Signal detection theory provides an approach for understanding how humans make decisions about detecting stimuli when there is uncertainty. It assumes the brain must differentiate between neural activity caused by background noise alone versus neural activity caused by a stimulus superimposed on the noise. The theory accounts for factors like sensitivity to the stimulus and cognitive biases. A key concept is that the brain establishes a criterion for determining whether the neural activity reflects a stimulus, which can be adjusted to prioritize hits or avoid false alarms. The sensitivity and specificity achieved for different criteria are represented using tools like receiver operating characteristic curves.
Medicines Used for Glaucoma Management _Optom LectureGauriSShrestha
the most commonly prescribe treatment for glucoma is eye drops. These medicine decreases IOP to the level that prevents damage to the optic nerve by either decrease acqueous secretion from the ciliary body or facilitating acqueous drainage through the trabecular or uveoscleral outflow systems. This presentation outlines the principal eye medicine currently used in ophthalmic practice.
Ocular steroids-Dexamethasone, Betamethasone, Prednisolone and FlurometholoneGauriSShrestha
Corticosteroids are secreted by the adrenal cortex.
Adrenocorticotrophic hormone(ACTH) stimulates the adrenal cortex to produce corticosteroids.
Types of adrenal cortex-related steroids are glucocorticoids and mineralocorticoids. Corticosteroids have anti-inflammatory and immunosuppressive effects
NSAIDs are analgesic, antipyretic and anti-inflammatory drugs.
Non-narcotic, non-opioid, aspirin-like drugs
Primarily, acts on peripheral pain mechanism and do not depress the central nervous system
Some protective role against cancer and cardiovascular diseases (e.g., aspirin, antithrombotic effects)
Accounts for 5% of all drugs prescribe globally
30 million people consume NSAIDs every day
Available over the counter medicine in most countries
Ocular anti-infective agents: Antibiotics, Antivirals and antifungalsGauriSShrestha
Anti-infective agents are effective against a variety of infections (e.g., virus, rickettsiae, bacteria, fungi and protozoa) and cause competitive inhibition of a biochemical process of pathogens. Minimum inhibitory concentration (MICs) are often used for common anti-infective drugs. In the eye, route of drug administration is determined by the locus of infection. However, this ppt covers mostly topical and common antibacterial, antiviral and antifungal medicines.
Pediatric refraction is one of the challenging areas of optometry practice. I am so glad to share some of the important aspect of pediatric refraction.
Medicines Used for Glaucoma Management _Optom LectureGauriSShrestha
the most commonly prescribe treatment for glucoma is eye drops. These medicine decreases IOP to the level that prevents damage to the optic nerve by either decrease acqueous secretion from the ciliary body or facilitating acqueous drainage through the trabecular or uveoscleral outflow systems. This presentation outlines the principal eye medicine currently used in ophthalmic practice.
Ocular steroids-Dexamethasone, Betamethasone, Prednisolone and FlurometholoneGauriSShrestha
Corticosteroids are secreted by the adrenal cortex.
Adrenocorticotrophic hormone(ACTH) stimulates the adrenal cortex to produce corticosteroids.
Types of adrenal cortex-related steroids are glucocorticoids and mineralocorticoids. Corticosteroids have anti-inflammatory and immunosuppressive effects
NSAIDs are analgesic, antipyretic and anti-inflammatory drugs.
Non-narcotic, non-opioid, aspirin-like drugs
Primarily, acts on peripheral pain mechanism and do not depress the central nervous system
Some protective role against cancer and cardiovascular diseases (e.g., aspirin, antithrombotic effects)
Accounts for 5% of all drugs prescribe globally
30 million people consume NSAIDs every day
Available over the counter medicine in most countries
Ocular anti-infective agents: Antibiotics, Antivirals and antifungalsGauriSShrestha
Anti-infective agents are effective against a variety of infections (e.g., virus, rickettsiae, bacteria, fungi and protozoa) and cause competitive inhibition of a biochemical process of pathogens. Minimum inhibitory concentration (MICs) are often used for common anti-infective drugs. In the eye, route of drug administration is determined by the locus of infection. However, this ppt covers mostly topical and common antibacterial, antiviral and antifungal medicines.
Pediatric refraction is one of the challenging areas of optometry practice. I am so glad to share some of the important aspect of pediatric refraction.
1. Signal Detection Theory
Resources: Visual Perception
A Clinical Orientation Steven H. Schwartz
"Signal detection theory". Encyclopedia of
Psychology. FindArticles.com. 03 Jun, 2010.
http://findarticles.com/p/articles/mi_g2699/is_000
3/ai_2699000316/
adapted from Professor David Heeger
Gauri S Shrestha, M.Optom
2. Background
The activity led to the development of the idea
of a threshold detection with stimulus
even though the level of stimulation remained
constant, people were inconsistent in detecting
the stimulus
There is no single, fixed value below which a
person never detects the stimulus and above
which the person always detects it
An approach to resolving this dilemma is
provided by signal detection theory
Gauri S. Shrestha, M.Optom
3. Back ground
This approach abandons the idea of a
threshold.
Instead, the theory involves treating
detection of the stimulus as a decision-
making process
Determinant of this process
thenature of the stimulus,
Sensitivity of a person to the stimulus, and
cognitive factors
Gauri S. Shrestha, M.Optom
4. Back ground
in a typical sensory experiment that involves a
large number of trials, an observer must try to
detect a very faint sound or light that varies in
intensity from clearly below normal detection
levels to clearly above.
There are two possible responses, "Yes" and
"No." There are also two different possibilities
for the stimulus, either present or absent.
when stimuli are difficult to detect, cognitive
factors are critical in the decision an observer
makes
Gauri S. Shrestha, M.Optom
6. The Human Threshold and Signal
detection theory
We do not manifest a perfect threshold
Due to decision criteria, attention, and internal
neural noise
What is the Signal Detection Theory?
Decision making takes place in the presence of some
uncertainty
A model that addresses the role of these factors in
determining a threshold
It provides a precise language and graphic notation for
analyzing decision making in the presence of uncertainty
Gauri S. Shrestha, M.Optom
7. SIGNAL DETECTION THEORY
The precise notion/model of analysis
decision making process in the presence
of uncertainty
Gauri S. Shrestha, M.Optom
8. The basic idea behind signal detection
theory is that
The level of neural noise fluctuates constantly.
When a faint stimulus, or signal, occurs, it
creates a neural response.
The brain must decide whether the neural
activity reflects noise alone, or whether there
was also a signal.
Gauri S. Shrestha, M.Optom
9. Signal detection theory
Neural Noise: Neurons are constantly sending
information to the brain, even when no stimuli are
present.
The level of neural noise fluctuates constantly.
When a faint stimulus, or signal, occurs, it creates a
neural response.
The brain must decide whether the neural activity
reflects
noise alone, or also a signal
When stimulus is difficult to detect= cognitive
factors are critical
Gauri S. Shrestha, M.Optom
10. Payoff Matrix: combination of rewards and
penalties for correct and incorrect decisions
There is always a trade-off between the
number of Hits and False Alarms
When a person is very willing to say that the
signal was present, that individual will show
more Hits, but will also have more False
Alarms.
mathematical approaches to determine the
sensitivity of an individual for any given pattern
of Hits and False Alarms- index of sensitivity
(d‘)
Gauri S. Shrestha, M.Optom
11. contents
Graphic interpretation of signal detection
theory
Receiver Operating Characteristics (ROC
curve)
Discriminability index (d')
Examples
Gauri S. Shrestha, M.Optom
12. Signal Detection Theory
Assumes there is random, fluctuating level of
background neural noise
A stimulus’ signal is superimposed on this
noise
This makes the observer’s task to differentiate:
A. The signal and noise combination
B. The noise alone
Gauri S. Shrestha, M.Optom
13. What To Remember…
The noise is random and fluctuating
The signal is constant
The noise is always present and the signal is
superimposed
The larger the signal, the easier it is for the
observer to detect
Gauri S. Shrestha, M.Optom
14. Internal response and internal noise
External noise: environmental factor,
smugs, light, etc .
Internal noise: Internal noise refers to the
fact that neural responses are noisy.
A doctor has a set of X detector neurons and
monitor the response of one of these neurons to
determine the likelihood that there is a X.
These hypothetical X detectors will give noisy
and variable responses
Gauri S. Shrestha, M.Optom
15. Internal response and internal noise
Internal response:
determines the one’s impression about whether
or not a x factor is present.
the state of the mind is reflected by neural
activity somewhere in the brain.
This neural activity might be concentrated in just
a few neurons or it might be distributed across a
large number of neurons.
refer to it as internal response
Gauri S. Shrestha, M.Optom
16. Detectability
d’
Internal response probability of occurrence curves for
noise-alone and for signal-plus-noise trials.
Gauri S. Shrestha, M.Optom
17. Detectability
Definition: The difference between the
means of N and N + S
Detectability increases as the distributions of
N and N + S become further apart
With a very large ‘d,’ there is no uncertainty
whether the stimulus is present
With a weak stimulus, the ‘d’ becomes much
smaller
Gauri S. Shrestha, M.Optom
18. Where does Confusion Occur?
Since the curves overlap, the internal response for a noise-alone trial
may exceed the internal response for a signal-plus-noise trial.
Vertical lines correspond to M.Optom
Gauri S. Shrestha, the criterion response
19. Information acquisition criterion
SIGNAL
R Present Absent
E
S YES HIT False alarm
HIT False alarm
P
O
N
NO Correct rejection
S Miss Correct rejection
E
Sensitivity= hit/hit+miss
Specificity= Correct rejection/CR+False alarm
Gauri S. Shrestha, M.Optom
20. Observer Responses
False Positive (False Alarm)
Observer reports stimulus when stimulus is not present
Correct Reject
Observer does not report stimulus when stimulus is
absent
Hit
Observer reports stimulus when stimulus is present
Miss
Observer does not report stimulus when stimulus is
present
Gauri S. Shrestha, M.Optom
21. Subject Criterion
Lax Criterion vs. Strict Criterion
Lax: Indicate a stimulus even with a great deal of
uncertainty (example: optometrist)
Strict: Do not indicate a stimulus until they are
certain one is present (Example: hunter)
A Lax criterion results in a substantial number
of false positives, but very few misses
A Strict criterion results in fewer hits, but a
lower number of false positives
Gauri S. Shrestha, M.Optom
24. The Receiver Operating Characteristic
captures the various alternatives that are available
to the examiner in a single graph
ROC curves are plotted with the false alarm rate on
the horizontal axis and the hit rate on the vertical
axis.
if the criterion is high, then both the false alarm rate
and the hit rate will be very low. If we move the
criterion lower, then the hit rate and the false alarm
rate both increase.
For any reasonable choice of criterion, the hit rate
is always larger than the false alarm rate, so the
ROC curve is bowed upward
Gauri S. Shrestha, M.Optom
26. A measure of goodness-of-fit is based
on the simultaneous measure of
sensitivity (True positive) and specificity
(True negative) for all possible cutoff
points.
Gauri S. Shrestha, M.Optom
27. Receiver Operating Characteristic (ROC)
a generalization of the set of potential
combinations of sensitivity and specificity
possible for predictors
AUC values closer to 1 indicate the reliable
screening measure whereas values at .50
indicate the predictor is no better than chance
Gauri S. Shrestha, M.Optom
28. Varying the noise
For stronger signals, the
probability of occurrence curve for
signal-plus-noise shifts right and
detection is easier
The spread of the curves: The
separation between the peaks is
the same but the second set of
curves are much skinnier. Clearly,
the signal is much more
discriminable when there is less
spread (less noise) in the
probability of occurrence curves.
Gauri S. Shrestha, M.Optom
29. When Does Criterion Not Effect?
d' = z(FA) - z(H)
d’ =0
Stimulus is so weak, no signal is produced
Regardless of criteria, the proportion of hits
will match the proportion of false positives
d’ = infinity
Stimulus is easily distinguished and will
always be seen by the observer (No false
positives)
Gauri S. Shrestha, M.Optom
30. Discriminability index (d'):
d' = separation / spread
This number, d', is an estimate of the
strength of the signal.
its value does not depend upon the criterion
the subject is adopting,
it is a true measure of the internal response
Gauri S. Shrestha, M.Optom
31. How Do We Determine
Thresholds?
Methods:
Method of Ascending Limits
Method of Descending Limits
Staircase Method
Method of Constant Stimuli
Method of Adjustment
Forced Choice Method
Gauri S. Shrestha, M.Optom
32. Method of Ascending Limits
Stimulus is initially presented below threshold
Stimulus is presented at increasingly intense
levels from presentation to presentation until
visible by observer
Advantage:
Relatively quick method
Disadvantage:
Participant Anticipation
How to Avoid: Start each trial with stimulus of a
different intensity
Gauri S. Shrestha, M.Optom
33. Method of Descending Limits
Reverse of Ascending Limits Method
Stimulus initially presented clearly visible
and reduced until no longer seen
Example: Visual Acuity
Disadvantage:
Patient Anticipation
How to Avoid: start each trial a different level
of visibility
Gauri S. Shrestha, M.Optom
34. Staircase Method
Combination of Ascending and Descending
How Does It Work?
Stimulus starts below threshold
Presented in discrete steps of increasing visibility until
observer reports stimulus
Visibility is reduced in discrete steps until stimulus can
no longer be detected
Staircase is again reversed
Thresholdis defined after three or four reversals
Advantage: Quick and Reliable
Example: Frequently used in Visual Field Testing
Gauri S. Shrestha, M.Optom
36. Method of Constant Stimuli
Stimulus is randomly varied from
presentation to presentation
Large number of stimuli presented at
each level of visibility
Advantage:
No Patient Anticipation
Disadvantage:
Time Consuming (not typically used
clinically)
Gauri S. Shrestha, M.Optom
37. Method of Adjustment
Participants adjust intensity until the
stimulus is barely visible
Advantage:
Relatively quick
Disadvantage:
Patient criteria skews results
Gauri S. Shrestha, M.Optom
38. Forced Choice Method
Minimizes the role of individual’s criterion
Patient is forced to choose between several
alternative choices (one contains the
stimulus)
A Different Number of Choices Can Be
Given:
2 Alternative Choice Method
4 Alternative Choice Method
Typically results in lower thresholds
Gauri S. Shrestha, M.Optom
39. Threshold Determination
Threshold = Midway between 100% correct and
‘chance’
Chance=percentage we expect observer to guess
correctly
2 Alternative Choice Method
‘Chance’ performance=50% correct
Threshold=75% correct
4 Alternative Choice Method
‘Chance’ Performance=25% correct
Threshold=62.5% correct
Gauri S. Shrestha, M.Optom
In other words, a person will be able to detect more intense sounds or lights more easily than less intense stimuli. Further, a more sensitive person requires less stimulus intensity than a less sensitive person would. Finally, when a person is quite uncertain as to whether the stimulus was present, the individual will decide based on what kind of mistake in judgment is worse: to say that no stimulus was present when there actually was one or to say that there was a stimulus when, in reality, there was none. An example from everyday life illustrates this point. Suppose a person is expecting an important visitor, someone that it would be unfortunate to miss. As time goes on, the person begins to "hear" the visitor and may open the door, only to find that nobody is there. This person is "detecting" a stimulus, or signal, that is not there because it would be worse to miss the person than to check to see if the individual is there, only to find that the visitor has not yet arrived.
If a person participates in an experiment and receives one dollar for each Hit and there is no penalty for a False Alarm, then it is in the person's best interest to say that the stimulus was present whenever there is uncertainty. On the other hand, if the person loses two dollars for each False Alarm, then it is better for the observer to be cautious in saying that a stimulus occurred. This combination of rewards and penalties for correct and incorrect decisions is referred to as the Payoff Matrix. If the Payoff Matrix changes, then the person's pattern of responses will also change. This alteration in responses is called a criterion shift.
For very intense signals, there is no problem in deciding if there was a stimulus because the neural effect of the signal far outweighs the neural effect of the noise. Similarly, when there is no signal, the nervous system does not respond as it does when an outside signal is present, so decisions are easy. On the other hand, for near-threshold signals, it can be difficult to know whether neural activity results from noise alone or from a signal plus noise. At this point, the observer makes a decision based on the payoff matrix.