This document appears to be a seminar submission on sepsis to Mrs. Nadiya Krishnan, an assistant professor. It includes definitions of sepsis, systemic inflammatory response syndrome (SIRS), and septic shock. It discusses risk factors, common infection sites, clinical manifestations, pathophysiology involving multiple organ systems, diagnostic tests, and management based on the Surviving Sepsis Campaign guidelines. The management focuses on initial resuscitation, screening, diagnosis, antimicrobial therapy, and meeting bundles within 3 and 6 hours to control infection and reduce mortality from sepsis.
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Multiple Organ Dysfunction Syndrome (MODS).Pinky Rathee
The presence of altered organ function in a client who is acutely ill such that hemeostasis cannot be maintained without intervention. MODS is present when two or more organs fail .MODS results from SIRS
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Multiple Organ Dysfunction Syndrome (MODS).Pinky Rathee
The presence of altered organ function in a client who is acutely ill such that hemeostasis cannot be maintained without intervention. MODS is present when two or more organs fail .MODS results from SIRS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
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STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Triangles of Neck and Clinical Correlation by Dr. RIG.pptx
sepsis .pptx
1. Submitted to
Mrs.Nadiya Krishnan
Assistant professor
College of nursing
AIIMS Bhubaneswar
seminar
Submitted by
Revathy S
1st year MSc Nursing
College of nursing
AIIMS Bhubaneswar
2.
3. Introduction
Infection is the most common cause of mortality in critically ill
patients
SIRS
Sepsis
Sepsis syndrome is the systemic host response to infection.
The incidence of sepsis syndrome is on the rise.
This condition claims life in very young, very old or
immunocompromised.
Sep 13
4. Definition
Sepsis is defined as one or most life-threatening organ
dysfunctions caused by a dysregulated host response to
infection
Septic shock is a subset of sepsis
5.
6. Non-septic triggers of dysregulated systemic
pro & anti inflammatory responses
Trauma
Pancreatitis
Major burns
Major surgical procedures
Hemorrhage
Ischemic tissue
Period of inadequate perfusion
7.
8. Risk factors
Extremes of age
People with chronic medical conditions – DM, Lung disease,
cancer
People with weakened immune system
Sepsis survivors
Malnutrition
Drug or alcohol abuse
Neutropenia
Splenectomy
Multiple organ failure
9.
10. Common sites
The most common sites of infection for severe sepsis varied by
gender. The sites and frequency were:
Respiratory: 42% men 36% women
Bacteremia: (site unspecified) 21% men 34% women
Abdominal: 9% men 10% women
Genitourinary: 10% men, 9% women
Wound/soft tissues: 9% men 8% women
Other sources: 9% men 10% women
Among older patients, the urinary tract was the most common
source of infection.
13. Cont.
Increased respiratory rate (early) or decreased RR (late)
Crackles
Change in sensorium
Decreased urine output
Increased temperature
14. Bacterial pathogens in sepsis
A final common pathway?
Gram-negative Gram-positive
Cell wall components
Extracellular products
Endotoxin and
other toxins
SEPSIS
INFLAMMATION
e.g. Staphylococcus aureus
Streptococcus pneumoniae
Enterococcus faecalis
e.g. Neisseria meningitidis
Escherichia coli
Host immune response Host immune response
15. Pathophysiology
Micro organism enters the body
Stimulate the inflammatory or immune system
Host pathogen interaction
Both invading organism and injured tissue release intracellular
protein
Activates enzyme cascade
Infection is contained and eradicated
16. When magnitude of the infectious insult
is great
Patient is physiologically unable to generate a effective host
response.
Containment fails.
Systemic release of the pathogen, activated cells, and
mediators including cytokines, which initiates a chain of
complex interaction
Uncontrolled SIRS
17. Infection
Immune system response
Release of mediators from WBCs and avascular endothelium
Increased
inflammation
Endothelial
damage
Decreased
fibrinolysis
Increased
inflammation
Altered tissue perfusion Microthrombi Capillary leak
Organ system
dysfunction
Edema
formation
Death
18. Cardiovascular alterations
Septic shock is associated with 3 main pathophysiologic effect on the CVS:
vasodilation, mal-distribution of blood flow and myocardial depression
Pro-inflammatory cytokines
Stimulate the release of NO from endothelial cells
NO is a potent vasodilator
Potent vasodilation
Decreased SVR
Decreased venous return to the heart
Decreased CO
19. Cont..
Release of endothelin
Causes vasoconstriction other vascular bed
Combination of vasoconstriction and dilation
Maldistribution of blood flow in all micro circulation
20. Pulmonary alterations
Affect the lung both directly and indirectly
Activation of SNS and release of epinephrine from the
adrenal medulla causes bronchodilation
However, inflammatory cytokines override the effect of
epinephrine and causes bronchoconstriction
Inflammatory mediators and activated neutrophils cause
capillary leak into the pulmonary interstitium- interstitial
edema, area of poor pulmonary perfusion, pulmonary
hypertension, and increased respiratory work
21. CONT..
As fluid collects in the interstitium, pulmonary compliance is
reduced, gas exchange is impaired, and hypoxemia occurs
Interstitial fluid also damages the alveolar epithelial barrier,
allowing fluid to accumulate in the alveoli. This further impairs
ventilation and oxygenation
22. HEMOTOLOGICAL ALTERATIONS
Endotoxin release
platelet aggregation
release of more vasoactive substances such as serotonin and
thromboxane A2
Platelet aggregates in the microvasculature
Over activation of the coagulation cascade without counter balance
of adequate fibrinolysis
Overtime clotting factors are depleted
coagulopathy
progressing to DIC
23. Metabolic alterations
Hyper metabolic state
Increase in resting energy consumption, extensive protein and
fat metabolism, negative nitrogen balance, hyperglycemia and
hepatic gluconeogenesis.
Excessive catecholamine’s release
Gluconeogenesis and insulin resistance
Hyperglycemia in critically ill patient who do not have diabetes
24. Lab findings
Cultures: blood, sputum, urine, surgical or non-surgical
wounds. Sinuses and invasive catheter
CBC: WBCs usually will be elevated
Chemistry panel: hyperglycemia may be evident,
followed by hypoglycemia in later stages
ABG: metabolic acidosis and compensatory respiratory
alkalosis
CT scan: to identify site of potential abscesses
25. Cont.
Chest and abdominal radiographs: reveals infectious processes
SvO2 or ScvO2: can assist in the assessment of adequacy of
oxygen delivery and consumption
Lactate level: decrease level indicate aerobic metabolism, elevated
level indicates anaerobic metabolism
EtCO2: decreased EtCO2 is an early indicator of inadequate
regional and global tissue perfusion
26. For severe sepsis
Lactate above upper limits laboratory normal
Urine output <0.5 mL/kg/h for more than 2 h despite adequate fluid
resuscitation
Acute lung injury with PaO2/FiO2 <250 in the absence of pneumonia as
infection source
Acute lung injury with PaO2/FiO2 <200 in the presence of pneumonia as
infection source
Creatinine [2.0 mg/dL
Bilirubin [2 mg/dL
Platelet count <100,000 /mic L
Coagulopathy (international normalized ratio [1.5)
27. Management
Medical management
Treatment of a patient in sepsis or septic shock requires a multifaceted
approach
The goal of treatment is to reverse the pathophysiologic responses,
control the infection, promote metabolic support
Supporting the CVS
Enhancing tissue perfusion
Identifying and treating the infection
Limiting the systemic inflammatory response
Restoring metabolic balance
Initiating nutrition therapy
28. Surviving sepsis campaign (SSC)
Within the first 3 hour of presentation(3 hour bundle)
Measure lactate level
Obtain blood culture before administering antibiotics
Administer broad spectrum antibiotics
Administer 30ml/kg crystalloid for hypotension or
lactate≥4mmol/L
Apply vasopressors if hypotensive during or after fluid
resuscitation to maintain MAP ≥ 65 mmHg
29. Cont.
Within the first 6 hour of presentation (6 hour bundle)
Apply vasopressor (for hypotension that does not respond to
initial fluid resuscitation) to maintain MAP ≥65mmHg
In the event of persistent hypotension that does not respond to
initial fluid administration (MAP <65mmHg) or if initial
lactate was ≥4mmol/L, reassess volume status and tissue
perfusion, and document the findings
Re-measure lactate if initial lactate elevated
30. Hour 1 bundle
Measure lactate level
Obtain blood cultures before administering antibiotics.
Administer broad-spectrum antibiotics.
Begin rapid administration of 30mL/kg crystalloid for
hypotension or lactate level ≥ 4 mmol/L.
Apply vasopressors if hypotensive during or after fluid
resuscitation to maintain MAP ≥ 65 mm Hg.
* Remeasure lactate if initial lactate is elevated (> 2 mmol/L).
31. SSC
Initial resuscitation
Screening for sepsis and performance improvement
Diagnosis
Antimicrobial therapy
Source control
Fluid therapy
Vasoactive medications
36. Screening for sepsis and performance
improvement
Sepsis screening for every
Acutely ill patients
High risk patient
Performance improvement program
Early recognition
Improved management
Improved patient outcome
37. Diagnosis
Microbiologic culture – at least 2 sets
Possible sites
Pan culture
Culture in correlation with clinical presentation
38. Antimicrobial therapy
Start in 1 hour of recognition
Not recommended in SIRS of non infectious orgin
Delay
↑LOS
AKI
ALI
Other organ injury
39. Antimicrobial therapy
Bolus infusion
Lengthy infusion
IM ?
Imipenem / cilastatin
Cefepime
Ceftriaxone
Ertapenem
Once culture sent
Once pathogen identified / clinical improvement
40. Antimicrobial therapy
How to select broad spectrum??
Pt history
Clinical status
Local epidemiological factors
Site of infection
Underlying disease
Chronic organ failure
Medication, Indwelling devices
Immunosuppression
Recent infection, previous receipt
Pt location at the time of infection acquisition
• Carbepenem
• β lactamase inhibitor
• 3rd gen cephalosporins
• Multidrug therapy
41. Factors in determining the appropriate
antimicrobial
Anatomic site of infection
Prevalent pathogens within the community, hospital, and even
hospital ward
The resistance patterns of those prevalent pathogens
The presence of specific immune defects
Age and patient comorbidities
43. Antimicrobial therapy
In SIRS – No need of giving sustained antimicrobial
prophylaxis
As per new studies
No clinical advantage of prophylactic antibiotic that outweigh their
long term adverse effect
But – strong suspicion
Indicated
Dose
• Aminoglycosides
• Fluoroqunolones
• Vancomycin
• β lactam
44.
45.
46. Antimicrobials
Antimicrobial treatment duration of 7–10 days is adequate for
most serious infections associated with sepsis and septic shock
longer courses are appropriate in patients who have a slow
clinical response, undrainable foci of infection, bacteremia with
S. aureus, some fungal and viral infections, or immunologic
deficiencies, including neutropenia
Daily assessment for de-escalation of antimicrobial therapy in
patients with sepsis and septic shock
47. Uncomplicated infection
(1) exclusion of endocarditis
(2) no implanted prostheses
(3) negative results of follow-up blood cultures drawn 2–4 days
after the initial set
(4) defervescence within 72 h after the initiation of effective
antibiotic therapy
(5) no evidence of metastatic infection.
Procalcitonin levels for de-escalation (diagnose, duration)
Galacatomannan – to assess invasive aspergillus
48. Source control
Specific anatomic diagnosis of infection
Prompt removal of intravascular access devices
Site of infection
Control in 6 – 12 hours
Drain
Debridement
Removal
Least invasive SC should be implemented
As per indication
58. Sedation and analgesics
Minimize
Daily sedation interruption
Use opioids alone
Use short acting sedatives
59. Glucose control
Monitor
Insulin
Arterial > capillary
Should avoid hyperglycemia, hypoglycemia, wide swing in
levels
With cessation of nutrition
With balanced nutrition
Critically ill patients should not be tested with a glucometer
60. RRT
IRRT
CRRT
Hemodynamically unstable patient
Sepsis + AKI + ↑ creatinine, oliguria = no need of RRT
61. Bicarbonate therapy
Suggest against use of:
In pt’s with hypoperfusion induced lactate acidosis (pH ≥7.15)
Improve hemodynamics
Helps in limiting tidal volume in ARDS in permissive
hypercapnia
63. Stress ulcer prophylaxis
Recommended in pt with risk of GI bleed
Disruption of protective mechanism against gastric acid
Gastric mucosal hypo perfusion
↑acid production
PPI
H2RA
64. N
u
t
r
i
t
i
o
n
Parenteral -against
Parenteral in combination with Enteral – against
Rather use IV glucose and initiate enteral as per tolerating
Start with trophic / hypocaloric feed
Against - Omega 3 fatty acid as an immune supplement
Against - Monitoring GRV, only in less tolerant pt and high risk of
aspiration
Prokinetic agents
Post pyloric feeding tubes - only in less tolerant pt and high risk of
aspiration
Against - Selenium
Against - Arginine
Against - Glutamine
65. Setting goals of care
Mortality
Survival
QOL
Shared decision- patient and family
Palliative care
66. Nursing management
Focus on
Infection prevention and transmission
Early recognition and treatment of sepsis and septic
shock
Supportive nursing care
67. Cont.
Prevention of sepsis and septic shock is one of the primary
responsibilities of the nurse in the critical care unit.
Identification of patients at risk and reduction of their risk factors,
including exposure to invading microorganisms
Handwashing, aseptic techniques, and an understanding of
evidence based practice to reduce nosocomial infection in
critically ill patients are essential components of preventive
nursing care.
Early identification allows for early treatment and decreases
mortality
68. Nursing interventions
Early identification of sepsis syndrome
Administering prescribed fluid, medication and nutrition
Providing comfort and emotional support
Preventing and maintaining surveillance for
complications
69. Reference
1. Jaya kuruvila. Essentials of critical care. 1st edition.
Newdelhi: India: Jaypee: 2007
2. Suzane M. Burns. Sarah A. Delgado. AACN essentials of
critical care nursing. 4th edition. United states. McGraw-Hill
Education books: 2014
3.Patrica gonce Morton. Dorrie k fontaine. Critical care nursing
a holistic approach. 11th edition: Wolters Kluwer
4. Andrew et al. SSC. International guideline for management
of sepsis and septic shock. 2016. conference report and expert
panel. Springer. Intensive care med. 2017