Plant lectins in cancer prevention and treatmentIvan Ivanov
Plant lectins are specific carbohydrate-binding proteins that are widely distributed
in various plant species. They participate in many physiological processes and are capable of
modulating the immune response. Recently, greater attention has been drawn to their remarkable
anticancer properties. Lectins are associated with cell adhesion, cell proliferation
and induction of apoptosis. However, some of the questions related to the molecular mechanism
/ metabolic pathways and biological effects of lectins are still open. New challenges in
the research of lectins are related to their application in nanotechnology and development
of glycoproteomics. In addition, glycoproteomics is a powerful tool in the characterization of
lectins and will be indispensable for development of lectin based drugs in the near future.
This review provides a brief outline of the up-to-date advances in the field of plant lectins,
focusing on their complex mechanisms implicated in apoptosis and autophagy. The current
applications in cancer treatment are also described.
Plant lectins in cancer prevention and treatmentIvan Ivanov
Plant lectins are specific carbohydrate-binding proteins that are widely distributed
in various plant species. They participate in many physiological processes and are capable of
modulating the immune response. Recently, greater attention has been drawn to their remarkable
anticancer properties. Lectins are associated with cell adhesion, cell proliferation
and induction of apoptosis. However, some of the questions related to the molecular mechanism
/ metabolic pathways and biological effects of lectins are still open. New challenges in
the research of lectins are related to their application in nanotechnology and development
of glycoproteomics. In addition, glycoproteomics is a powerful tool in the characterization of
lectins and will be indispensable for development of lectin based drugs in the near future.
This review provides a brief outline of the up-to-date advances in the field of plant lectins,
focusing on their complex mechanisms implicated in apoptosis and autophagy. The current
applications in cancer treatment are also described.
The chief vegetable purgatives are aloes, colocynth, gamboge, jalap,
scammony, seeds of castor-oil plant, croton-oil, elaterium, the
hellebores, and colchicum. All these have, either alone or combined,
proved fatal. The active principle in aloes is aloin; of jalap, jalapin;
of white hellebore, veratria; and of colchicum, colchicin. Morrison's
pills contain aloes and colocynth; aloes is also the chief ingredient in
Holloway's pills
These slides represent a comprehensive view of history of using natural products caused to appearance of pharmacognosy as a science and show several aspects of pharmacognosy and natural products use and final their importance in discovering new drugs.
The chief vegetable purgatives are aloes, colocynth, gamboge, jalap,
scammony, seeds of castor-oil plant, croton-oil, elaterium, the
hellebores, and colchicum. All these have, either alone or combined,
proved fatal. The active principle in aloes is aloin; of jalap, jalapin;
of white hellebore, veratria; and of colchicum, colchicin. Morrison's
pills contain aloes and colocynth; aloes is also the chief ingredient in
Holloway's pills
These slides represent a comprehensive view of history of using natural products caused to appearance of pharmacognosy as a science and show several aspects of pharmacognosy and natural products use and final their importance in discovering new drugs.
2. Iz rastline (Ricinus communis) preko ricinusovih zrn do balzama
Uporaba ricinusovega olja:
zaprtje, obkladki, kozmetika, ličila, barvila
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3. • Citotoksičen,
• v celici prepreči sintezo proteinov,
• vstop v telo:
• dihala,
• zaužitje,
• skozi kožo,
• injiciranje,
• simptomi:
• oteženo dihanje,
• bruhanje in driska,
• znižanje krvnega tlaka,
• rdečica in bolečina.
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LD50 znaša 2,000 ng/kg
4. Veriga A in veriga B, povezani z disulfidno vezjo
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5. Aktivnost verige A
• Glikozidaza.
• odstrani adeninski ostanek iz
izpostavljene zanke 28 S rRNK,
• ena molekula deaktivira nekaj tisoč
ribosom na minuto
smrt celice
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6. Aktivnost verige B
• dve globularni domeni,
• sposobnost vezave na galaktozo.
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7. Pot ricina
• veriga B omogoči prehod toksina v
celice,
1. endocitoza,
2. trans Golgijevo omrežje,
3. Golgijev aparat,
4. endoplazemski retikulum,
5. citosol.
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