A short presentation on the role of Diabetes mellitus in male reproductive system presented by ISHFAQ and Shri. Ramya

1. Role of Diabetes Mellitus in Male Reproductive system
Jayita Das, Manjeet, Gourav Wadhwa, Sanjay, Ishfaq Bhat, Sri Ramya
Department of Pharmacology and Toxicology
National Institute of Pharmaceutical
Education and Research, SAS Nagar,
Punjab

2. Flow of presentation
 Introduction
 Diabetes mellitus and reproductive dysfunction
 Areas mainly affected in male reproductive health
 Pathogenic factors involved in reproductive dysfunction
 Molecular mechanisms of reproductive dysfunction
 conclusion

3. Introduction
 Diabetes mellitus (DM) is a chronic metabolic disease
characterized by hyperglycemia .
 According to an International Diabetes Federation report, 382
million people were affected by diabetes worldwide in 2013
and the diabetes prevalence is expected to be 522 million by
the year 2030 .
 Increase in diabetes among young people is a great concern as
it might affect the reproductive functions .

4. Diabetes mellitus and reproductive
dysfunction(RD)
 RD is one of the most secondary complication in both
diabetic animals and humans
 DM harmfully affects male reproductive functions in
multiple areas:
i. spermatogenesis
ii. Sperm maturation
iii. fertility capability
iv. Penile erection and ejaculation
 Decrease in Gonadosomatal-index (GSI)
 Exact reasons for diabetic male reproductive dysfunction
are not completely understood

5. Diabetes and endocrine hormone disorder

6. Mechanisms of diabetic male reproductive
system damage
1. Reduced serum endocrine hormones level
2. Increased oxidative stress
3. Degenerative and apoptotic changes in the
testis
4. Aberrant autophagy
5. Neuropathy and vascularization
6. Endothelial dysfunction
7. Energy metabolism disorder that potentially
affecting directly or indirectly

7. Diabetic reproductive injury and oxidative stress

8. Diabetic reproductive injury and hypothalamic pituitary testis axis

9. Diabetic reproductive injury and germ cell apoptosis

10. Diabetic reproductive injury and germ cell autophagy

11. Conclusion:
 Although diabetic reproductive system damage has
been widely studied, there are still many areas not
clearly understood
 Factors such as disease duration, glycemic levels, and
associated comor- bidities may obscure the real
impact of DM in male fertility
 Modern pharmacological research suggests that
molecular mechanisms of testicular dysfunction might
be associated with oxidative stress, apoptosis, and
endocrine disorder.