Sonic hedgehog (Shh) is a protein that plays an important role in the development of the nervous system. During development, Shh signaling helps establish dorsal-ventral polarity in the neural tube and patterns cell types along this axis. Shh is produced in the floor plate and notochord and forms concentration gradients that determine cell fates in the spinal cord and brain. Alterations to Shh signaling can lead to neural developmental defects and craniofacial abnormalities.

1. IN THE NAME OF GOD
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2. Role of Sonic hedgehog (Shh) protein in development of the
nervous system
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3. Development of the nervous system
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http://dx.doi.org/10.3389/fgene.2012.00081

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5. Gastrulation and nerulation
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6. Neural tube formation
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Neural Groove
Neural Tube
Brain
Spinal Cord

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DEVELOPMENTAL BIOLOGY 3230

8. The developing neural tube is divided into 4 plates
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Roof plate: signaling center, Alar plate: sensory, Basal plate: motor, Floor plate:
signaling center

9. Shh & BMPs gradients in the vertebrate neural tube
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Nature Reviews Neuroscience 5, 409-419 (May 2004)

10. Roles of Shh & BMPs signaling in neural development
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Home , Vol 36, No 11 (2015), AlKattan

11. Dorsal-ventral axis in the neural tube
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Dorsal-ventral polarity in the neural tube is established by TGF-ß family, BMPs and
Sonic hedgehog (Shh).
Gilbert, S.F. (2000). Developmental Biology

12. BMP Family and Signaling Pathways
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Genes & Diseases. Volume 1, Issue 1, September 2014, Pages 87–105

13. Roles of Shh signaling in neural development
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http://dx.doi.org/10.3389/fncel.2013.00087

14. Production and secretion of Shh protein
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Gilbert, S.F. (2000). Developmental Biology

15. Sonic hedgehog (Shh) signaling
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Herzog, W. et al. (2003). Developmental Biology. 254. 1.
Shh interacts with two transmembrane proteins as it interacts with cells in the neural
tube.

16. Role of Shh and Ihh in the endodermal-mesodermal tissue
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Physiological Reviews Published 1 October 2007 Vol. 87 no. 4, 1343-1375
Three mammalian hedgehog genes, sonic hedgehog (Shh), indian hedgehog (Ihh),
and desert hedgehog (Dhh) have been identified.

17. Alcohol-induced craniofacial abnormalities
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Brain Sci. 2013, 3(2), 964-991

18. Craniofacial Malformations in Fetal Alcohol Syndrome (FAS)
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Embryonic Development of Craniofacial Malformations in Fetal Alcohol Syndrome
(FAS)
Liz Shaw.Last modified February 21, 2011.

19. Sonic hedgehog in the mammalian tissue
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Western Blot: Sonic Hedgehog Antibody [NBP2-22139] - WB detection of Sonic
Hedgehog in A. human stomach, B. human fetal liver membrane, C. PC12 and D.
.fibroblast-like cell line derived from monkey kidney tissue
Support: 1-888-506-6887 | technical@novusbio.com

20. References
• The genetic and epigenetic journey of embryonic stem cells into mature neural
cells. Brendan M. Olynik, and Mojgan Rastegar. Front. Genet., 18 May 2012.
• En1 and Wnt signaling in midbrain dopaminergic neuronal development.
• Maria TM Alves dos Santos and Marten P Smidt. Neural Development 2011.
• Glial specification in the vertebrate neural tube. David H. Rowitch. Nature
Reviews Neuroscience 5, 409-419 (May 2004)
• Gilbert, S.F. (2000). Developmental Biology (Sunderland, Massachusetts: Sinauer
Associates, Inc., Publishers).
• Herzog, W. et al. (2003). Adenohypophysis formation in the zebrafish and its
dependence on sonic hedgehog. Developmental Biology. 254. 1.
• BMP signaling in telencephalic neural cell specification and maturation.
Beatriz Gámez, Edgardo Rodriguez-Carballo and Francesc Ventura. Front. Cell.
Neurosci., 04 June 2013.
• Bone Morphogenetic Protein (BMP) signaling in development and human
diseases. Richard N. Wang, Jordan Green, Zhongliang Wang. Genes & Diseases.
Volume 1, Issue 1, September 2014, Pages 87–105
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21. • Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal
Tract. Gijs R. van den Brink. Physiological Reviews Published 1 October 2007 Vol.
87 no. 4, 1343-1375
• Transport of maternal cholesterol to the fetus is affected by maternal plasma
cholesterol concentrations in the Golden Syrian hamster. Katie T. Burke, Perry
L. Colvin, Leslie Myatt, et al. Manuscript received 19 October 2008 and in revised
form 11 December 2008 and in re-revised form 23 December 2008.
• Mechanisms of Alcohol-Induced Damage to the Developing Nervous System.
Charles R. Goodlett, Ph. D , and Kristin H. Horn
• Role of Sonic Hedgehog (Shh) in Alcohol-Induced Craniofacial Abnormalities.
by Erica O'Neil Keywords
• Fetal Alcohol Spectrum Disorder (FASD) Associated Neural Defects: Complex
Mechanisms and Potential Therapeutic Targets. Pooja Muralidharan ,
Swapnalee Sarmah , Feng C. Zhou and James A. Marrs. Brain Sci. 2013, 3(2),
964-991
• The pathogenesis of the clinical features of oral-facial-digital syndrome type I.
Wael M. AlKattan, MBBS, Mohammad M. Al-Qattan, MBBS, Sameer A. Bafaqeeh,
MBBS. Home , Vol 36, No 11 (2015), AlKattan
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22. Thank you
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