Support, Easy tracking and sharing with high user compliance
 Quantitative: Time saving

12. © 2017 CSols, Inc.
Use Case: Collaborative Template Design that Provides a “Hub” application
for user workflows.
Phase I: Strategy Cont.
 Issue: One project, multiple groups, multiple templates
Study Director
Study Coordinators
Study Request
Study Design
Chemistry Formulation In Vivo Bioanalytical
Template 1
Template 2
Template 3 Template 4 Template 5 Template 6
Consultation Dpt. Heads PTL, authorization etc...

13. © 2017 CSols, Inc.
Solution: One Project, Multiple Groups One Single User Friendly Interface
Use Case: Collaborative Template Design that Provides a “Hub” application
for user workflows.
Phase II: Strategy Cont.

14. © 2017 CSols, Inc.
Solution: One Project, Multiple Groups One Single User Friendly Interface
Use Case: Collaborative Template Design that Provides a “Hub” application
for user workflows.
Phase II: Strategy Cont.

15. © 2017 CSols, Inc.
Solution: One Project, Multiple Groups One Single User Friendly Interface
Use Case: Collaborative Template Design that Provides a “Hub” application
for user workflows.
Phase II: Strategy Cont.

16. © 2017 CSols, Inc.
Solution: One Project, Multiple Groups One Single User Friendly Interface
Use Case: Collaborative Template Design that Provides a “Hub” application
for user workflows.
Phase II: Strategy Cont.

17. © 2017 CSols, Inc.
Solution: One Project, Multiple Groups One Single User Friendly Interface
Use Case: Collaborative Template Design that Provides a “Hub” application
for user workflows.
Phase II: Strategy Cont.

18. © 2017 CSols, Inc.
Solution: One Project, Multiple Groups One Single User Friendly Interface
Use Case: Collaborative Template Design that Provides a “Hub” application
for user workflows.
Phase II: Strategy Cont.

19. © 2017 CSols, Inc.
Solution: One Project, Multiple Groups One Single User Friendly Interface
Use Case: Collaborative Template Design that Provides a “Hub” application
for user workflows.
Phase II: Strategy Cont.

20. © 2017 CSols, Inc.
Summary
 Unify lab data management and document management
workflow
 Automatic integration of lab systems and instrumentation
 Improve legibility for audit trail and patent purposes
 Coordinating efforts of different groups
 Handling large quantities of screening data
 Locating/tracking products/supplies
 Maintaining adequate security

21. © 2017 CSols, Inc.
Thank you
Farid A. Said
ELN Consultant
www.csolsinc.com
Questions?