We took a look at the stats on drug discovery companies in the San Diego area to see what we could learn about the community and how it works. Here are the results.
The Exhaustive Study for “23andMe Market” Research Report is added on Orbisresearch.com database. The report covers the market landscape and its growth prospects over the coming years. The report also includes a discussion of the key vendors operating in this market.
Tracxn Startup Research — Life Sciences Landscape, October 2016Tracxn
There were 20+ acquisitions in this space in 2016; IBM’s $2.6B acquisition of Truven Analytics, and Affymetrix’s acquisition by Thermo Fisher Scientific for $1.6B were the largest M&A events for the sector this year.
The Exhaustive Study for “23andMe Market” Research Report is added on Orbisresearch.com database. The report covers the market landscape and its growth prospects over the coming years. The report also includes a discussion of the key vendors operating in this market.
Tracxn Startup Research — Life Sciences Landscape, October 2016Tracxn
There were 20+ acquisitions in this space in 2016; IBM’s $2.6B acquisition of Truven Analytics, and Affymetrix’s acquisition by Thermo Fisher Scientific for $1.6B were the largest M&A events for the sector this year.
R&D To Commercialisation - LSX C-Suite Challenges in Life Sciences Survey 201...Covance
Learn key insights from biotech executives about their path from R&D to commercialisation in this whitepaper, part of the LSX C-Suite Challenges in Life Sciences Survey 2018 report.
Biotech CxO Challenges in Life Sciences Survey 2018Covance
Learn how your strategic concerns reflect the barriers C-level executives see during key stages in asset development and biotech firm leadership. Topics include: investment and IPOs, M&A and deal making, regulation and compliance, R&D and more.
Strand featured in CIO Review: Pharma and Life Science Special edition - July 2014
Strand Genomics Inc recognised by CIO Review as one among 20 most promising Tech solution providers to Pharma and Life science industry 2014
Strategies for Conducting New Product Scientific Assessment - Yavuz SILAY - D...Yavuz Silay
Strategies for Conducting New Product Scientific Assessment - Due Diligence - New Strategies for Successful Licensing Acquisitions , DIA , Session Panel, June 22 2008,
2014 Overview of significant trends in the life sciences (Biotechnology, Pharmaceutical, Device and Diagnostics) industry with Big Data in the Life Sciences featured articles.
Big risks require big data thinking, Global Forensic Data Analytics Survey 2014EY
This presentation is based on EY FIDS' report on Forensic Data Analytics and comprises global as well as India findings.
For further information, please visit: http://www.ey.com/FIDS
Playing to win in the life science tools marketBill Kelly
For the last year, clients have repeatedly been asking us similar questions:
- What's the outlook for life science funding?
- What's the impact of large mergers on the competitive environment?
- Are the ways scientists purchase products changing?
- Do new technologies represent a threat or an opportunity?
BioInformatics LLC has decided to answer these questions in our latest multi-sponsor research report, Competitive Strategies in an Era of Consolidation & Disruptive Technologies. We will undertake a comprehensive assessment of the current state of the global life science through extensive interviews with market participants, industry observers, procurement specialists and a survey of more than a thousand scientific customers from all market segments.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
R&D To Commercialisation - LSX C-Suite Challenges in Life Sciences Survey 201...Covance
Learn key insights from biotech executives about their path from R&D to commercialisation in this whitepaper, part of the LSX C-Suite Challenges in Life Sciences Survey 2018 report.
Biotech CxO Challenges in Life Sciences Survey 2018Covance
Learn how your strategic concerns reflect the barriers C-level executives see during key stages in asset development and biotech firm leadership. Topics include: investment and IPOs, M&A and deal making, regulation and compliance, R&D and more.
Strand featured in CIO Review: Pharma and Life Science Special edition - July 2014
Strand Genomics Inc recognised by CIO Review as one among 20 most promising Tech solution providers to Pharma and Life science industry 2014
Strategies for Conducting New Product Scientific Assessment - Yavuz SILAY - D...Yavuz Silay
Strategies for Conducting New Product Scientific Assessment - Due Diligence - New Strategies for Successful Licensing Acquisitions , DIA , Session Panel, June 22 2008,
2014 Overview of significant trends in the life sciences (Biotechnology, Pharmaceutical, Device and Diagnostics) industry with Big Data in the Life Sciences featured articles.
Big risks require big data thinking, Global Forensic Data Analytics Survey 2014EY
This presentation is based on EY FIDS' report on Forensic Data Analytics and comprises global as well as India findings.
For further information, please visit: http://www.ey.com/FIDS
Playing to win in the life science tools marketBill Kelly
For the last year, clients have repeatedly been asking us similar questions:
- What's the outlook for life science funding?
- What's the impact of large mergers on the competitive environment?
- Are the ways scientists purchase products changing?
- Do new technologies represent a threat or an opportunity?
BioInformatics LLC has decided to answer these questions in our latest multi-sponsor research report, Competitive Strategies in an Era of Consolidation & Disruptive Technologies. We will undertake a comprehensive assessment of the current state of the global life science through extensive interviews with market participants, industry observers, procurement specialists and a survey of more than a thousand scientific customers from all market segments.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
2. Overview
San Diego’s Drug
Discovery community is
complex, multi-layered, and
multi-player.
We take a look at the
scientific and business
trends across the
community using data from
the Pharm2Market
platform.
4. San Diego Drug Discovery Community
The data for this presentation comes from
the Pharm2Market’s San Diego database
which contains data on over 250 drug
discovery companies in the San Diego
area.
The database includes information on
● therapeutic areas,
● therapeutic classes,
● pipelines,
● targets and
● financing mechanisms.
5. Therapeutic Areas
Oncology remains the most
highly-represented therapeutic
area, followed by Neuroscience
& Pain.
Oncology: 78 (25%)
Neuroscience & Pain: 39 (12%)
Anti-infectives: 25 (8%)
Inflammation: 22 (7%)
6. Therapeutic Classes
San Diego has a history of
fostering companies that bring new
innovative therapeutic classes to
market.
However, small molecule discovery
remains the most frequently used
therapeutic class accounting for
46% of companies; followed by
antibody discovery programs
(10%), vaccines (4%) and gene
therapies (2%).
7. Company Types
Over 80% of drug discovery
companies in San Diego have
< 50 employees. These stats
align with San Diego’s strength
as a hub for incubating new
ideas.
8. Company Funding
71% of companies are not
venture funded, and 80% have
not filed IPOs.
Much of the funding for these
companies comes from SBIR
grants, collaborations, services,
and angel funding.
9. Evolutionary Milestones
Discovery Preclinical Phase IIPhase I Phase III Registration Marketing
How advanced are San Diego drug
companies?
The vast majority (n=129) of
companies have discovery programs
that have not yet advanced to the
preclinical or clinical stage.
But we see a nearly equal number
(n=130) of companies with clinical
stage programs.
10. Local Resources
Resources provide startup companies with
everything from legal advice, laboratory
equipment and real estate to help building
the next blockbuster.
San Diego’s community includes a number
of CROs & CMOs (currently at 32), along
with research products vendors (n=21).
Incubators provide startups with everything
from co-working space, bench space and
access to the latest equipment to help
identifying potential investors and business
strategy development.
11. Most Active Local Investors
Most active investors with
presence in San Diego:
● Tech Coast Angels
● Domain Associates
● Torrey Pines Investment
● Avalon Ventures (11.8%)
● BioMed Ventures
● City Hill Ventures
13. Get Started
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