List the glucose transporters present in proximal convoluted tubules (PCT) Explain the process of reabsorption of glucose in PCT Illustrate the effects of inhibition of glucose transporter in nephrons

2. Role of kidney in
regulation of
blood glucose

3. A Case
• A recently diagnosed type 2 diabetes obese male of
50 years
• Put on Oral Hypoglycemic Drugs
• Few days later he developed urinary complains of
burning micturition, increased frequency of
urination and lethargy.
• He relate his symptoms with initiation of treatment.
• He wants to know more about the beneficial and
side effects of this drug.

4. Brainstorming
Do you think kidney
plays role in
regulation of blood
glucose?

5. OBJECTIVES
By the end of the lecture all attendees should be able to
List the glucose transporters present in proximal
convoluted tubules (PCT)
Explain the process of reabsorption of glucose in PCT
Illustrate the effects of inhibition of glucose transporter
in nephrons

6. Two sodium glucose transporters, cause
glucose reabsorption, have been identified:
SGLT-1 and SGLT-2.
• SGLT-2 is found only in the proximal
tubule of the kidney, accounts for 90% of
the re-absorption of glucose
• SGLT-1 is found in the proximal tubule of
the kidney, accounts for approximately
10% of glucose reabsorption
6
Types of Glucose Transporters in Kidneys

7. Types of Glucose Transporters in Kidneys

8. Glucose Excretion in Healthy Individuals

9. Glucose Excretion in Hyperglycaemia

10. Glucose Excretion in Diabetic Individuals

11. What happens when
the transporter that
reabsorb glucose in
nephron is blocked?

12. What happens when
SGLT2 is blocked?

13. What happens when
SGLT2 is blocked?

14. Questions
Name the transporters reabsorb most of the filter glucose ?
What is the most immediate effect of blocking these transporters?
What is the reason of weight loss when reabsorption of glucose is blocked?

15. Summary
 Kidney regulate blood glucose due to presence of specific
transporters.
 These transporters reabsorb glucose up to certain levels of
serum glucose concentrations
 Inhibitors of these transporters has beneficial as well as
adverse effects.
 Increased excretion of glucose in urine leads to decreased
blood glucose level.
 Osmotic diuresis leads to dehydration and increased
susceptibility to develop UTI.