Alopecia areata is a common cause of hair loss seen in 3.8% of patients in dermatology clinics and in 0.2% to 2.0% of the general US population. The pathology of the disease remains poorly understood. Hair loss in alopecia areata can range from a single patch to 100% loss of body hair. When hair regrowth occurs in alopecia areata, the new hair may demonstrate pigment alterations, but a change in hair texture (ie, curly or straight) has rarely been reported as a consequence of alopecia areata.
The combined effects of Aloe vera gel and silver nanoparticles on wound heali...Nanomedicine Journal (NMJ)
Objective(s): This study was aimed at investigating the synergy effects of Aloe vera gel and silver nanoparticles on the healing rate of the cutting wounds.
Materials and Methods: In order to determine the concentration of silver nanoparticles in Aloe vera gel, the MBC methods were applied on the most common bacteria infecting wounds, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa. The cutting wounds with Full-thickness skin were dorsally created on rats; then the rats were divided into 4 groups. The treatments groups included: mixture of Aloe vera gel and silver nanoparticles, Aloe vera gel alone and silver nanoparticles alone in addition to control groups. The treatment was carried out for 2 weeks and the size of the wound closures were measured by an image software analysis.
Results:There was no significant difference (p<0.05) in healing rate between the control and mixture group. However, there were significant differences between the silver nanoparticles and Aloe vera groups using Tukey’s analysis on the 6th, 8th and 10th days.
Conclusion:The Aloe vera gel increased the rate of wound healing whereas the silver nanoparticles had a delay effect; and when they were mixed, it was similar to the average effect of both Aloe vera gel and silver nanoparticles.
“Immunomodulation in Periodontics”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme at Sri Sai College of Dental Surgery, Vikarabad, India on 24/10/2011.
The Benefits of Calendula Officinalis on Protecting the Skin from the Harmful...My Girls Skin Care
Radiation therapy kills tumor cells, yet has acute side effects that may include: dermatitis, diarrhea, dry mouth, fatigue, hair loss, immune suppression, incontinence, mucositis, nausea, shortness of breath and sexual problems. This slide presentation summarizes clinical and non-clinical studies on Calendula studied in laboratories around the world, and its' benefits on protecting the skin from the harmful effects of radiation therapy.
The combined effects of Aloe vera gel and silver nanoparticles on wound heali...Nanomedicine Journal (NMJ)
Objective(s): This study was aimed at investigating the synergy effects of Aloe vera gel and silver nanoparticles on the healing rate of the cutting wounds.
Materials and Methods: In order to determine the concentration of silver nanoparticles in Aloe vera gel, the MBC methods were applied on the most common bacteria infecting wounds, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa. The cutting wounds with Full-thickness skin were dorsally created on rats; then the rats were divided into 4 groups. The treatments groups included: mixture of Aloe vera gel and silver nanoparticles, Aloe vera gel alone and silver nanoparticles alone in addition to control groups. The treatment was carried out for 2 weeks and the size of the wound closures were measured by an image software analysis.
Results:There was no significant difference (p<0.05) in healing rate between the control and mixture group. However, there were significant differences between the silver nanoparticles and Aloe vera groups using Tukey’s analysis on the 6th, 8th and 10th days.
Conclusion:The Aloe vera gel increased the rate of wound healing whereas the silver nanoparticles had a delay effect; and when they were mixed, it was similar to the average effect of both Aloe vera gel and silver nanoparticles.
“Immunomodulation in Periodontics”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme at Sri Sai College of Dental Surgery, Vikarabad, India on 24/10/2011.
The Benefits of Calendula Officinalis on Protecting the Skin from the Harmful...My Girls Skin Care
Radiation therapy kills tumor cells, yet has acute side effects that may include: dermatitis, diarrhea, dry mouth, fatigue, hair loss, immune suppression, incontinence, mucositis, nausea, shortness of breath and sexual problems. This slide presentation summarizes clinical and non-clinical studies on Calendula studied in laboratories around the world, and its' benefits on protecting the skin from the harmful effects of radiation therapy.
Comparative macroscopic study between Oil extracted Annona seed AlGaInP Laser...inventionjournals
Recent studies suggest the effectiveness of AlGaInP Laser, Therapeutic Ultrasound (UST) and the oil extracted Annona seed as therapeutic resources in the treatment of cutaneous wound healing. The objective was to comparatively evaluate the macroscopic process of healing of skin wounds in mice. The sample consisted of 32 male mice (Mus musculus) divided into four groups: group 1 (control), group 2 (pulsed UST 3 MHz), group 3 (topical application of oil extracted Annona seed) and group 4 (660nm laser AlGaInP). The animals were anesthetized and then shaved. The surgical incision was made with a punch of 8 mm diameter perpendicular to the back of the animal. The treatments were started 24 hours after injury. Each group was divided into subgroup A (n = 4, five applications) and B (n = 4 eleven applications) as observation period, with euthanasia at 7 and 14 days, respectively. Statistical analysis was obtained through non-parametric Mann Whitney and significance at p <0.05, by GraphPad Prism v program. 5.0. It was concluded that all treatment groups were effective in regression of cutaneous wound 14 days of the healing process when compared to the control group
Comparative macroscopic study between Oil extracted Annona seed AlGaInP Laser...inventionjournals
: Recent studies suggest the effectiveness of AlGaInP Laser, Therapeutic Ultrasound (UST) and the oil extracted Annona seed as therapeutic resources in the treatment of cutaneous wound healing. The objective was to comparatively evaluate the macroscopic process of healing of skin wounds in mice. The sample consisted of 32 male mice (Mus musculus) divided into four groups: group 1 (control), group 2 (pulsed UST 3 MHz), group 3 (topical application of oil extracted Annona seed) and group 4 (660nm laser AlGaInP). The animals were anesthetized and then shaved. The surgical incision was made with a punch of 8 mm diameter perpendicular to the back of the animal. The treatments were started 24 hours after injury. Each group was divided into subgroup A (n = 4, five applications) and B (n = 4 eleven applications) as observation period, with euthanasia at 7 and 14 days, respectively. Statistical analysis was obtained through non-parametric Mann Whitney and significance at p <0.05, by GraphPad Prism v program. 5.0. It was concluded that all treatment groups were effective in regression of cutaneous wound 14 days of the healing process when compared to the control group.
Can Blackcurrant (Ribes Nigrum L) Help in Control of Ligneous Conjunctivitis?...CrimsonpublishersMSOR
Can Blackcurrant (Ribes Nigrum L) Help in Control of Ligneous Conjunctivitis? by Mariana Granito Ponte de Oliveira in Medical & Surgical Ophthalmology Research
Photodynamic therapy in treatment of oral lichen planus: Dr AparnaAparna Srivastava
PHOTODYNAMIC THERAPY is also known as Photoradiation therapy,
Phototherapy,
Photochemotherapy.
Photodynamic therapy (PDT) is a treatment that uses a drug, called a photosensitizer or photosensitizing agent.
Photosensitizers are exposed to a specific wavelength of light, photoactivation causes the formation of singlet oxygen, which produces peroxidative reactions that can cause cell damage and death.
The efficacy of Isotretinoin-loaded solid lipid nanoparticles in comparison t...Nanomedicine Journal (NMJ)
Abstract
Topical retinoids are considered as the first line therapy in the treatment of acne vulgaris, but they are associated with cutaneous irritation. In this study, isotretinoin-loaded solid lipid nanoparticles(IT-SLN) were prepared to treat the mild to moderate acne. Also using IT-SLN would minimize IT adverse effects in comparison to commercial product, Isotrex®.
This study was conducted to prepare and characterize IT-SLN and assessing the efficiency of IT-SLN comparing to Isotrex® acne.
IT-SLN was prepared using hot high pressure homogenization method. IT-SLN contained 0.05% IT in 5% of lipid phase (Glyceryl monostearate- GMS) and tween 80 (2.5 % w/v) was used as surfactant in the aqueous phase. IT-SLN was characterized by particle size analyzing, differential scanning calorimetry and transmission electron microscopy. Encapsulation efficacy was also obtained using spectrophotometry. The efficacy of IT-SLN was evaluated in a randomized, single-blind, parallel-group study and compared with Isotrex®. Forty patients encountered in the study and divided in two groups. Treatment regimen was once-nightly topical administration accompanied with topical administration of clindamycin 2% solution twice a day for 8 weeks.
The particle size of IT-SLN was around 60 nm with PDI of 0.4 and zeta potential was about -40 mV. Encapsulation efficacy of IT in SLN in crystalline form was 84±0.21%. IT-SLN produced significantly better treatment than Isotrex® in both non-inflammatory and inflammatory lesions according to its recovery percent after 8 weeks. Also IT-SLN gained better global assessment scores.
Our results showed that IT-SLN had higher efficacy than Isotrex® to clear non-inflammatory and inflammatory lesions.
Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Pat...science journals
We carried out a controlled study on 240 patients diagnosed with Peyronie's Disease (PD). We have divided two treatment groups, which differ from each other only for the association with PTX-penile injection.
Analgesic Effect of Lidocaine in Orofacial Pain Of RatsQUESTJOURNAL
ABSTRACT: In dental treatment, lidocaine is currently used as local anesthetic, but studies on the control of orofacial pain are limited. The aim of this study was to investigate whether pre-treatment with lidocaine would involved in pain modulation in inflammatory orofacial pain.Male Sprague-Dawley white rats (240-280g) were used. The experimental group were divided into 3 groups(n=5); formalin (5 %, 50 μL), Administer 0.2%, 2% lidocaine, after administration, formalin (s.c). To induced orofacial pain, 5% formalin (50 μL) was injected under the skin on the right region of the whiskers of the experimental animals (n=5), and the act of rubbing or scratching the facial area in which the drug was injected was considered pain index. The administration of lidocaine at 2% concentration was found that the formalin-induced pain behavioral reaction was effectively reduced. The level of Nrf2 protein expression increased by formalin noticeably decreased in the medulla oblongata after lidocaine administration. Nuclear factor erythroid 2–related factor 2 (Nrf2) is an oxidative stress-mediated transcription factor. Both ginsengs significantly down-regulated the increased Nrf2 level in formalin group. These results indicate that lidocaine could be a promising regulated in the treatment of inflammatory orofacial pain
The Efficacy of Biological Therapies for Psoriasis - Review Articlepaperpublications3
Abstract: Background: it is indicated that Biological Therapies has great effect in dealing with Psoriasis. Differences in response rates of biologics for the treatment of moderate-to-severe plaque psoriasis have been reported in many published articles.
Objective: this paper aims to declare the effectiveness of biological therapies for psoriasis.
Methods: using the search engine PubMed to prepare comprehensive literature about the specified topic.
Main results: it is indicated that psoriasis is a chronic inflammatory skin disease condition that involves altered expression of a broad spectrum of proinflammatory cytokines which are associated with activation of T cells and proliferation of keratinocytes.
Conclusion: The introduction of targeted biologic therapies has greatly improved the treatment options for psoriasis although the pathogenesis of the autoimmune skin disease has not been fully elucidated. The potential for psoriasis disease is implicit because altered expressions of cutaneous and systemic cytokines are well demonstrated in psoriasis patients.
A 5-year old boy, with an established diagnosis of a topic
dermatitis, previously treated by topical corticosteroids and emollient cream with a good improvement, developed widespread papules on his legs, hands and forearm that appeared 5 months ago.
Methods: Retrospectively, the file records of the patients who underwent sleeve gastrectomy were examined. Demographic features, Body Mass Index (BMI), the mouth opening, Mallampati score, thyromental distance, sternomental distance, neck circumference measurements and videolaryngoscopic examination results were recorded Results: In a total of 140 consecutive patients (58 male, 82 female) were included in the study. The mean age of the study participants was 35.40 ± 9.78 and the mean BMI of the patients was 44.33 ± 7.52 kg/m2
. The mean mouth opening of the patients was 4.82 ± 0.54 cm
and the mean neck circumference was 43.52 ± 4.66 cm. The mean thyromental distance was 8.02 ± 1.00 cm and the mean sternomental distance was16.58 ± 1.53 cm. Difficult intubation was determined in 8 (5.7%) patients. In logistic regression analysis, age (p : 0.446), gender (p : 0.371), BMI (p : 0.947), snoring (p : 0.567), sleep apnea (p : 0.218), mouth opening (p : 0.687), thyromental distance (p :0.557), sternomental (p : 0.596) and neck circumference (p : 0.838) were not the independent predictors of difficult intubation. However, Mallampati score (p : 0.001) and preoperative direct laryngoscopy findings (p : 0.037) performed in outpatient clinic were the significant
predictors of difficult intubation. Interestingly, all patients with grade 4 laryngoscopy findings had difficult intubation.
More Related Content
Similar to Scientific Journal of Clinical Research in Dermatology
Comparative macroscopic study between Oil extracted Annona seed AlGaInP Laser...inventionjournals
Recent studies suggest the effectiveness of AlGaInP Laser, Therapeutic Ultrasound (UST) and the oil extracted Annona seed as therapeutic resources in the treatment of cutaneous wound healing. The objective was to comparatively evaluate the macroscopic process of healing of skin wounds in mice. The sample consisted of 32 male mice (Mus musculus) divided into four groups: group 1 (control), group 2 (pulsed UST 3 MHz), group 3 (topical application of oil extracted Annona seed) and group 4 (660nm laser AlGaInP). The animals were anesthetized and then shaved. The surgical incision was made with a punch of 8 mm diameter perpendicular to the back of the animal. The treatments were started 24 hours after injury. Each group was divided into subgroup A (n = 4, five applications) and B (n = 4 eleven applications) as observation period, with euthanasia at 7 and 14 days, respectively. Statistical analysis was obtained through non-parametric Mann Whitney and significance at p <0.05, by GraphPad Prism v program. 5.0. It was concluded that all treatment groups were effective in regression of cutaneous wound 14 days of the healing process when compared to the control group
Comparative macroscopic study between Oil extracted Annona seed AlGaInP Laser...inventionjournals
: Recent studies suggest the effectiveness of AlGaInP Laser, Therapeutic Ultrasound (UST) and the oil extracted Annona seed as therapeutic resources in the treatment of cutaneous wound healing. The objective was to comparatively evaluate the macroscopic process of healing of skin wounds in mice. The sample consisted of 32 male mice (Mus musculus) divided into four groups: group 1 (control), group 2 (pulsed UST 3 MHz), group 3 (topical application of oil extracted Annona seed) and group 4 (660nm laser AlGaInP). The animals were anesthetized and then shaved. The surgical incision was made with a punch of 8 mm diameter perpendicular to the back of the animal. The treatments were started 24 hours after injury. Each group was divided into subgroup A (n = 4, five applications) and B (n = 4 eleven applications) as observation period, with euthanasia at 7 and 14 days, respectively. Statistical analysis was obtained through non-parametric Mann Whitney and significance at p <0.05, by GraphPad Prism v program. 5.0. It was concluded that all treatment groups were effective in regression of cutaneous wound 14 days of the healing process when compared to the control group.
Can Blackcurrant (Ribes Nigrum L) Help in Control of Ligneous Conjunctivitis?...CrimsonpublishersMSOR
Can Blackcurrant (Ribes Nigrum L) Help in Control of Ligneous Conjunctivitis? by Mariana Granito Ponte de Oliveira in Medical & Surgical Ophthalmology Research
Photodynamic therapy in treatment of oral lichen planus: Dr AparnaAparna Srivastava
PHOTODYNAMIC THERAPY is also known as Photoradiation therapy,
Phototherapy,
Photochemotherapy.
Photodynamic therapy (PDT) is a treatment that uses a drug, called a photosensitizer or photosensitizing agent.
Photosensitizers are exposed to a specific wavelength of light, photoactivation causes the formation of singlet oxygen, which produces peroxidative reactions that can cause cell damage and death.
The efficacy of Isotretinoin-loaded solid lipid nanoparticles in comparison t...Nanomedicine Journal (NMJ)
Abstract
Topical retinoids are considered as the first line therapy in the treatment of acne vulgaris, but they are associated with cutaneous irritation. In this study, isotretinoin-loaded solid lipid nanoparticles(IT-SLN) were prepared to treat the mild to moderate acne. Also using IT-SLN would minimize IT adverse effects in comparison to commercial product, Isotrex®.
This study was conducted to prepare and characterize IT-SLN and assessing the efficiency of IT-SLN comparing to Isotrex® acne.
IT-SLN was prepared using hot high pressure homogenization method. IT-SLN contained 0.05% IT in 5% of lipid phase (Glyceryl monostearate- GMS) and tween 80 (2.5 % w/v) was used as surfactant in the aqueous phase. IT-SLN was characterized by particle size analyzing, differential scanning calorimetry and transmission electron microscopy. Encapsulation efficacy was also obtained using spectrophotometry. The efficacy of IT-SLN was evaluated in a randomized, single-blind, parallel-group study and compared with Isotrex®. Forty patients encountered in the study and divided in two groups. Treatment regimen was once-nightly topical administration accompanied with topical administration of clindamycin 2% solution twice a day for 8 weeks.
The particle size of IT-SLN was around 60 nm with PDI of 0.4 and zeta potential was about -40 mV. Encapsulation efficacy of IT in SLN in crystalline form was 84±0.21%. IT-SLN produced significantly better treatment than Isotrex® in both non-inflammatory and inflammatory lesions according to its recovery percent after 8 weeks. Also IT-SLN gained better global assessment scores.
Our results showed that IT-SLN had higher efficacy than Isotrex® to clear non-inflammatory and inflammatory lesions.
Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Pat...science journals
We carried out a controlled study on 240 patients diagnosed with Peyronie's Disease (PD). We have divided two treatment groups, which differ from each other only for the association with PTX-penile injection.
Analgesic Effect of Lidocaine in Orofacial Pain Of RatsQUESTJOURNAL
ABSTRACT: In dental treatment, lidocaine is currently used as local anesthetic, but studies on the control of orofacial pain are limited. The aim of this study was to investigate whether pre-treatment with lidocaine would involved in pain modulation in inflammatory orofacial pain.Male Sprague-Dawley white rats (240-280g) were used. The experimental group were divided into 3 groups(n=5); formalin (5 %, 50 μL), Administer 0.2%, 2% lidocaine, after administration, formalin (s.c). To induced orofacial pain, 5% formalin (50 μL) was injected under the skin on the right region of the whiskers of the experimental animals (n=5), and the act of rubbing or scratching the facial area in which the drug was injected was considered pain index. The administration of lidocaine at 2% concentration was found that the formalin-induced pain behavioral reaction was effectively reduced. The level of Nrf2 protein expression increased by formalin noticeably decreased in the medulla oblongata after lidocaine administration. Nuclear factor erythroid 2–related factor 2 (Nrf2) is an oxidative stress-mediated transcription factor. Both ginsengs significantly down-regulated the increased Nrf2 level in formalin group. These results indicate that lidocaine could be a promising regulated in the treatment of inflammatory orofacial pain
The Efficacy of Biological Therapies for Psoriasis - Review Articlepaperpublications3
Abstract: Background: it is indicated that Biological Therapies has great effect in dealing with Psoriasis. Differences in response rates of biologics for the treatment of moderate-to-severe plaque psoriasis have been reported in many published articles.
Objective: this paper aims to declare the effectiveness of biological therapies for psoriasis.
Methods: using the search engine PubMed to prepare comprehensive literature about the specified topic.
Main results: it is indicated that psoriasis is a chronic inflammatory skin disease condition that involves altered expression of a broad spectrum of proinflammatory cytokines which are associated with activation of T cells and proliferation of keratinocytes.
Conclusion: The introduction of targeted biologic therapies has greatly improved the treatment options for psoriasis although the pathogenesis of the autoimmune skin disease has not been fully elucidated. The potential for psoriasis disease is implicit because altered expressions of cutaneous and systemic cytokines are well demonstrated in psoriasis patients.
A 5-year old boy, with an established diagnosis of a topic
dermatitis, previously treated by topical corticosteroids and emollient cream with a good improvement, developed widespread papules on his legs, hands and forearm that appeared 5 months ago.
Methods: Retrospectively, the file records of the patients who underwent sleeve gastrectomy were examined. Demographic features, Body Mass Index (BMI), the mouth opening, Mallampati score, thyromental distance, sternomental distance, neck circumference measurements and videolaryngoscopic examination results were recorded Results: In a total of 140 consecutive patients (58 male, 82 female) were included in the study. The mean age of the study participants was 35.40 ± 9.78 and the mean BMI of the patients was 44.33 ± 7.52 kg/m2
. The mean mouth opening of the patients was 4.82 ± 0.54 cm
and the mean neck circumference was 43.52 ± 4.66 cm. The mean thyromental distance was 8.02 ± 1.00 cm and the mean sternomental distance was16.58 ± 1.53 cm. Difficult intubation was determined in 8 (5.7%) patients. In logistic regression analysis, age (p : 0.446), gender (p : 0.371), BMI (p : 0.947), snoring (p : 0.567), sleep apnea (p : 0.218), mouth opening (p : 0.687), thyromental distance (p :0.557), sternomental (p : 0.596) and neck circumference (p : 0.838) were not the independent predictors of difficult intubation. However, Mallampati score (p : 0.001) and preoperative direct laryngoscopy findings (p : 0.037) performed in outpatient clinic were the significant
predictors of difficult intubation. Interestingly, all patients with grade 4 laryngoscopy findings had difficult intubation.
Introduction: Laparoscopic surgery has been performed in Mexico since 1989, but no reports about training tendencies exist. We conducted a national survey in 2015, and here we report the results concerning training characteristics during the surgical residence of the respondents. Materials and Methods: A prospective study was conducted through a survey questioning demographic data, laparoscopic training during pre and post surgical residency and other of areas of laparoscopic practice. The sample was calculated and survey piloted before
application. Special interest in this report was placed on type and quality of training received. Data are reported in percentages.
Heterotopic Ossification (HO) is defined as pathological bone formation at locations where bone normally does not exist. The
presence of HO has been found to be a rare complication after stroke in several studies, whereas there are only sporadic references relating HO to Cerebral Palsy (CP) and few for CP and stroke. No effective treatment for HO has yet been found, whereas the cellular and molecular mechanisms have not been completely understood. Therefore, increased awareness among physicians is required, as a challenge for early diagnosis and treatment. A case of a male patient with CP, who developed HO on the paretichip joint following an ischemic stroke is presented.
Objectives: To assess the practice of food hygiene and safety, and its associated factors among street food vendors in urban areas of Shashemane, West Arsi Zone, Oromia Ethiopia, 2019.
Methods: Cross-sectional study design was applied from December 28, 2019 to January 27, 2020. Data was collected from 120 food handlers, which were selected by purposive sampling techniques. Information was gathered from interview and field observation by conducting food safety survey and using questionnaires via face to face interview. The collected data was entered using Epi Data 3.1 and finally, it was analyzed using SPSS VERSION 20.
A Division I football athlete experienced acute posterior leg pain while pushing off on the line of scrimmage. Ultrasound (US) showed a midsubstance plantaris tendon rupture, an injury that, to our knowledge, has only been described once before in the medical literature [1]. US was also used to assist with rehab progression and return to previous level of activity, which was achieved three weeks after the injury. While there currently are no guidelines regarding return to sport after this injury, this case demonstrates that once pain is controlled and ROM restored, progression through rehabilitation and return to elite level sport is simply based on symptoms.
Type 1 Diabetes (T1D), is a severe disease, representing 5-10% of all reported cases of diabetes worldwide. Fulminant Type 1 Diabetes Mellitus (FT1D) is a subtype of type 1 diabetes mellitus that is largely characterized by the abrupt onset of Diabetic Ketoacidosis (DKA) and severe hyperglycemia without insulin defi ciency. Viral infections have been hypothesized to play a major role in the pathogenesis of Fulminant Type 1 Diabetes Mellitus (FT1D) through the complete and rapid destruction of pancreatic beta cells. Coxsackie viral infection has been detected in islets of 50% of the pancreatic tissue recovered from recent-onset Type 1 Diabetes (T1D) patients. In this report we have highlighted a case where the patient developed a Group B Coxsackie virus infection culminating in the development of Fulminant Type 1 Diabetes Mellitus (FT1D).
Methods: Cercariae are released by infected water snails. To determine the occurrence of cercariae-emitting snails in SchleswigHolstein, 155 public bathing places were visited and searched for fresh water snails. Family and genus of the collected snails were determined and the snails were examined for the shedding of cercariae, using a standard method and a newly developed method.
Objective: To generate preliminary information about of enteroviruses and Enterovirus 71 (EV71) in patients with aseptic meningitis in Khartoum State, Sudan.
Method: Cerebrospinal fluid specimens were collected from 89 aseptic meningitis patients from different Khartoum Hospitals
(Mohammed Alamin Hamid Hospital, Soba Teaching Hospital, Omdurman Military Hospital, Alban Gadeed Teaching Hospital and Police Hospital) within February to May 2015. Among these 89 patients, 43 (48%) were males and 46 (52%) were females. The patient’s age ranged between 1 day and 30 years old. The collected specimens were assayed to detect enteroviruses and EV71 RNA using Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) technique
Femoral hernias, comprise 2% to 4% of all hernias in the inguinal region, and occur most commonly in women. Th ey present typically with a mass below the level of the inguinal ligament. The sac may contain preperitoneal fat, omentum, small bowel, or other structures and have a high rate of incarceration and strangulation due to the small size of the hernia neck orifice, requiring emergency surgery. We present the case of a 54-year-old female patient with intestinal occlusion due to incarcerated femoral hernia, repaired by laparoscopic approach, that gave the patient the opportunity to attend her daughter’s wedding the same day.
Small Supernumerary Marker Chromosome (sSMC) is a rare genetic condition marked by the presence of an extra chromosome to the 46 human chromosomes. This case report describes a 4 year old child with SSMC on the 46th chromosome. The child presented with delayed speech and language development, seizures and mild developmental delay. Speech and Language evaluation was carried out and management options are discussed.
A catheter is a thin tube made from medical grade materials that serve a broad range of functions, but mainly catheters are medical devices that can be inserted in the body to treat disease or perform surgical procedures. Catheters have been inserted into body cavities, ducts, or vessels to allow for drainage, administration of therapeutic fluids or gases, operational access for surgery. Catheters help perform tasks in various systems such as cardiovascular, urological, gastrointestinal, neurovascular, and ophthalmic systems. A dataset of 12 patients with varying “weights” and “heights” was recorded along with the lengths of their catheter tubes. This data set was found from two revered statistical textbooks on linear regression and the Department of Scientific Computing at Florida State University. This data set was not able to be linked to any particular clinical or experimental research studies, but the data set can be used to help catheter manufacturers and medical professionals better decide on what particular catheter lengths to use for patients knowing only their height & weight. These research insights could be helpful to healthcare professionals that have patients with incomplete or no healthcare records
to decide what catheter length to use. The main investigative inquiry that needed to be answered was how does patient weight & height influence catheter length together and separately? We conducted linear regression and other statistical analysis procedures in R program & Microsoft Excel and discovered that this data exhibited a quality called multi collinearity. With multi collinearity, all predictors (2 or more
independent variables) are not significant in an all encompassing linear aggression, but the predictors might be significant in their own individual linear regressions. Individual linear regression analyses were conducted for both patient height & weight to see how much they both contribute to varying catheter length. Patient weight was found to be more impatful than patient height in relationship to catheter length, even though height and weight are a classical example of multi collinearity predictors.
Bovine mastitis has a negative impact through economic losses in the dairy sector across the globe. A cross sectional study was carried out from September 2015 to July 2016 to determine the prevalence of bovine mastitis, associated risk factors and isolation of major causative bacteria in lactating dairy cows in selected districts of central highland of Ethiopia. A total of 304 lactating cows selected randomly from five districts were screened by California Mastitis Test (CMT) for subclinical mastitis. Based on CMT result and clinical examination, over all prevalence of mastitis at cow level was 70.62% (214/304).
Two hundred fourteen milk samples collected from CMT positive cows were cultured for isolation of major causative bacteria. From 214 milk samples,187 were culture positive and the most prevalent isolates were Staphylococcus aureus 42.25% (79/187) followed by Streptococcus agalactiae 14.43%
(27/187). Other bacterial isolates were included Coagulase Negative Staphylococcus species 12.83% (24/187), Streptococcus dysgalactiae 5.88% (11/187), Escherichia coli 13.38% (25/187) and Entrococcus feacalis 11.23% (21/187) were also isolated. Moreover, age, parity number, visible teat abnormalities,husbandry practice, barn fl oor status and milking hygiene were considered as risk factors for the occurrence of bovine mastitis and they were found significantly associated with the occurrence of mastitis (p < 0.05). The findings of this study warrants the need for strategic approach including dairy extension that focus on enhancing dairy farmers’ awareness and practice of hygienic milking, regular screening for subclinical mastitis, dry cow therapy and culling of chronically infected cows.
Kratom is an herbal product that is derived from Southeast Asian Mitragyna speciose tree leaves [1-10]. This compound is used for many purposes such as stimulation, euphoria, or analgesia [1-10]. It has been recently identified as a drug of abuse by the United States Drug Enforcement Administration [2,8]. Side-effects from this compound have not been well documented. We describe a case of a 36-year-old female who develop nephrotoxicity after taking an herbal supplement. She took kratom as an adjunctive therapy for back pain management. She developed right upper quadrant pain and nausea. Laboratory tests showed elevated liver enzymes without evidence of bile duct obstruction. Liver enzymes normalized several weeks after Kratom discontinuation. We advise clinicians to be vigilant about Kratom’s hepatotoxic potential on patient health.
The assessment, diagnosis and treatment of critically ill patients is extremely challenging. Patients often deteriorate whilst being
reviewed and their rapidly changing pathophysiology barrages healthcare professionals with new data. Furthermore, comprehensive assessments must be postponed until the patient has been stabilised. So, important data and interventions are often missed in the heat of the moment. In emergency situations, suboptimal management decisions may cause signifi cant morbidity and mortality. Fortunately, standardisation and careful design of documentation (i.e. proformas and checklists) can enhance patient safety. So, I have developed a series of checklist proformas to guide the assessment of critically ill patients. These proformas also promote the systematic recording and presentation of information to facilitate the retrieval of the precise data required for the management for critically ill patients. The proformas have been modifi ed extensively over the last twenty years based on my personal experience and extensive consultation with colleagues in several world-renowned centres of excellence. The proformas were originally developed for use in the intensive therapy unit
or high dependency unit. However, they have been adapted for use by outreach teams reviewing patients admitted outside of critical care areas. The use of these tools can direct eff orts to provide appropriate organ support and provides a framework for diagnostic reasoning.
Systemic Hypertension (HTN) accounts for the largest amount of attributable Cardiovascular (CV) mortality worldwide. There are several factors responsible for the development of HTN and its CV complications. Multicenter trials revealed that risk factors responsible for Micro Vascular Disease (MVD) are similar for those attributable to Coronary Artery Disease (CAD) which include tobacco use, unhealthy cholesterol levels, HTN, obesity and overweight, physical inactivity, unhealthy diet, diabetes, insulin resistance, increasing age and genetic predisposition. In addition, the defective release of Nitric Oxide (NO) could be a putative candidate for HTN and MVD. This study reviewed the risk stratification of hypertensive population employing cardiac imaging modalities which are of crucial importance
in diagnosis. It further emphasized the proper used of cardiac imaging to determine patients at increased CV risk and identify the management strategy. It is now known that NO has an important effect on blood pressure, and the basal release of endothelial Nitric Oxide (eNOS) in HTN may be reduced. Although there are different forms of eNOS gene allele, there is no solid data revealing the potential role of the polymorphism of the eNOS in patients with HTN and coronary vascular diseases. In the present article, the prevalence of eNOS G298 allele in hypertensive patients with micro vascular angina will be demonstrated. This review provides an update on appropriate and justified use of non-invasive imaging tests in hypertensive patients and its important role in proper diagnosis of MVD and CAD. Second, eNOS gene allele and its relation to essential hypertension and angina pectoris are also highlighted.
Methods: Two groups were selected by non-probability random sampling technique including case group of 154 patients with
suspected dengue (fever>2days and <10days) and control group of 146 patients with febrile illness other than dengue. Clinical,hematological and serologic markers of cases and control groups were analyzed. The frequency distribution was used to compare categorical serologic markers and paired sample T test was applied for hematologic variables before and after treatment of dengue using SPSS version 21.
Researchers from Utrecht recently published yet another paper on the use of Magnetic Resonance Imaging (MRI)demonstrating an additional failed attempt to understand the importance of qualitative versus quantitative imaging, and anatomic versus physiologic imaging. Th e implications of this failure here cannot be overstated.
Introduction: Stroke is an even more dramatic major public health problem in young people. Goal of the study: Contribute to the knowledge of strokes in young people. Methodology: This was a retrospective study carried out over a period of 02 years (January 2017 to December 2018) including the files of patients aged 18 to 49 years hospitalized for any suspected case of stroke in the Neurology department of the University Hospital
Center of the Sino-Central African Friendship (CHUSCA) of Bangui.
Background: This report describes a unique case of a patient that developed psychotic symptoms believed to be secondary
to a tentorial meningioma with associated hydrocephalus. These psychotic symptoms subsequently abated with placement of a
ventriculoperitoneal shunt. Case description: 60-year-old female was admitted to an inpatient psychiatric facility on a psychiatric involuntary commitment petition due to progressive paranoia, homicidal ideation and psychosis. The work up showed a calcified six cm tentorial meningioma with associated hydrocephalus. The patient initially rejected treatment but later became amenable to placement of Ventriculoperitoneal Shunt
(VPS).
More from SciRes Literature LLC. | Open Access Journals (20)
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
2. Cite this Article: Luigi L. Alopecia Areata: A Combinated
Sub-Dermal Infiltrative Therapy. Sci J Clin Res Dermatol.
2015;1(1): 001-003.
SCIRES Literature - Volume 1 Issue 1 - www.scireslit.com Page - 002
Scientific Journal of Clinical Research in Dermatology
INTRODUCTION
Alopecia areata (AA) is a common cause of hair loss seen in
3.8% of patients in dermatology clinics and in 0.2% to 2.0% of the
general US population. The pathology of the disease remains poorly
understood. Hair loss in alopecia areata can range from a single patch
to 100% loss of body hair. When hair regrowth occurs in alopecia
areata, the new hair may demonstrate pigment alterations, but a
change in hair texture (ie, curly or straight) has rarely been reported
as a consequence of AA.
Several researchers have shed new light on the importance of the
action of extracellular nucleotides and nucleosides in increasing cell
proliferation and reducing inflammation. PDRN, an A2A adenosine
receptor, acts as mitogen for fibroblasts, endothelial cells, and
preadipocytes [1, 2] working with different growth factors (VEGF,
PGF, and FGF). PDRN is used in plastic and dermatologic surgery,
and recently in urology, for its regenerative properties, restorative
effects in ischemic skin flaps [3], and being used to improve
intratesticular vascularisation [4]. Recently, the effects of PDRN have
been analysed in a number of tissues, such as corneal epithelium [5],
human bone [6], and skin [3]. PDRN is involved in protective and
regenerative effects on UV irradiated mouse cell cultures [7] and
UV-irradiated dermal fibroblast [8]. PDRN has shown proliferation
effects in human preadipocytes, which represent the richest reservoir
of human adult stem cells [9]. In the light of these preliminary results,
and because of these specific properties, we decided to perform the
clinical observation, before and after therapy, of a local subdermal
administration of PDRN in lichen sclerosus genital lesions, focusing
on the anti-inflammatory and positive regenerative effects of this
A2A adenosine receptor.
Aim of the study
To compare, in a group of 16 patients (Group A - 10 male, 6
female, aged from 19 to 43 Year old) affected by AA, the usefulness as
adjuvant therapy of polydeoxyribonucleotides, in a micro-infiltrative
local sub-dermal, in combination with triamcinolone acetonide,
respect to a group of AA patients who received only the micro-
infiltative triamcinolone acetonide therapy (Group B - 14 patients 9
male 5 female aged from 21 to 42 Year old).
MATERIALS AND METHODS
Materials
We used polydeoxyribonucleotide (PDRN) in a commercial
preparation for human use, containing 5625 mg of PDRN in a 3 mL
ampoule sterilized at 121°C for 20 min. PDRN is a pure substance at
95%, constituted of different lengths of PDRN (from 50 to 2000 base
pairs) obtained from sperm of salmon trout (Oncorhynchus mykiss)
for human alimentation, through an original purification and
sterilization process. In addition, for we use triamcinolone acetonide
in a commercial preparation 10mg/mL
Methods
We proposed for Group A, an 8 session therapy. In every
session we performed subdermal infiltrations with PDRN addicted
to triamcinolone acetonide 10mg/ml solution, corresponding to the
lesions of lichen sclerosus and some neighboring areas. This was
performed using a 30-gauge needle In every session we performed
subdermal infiltrations with PDRN, corresponding to the lesions of
AA and some neighboring areas. The same sessions were performed
for Group B, without PDRN.
RESULTS
We have tested for all patients, significant improvements of the
disease, related to a hair regrowth on all treated areas.
These improvements were more evident for group A, alredy
from the second session, while for group B, around third/fourth
session. In the group A has been possible to appreciate clinically and
trichoscopically, a more homogeneous disposition of the regrowth of
hair, with a normalization of the average diameters.
We observed in 8 patients of Group A, a complete regrowth of all
hair, kept up to 2 months after discontinuation of treatment, while
only 2 patients in group B achieved a complete regrowth, kept for 2
months after discontinuation of treatment.
DISCUSSION
Becauseofthesecharacteristics,wehypothesizedthatPDRNcould
play a role in reducing the primary cause of AA, the inflammation
of the tissue, and in part, inducing tissue regeneration. We therefore
wanted to challenge some of the regenerative effects demonstrated
by PDRN in association with anti-inflammatory effects demonstrated
by Triamcinolone acetonide 10mg/ml, that seemed to be useful
to counteract the progression of AA. In particular, preliminary
experiments showed that PDRN determined a statistically significant
increase in fibroblast growth, as reported by Sini et al. [1]. Fibroblasts
areimportantprecursorsofcollagens,glycosaminoglycans,andelastic
and reticular fibers glycoproteins that can be found in extracellular
matrix. Stimulation of these cells may play a key role in tissue
regeneration in the course of LS. Again, it has been proved that PDRN
plays a role in the reduction of proinflammatory cytokines, which
leads to an anti-inflammatory effect in several autoimmune diseases,
as reported by Bitto et al. [2]. It is already known that the primary
pathogenetic path of AA is the skin inflammation. The demonstrated
[3] anti-inflammatory effect of PDRN, bound to the reduction of
cytokine production, may impact in some way the progression of the
disease, counteracting the primum movens due to several pathological
effects. Last, but not least, we have demonstrated the effects of PDRN
in promoting growth and differentiation of human preadipocytes
ABSTRACT
Alopecia areata is a common cause of hair loss seen in 3.8% of patients in dermatology clinics and in 0.2% to 2.0% of the general US
population. The pathology of the disease remains poorly understood. Hair loss in alopecia areata can range from a single patch to 100%
loss of body hair. When hair regrowth occurs in alopecia areata, the new hair may demonstrate pigment alterations, but a change in hair
texture (ie, curly or straight) has rarely been reported as a consequence of alopecia areata.
3. Cite this Article: Luigi L. Alopecia Areata: A Combinated
Sub-Dermal Infiltrative Therapy. Sci J Clin Res Dermatol.
2015;1(1): 001-003.
SCIRES Literature - Volume 1 Issue 1 - www.scireslit.com Page - 003
Scientific Journal of Clinical Research in Dermatology
[4], which constitute the largest and most accessible reserves of adult
stem cells. These cells are known to have an effect on the regeneration
and tissue repair and on cellular aging; this could be another positive
action performed by PDRN in the pathogenesis.
CONCLUSION
Despite many therapeutic approaches proposed over the years,
the definitive treatment of AA is still being codified. We maintain
that a valid therapeutic proposal is not confined to a drug, but to a
therapeutic set and to a proper therapeutic approach, based on the
type and the severity degree of the disease. In this context, through
this preliminary study, and for the first time in this dermatological
disease (recent dermatological studies that compare an infiltrative
therapy with PDRN are interested Lichen sclerosus) [5,6] we have
highlighted the efficacy, tolerability, and safety profile demonstrated
by PDRN in association with Triamcinolone acetonide, which could
be cited, (if further studies confirm these early data) as one of the
effective adjuvant therapies in the management of AA, even reducing
the quote of steroid percentage.
Figure 1: Notice the complete regrowth of the whole scalp (the images are taken monthly for 4 months).
REFERENCES
1. P. Sini, A. Denti, G. Cattarini, M. Daglio, M. E. Tira, and C. Balduini, “Effect
of polydeoxyribonucleotides on human fibroblasts in primary culture,” Cell
Biochemistry and Function, vol. 17, no. 2, pp. 107–114, 1999.
2. A. Bitto, F. Polito, N. Irrera et al., “Polydeoxyribonucleotide reduces cytokine
production and the severity of collagen-induced arthritis by stimulation of
adenosine A2A receptor,” Arthritis and Rheumatism, vol. 63, no. 11, pp.
3364–3371, 2011.
3. A. Bitto, F. Polito, N. Irrera et al., “Polydeoxyribonucleotide reduces cytokine
production and the severity of collagen-induced arthritis by stimulation of
adenosine A2A receptor,” Arthritis and Rheumatism, vol. 63, no. 11, pp.
3364–3371, 2011.
4. E. Raposio, C. Guida, R. Coradeghini et al., “In vitro polydeoxyribonucleotide
effects on human pre-adipocytes,” Cell Proliferation, vol. 41, no. 5, pp. 739–
754, 2008.
5. Laino L, Suetti S, Sperduti I. Polydeoxyribonucleotide Dermal Infiltration in
Male Genital Lichen Sclerosus: Adjuvant Effects during Topical Therapy.
Dermatol Res Pract. 2013;2013:654079.
6. Laino L. Adjuvant clinical effects of polydeoxyribonucleotide in lichen
sclerosus. Eur J Dermatol. 2012 Jul-Aug;22(4):575-6.