The document summarizes the five human senses - vision, hearing, touch, taste, and smell. It describes the basic anatomy and physiology of each sensory system, from the sensory receptors to the pathways in the brain where sensory information is processed. It also provides examples from the Pirates of the Caribbean movies of how Captain Jack Sparrow relies on and uses each of his senses in various situations.
An introductory exploration of the science and power of sound to affect our emotions and help us to better engage "The Flow" of life. This .pdf includes speaker notes!
Senses : any of the physical processes by which stimuli are received, transduced, and conducted as impulses to be interpreted in the brain.
The special senses consist of the eyes, ears, nose, throat and skin.
Each of these organs have specialized functions that make if possible for us to experience our environment and to make that experience more pleasant
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS
Sensing the World Assignment: Captain Jack Sparrow
1.
2.
Vision
Pulses of electromagnetic energy strike the eye which is what we see as visible light. The
light enters the eye through the cornea, which bends the light for focus, before passing
through the pupil, the adjustable black hole in the center of the eye, which is surrounded
by the iris, a ring of muscle tissue that forms the colored part of the eye and controls the
size of the pupil opening (dilation or constriction). The lens, the transparent structure
behind the pupil, focuses the light rays of the image on the retina, the light sensitive inner
surface of the eye, through a process called accommodation where the lens changes its
shape to focus near or far objects on the retina.
On the retina are receptor cells called rods and cones. The cones are responsible for
detecting color and details while functioning in daylight or well lit areas. The rods are
responsible for working when the cones can’t. They are responsible for peripheral and
night vision by detecting black, white, and gray. The rods and cones convert the light
energy to neural signals that activate bipolar cells that in turn activate ganglion cells. The
axons of these cells converge to form the optic nerve.
The neural impulses travel through the optic nerve to the thalamus where it is then routed
to the visual cortex in the occipital lobe. In the visual cortex, feature detectors respond to
specific features of the received image and passes them to other cortical areas for
processing like for perceiving faces or a familiar place.
Captain Jack Sparrow relies on his sight for recognizing other ships at sea. He must know
the difference between an ally like his crew on the Black Pearl or a threat like the Flying
Dutchman. In the first movie, he is able to visually process the Elizabeth Swann’s necklace
as the last piece of Aztec gold, a crucial part of the curse that plagues the pirates.
3. The ear detects changes in air pressure known as sound waves, the bands of
compressed or expanded air. Starting with the outer ear, sound waves are channeled
through the auditory canal to the ear drum, a tight membrane that vibrates with the
sound waves. After the eardrum, the middle ear concentrates the vibrations from the
eardrum on the cochlea's oval window using the following three bones: the hammer,
anvil, and stirrup. These little bones acts as a piston by passing down the vibrations
to each other until it causes the cochlea’s membrane, the oval window, to vibrate.
This causes the fluid inside to shake which in turn causes the basilar membrane, also
in the cochlea, to ripple. This causes hair cell movement on its surface to bend
which triggers neural impulses in the nerve cells that converge to form the auditory
nerve. These messages are routed from the thalamus to the auditory cortex of the
brain.
In the auditory cortex, the brain determines the pitch of sound based on the
frequency of pulses traveling to the brain or by where on the basilar membrane a
sound wave stimulated. The frequency of the waves is deciphered by the brain and
helps us to hear high pitched sounds. Sounds in the middle range are heard by both
these theories.
Captain Jack is known for his cunning rather than his brawn. He is very sly and
relies on his sense of hearing to eavesdrop on other pirates’ conversations. This is
how he finds his information.
Hearing
4.
Touch
The sense of touch is actually the combination of pressure, warmth, cold, and pain
nerves that determines what we sense when we touch something. The only
identifiable receptors are for pressure. All other sensations are variations of the
main four. For example, stimulation of cold and warm spots produce the sensation
of hot.
Kinesthesis is the system for sensing the position and movement of individual body
parts through important sensors in the joints, tendons, bones, ears, and skin.
Vestibular sense is the sense of body movement and position, including the sense of
balance. Our body gets its sense of equilibrium from the semicircular canals in the
inner ear and the vestibular sacs that connect the canals with the cochlea. Both of
these contain fluid that moves with our head. It stimulates receptors that send
messages to the cerebellum to tell us our body position and give us a sense of
balance.
For touch and kinesthesis, sensory neurons send messages up the spinal cord to the
brain for processing in the sensory cortex in front of the parietal lobe. Our
perception of touch can rely heavily on thresholds. People who were born unable to
to feel pain will not have the same experience with touch as a normal person.
Culture also affects pain. If more people around us express their pain, we tend to
experience more pain, too.
Captain Jack relies on his vestibular sense to stay balanced on and off land. His
trademark drunken swagger may look strange, but his brain works hard enough
through the rum to keep him on his two feet. Captain Jack uses his kinesthesis
when involved in swordplay, especially in the second movie, where he was in a
sword fight on top of a moving wheel.
5. We have 5 different types of receptors for sensations with all other
tastes coming from a combination of these 5. They are sweet, salty, sour,
bitter, and umami (the savory meaty taste). The chemicals in food
stimulate the taste buds when caught in the taste buds’ pores inside the
papillae , little bumps on the tongue. In the taste bud pores, 50-100
receptor cells with very tiny hairs that sense the food molecules.
Through specialized taste nerves these receptors send signals to the
thalamus and then to an area of the temporal lobe close to where smell
is processed. This is why our perception of a food’s taste comes partly
from what it smells like. Most of the time if you don’t like the way
something smells, you probably don’t like the taste of that food.
Captain Jack loves the taste of rum. Throughout all the movies, this is all
he drinks. Luckily for him, this is a great survival advantage because
drinking water back in his days could have been deadly if contaminated
with bacteria. In the process of making the alcohol, the fermentation
made the rum last longer than fresh water and thereby making it a
much safer drink. He has adapted so much to the taste of rum that he
can immediately spot the difference between rum and other drinks. One
of his common quotes about his drink choice was “Why is the rum
gone?”
Taste
6.
Molecules of a substance carried in the air activate olfactory
nerves at the top of the nasal cavity. They send signal through
axon fibers to the olfactory bulb that relays these messages to
the temporal lobe and parts of the limbic system. Smell can
evoke emotions and memories because of the closeness of the
parts of the brain that process smell and memory. How we feel
when we smell something is stored for later so that when we
smell the same odor again, our previous experience and
emotions determines how we may like a particular scent
Captain Jack’s sense of smell is highly adapted to recognize
scents that are important and ignore unimportant scents. For
example, Jack is able to live on a ship with a bunch of sweaty,
smelly men and not throw up everyday at sea. His smell is
acute when it comes to important things like gunpowder and
fire. He is able to immediately smell the smoke while he is
trapped in jail when the town is set to flames in the first
movie. When he smells gunpowder, he prepares himself for
cannons or guns from people who may not be his friends. This
gives him a chance to hide out for a while.
Smell
7.
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circumvallate-papillae-are-made-up
Myers, D. (2009) Psychology in Modules, 9th edition. New York, New York: Worth
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National Institute on Deafness and Other Communicarion Disorders. (2009,
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http://www.nidcd.nih.gov/health/smelltaste/pages/taste.aspx
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Citations