This meta-analysis reviews the effectiveness of internet-based cognitive behavioral therapy (CBT) for symptoms of depression and anxiety across 12 randomized controlled trials involving 2,334 participants. The findings indicate a moderate to large overall effect size for internet-based CBT, with significant variations in effects based on symptom type and therapist support, showing larger effects for anxiety than depression. Interventions with therapist assistance yielded better outcomes compared to those without support, highlighting the importance of therapist involvement in treatment efficacy.