Invasion of the skin or mucous membranes by a pathogenic organism or parasite.
Infection in which entrance of the pathogenic organism (or the parasite) occurs through the skin or mucus membranes.
Some infectious agents can invade the intact (undamaged) skin or mucous membranes, but the majority needs injured surfaces in the form of abrasions, scratches, wounds or ulcers.
Oral Manifestation of HIV. In detail history of the origin of HIV, the Virus pathology, Classification of HIV.
Systematic manifestation and Oral Manifestation of HIV.
The various tests available for HIV testing and Drug regimens for HIV, Immuno-compromised, pregnant and PCP'S
Invasion of the skin or mucous membranes by a pathogenic organism or parasite.
Infection in which entrance of the pathogenic organism (or the parasite) occurs through the skin or mucus membranes.
Some infectious agents can invade the intact (undamaged) skin or mucous membranes, but the majority needs injured surfaces in the form of abrasions, scratches, wounds or ulcers.
Oral Manifestation of HIV. In detail history of the origin of HIV, the Virus pathology, Classification of HIV.
Systematic manifestation and Oral Manifestation of HIV.
The various tests available for HIV testing and Drug regimens for HIV, Immuno-compromised, pregnant and PCP'S
Major reason for failures in the field of medicine is infections. So its a prime duty to know and follow the protocols to infection control, in the dental field as well.
Remember AIDS does not discriminate cast, creed, religion, education or social status.
Prevention of AIDS is our joint responsibility
Education and awareness is only weapon in our hand..
Group of communicable diseases in which sexual contact is the most important mode of transmission.
Importance:
1. Increasing incidence worldwide.
2. The cost and difficulties in the treatment of the diseases and their complications.
3. It is a socioeconomic problem as well as behavioral one since it is linked to addiction, low level of religious values, increase age of marriage, etc.
Invasion of the skin or mucous membranes by a pathogenic organism or parasite.
Infection in which entrance of the pathogenic organism (or the parasite) occurs through the skin or mucus membranes.
Some infectious agents can invade the intact (undamaged) skin or mucous membranes, but the majority needs injured surfaces in the form of abrasions, scratches, wounds or ulcers.
Major reason for failures in the field of medicine is infections. So its a prime duty to know and follow the protocols to infection control, in the dental field as well.
Remember AIDS does not discriminate cast, creed, religion, education or social status.
Prevention of AIDS is our joint responsibility
Education and awareness is only weapon in our hand..
Group of communicable diseases in which sexual contact is the most important mode of transmission.
Importance:
1. Increasing incidence worldwide.
2. The cost and difficulties in the treatment of the diseases and their complications.
3. It is a socioeconomic problem as well as behavioral one since it is linked to addiction, low level of religious values, increase age of marriage, etc.
Invasion of the skin or mucous membranes by a pathogenic organism or parasite.
Infection in which entrance of the pathogenic organism (or the parasite) occurs through the skin or mucus membranes.
Some infectious agents can invade the intact (undamaged) skin or mucous membranes, but the majority needs injured surfaces in the form of abrasions, scratches, wounds or ulcers.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Shakhidulla Aiymzhan 5 ppt.pptx
1. Department of «Infectious diseases and
Dermatovenereology»
FACULTY: General Medicine
SUBJECT:Infectious
Submitted by:Shakhidulla Aiymzhan
Group : 09-20
Submitted to: Polukchi T. V.
Viral hepatitis (A, E, B, C, D)
2. Discussed questions:
1. The problem of viral hepatitis
2. Classification of hepatitis viruses.
-Hepatitis A virus. Taxonomy. Virion structural features, cultivation, resistance, ways of infection.
Pathogenesis of the disease, clinic. Microbiological diagnosis, specific treatment and prevention.
- Hepatitis B virus. Taxonomy. Structural characteristics of the virion, antigens - HBs, HBс, HBe, HBx,
reproduction characteristics, cultivation, persistence, ways of infection. Pathogenesis of the disease,
mechanism of persistence, clinic. Immunity. Microbiological diagnosis, specific treatment and
prevention
- Hepatitis D virus. Virion structural features, antigens, cultivation. Features of delta-infection
(coinfection, superinfection), pathogenesis of the disease. Microbiological diagnosis, treatment and
prevention
- Hepatitis C virus. Virion structural features, genotypes, antigenic variability, cultivation,
persistence, ways of infection. Pathogenesis, clinic, chronicity of the disease. Microbiological
diagnosis, treatment and prevention
-Hepatitis E virus. Virion structural features, genome, antigens, cultivation, persistence, ways of
infection. Pathogenesis, clinic, complications of the disease (during pregnancy). Microbiological
diagnosis, main markers of infection, specific treatment and prevention
-Hepatitis G virus. Virion structural features, genome, variability, epidemiology, clinical forms,
complications. Microbiological diagnosis and treatment.
3. Purpose of the lesson:
• To acquaint students with the problem of viral hepatitis, to provide information
about the morpho-biological characteristics of hepatitis A, B, C, D, E, G viruses, to
introduce them to the methods of microbiological diagnosis of viral hepatitis.