This document summarizes a monograph by P.P. Gariaev that proposes new perspectives on understanding genetic mechanisms. It critiques the classical triplet genetic code model and proposes that DNA, RNA, and proteins should be viewed as texts, not just metaphors. Gariaev's work suggests the genome functions as a quantum biocomputer, with homonymy in the genetic code allowing for quasi-consciousness. Experimental evidence demonstrates wave transmission of genetic information over kilometers. The monograph advances understanding of embryogenesis and the linguistic and quantum nature of genetic operations.

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REVIEWS
I have known P.P. Gariaev since my student years, when we both
studied at Moscow State University, he was in the department of Molecular
Biology, and I was in the department of Embryology. Back then, we made
our first attempts to understand the molecular mechanisms of zygote
transformation into an adult organism. Like then, now, I am working with
homeotic proteins that direct differentiation of embryonic cells and induce
either apoptosis or forced differentiation of malignant cells. Their
biological role is enormous, as evidenced by the work of numerous
research groups around the world, as well as our experimental data. More
is understood about the mechanisms of cytodifferentiation, but not
everything. Publications of P.P. Gariaev and his co-authors, including his
monographs "The Wave Genome" (1994) and "The Wave Genetic Code"
(1997), and this, his third monograph, allow us to open new perspectives
for understanding the mechanisms of embryogenesis and cell
differentiation. These works are aimed to solve one key problem – to
understand the functioning of the genetic apparatus. Without rejection of
classical ideas, P.P. Gariaev persistently, and on a new modern platform,
develops the ideas of Russian scientist Alexander Gurwitsch, about the
wave nature of the chromosomes operation. Understanding the wave
function of the genome is the scene of hot debate, which indirectly
indicates the enormous potential value of these works. P.P. Gariaev and
his colleagues have made significant theoretical and experimental
contributions to this complex area of natural sciences.
I am interested in the wave principles of chromosomes, and I
resonate most with Gariaev’s ideas on morphogen functions, and
especially homeotic proteins as their main component. In this monograph
P.P. Gariaev lays the foundations for linguistic genetics. The starting point
is an in-depth critical analysis of the basic provisions of genetics – the
triplet model of the genetic code, proposed by F. Crick more than forty
years ago. This model allowed us to make breakthroughs in terms of
understanding the functions of the genetic apparatus of all living beings
inhabiting the Earth. However, canonized by biologists, this model has
become a hindrance for the development toward a deeper understanding
of genome function, as was demonstrated by P.P. Gariaev and his co-
authors. Logical consequence of this theoretical analysis of the genetic
code resulted in a profound statement that DNA, RNA and proteins

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represent texts, not in a metaphorical sense as it was essentially
postulated earlier, but texts in a real sense. Multiple studies led to this
idea, this includes the works done by P.P. Gariaev and his co-authors that
made comparative mathematic-linguistic analysis of the texts of DNA
genes and human speech, independent of the language used to create the
texts. Key arguments lie in the in-depth theoretical and practical analysis
of the genetic code model that led to the conclusion that the genome on
the level of synthesis and application of DNA-RNA-protein texts, is in
actuality a quantum biocomputer. This idea cardinally changes our
understanding of protein functions, especially of the cerebral cortex
proteins as correlates of consciousness and intellect. Biochemistry
involving proteins play a leading role in the function of the organism now
may and must be understood as an intelligent quasi-speech biosystem
control. The role of homeotic proteins in embryogenesis, as factors of
intelligent organization of the developing embryo, becomes clear. Any
fundamental idea in this area is of great interest and requires further
experimental and theoretical development.
Hopyorskaya O.A.
Ph.D. in Biology

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In the book "Wave Genome. Theory and Practice" P.P. Gariaev
touches upon the fundamental questions of the genetic code related to the
structure, function, and, if I may say so, "origin" of chromosomal DNA.
It is clear how far we are from complete disclosure of all the
secrets of genetic code, however, the ideas of Prof. Gariaev and his
colleagues, give us an opportunity to see absolutely new perspectives of
operation of the chromosome apparatus in living cells, in particular, a new
scientific and practical direction, which could be called "genetic-wave
navigation and regulation in biosystems". This new direction is introduced
by the author within the framework of theoretical models, confirmed by
his own research and independent experimental research. The quantum
component of genetic cell operation is of extreme importance. It is clear,
that metabolism of cells, tissues, and organisms as a whole, which is
extreme in its complexity and scale, needs some regulation. The author
introduces a new substantial idea of genetic quantum biocomputing.
Such an approach is of interest to optical-radio electronics, radio
technology, computing, navigation and management systems. Moreover,
wave mechanisms of cell operation directly relate to nanoelectronics.
Living organisms clearly demonstrate examples of nanobiotechnologies,
effectively utilizing their own wave biocomputer regulation on
nanostructures such as enzymes, ribosomes, mitochondria, membranes,
cytoskeletons and chromosomes.
Nanotechnological mechanisms of cell operation and their genetic
apparatus, need theoretical and biological consideration, and physical-
mathematical analysis to develop, amongst other things, not known
before, principally new laser-radio wave technologies for genetic
regulation of multicellular organism metabolism. Application of such
technologies by Gariaev’s team has produced impressive results. The
author has correctly and comprehensively demonstrated remote (over
many kilometers) wave transmission of directive genetic information from
Donor (living tissue) to the Recipient (organism). Until recently such
transmission was considered to by principally impossible; now this is a
fundamental fact.
Now we have found the opportunity to build completely new
unique molecular-optical-radio-electronic equipment that should be able
to perform complex navigation-regulatory functions for positive control of
genetic-physiological functions in organisms. The task for the creation of
the genetic laser is under investigation. Proof of laser pumping of DNA

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and chromosomes in vitro was demonstrated and published by Prof.
Gariaev and his colleagues in 1996 and was confirmed by Japanese
researchers in 2002. Such a laser will perform many previously unknown
functions of the genetic apparatus to solve many problems in biology,
medicine and agriculture. Other opportunities for this work is application
of the coherent states and radiation of living cells and their information
structures for developing biocomputers, based on the principles of
holography, solitonics, and quantum nonlocality. In fact, the prototype of
such a biocomputer was created by Gariaev’s team that allowed the
collection of unique results on quantum gene transmission and remote
wave genetic bioregulation. Chromosome laser and biocomputer
application is not limited by the aforementioned, and extends beyond the
biosystem’s limits - to space communication, regulation of super complex
technical processes, aircraft navigation, etc.
This book points out a number of unresolved problems, including
the investigation of DNA wave replicas and laser-radio wave processes
during scanning and transmission of quantum biological information from
donor to recipient.
I believe that the publication of P.P. Gariaev’s monograph will
promote further investigation of one of the divine mysteries - mysteries of
the genetic code and will lead to the application of new ideas for the
benefit of the Humanity.
V.A. Matveev
Doctor of Technical Sciences,
Professor of Moscow State Technical University
named after N.E. Bauman,
Dean of the Faculty "Information and Management Systems",
Honored Scientist of Russia,
Laureate of Prizes of the Russian Government
and the City of Moscow

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What characterizes today’s genetics and molecular biology? No
doubt, it is the great progress in methodology and research technical
equipment. An expensive and long-standing "Human Genome Project" is a
good example of this. This program helped to discover the sequence of the
3 billion letters in human chromosomal DNA. This is, certainly, a
wonderful event. However, one would expect much more out of such a
titanic work. Why is it so?
In the first part of his monograph P.P. Gariaev makes a long-
awaited, deep, and most importantly, honest theoretical analysis of the
actual causes for the failure of this program. The causes, oddly enough, are
found in the biologists conventional canonized genetic code model.
Relying on pure logic and on a great experimental work of the huge global
scientific community, the author leads the reader to believe that in reality
only a small part of the functions of the genetic apparatus is known and
understood. The model of the genetic code, developed by Noble Prize
Laureate F. Crick, is incomplete. ‘The model does not fully explain some of
Crick’s own postulates’, - Gariaev says.
These postulates (the so-called ‘wobble hypothesis’) are very
important in order to understand rules of nucleotide pairing during
anticodon-codon recognition in the process of protein biosynthesis.
Following ‘the rules of ‘wobble hypothesis’ we see another (previously
missing) fundamental characteristic of the genetic code – its homonymy, -
Gariaev states. This is the second vector of degeneracy of the triplet code
(Synonymy is the first vector of degeneracy), i.e., the code’s unambiguity
for selection of different codons was detected immediately. It is well
understood and well-examined in the functions of isoacceptor transfer
RNA (tRNA). Homonymy is about the code’s ambiguity of the first
identical two nucleotides in these codons. The third nucleotide’s "wobble"
(the 3rd
nucleotide may be any of the 4 bases) and that is why they are not
involved in the coding of amino acids. In other words, the ribosome reads
the messenger RNA according to the "Two-out-of-Three" Rule. In 1978,
this was found by Swedish researcher, Ulf Lagerkvist, but then, disregarded
by the scientific community. It is obvious, that when a ribosome follows
this rule, it creates the ambiguity in homonymous codon reading. For this
reason, there is a risk of selecting the wrong amino acid or a stop codon.
This can lead to incorrect protein synthesis and death of the organism.
However, the synthesis of proteins is a very accurate process. Why do
ribosomes never fail and make a mistake? Experiments indicate that the
protein synthesizing cellular apparatus uses the linguistic mechanism of

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context orientations for correct ribosome reading of the homonymous
codon. This brings up the question (which Gariaev raises too): is the term
"reading" relating to ribosome reading (in a complex with transfer RNA) of
messenger RNA a metaphor (as is considered in genetics) or an intellectual
process, actual reading and understanding? One can assign an accurate
meaning to a homonym, only if one understands the meaning of entire
text (the context). So, does it mean that a cellular ribosomal apparatus
reads and understands the RNA in non-metaphorical sense? A definite
answer to this question is a stumbling block. It is not easy for biologists to
accept the idea of quasi-consciousness, rationality of the genome. Gariaev
thoroughly analyzes this theoretical and in the larger sense, philosophical
dead-end, and defines a genetic and biological role for homonymous
degeneracy of the triplet code. According to Gariaev, the codes homonymy
is a factor which takes the ribosomal apparatus operation, and the entire
cell, to a quasi-consciousness level, and hence, to other multi-dimensional
semantic realms. In fact, the case of coded effects of mRNA contexts is
retroactively recognized by molecular biology as a "second genetic code",
without any explanation of what kind of code it is. Here, the author
explains and demonstrates the significance of homonymy with the
example of a global danger of reckless use of transgenic manipulation with
chromosomes in genetically modified foods. What namely do transgenic
"engineers" do? They introduce foreign protein genes into the
chromosomes of organisms, and this automatically changes the genetic
contexts. This leads to misunderstanding of homonymous codons and
incorrect transposition (e.g. jumps) of ribosomes on the mRNA. This leads
to distortion of the second (linguistic, according to Gariaev) genetic code.
As a result, erroneous proteins with abnormal functions are synthesized.
There are formidable and global warnings: such transgenic manipulations
are already leading to the extinction of honeybees in the United States.
The bees collect and feed themselves with nectar and pollen from
transgenic crops – this is a reason, and probably the main one, for their
death. ‘Is Human population next?’ - asks Gariaev. Misunderstanding of
the second genetic code mechanisms, misunderstanding of the real (non-
metaphorical) linguistic nature of DNA leads not only to the
misinterpretation of proteins biosynthesis but also of embryogenesis, and
this is not less dangerous than the curse of "transgene magic".
Gariaev’s theoretical studies are not limited by the critical analysis
of the triplet code model, they go further, to the quantum mechanisms of
chromosomes. This part of the theoretical work is performed by Gariaev in
close collaboration with major physicists and mathematicians from the

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Lebedev Physical Institute of the Russian Academy of Sciences, Moscow
State University, Institute of Control Sciences named after
V.A. Trapeznikov, Russian Academy of Sciences, and foreign scientists
from Canada, England, Germany and Austria. All this laid the foundation
for the consideration of chromosome operations as a quantum
biocomputer. To Gariaev and his co-authors, genomic quantum computing
applies the principles of chromosomes coherent radiation, the principles
of bioholography and quantum nonlocality of genetic information.
The experimental part of the monograph confirms the theoretical
ideas of the author and his colleagues, the most important of which is that
genetic information may exist and work in a form of physical fields, from
photon level to radio wave level. The author and his associates conducted
experimental research in this field in Russia and Canada. They were the
first in the world, who performed remote (over many kilometers)
transmission of wave genetic information for regeneration of the pancreas
in animals and discovered the phenomenon of wave immunity.
This monography contributes to, and clearly demonstrates that
genetics and molecular biology need to transcend to a significantly higher
level of development, moreover, it contributes to this transcendence.
V.N. Volchenko
Ph.D., Professor of Moscow State Technical University
named after N.E. Bauman,
Russian Academy of Natural Sciences