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Welcome Backs, New Starters & Leavers in R&D
Jennifer Dash
Research Midwife
At the beginning of September we welcomed Jenny back to the department after her
maternity leave following the arrival of her daughter. Jenny has wasted no time in
getting back on top of the studies open in maternity and attracting others to the Trust.
Carol Keel
Primary Care Research Manager
After 8 years of service as one of the pillars of primary care research across the East
of England, Carol (pictured right) has now joined the University of Cambridge’s
Institute of Metabolic Science on the Cambridge Biomedical Campus as their ‘Research
Nurse Manager’. All the very best Carol on this new and exciting chapter in your career.
You will be missed.
Alison Allen
Primary Care Research Manager
A face known to the Trust from her time working as the Lead Research Nurse for the
Essex & Hertfordshire CLRN. Alison has joined us from the Royal Free Hospital where
she has been working as their Lead Research Nurse and will now be heading up our
‘Primary Care Research Team’ based in Epping. A warm welcome to the team Alison.
Welcome to the fourth Edition of ‘RESEARCH Focus’
Welcome to the fourth edition of our departmental newsletter. What a last 3 months it has been! Thanks to the growing research
culture in the Trust, we remain the top recruiting District General Hospital in the entire East of England region (article on page 4)
with members of our team being put forward for national awards adding to the good name and reputation of the Trust as a centre
of excellence. This edition of ‘Research Focus’ covers recent local and national work we have been supporting and the 66
manuscripts that have been published over the past 3 months. We focus on the latest national funding opportunities for your
research and innovation ideas and give you an insight into a ‘day in the life’ of a research nurse. A lot to share and celebrate in this
edition!
News
News
Performance
Nursing Times Awards 2017 – Finalists in Two Categories
At the beginning of August the ‘Research Nurse Team’ learned that they had been
shortlisted for this year’s awards, in not just one but in two or the 22 categories! The team
have made the final in the ‘Clinical Research Nursing’ and ‘Team of the Year’ categories.
“It was such a wonderful surprise to hear of our nomination. Win or lose on the night, I think
we all feel like winners already seeing our name alongside some of the UK’s most celebrated
teaching hospitals. It will be an honour to represent the hospital and the Essex region at the
awards” Sue Smolen, Senior Research Nurse.
The team were asked to present to and be interviewed by the award’s judging panel in
London on the 12
th
September with the ultimate winners of these prestigious awards being
announced at a gala dinner at the Grosvenor House Hotel in London on the 2
nd
November
2017. To say thank you, the team will be repeating their presentations in Lecture Theatre 1
on Friday 20th October between 2-3pm. If you have time please come along.
Enjoy your evening at the awards ladies and gentleman. The Trust is rooting for you!
Events InnovationsPublications
IN THIS ISSUE
New Studies Page 2
MEHT National Finalist Page 2
MEHT Nurse in Spotlight Page 2
CRN Team of the Month Page 2
Mentions in Dispatches Page 3
Top DGH in E of England Page 4
‘A Day in the Life’ Page 5
Research Training Page 6
Publications Page 7
Research Funding Page 9
Innovations Page 10
New R&D Framework Page 11
Research Design Service Page 11
Newsletter
Autumn
2017
“Delivering today’s research into tomorrow’s healthcare”
Research, Development & Innovation Page 2 of 11
Recently Opened Studies (1st
July 2017 – 30th
September 2017)
NIHR portfolio adopted studies:
 ‘ECUSTEC Trial’ (NIHR 32199), Dr Job Cyriac, Paediatrics.
 ‘Head & Neck 5000 – Follow-up’ (NIHR 32797), Dr Abdel Hamid, Oncology.
 ‘PROMINENT: Triglycerides in Patients with Diabetes’ (NIHR 33472), Dr Gerald Clesham, CV.
 ‘REDUCE: Efficacy of Indwelling Pleural Catheters’ (NIHR 17127), Dr Said Isse, Respiratory.
 ‘SIMPLIFIED: Cholecalciferol in patients on dialysis’ (NIHR 31929), Dr Anthony Chan, Renal.
 ‘NOVELTY: Personalised Treatment of Asthma and COPD’ (NIHR 31744), Dr Keith Hattotuwa, Respiratory.
Non-NIHR portfolio studies:-
 ‘EPIC 3: Extended Prevalence of Infection in Intensive Care’, Dr Cath Spoors, Critical Care.
 ‘Physiological monitoring using video analysis software – Cardioversion’, Dr Gerald Clesham, CV.
MEHT Research Nurse in the National Spotlight
As part of their ‘Research makes the difference’ campaign, the National
Institute for Health Research visited the Trust over the summer to interview our very own
Christine Catley (Renal Research Nurse) about her role and day-to-day work
interacting with patients within the Renal Unit.
It’s a wonderful article. We are very proud to work with Christine and all the excellent
research nurses we are blessed to have here within R&D at the hospital.
Visit the link below to read the full article:
https://www.nihr.ac.uk/news/i-fell-in-love-with-working-in-research/6756
CRN: North Thames – MEHT Inaugural ‘Team of the Month’
Congratulations to the Broomfield Research Team who were named the inaugural
winners of CRN North Thames’ ‘Team of the Month for July’ for recruiting a
participant to a research study within the shortest possible time.
The team entered the competition for their recruitment to PORUS, a study that
aimed to describe treatment patterns and response to treatment for patients who
received second line therapy for Advanced Renal Cell Carcinoma. The team quickly
identified patients eligible for the trial, and amazingly, they managed to recruit two
patients to this observational study on the day of opening and had enrolled and
entered all data for 14 patients within a fortnight, a fantastic achievement!
MEHT Finalists in National NIHR ‘Let’s Get Digital’ Photo Competition
This competition was designed to celebrate the interesting digital ways people across the NIHR promote
research and capture why research is vital to the development of new and better treatments in the
NHS. The awards were split into five categories; ‘video’, ‘photograph’, ‘online community’, ‘website’ and
‘infographic’.
MEHT were selected as one of the five finalists in the ‘photo’ category with our picture (left) entitled ‘ A
day in the life’ depicting research being offered as a routine care option to patients within the Trust’s
renal unit. The winning entry was a heart-warming picture of Dr Bob Phillips (Paediatric Oncologist,
Leeds Teaching Hospital) and his 6 year old patient Ruddi; whom he has been treating since age 6
months and depicts the excellent rapport between the a clinician and his young patient.
To view the winning entries in each category please click on the link below:-
https://www.nihr.ac.uk/news-and-events/support-our-campaigns/2017-winners.htm
Research, Development & Innovation Page 3 of 10
Recognising Recruitment Performances Over The Past 3 Months
ASCOT (17783) - Lifestyle study for cancer survivors.
 Oncology. PI: Tracey Camburn, R&D Office Lead: Lauren Shillito.
 Top recruiting site nationally (of 9 sites); recruiting a total of 1,588 participants to date.
The 65 Trial (34222) – Permissive hypotension in critically ill patients.
 Critical Care, PI: Jay Radhakrishnan, R&D Office Lead: Fiona McNeela.
 2nd
highest recruiting site nationally (of 34 sites); recruiting a total of 16 participants to date.
ExPEC (33422) – Patients with ExPEC disease following TRUS-PNB.
 Urogenital. PI: Bill McAllister, R&D Office Lead: Lauren Shillito.
 Top recruiting site nationally (of 6 sites); recruiting a total of 145 participants to date.
PORUS-aRCC (31161) - Advanced renal cell carcinoma study.
 Oncology. PI: Gopalakrishnan Srinivasan, R&D Office Lead: Lauren Shillito
 Top recruiting site nationally (of 5 sites) in 2017/18; recruiting a total of 9 participants.
STAR (10674) – Standard vs. modified drug therapy in renal cancer.
 Oncology. PI: Gopalakrishnan Srinivasan, R&D Office Lead: Bryan Singizi.
 Top recruiting site nationally (of 52 sites) in 2017/18; recruiting a total of 35 participants.
Senior-Rita (31701) – Older patients with non-ST segment elevation myocardial infarction.
 Cardiovascular. PI: Gerald Clesham, R&D Office Lead: Sarah Williams, Kim Holland.
 2nd
highest recruiting site nationally (26 sites) during September 2017; 4 participants to date.
CALYPSO (30435) - MEDI4736 combinations in metastatic renal cell carcinoma.
 Oncology. PI: Gopalakrishnan Srinivasan, R&D Office Lead: Brian Singizi.
 Top recruiting site nationally (of 8 sites) during 2017/18; recruiting a total of 4 participants to date.
PREDICT-RA (17790) - Dose Tapering of Adalimumab of rheumatoid arthritis patients in remission.
 Musculoskeletal. PI: Win Win Maw, R&D Office Lead: Sue Smolen.
 Top recruiting site in 2017/18 (of 5 sites); recruiting a total of 3 participants.
ICON 8 (9812) - dose-fractionated chemotherapy & bevacizumab compared to either strategy.
 Oncology. PI: Helena Nam, R&D Office Lead: Yvonne Lester.
 3rd
highest recruiting site in 2017/18 (of 85 sites); recruiting a total of 35 participants to date.
PQuIP (32256) - Perioperative Quality Improvement Programme.
 Anaesthesia. PI: Al Hughes, R&D Office Lead: Fiona McNeela.
 4th
highest recruiting site in 2017/18 (of 51 sites); recruiting a total of 117 participants to date.
EMBARC (18252) – European Bronchiectasis Registry.
 Respiratory. PI: Keith Hattatouwa, R&D Office Lead: Mandy Lyle.
 Highest recruiting site in Q2 2017/18 (of 81 sites); recruiting a total of 73 participants to date.
Cleft Palate Speech (16436) - Identification of factors associated with speech disorder-cleft palate.
 Paediatrics. PI: Marie Pinkstone, R&D Office Link: Karen Cranmer.
 2nd
Highest recruiting site in 2017/18 (of 12 sites); recruiting a total of 44 participants to date.
Head & Neck 5000 (32797) - People with head and neck cancer from across the United Kingdom.
 Oncology. PI: Abdel Hamid, R&D Office Link: Victoria Apps.
 2nd
highest recruiting site in September 2017 (of 43 sites); recruiting 13 participants to date.
Positive Voices (14460) - National Survey of People with HIV.
 Infectious Diseases. PI: Huw Price, R&D Office Link: Mandy Austin.
 First study hosted at The Fairland Centre in the City Centre. 5th
highest site in surpassing initial
recruitment target
1st
2nd
1st
1st
1st
1st
1st
1st
2nd
3rd
4th
2nd
2nd
Performance
218%
Research, Development & Innovation Page 4 of 11
Top District General Hospital in the East of England for Delivering Quality Research
Our wonderful start to participant recruitment into high-quality ‘National Institute for Health Research’ (NIHR) portfolio studies
has continued throughout 2017/18 as the graph below shows for Q1-Q2. To date we have recruited 1,556 participants across
45 studies, as well as performing multiple follow-up visits for participants already enrolled in legacy studies. We are delighted
by these numbers and to have already surpassed our previous recruitment record set in 2016/17 of 1,500 participants with a
full 6 months of the financial year remaining!
There is still a lot of the year to go, but we are currently the top recruiting District General Hospital into research studies across
the entire East of England region (see graph below). We hope to finish the year in this position but our colleagues in Basildon
are giving us a good run for the prize with their excellent recruitment figures attained during Q2 with Southend currently
residing in 7
th
place out of the 14 Trusts.
What is most gratifying in our recruitment numbers is that the majority of this activity has been in relation to interventional
studies (55%). Interventional studies are often viewed as being of the ‘highest quality’ and the studies most likely to translate
into improvements in the health of those that take part in them and most likely to quickly translate into improvements in
clinical practice (i.e. new approved medicines). Again when we look at the graph below we can see that MEHT has welcomed
the highest number of patients into interventional studies across all district general hospitals in the East of England…by quite
some margin too.
As well as delivering high quality (55% of recruitment into interventional studies), and a high quantity of research activity (1%
of patients treated in the Trust consenting to take part in research), MEHT has demonstrated fantastic value for money to our
main funders the NIHR when compared to other district general hospitals in the region (see graph below).
Research, Development & Innovation Page 5 of 12
A Day In The Life Of A Research Nurse
Jo Topliffe – Research Nurse
The day starts with a visit to the Stroke Unit to listen to the clinical
handover meeting to assess if any patients have arrived on the Unit
overnight who may be eligible for a research study we have recently
opened. I have been working alongside the stroke team for over 5 years
now and clearly last night had been a busy night for them! The study I am
recruiting to is called ‘Xilo-Fist’. The study is investigating if allopurinol (a
drug normally used to treat Gout) can improve patient outcomes
following a stroke; particularly with regard to cognitive decline
and hypertension. The team talk about a patient who came in and
it looks like they meet the strict inclusion / exclusion criteria that
we have to adhere to for any study. I arrange to come back to the
ward later to speak to the patient before heading off to my
dermatology research clinic.
My mind switches from ‘Xilo-Fist’ to ‘BADBIR’; a clinical study to monitor the long-term safety of drugs (biologics) used
to treat psoriasis. Today I am performing follow up visits with 4 participants already enrolled in the study and have 1
new patient who is coming to see me to hear more about the research (informed consent). I have a general discussion
about how their health has been and this gives them time to share their experiences of their treatment and how their
skin affects their wellbeing. They then complete some questionnaires and I extract data from their clinical notes and
record their height and weight. This information all feeds back to the register looking at long term changes in the health
and safety of these new therapeutics.
Before lunch I see a patient in the Research Centre who is currently on a clinical trial, he is returning for a scheduled
blood test to ensure he is doing well on the new medication. His liver function results were slightly abnormal. I contact
the lead research doctor for the study in the Trust (aka Principal Investigator) to make them aware of the situation and
the steps we need to take to restore the participants health (closer monitoring, withdrawal of trial medication) as the
safety of the participant is absolutely paramount to us. The patient also has some questions as he is new on the study,
so I spend some time with him ensuring he is put at ease and has all the information he requires.
I return to the Stroke Unit and check the patient’s notes again to make sure nothing has changed since this morning
that may make the m unsuitable for the study. I spend time discussing the known risks and benefits of taking part in the
‘Xilo-Fist’ study with the patient and their relative and give them a ‘Patient Information Sheet’ which covers everything I
have said in writing. All research studies have these and it is good practice to give the patient as much time as possible
to consider their involvement and ask any questions they have before welcoming them onto the study. They agree for
me to revisit them tomorrow to discuss further and I document this in their medical notes.
I call into medical records to pull one set of notes that I require some extra information from to answer some data
queries regarding one of our research participants. The person had a recent admission to A&E with a fall. Although
unlikely to be directly related to the research, we report all safety events back to the study sponsor immediately upon
knowledge. It is important that if there is any safety issues (i.e. perhaps dizziness in this instance) that these will be
quickly acted upon. The safety and wellbeing of the patients is our first concern in research.
I make telephone calls to patients later in the afternoon to offer them information on a study they may be eligible for. If
they are interested I post the patient information sheet to them and make an agreement to call them back again in a
few days once they have considered. I then make a call to a patient already on a stroke study to ask if all is ok with him.
It has been 4 weeks since our previous follow up appointment. We also discuss how he is getting on with giving up
smoking, as he hoped to stop. He asked me to refer him to the Smoking Cessation team. Health Promotion also
plays a big part in my role. It is rewarding to be able to spend time supporting patients in this way.
A new stroke study has been sent to me to look at this afternoon via email to check through its requirements
and whether it is feasible to open in the hospital from a research nurse perspective. My feedback is used
within the Research and Development team to ensure that we participate in high quality studies that awe
can deliver in the hospital to advance patient care.
Research, Development & Innovation Page 6 of 11
Good Clinical Practice Training
Working to the principles of Good Clinical Practice (GCP) are the cornerstone for anyone
involved in research. All people new to research must receive introductory training in
GCP and update (refresher) training every 2 years.
We run several taught and online ‘Introductory’ and ‘Refresher’ training courses to support
you in understanding and applying the principles of GCP into practice. Our forthcoming
classroom courses are on:-
‘Introduction to GCP’ Friday 3
rd
November 2017, 9.30am-4.00pm, Olga Rippon Room, MAU.
6 CPD points Thursday 25
th
January 2018, 9.30am-4.00pm, Lecture Theatre 1, MAU
‘Refresher GCP Training’ Friday 26
th
January 2018, 2.00-5.00pm, Olga Rippon Room, MAU
4 CPD points
If none of the dates are convenient for you, we are happy to schedule further events.
For further information, or to register for online training contact Paul Roberts on ext. 6454 or at paul.roberts2@meht.nhs.uk
“I have been to several GCP courses/refreshers over the years
and this is, hands down, the best!” Consultant Anaesthetist, MEHT
Principal Investigator Oversight Master Class Training
Events
Regional Renal & Urology Research Symposium – Chelmsford, 30th
January 2018
The Clinical Research Network for North Thames are holding their first ‘Renal &
Urology Research Symposium’ at Broomfield Hospital on Tuesday 30
th
January
(9am to 5pm in the Medical Academic Unit). Broomfield Hospital was selected to
host the event due to the Trust being the highest recruiting NHS organisation into
renal and urology studies within the region during 2017 thus far. Sessions on the
day will include:
 Key Note lecture from Prof John Feehally (Leicester) on the ‘UK Renal
Research Strategy’
 Prof Martin Wilkie (Sheffield) speaking about the UKPDOPPS study
 The Mid Essex Research Team
 Patient experience and story
 EXPEC, SIMPLIFIED trial case studies
 Future studies
This event is open to all investigators and their research teams working in the CRN North Thames area.
Further details about the programme & how to register can be found on the link below:-
https://www.eventbrite.co.uk/e/crn-north-thames-renal-urology-symposium-tickets-36655271905?aff=es2
We are pleased to announce a new training course to research staff across the
region. This course has been designed for experienced Principal Investigators (PIs),
to offer practical solutions to enhance effective study oversight and management.
The master class applies an evidence-based adult learning approach, which enables
PIs to utilise their existing knowledge, learn from others and consider how they can
apply what they are learning directly to their practice.
Our next course (8 spaces, 3 CPD points) will be held on:-
Friday 3
rd
November, 2.00pm-4.30pm.
For further information, or to register, contact Paul Roberts on ext. 6454 or at
paul.roberts2@meht.nhs.uk
Research, Development & Innovation Page 7 of 11
Known Research Publications Authored by Trust Staff in Q2 2017/18 (July 2017 –September 2017)
Names of MEHT authors highlighted below
1. Abbott T.E.F.; Lee A.M.; Pearse R.M.; Ackland G.L.; Minto G.; King A.; Pollak C.; Williams C.; Patrick A.; West C.; Vickers E.; Green R.; Clark M.; Whittle J.; Paredes
L.G.; Stephens R.C.M.; Jones A.; Otto J.; Lach A.; Del Arroyo A.G.; Toner A.; Williams A.; Owen T.; Pradhu P.; Hull D.; Montague L.; MacDonald N.; Parnell W.;
Niebrzegowska E.; Gallego L.; McAlees E.; Januszewska M.; Smith A.; Gillies M.; Antonelli J.; Beattie C.; McCulloch C.; Young N.; Cameron D.; McKeown D.; Walsh
T.; Wilson E.; Hope D.; Hay A.; Beatty M.; Parks R.; Lynn K.; Blunt M.; Young P.; Moondi P.; Gibson J.; Carter J.; Watson B.; Hobbinger H.; Abdy S.; Pretorius R.;
Shafeek S.; Wong K.; Gent E.; Wolf R.; Wijewardena G.; Young B.; Irvine M.; Elliot S.; Griffiths K.; Beardow Z.; Breen A.; Howell S.; Birch S.; Berridge J.; Mohr O.;
Reynolds T.; Fawcett E.; Baytug B.; Hester N.; Sothisrihari S.; Cronin J.; Mullenheim J.; Clarkson R.; Dark P.; Kershaw M.; Stubbs C.; Walsh A.; Baldwin J.; Rice L.;
Tricklebank S.; Smith J.; Lei K.; Sanderson B.; Pearce A.; Ostermann M.; Wan R.; McKenzie C.; Berry W.; Kirk-Bayley J.; Clements D.; Dickinson M.; Shankar S.;
Carvalho P.; Kelliher L.; Jones C.; Maddison B.; Wright C.; McNeela F.; Swan K.; Topliffe J.; Williams S.; Smolen S. et al. (2017) ‘Elevated preoperative heart rate is
associated with cardiopulmonary and autonomic impairment in high-risk surgical patients.’ British Journal of Anaesthesia’ 119: 87-94.
2. Albert, V., Mndolo, S., Harrison, E. M., O'Sullivan, E., Wilson, I. H., Walker, I. A. (2017) ‘Lifebox pulse oximeter implementation in Malawi: evaluation of educational
outcomes and impact on oxygen desaturation episodes during anaesthesia’ Anaesthesia 72: 686-693.
3. Allori, A.C., Kelley, T., Meara, J.G., Albert, A., Bonanthaya, K., Kuchhal, R., Chapman, K., Cunningham, M., Daskalogiannakis, J., Long, R.E., De Gier, H., Heggie, A.A.,
Hernandez, C., Jackson, O., Taylor, J.A., Jones, Y., Williams, C., Kangesu, L., Thorburn, G., Koudstaal, M.J., Lohmander, A., Magee, L., Monson, L., Wirthlin, J.O.,
Rose, E., Sitzman, T.J., Van Eeden, S., Wong K.W. (2017) ‘A standard set of outcome measures for the comprehensive appraisal of cleft care’ Cleft Palate-Craniofacial
Journal 54: 540-554.
4. Bache, S.E., Fitzgerald O’Connor, E., Theodorakopoulou, E., Frew, Q., Philp, B., Dziewulski, P. (2017) ‘The Hand Burn Severity (HABS) score: A simple tool for
stratifying severity of hand burns.’ Burns 43: 93-99.
5. Battersby, C., Michaelides, S., Upton, M., Rennie, J.M., Babirecki, M., Harry, L., Rackham, O., Wickham, T., Hamdan, S., Gupta, A., Wigfield, R., Wong, L., Mittal, A.,
Nycyk, J., Simmons, P., Singh, A., Seal, S., Hassan, A. et al. (2017) ‘Term admissions to neonatal units in England: A role for transitional care? A retrospective cohort
study’ BMJ Open 7: (no. 5).
6. Bouras, T., Fennema, P., Burke, S., Bosman, H. (2017) ‘Stenotic intercondylar notch type is correlated with anterior cruciate ligament injury in female patients using
magnetic resonance imaging.’ Knee Surg Sports Traumatol Arthrosc. [Epub ahead of print]
7. Charalabopoulos, A., Lorenzi. B., Kordzadeh, A., Tang, C.B., Kadirkamanathan, S., Jayanthi, N.V. (2017) ‘Role of 3D in minimally invasive esophagectomy.’
Langenbeck's Archives of Surgery 402: 555-561.
8. Cheong, R.C., Bowles, P., Moore, A., Watts, S. (2017) ‘Peri-operative management of high-risk paediatric adenotonsillectomy patients: A survey of 35 UK tertiary
referral centres.’ Int J Pediatr Otorhinolaryngol. [epub ahead of print].
9. Cobb, M., Little, M., Liggins, S. (2017) ‘Mediastinal abscess and empyema complicating an odontogenic infratemporal fossa abscess.’ The British Journal of Oral &
Maxillofacial Surgery’ 55: 339-340.
10. Das D.; Nair R. (2017). ‘Bilateral trans-muscular quadratus lumborum blocks, unilateral PECS blocks and serratus plane block for analgesia after DIEP flap breast
reconstruction surgery’ Anaesthesia 72: 76.
11. Datta, M., Anderson, J., Brewis, A.J. (2017) ‘Rapid response to unexpected death; A service improved, a countywide approach’ Archives of Disease in Childhood
[epub ahead of print].
12. Donker, T., Grundmann, H., Reuter, S., Torok, M.E., Peacock, S.J., Bentley, S.D., Holden, M.T.G., Parkhill, J., Scriberras, J., Feil, E.J., Reynolds, R., Brown, N.M.,
James, R., Aenensen, D.M., Spratt, B.G., Cherian, B., Elston, T., Kent, R., Hayward, J., Teare, L., Foweraker, J., Enoch, D., Elhag, N., Singh, P., Tilley, R. (2017).
‘Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns. Microbial Genomics 3: 7.
13. Emile, J.F., Julié, C., Le Malicot, K., Lepage, C., Tabernero, J., Mini, E., Folprecht, G., Van Laethem, J.L., Dimet, S., Boulagnon-Rombi, C., Allard, M.A., Penault-Llorca,
F., Bennouna, J., Laurent-Puig, P., Taieb, J, Tahir, S. et al. (2017) ‘Prospective validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients
treated with adjuvant FOLFOX’ European Journal of Cancer 82: 16-24.
14. Farhangmehr, N., Ahmed, N., Jayanthi, N.V. (2017) ‘Laparoscopic retrocolic roux-en-y biliary bypass for the management of a retained 5 cm common bile duct stone’
Surgical Endoscopy and Other Interventional Techniques 31: (no. 2).
15. Farhangmehr, N., Tang, C.B., Lorenzi, B., Charalabopoulos, A., Kadirkamanathan, S., Siriwardana, P., Mansour, S., Jayanthi, N.V. (2017) ‘Thoracoscopic hand-sewn
anastomosis for minimal access Ivor-lewis oesophagectomy’ Surgical Endoscopy and Other Interventional Techniques 31: (no. 2).
16. Giesen, T., Calcagni, M., Elliot, D. (2017) ‘Primary Flexor Tendon Repair with Early Active Motion: Experience in Europe.’ Hand Clin. 33: 465-472.
17. Giesen, T., Klein, H.J., Franchi, A., Medina, J.A., Elliot, D. (2017). ‘Thumb carpometacarpal joint denervation for primary osteoarthritis: A prospective study of 31
thumbs.’ Hand surgery & rehabilitation 36: 192-197.
18. Gill, I., Brezina, L., Siddiqi, J. (2017) ‘Unexpected case of sclerosing mucoepidermoid carcinoma of the submandibular salivary gland’ British Journal of Oral and
Maxillofacial Surgery 55: 646-647.
19. Gopal, A., Redman, M., Cox, D., Foreman, D., Elsey, E., Fleming, S. (2017) ‘Academic poster design at a national conference: a need for standardised guidance?’ The
Clinical Teacher 14: 360-364.
20. Gorur, V., Burgess, A., Zachariah, G. (2017) ‘P1-4 - Thrombolysis in extremes of age-Two case reports pushing the boundaries of convention.’ Journal of Stroke &
Cerebrovascular Diseases 26: 898-898.
21. Govind, G., Siriwardana, H.P.P., Sdralis, E., Ram, M., Lee, P.,1, Charalabopoulos, A. (2017) ‘Chronic ileitis with transmural migration of ingested foreign body treated
by laparoscopy.’ Acta chirurgica Belgica 1: 1-5.
22. Gravante, G., Stephenson, J.A., Elshaer, M., Osman, A., Vasanthan, S., Mullineux, J.H., Gani, M.A.D., Sharpe, D., Yeung, J., Norwood, M., Miller, A., Boyle, K.,
Hemingway, D. (2017) ‘Analysis of outcomes achieved with squamous cell carcinomas of the anus in a single university hospital over the last two decades: Clinical
response rate, relapse and survival of 190 patients.’ Journal of Surgical Oncology (epub ahead of print).
23. Henderson, J.R., Thilagarajah, R. (2017) ‘Impact of national guidance on service delivery; potential pitfalls of reacting too swiftly’ Journal of One-Day Surgery 27: 4-8.
24. Hendra, H., Gorur, V., Nagi, W. (2017) ‘Audit on management of high international normalized ratio (INR) in warfarinised inpatients’ Haematologica 102: 402.
25. Heptinstall, L., Carroll, C., Siddiqi, J., Kamel, D., Petkar, M. (2017) ‘Sclerosing Mucoepidermoid Carcinoma of the Submandibular Gland Presenting as Chronic
Sialadenitis: A Case Report and Review of Literature.’ Head and Neck Pathology [Epub ahead of print].
26. Johnson, L., O'Donoghue, J.M., Lennard, A., Collis, N., McLean, N., Turton, P., Khan, A.A., Turner, S.D., Butterworth, M., Krupa, K., Gui, G., MacNeill, F.A., Bristol, J,
Hurren, J., Smith, S., Grover, K., Spyrou, G., Azmy, I.A., Young, I.E., Staiano, J.J., Khalil, H. (2017). ‘Breast implant associated anaplastic large cell lymphoma: The UK
experience. Recommendations on its management and implications for informed consent.’ European Journal of Surgical Oncology 43: 1393-1401.
27. Kimakhe, J., Gilleard, O., Swan, M.C., Pandya, P., Thakur, V., Ushakov, F., Regan, L., Minhas, M., Bailey, J., Hughes, J., Codling, P., Morris, P., Thorburn, G., Lees,
M., McEvoy, M., Abel, F., Cochrane, L., Harding, L., Nambiar,S., Chorbachi, R., Seselgyte, R., Hay, N., Patel, B., Kangesu, L. (2017) ‘Prenatal ultrasound detection of
micrognathia and its association with Robin sequence.’ Journal of Plastic, Reconstructive and Aesthetic Surgery 70: 1308-1311.
28. Kinnear, J., Wilson, N. (2017) ‘Assessing the association between thinking dispositions and clinical error.’ Postgraduate Medical Journal (epub ahead of print).
29. Kordzadeh , A., Browne, T., Panayiotopoulos, Y.P., Parsa, A.D., Askari, A. (2017) ‘The Clinical Implication of Blood Product Transfusion on Morbidity and Mortality of
Ruptured Abdominal Aortic Aneurysm.’ Clinical and Applied Thrombosis/Hemostasis 23: 601-606.
30. Kordzadeh ,A., Panayiotopolous, Y. (2017) ‘S-shaped versus conventional straight skin incision: Impact on primary functional maturation, stenosis and thrombosis of
autogenous radiocephalic arteriovenous fistula: Impact of incision on maturation, stenosis & failure of RCAVF. Study design: Prospective observational comparative.’
Annals of Medicine and Surgery 22: 16-21.
Publications
Research, Development & Innovation Page 8 of 11
…continued
31. Kordzadeh, A., Askari, A., Hoff, M., Smith, V., Panayiotopoulos, Y. (2017) ‘The Impact of Patient Demographics, Anatomy, Comorbidities, and Peri-operative
Planning on the Primary Functional Maturation of Autogenous Radiocephalic Arteriovenous Fistula.’ European journal of vascular and endovascular surgery 53: 726-
732.
32. Kordzadeh, A., Charalabopoulos, A. (2017) ‘The little old lady's hernia.’ Surgery (epub ahead of print).
33. Kordzadeh, A., Hoff, M., Tokidis, E., King, D.H., Browne, T., Prionidis, I. (2017) ‘Novel Assessment (BlueDop) Device for Detection of Lower Limb Arterial Disease: A
Prospective Comparative Study.’ J Ultrasound Med (Epub ahead of print).
34. Kordzadeh, A., Liu, M.O., Jayanthi, N.V. (2017) Male infertility following inguinal hernia repair: a systematic review and pooled analysis. Hernia 21: 1-7.
35. Kordzadeh, A., Panayiotopolous, Y.P. (2017) ‘Algorithmic salvage techniques in non-maturing radiocephalic arteriovenous fistulae with their long-term patency.’
Journal of Vascular Access 18: 443-449.
36. Kordzadeh, A., Tokidis, E., Panayiotopoulos, Y., Hoff, M., Askari, A. (2017) ‘The independent association of preoperative serum albumin on the functional
maturation of radiocephalic arteriovenous fistulae’ Journal of Vascular Access 18: 148-152.
37. Laing, T.A., Sierakowski, A., Elliot, D. (2017) ‘Management of painful scar-tethered cutaneous nerves of the upper limb.’ Hand Surgery & Rehabilitation 36: 208-214.
38. Masud, D., Haram, N., Moustaki, M., Chow, W., Saour, S., Mohanna, P.N. (2017) ‘Microsurgery simulation training system and set up: An essential system to
complement every training programme.’ Journal of Plastic, Reconstructive & Aesthetic Surgery 70: 893-900.
39. Mukherjee, C., Ewins, K., Green, J., Hodby, F. (2017) ‘A new approach to assessing nutrition and hydration capacity in patients with dementia.’ BGS Newsletter
(British Geriatrics Society) 62:4-7.
40. Naji, S., Loh, C.Y.Y., Tare, M. (2017) ‘The exquisitely painful fingertip – subungual glomus tumours’ International Wound Journal (epub ahead of print).
41. Patel, J.,Siriwardana, H.P. P., Hammond, T.,;Hanif, M.A. (2017) ‘Successful ultrasound-guided drainage of an intra-abdominal collection in late pregnancy.’ BMJ case
reports vol. 2017.
42. Pidgeon, T.E., Limb, C., Agha, R.A., Whitehurst, K., Chandrakumar, C., Wellstead, G., Fowler, A.J., Orgill, D.P. (2017) ‘The use of study registration and protocols in
plastic surgery research: A systematic review’ International Journal of Surgery 44: 215-222.
43. Pournaras, D.J., Photi, E.S., Barnett, N., Challand, C.P., Chatzizacharias, N.A., Dlamini, N.P., Doulias, T., Foley, A., Hernon, J., Kumar, B., Martin, J., Nunney, I.,
Panagiotopoulou, I., Sengupta, N., Shivakumar, O., Sinclair, P., Stather, P., Than, M.M., Wells, A.C., Xanthis, A., Dhatariya, K. (2017) ‘Assessing the quality of
primary care referrals to surgery of patients with diabetes in the East of England: A multi-centre cross-sectional cohort study.’ International Journal of Clinical Practice
71: (no. 7).
44. Raine, C., Stapleton, P.P., Merinopoulos, D., Maw, W.W., Achilleos, K., Gayford, D., Mapplebeck, S., Mackerness, C., Schofield, P., Dasgupta, B. (2017) ‘A 26-week
feasibility study comparing the efficacy and safety of modified-release prednisone with immediate-release prednisolone in newly diagnosed cases of giant cell
arteritis.’ Int J Rheum Dis (Epub ahead of print).
45. Rashid, M.S., Aziz, S., Haydar, S., Datta, A., Fleming, S.S. (2017) ‘Intra-operative fluoroscopic radiation exposure in orthopaedic trauma theatre.’ European Journal of
Orthopaedic Surgery and Traumatology 1: 1-6.
46. Roshdy, A. (2017) ‘Intensive care medicine: Navigation into the future!’ Trends in Anaesthesia and Critical Care [epub ahead of print].
47. Roshdy, A. (2017) ‘Suprasternal Doppler as a haemodynamic tool in emergency care.’ Emergency Medicine Australasia 29: 476-476.
48. Saddington, F., Maddison, B., Wang, C. (2017) ‘Human factors in a maternal cardiac arrest secondary to massive obstetric haemorrhage-utilising people and
resources’ Anaesthesia 72: 68.
49. Saour, S., Libondi, G., Ramakrishnan, V. (2017) ‘Microsurgical refinements with the use of internal mammary (IM) perforators as recipient vessels in transverse
upper gracilis (TUG) autologous breast reconstruction.’ Gland Surgery 6: 375-379.
50. Sdralis, E.K., Rashid, F., Lorenzi, B., Charalabopoulos, A., Petousis, S. (2017) ‘Epidemiology, diagnosis, and management of esophageal perforations: systematic
review.’ Diseases of the Esophagus 30: 1-6
51. Sherring, K., Waites, C., Kadri, M., Petkar, M. (2017) ‘Lymphoepithelioma-like carcinoma of the skin: A rare primary cutaneous carcinoma presenting as a metastatic
cervical lymph node.’ British Journal of Dermatology; 177: 138.
52. Sinha, K., Petkar, M., Sinclair, C., Altamura, D., Dziewulski, P. (2017) ‘Clinicopathological features of melanoma in children and young adults - Not as easy as ABC: A
10-year tertiary-referral-centre experience.’ British Journal of Dermatology 177: 59.
53. Soblet, J., Mendola, A., Helaers, R., Uebelhoer, M., Limaye, N., Boon, L.M., Vikkula, M., Kangas, J., Natynki, M., Kaakinen, M., Eklund, L., Cordisco, M., Lanoel, A.,
Dompmartin, A., Enjolras, O., Holden, S., Irvine, A.D., McAleer, M.A., Watson, R., Kangesu, L., Leaute-Labreze, C., Lokmic, Z., Penington, A., Maas, S., Rieu, P.,
Syed, S., van der Vleuten, C., Fishman S.J., Mulliken, J.B. (2017) ‘Blue Rubber Bleb Nevus (BRBN) Syndrome Is Caused by Somatic TEK (TIE2) Mutations’ Journal of
Investigative Dermatology 137: 207-216.
54. Sothisrihari, S.R., Wright, C., Hammond, T. (2017) ‘Should preoperative optimization of colorectal cancer patients supersede the demands of the 62-day pathway?’
Colorectal Disease 19: 617-620.
55. Staruch, R.M., Beverly, A., Lewis, D., Wilson, Y., Martin, N. (2017) ‘Should early amputation impact initial fluid therapy algorithms in burns resuscitation? A
retrospective analysis using 3D modelling’ Journal of the Royal Army Medical Corps 163: 58-64.
56. Steinack, C., Franzen, D., Lenherr R., Hendra, H. (2017) ‘The use of life-saving extracorporeal membrane oxygenation (ECMO) for pregnant woman with status
asthmaticus’ Journal of Asthma 54: 84-88.
57. Tang, S.S., Kaptanis, S., Haddow, J.B., Mondani, G., Elsberger, B., Tasoulis, M.K., Obondo, C., Johns, N., Ismail, W., Syed, A., Kissias, P., Venn, M., Sundaramoorthy,
S., Irwin, G., Sami, A.S., Elfadl, D., Baggaley, A., Remoundos, D.D., Langlands, F., Charalampoudis, P., Barber, Z., Hamilton-Burke, W.L.S., Khan, A., Sirianni, C.,
Merker, L.A.G., Saha, S. et al. (2017) ‘Current margin practice and effect on re-excision rates following the publication of the SSO-ASTRO consensus and ABS
consensus guidelines: a national prospective study of 2858 women undergoing breast-conserving therapy in the UK and Ireland.’ European Journal of Cancer 84: 315-
324.
58. Thaler, J., Greil, R., Gaenzer, J., Eisterer, W., Tschmelitsch, J., Keil, F., Samonigg, H., Zabernigg, A., Schmid, F., Steger, G., Steinacher, R., Andel, J., Jagdt, B., Lang, A.,
Fridrik, M., Fugger, R., Hofbauer, F., Woell, E., Geissler, D., Lenauer, A., Prager, M., Demolin, G., Kerger, J., Deboever, G., Ghillebert, G., Polus, M., Van Cutsem, E.,
Kalantari, H.R., Delaunoit, T., Goeminne, J.C., Peeters, M., Vergauwe, P., Houbiers, G., Humblet, Y., Janssens, J., Schrijvers, D., Tahir, S. et al. (2017) ‘Prospective
validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients treated with adjuvant FOLFOX.’ European Journal of Cancer 82: 16-24.
59. Thomas R.J., Creasy, H., Dheansa, B. (2017) ‘Community over-the-counter management of burns wounds: Is there an education gap?’ Burns (epub ahead of print).
60. Toscani, L., Aya, H.D., Antonakaki, D., Bastoni, D., Watson, X., Arulkumaran, N., Rhodes, A., Cecconi, M. (2017) ‘What is the impact of the fluid challenge technique
on diagnosis of fluid responsiveness? A systematic review and meta-analysis.’ Critical Care 21: (no. 1).
61. Trinh, S., Siddiqi, O., Zachariah, G., Mathews, A. (2017) ‘Prehospital times and their influence on stroke to needle times’ European Stroke Journal; 2: 413-414.
62. Upadhyaya, K., Hampanna, H., Brayshaw, S. (2017). ‘ Labour epidural monitoring: a quality improvement project at Mid Essex Hospital Services NHS Trust.’
Anaesthesia 72: 105.
63. Waites C.; Kadri M.; Sherring K.; Petkar M. (2017) ‘Atypical fibroxanthoma: Histological and immunohistochemical review of 98 cases from a single centre.’ British
Journal of Dermatology; 177: 134.
64. Waites, C., Sherring, K., Kadri, M., Kempalingaiah, A., Petkar, M. (2017) ‘Clear cell atypical fibroxanthoma: Report of three cases of an uncommon variant of atypical
fibroxanthoma.’ British Journal of Dermatology 177: 134.
65. Witoelar, A., Wang, Y., Djurovic, S., Bettella, F., Andreassen, O.A., Jansen, I.E., Heutink, P., Blauwendraat, C., Hernandez, D.G., Gasser, T., Sharma, M., Simon-
Sanchez, J., Berg, D., Brockmann, K., Wurster, I., Matzler, W., Desikan, R.S., Schork, A.J., McEvoy, L.K., Dale, A.M., Gibbs, J.R., Singleton, A.B., Nalls, M.A., Arepalli,
S., Brooks, J., Majounie, E., Chong, S., Cookson, M.R., Dillman, A., Moore, M., Traynor, B.J., Van Der Brug, M., Thompson, W.K,. Lie, B.A., Ellinghaus, D., Franke, A.,
Karlsen, T.H., Lesage, S., Brice, A., Morris, H.R., Mudanohwo, E., Wood, N.W., Hardy, J., Sheerin, U.-M., Bras, J.M., Charlesworth, G., Gardner, M., Guerreiro, R.,
Ryten, M., Trabzuni, D., Hardy, J.A., Schulte, C., Plagnol, V., Saad, M., Martinez, M., Corvol, J.C., Durr, A., Sveinbjornsdottir S. et al. (2017) ‘Genome-wide
pleiotropy between Parkinson disease and autoimmune diseases’ JAMA Neurology 74: 780-792.
66. Wormald, J.C.R., Jain, A., Lloyd-Hughes, H., Gardiner, S., Gardiner, M.D. (2017) ‘A systematic review of the influence of burying or not burying Kirschner wires on
infection rates following fixation of upper extremity fractures’ Journal of Plastic, Reconstructive and Aesthetic Surgery 70: 1298-1301.
Research, Development & Innovation Page 9 of 11
Funding£
National Research Grant Funding Opportunities & Deadlines
Below are some of the currently open nationally competitive research funding calls that are applicable to the Trust. The list below
is by no means an exhaustive list of opportunities; just the main (NIHR badged) ones. You are encouraged to contact the R&D
office if seeking funding to support your research idea at the earliest opportunity. Especially if your proposed study is likely to
need the services of a Clinical Trials Unit. We are here to help search for the most appropriate funding opportunities that are
available both nationally and internationally to you.
NIHR ‘RESEARCH FOR PATIENT BENEFIT’ (UP TO £350,000)
Researcher-led call. All specialities. 2 stage application process.
 Purpose is to realise, through evidence, the huge potential for improving, expanding and strengthening the way that
healthcare is delivered for patients, the public and the NHS.
 Current Competition 34: deadline 22
nd
November 2017
 Current Competition 35: deadline TBA (likely mid-March 2018)
http://www.nihr.ac.uk/funding-and-support/funding-for-research-studies/how-to-apply/research-programmes/research-
for-patient-benefit/
NIHR ‘PUBLIC HEALTH RESEARCH PROGRAMME’
Commissioned call for proposals that address specific topics, identified by the PHRP
17/103 - Prevention of unintentional injury in the home in children under 5 years: deadline 20
th
March
https://www.nihr.ac.uk/funding-and-support/funding-opportunities/17103-prevention-of-unintentional-injury-in-the-
home-in-children-under-5-years/6870?diaryentryid=26095
NIHR ‘HEALTH TECHNOLOGY ASSESSMENT PROGRAMME’
Commissioned call for proposals that address specific topics, identified by the HTA
17/89 - Interventions for babies born late preterm and early term: deadline 25th January 2018.
17/88 - Fluid resuscitation regimens for burn injuries: deadline 25
th
January 2018.
17/95 - Treatments for women with stress urinary incontinence after failed primary surgery: deadline 25
th
January 2018.
https://www.nihr.ac.uk/funding-and-support/current-funding-opportunities/?&start=21&custom_in_Programme=5239
NIHR ‘HEALTH SERVICES AND DELIVERY RESEARCH PROGRAMME
Research-led (evidence synthesis) call.
Deadline for applications: 11
th
January 2018
http://www.nihr.ac.uk/funding-and-support/funding-opportunities/1745-health-services-and-delivery-research-
programme-researcher-led-evidence-synthesis/6146?diaryentryid=22806
BRITISH HEART FOUNDATION – PROJECT GRANTS (<£300,000)
No deadline, submit application when ready
https://www.bhf.org.uk/research/information-for-researchers/what-we-fund/project-grants
THE STROKE ASSOCIATION – PROJECT GRANT AWARD (UP TO £210,000)
Researcher-led call.
Deadline for applications: February 2018.
https://www.stroke.org.uk/research/looking-funding/project-grants-0
JOINT STROKE ASSOCIATION / BRITISH HEART FOUNDATION – ‘CLINICAL STUDY IN STROKE AWARD’ (UP TO £1,500,000)
Researcher-led call.
Deadline for applications: February 2018.
https://www.stroke.org.uk/research/looking-funding/joint-stroke-association-british-heart-foundation-clinical-study-stroke-0
For further information and support in writing an application for any of the above, or to learn about other
funding avenues, please contact Paul Roberts (Home-Grown Research Project Manager) on
paul.roberts2@meht.nhs.uk or ext. 6454 at the earliest convenience.
nnrnrnynyr
MedTech Accelerator Programme – ‘Call 3’ Funding Deadline Approaching
Following the success of ‘Calls 1 & 2’, Health Enterprise East are pleased to announce ‘Call 3’
of the MedTech Accelerator Programme; a new proof of concept financial awards
scheme to progress medical device, diagnostics, software and e-health ideas developed
primarily from within the NHS.
With a funding pot of £1.5 million, awards on offer range from £15K-£125K. The MedTech Accelerator will support and finance
technology ideas at a very early stage in their development in order to maximise the potential for success in bringing new life
enhancing technologies to patients. Awards are aimed at supporting early proof of concept work; which typically includes:-
Market Research > IP Protection > Product and Market Validation > Prototype Development & Testing
They hope that through their support, new technology ideas in the NHS can be supported and eventually spun out into being new
commercial companies in a similar way to how Universities have been so successful over the past few decades. Time to bring your
innovations forward and be fully supported in turning your ideas into a commercial reality!
The deadline for ‘Call 3’ applications is Friday 1
st
December 2017, with short-listed applicants invited to present to the awards
panel on the 11
th
January in Cambridge.
For more information please contact the R&D office at the earliest opportunity so that we can work up your application with you or
visit the MedTech Accelerator website.
‘Clinical Entrepreneurs Forum – Developing Your Business Case’ 27th October, Girton College, Cambridge
With the aim of creating networks and communities of clinical entrepreneurs who are better placed to overcome barriers to
innovation in healthcare, Health Enterprise East are pleased to announce details of their latest Clinical Entrepreneurs Forum. This
forum (9am-1pm) is free to attend and open to all aspiring clinical and allied health professional entrepreneurs, and other NHS
innovators operating in the eastern region. To view the programme and book please visit:-
https://www.eventbrite.co.uk/e/clinical-entrepreneurs-forum-developing-your-business-case-tickets-37454704028
Innovations
Health Enterprise East Innovation Award Winners 2017
Now in its 11th year, the competition challenges NHS staff and small/medium size
businesses across the East of England, East Midlands and London to come forward
with innovative ideas for products and services that address unmet needs in the
NHS and improve patient services. Hosted by the science broadcaster Vivienne
Parry, the awards at this year’s ceremony at Sturmer Hall, Haverhill on the 20
th
September went to:-
Medical Technology – ‘Novel urinary catheter’, Cambridge University Hospital
Service Improvement – ‘IV plastic training arm’, Cambridge University Hospital
Primary Care – ‘C the signs - early cancer diagnosis’, Herts Valley CCG
SME Innovation - ‘Training aid for vascular surgeons’, Oxford Heartbeat Ltd
Diabetes – ‘EGGS: a new breed of antenatal care’ Basildon Hospital
Clinical Entrepreneur – KLIPS, Queen Elizabeth Hospital, Kings Lynn
https://www.hee.org.uk/news/2017/09/health-enterprise-east-announce-
winners-in-nhs-innovation-competition-2017
Application Deadline – Friday 1st
December 2017
New ‘Research Governance Framework for Health & Social Care Published
Transparency, public involvement, safety and proportionality must be at the centre of UK
health research, a new position statement published by the Health Research Authority on
the 16
th
October has demanded. The new guidelines replace separate ‘Research Governance
Frameworks’ in each UK country with a single, modern set of principles for the whole UK.
The document sets out ‘19 principles of good practice in research’ for those who manage
and conduct health and social research in the UK. This is the key regulatory document that
the R&D department in the Trust needs to ensure we are fully compliant with.
Since the previous frameworks were issued (back in 2001 & 2005), the environment for health
research has changed considerably; with technological developments and shifts in societal
attitudes meaning a number of new areas needed to be addressed. These include:-
 Patients, service users & public being involved in the design, management and conduct of research.
 Registering research and making it publicly available.
 Ensuring researchers pass the research findings on to the people who take part in their studies.
 Research regulation should be proportionate to the level of risk the participants are exposed to.
 R&D offices should share good practice with the wider community and publish a statement of their research capacity.
We welcome the publication of this document. The Trust is already compliant with the framework and working towards
greater patient involvement in the design of research studies for patient benefit. Full document can be accessed via link below.
http://beta.hra.nhs.uk/planning-and-improving-research/policies-standards-legislation/uk-policy-framework-health-social-care-research/
and finally…
  
Research, Development & Innovation
C254 West Wing,
Broomfield Hospital,
Court Road,
Chelmsford,
Essex, CM1 7ET
 Telephone: (01245) 515136
 E-mail: research@meht.nhs.uk
 Website: www.meht.nhs.uk/research
 Twitter: @MEHTresearch
The NIHR Research Design Service – Free guidance in support of grant applications
The NIHR Research Design Service (RDS) provides support to clinicians and researchers
who intend applying to national peer-reviewed funding programmes to undertake
applied health or social care research. RDS advisers offer a unique breadth of
experience in helping both novice and more experienced researchers to develop
competitive research applications. Advice is confidential and free of charge.
If you are developing a research proposal to attract nationally competitive funding,
please contact Paul Roberts in the R&D department (paul.roberts2@meht.nhs.uk ext. 6454)
in the first instance. Paul will support you in writing your bid and will liaise with the RDS
to set up an initial meeting to talk through your research ideas and provide ongoing support
to enhance the bid.
The RDS holds regular ‘bid development workshops’ and also offers ‘pre-submission’ review panels.
Bid Development Panel – 16
th
November 2017 Cambridge, Cambridgeshire (Submit proposals by 9 November 2017).
Pre-submission panel – 9
th
January 2018 (Submit proposals by 19
th
December 2017
To learn more about the RDS, please visit their website www.rds-eoe.nihr.ac.uk

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Research Focus - Q3 201718 Autumn R&D Newsletter

  • 1. Research, Development & Innovation Page 1 of 12 Welcome Backs, New Starters & Leavers in R&D Jennifer Dash Research Midwife At the beginning of September we welcomed Jenny back to the department after her maternity leave following the arrival of her daughter. Jenny has wasted no time in getting back on top of the studies open in maternity and attracting others to the Trust. Carol Keel Primary Care Research Manager After 8 years of service as one of the pillars of primary care research across the East of England, Carol (pictured right) has now joined the University of Cambridge’s Institute of Metabolic Science on the Cambridge Biomedical Campus as their ‘Research Nurse Manager’. All the very best Carol on this new and exciting chapter in your career. You will be missed. Alison Allen Primary Care Research Manager A face known to the Trust from her time working as the Lead Research Nurse for the Essex & Hertfordshire CLRN. Alison has joined us from the Royal Free Hospital where she has been working as their Lead Research Nurse and will now be heading up our ‘Primary Care Research Team’ based in Epping. A warm welcome to the team Alison. Welcome to the fourth Edition of ‘RESEARCH Focus’ Welcome to the fourth edition of our departmental newsletter. What a last 3 months it has been! Thanks to the growing research culture in the Trust, we remain the top recruiting District General Hospital in the entire East of England region (article on page 4) with members of our team being put forward for national awards adding to the good name and reputation of the Trust as a centre of excellence. This edition of ‘Research Focus’ covers recent local and national work we have been supporting and the 66 manuscripts that have been published over the past 3 months. We focus on the latest national funding opportunities for your research and innovation ideas and give you an insight into a ‘day in the life’ of a research nurse. A lot to share and celebrate in this edition! News News Performance Nursing Times Awards 2017 – Finalists in Two Categories At the beginning of August the ‘Research Nurse Team’ learned that they had been shortlisted for this year’s awards, in not just one but in two or the 22 categories! The team have made the final in the ‘Clinical Research Nursing’ and ‘Team of the Year’ categories. “It was such a wonderful surprise to hear of our nomination. Win or lose on the night, I think we all feel like winners already seeing our name alongside some of the UK’s most celebrated teaching hospitals. It will be an honour to represent the hospital and the Essex region at the awards” Sue Smolen, Senior Research Nurse. The team were asked to present to and be interviewed by the award’s judging panel in London on the 12 th September with the ultimate winners of these prestigious awards being announced at a gala dinner at the Grosvenor House Hotel in London on the 2 nd November 2017. To say thank you, the team will be repeating their presentations in Lecture Theatre 1 on Friday 20th October between 2-3pm. If you have time please come along. Enjoy your evening at the awards ladies and gentleman. The Trust is rooting for you! Events InnovationsPublications IN THIS ISSUE New Studies Page 2 MEHT National Finalist Page 2 MEHT Nurse in Spotlight Page 2 CRN Team of the Month Page 2 Mentions in Dispatches Page 3 Top DGH in E of England Page 4 ‘A Day in the Life’ Page 5 Research Training Page 6 Publications Page 7 Research Funding Page 9 Innovations Page 10 New R&D Framework Page 11 Research Design Service Page 11 Newsletter Autumn 2017 “Delivering today’s research into tomorrow’s healthcare”
  • 2. Research, Development & Innovation Page 2 of 11 Recently Opened Studies (1st July 2017 – 30th September 2017) NIHR portfolio adopted studies:  ‘ECUSTEC Trial’ (NIHR 32199), Dr Job Cyriac, Paediatrics.  ‘Head & Neck 5000 – Follow-up’ (NIHR 32797), Dr Abdel Hamid, Oncology.  ‘PROMINENT: Triglycerides in Patients with Diabetes’ (NIHR 33472), Dr Gerald Clesham, CV.  ‘REDUCE: Efficacy of Indwelling Pleural Catheters’ (NIHR 17127), Dr Said Isse, Respiratory.  ‘SIMPLIFIED: Cholecalciferol in patients on dialysis’ (NIHR 31929), Dr Anthony Chan, Renal.  ‘NOVELTY: Personalised Treatment of Asthma and COPD’ (NIHR 31744), Dr Keith Hattotuwa, Respiratory. Non-NIHR portfolio studies:-  ‘EPIC 3: Extended Prevalence of Infection in Intensive Care’, Dr Cath Spoors, Critical Care.  ‘Physiological monitoring using video analysis software – Cardioversion’, Dr Gerald Clesham, CV. MEHT Research Nurse in the National Spotlight As part of their ‘Research makes the difference’ campaign, the National Institute for Health Research visited the Trust over the summer to interview our very own Christine Catley (Renal Research Nurse) about her role and day-to-day work interacting with patients within the Renal Unit. It’s a wonderful article. We are very proud to work with Christine and all the excellent research nurses we are blessed to have here within R&D at the hospital. Visit the link below to read the full article: https://www.nihr.ac.uk/news/i-fell-in-love-with-working-in-research/6756 CRN: North Thames – MEHT Inaugural ‘Team of the Month’ Congratulations to the Broomfield Research Team who were named the inaugural winners of CRN North Thames’ ‘Team of the Month for July’ for recruiting a participant to a research study within the shortest possible time. The team entered the competition for their recruitment to PORUS, a study that aimed to describe treatment patterns and response to treatment for patients who received second line therapy for Advanced Renal Cell Carcinoma. The team quickly identified patients eligible for the trial, and amazingly, they managed to recruit two patients to this observational study on the day of opening and had enrolled and entered all data for 14 patients within a fortnight, a fantastic achievement! MEHT Finalists in National NIHR ‘Let’s Get Digital’ Photo Competition This competition was designed to celebrate the interesting digital ways people across the NIHR promote research and capture why research is vital to the development of new and better treatments in the NHS. The awards were split into five categories; ‘video’, ‘photograph’, ‘online community’, ‘website’ and ‘infographic’. MEHT were selected as one of the five finalists in the ‘photo’ category with our picture (left) entitled ‘ A day in the life’ depicting research being offered as a routine care option to patients within the Trust’s renal unit. The winning entry was a heart-warming picture of Dr Bob Phillips (Paediatric Oncologist, Leeds Teaching Hospital) and his 6 year old patient Ruddi; whom he has been treating since age 6 months and depicts the excellent rapport between the a clinician and his young patient. To view the winning entries in each category please click on the link below:- https://www.nihr.ac.uk/news-and-events/support-our-campaigns/2017-winners.htm
  • 3. Research, Development & Innovation Page 3 of 10 Recognising Recruitment Performances Over The Past 3 Months ASCOT (17783) - Lifestyle study for cancer survivors.  Oncology. PI: Tracey Camburn, R&D Office Lead: Lauren Shillito.  Top recruiting site nationally (of 9 sites); recruiting a total of 1,588 participants to date. The 65 Trial (34222) – Permissive hypotension in critically ill patients.  Critical Care, PI: Jay Radhakrishnan, R&D Office Lead: Fiona McNeela.  2nd highest recruiting site nationally (of 34 sites); recruiting a total of 16 participants to date. ExPEC (33422) – Patients with ExPEC disease following TRUS-PNB.  Urogenital. PI: Bill McAllister, R&D Office Lead: Lauren Shillito.  Top recruiting site nationally (of 6 sites); recruiting a total of 145 participants to date. PORUS-aRCC (31161) - Advanced renal cell carcinoma study.  Oncology. PI: Gopalakrishnan Srinivasan, R&D Office Lead: Lauren Shillito  Top recruiting site nationally (of 5 sites) in 2017/18; recruiting a total of 9 participants. STAR (10674) – Standard vs. modified drug therapy in renal cancer.  Oncology. PI: Gopalakrishnan Srinivasan, R&D Office Lead: Bryan Singizi.  Top recruiting site nationally (of 52 sites) in 2017/18; recruiting a total of 35 participants. Senior-Rita (31701) – Older patients with non-ST segment elevation myocardial infarction.  Cardiovascular. PI: Gerald Clesham, R&D Office Lead: Sarah Williams, Kim Holland.  2nd highest recruiting site nationally (26 sites) during September 2017; 4 participants to date. CALYPSO (30435) - MEDI4736 combinations in metastatic renal cell carcinoma.  Oncology. PI: Gopalakrishnan Srinivasan, R&D Office Lead: Brian Singizi.  Top recruiting site nationally (of 8 sites) during 2017/18; recruiting a total of 4 participants to date. PREDICT-RA (17790) - Dose Tapering of Adalimumab of rheumatoid arthritis patients in remission.  Musculoskeletal. PI: Win Win Maw, R&D Office Lead: Sue Smolen.  Top recruiting site in 2017/18 (of 5 sites); recruiting a total of 3 participants. ICON 8 (9812) - dose-fractionated chemotherapy & bevacizumab compared to either strategy.  Oncology. PI: Helena Nam, R&D Office Lead: Yvonne Lester.  3rd highest recruiting site in 2017/18 (of 85 sites); recruiting a total of 35 participants to date. PQuIP (32256) - Perioperative Quality Improvement Programme.  Anaesthesia. PI: Al Hughes, R&D Office Lead: Fiona McNeela.  4th highest recruiting site in 2017/18 (of 51 sites); recruiting a total of 117 participants to date. EMBARC (18252) – European Bronchiectasis Registry.  Respiratory. PI: Keith Hattatouwa, R&D Office Lead: Mandy Lyle.  Highest recruiting site in Q2 2017/18 (of 81 sites); recruiting a total of 73 participants to date. Cleft Palate Speech (16436) - Identification of factors associated with speech disorder-cleft palate.  Paediatrics. PI: Marie Pinkstone, R&D Office Link: Karen Cranmer.  2nd Highest recruiting site in 2017/18 (of 12 sites); recruiting a total of 44 participants to date. Head & Neck 5000 (32797) - People with head and neck cancer from across the United Kingdom.  Oncology. PI: Abdel Hamid, R&D Office Link: Victoria Apps.  2nd highest recruiting site in September 2017 (of 43 sites); recruiting 13 participants to date. Positive Voices (14460) - National Survey of People with HIV.  Infectious Diseases. PI: Huw Price, R&D Office Link: Mandy Austin.  First study hosted at The Fairland Centre in the City Centre. 5th highest site in surpassing initial recruitment target 1st 2nd 1st 1st 1st 1st 1st 1st 2nd 3rd 4th 2nd 2nd Performance 218%
  • 4. Research, Development & Innovation Page 4 of 11 Top District General Hospital in the East of England for Delivering Quality Research Our wonderful start to participant recruitment into high-quality ‘National Institute for Health Research’ (NIHR) portfolio studies has continued throughout 2017/18 as the graph below shows for Q1-Q2. To date we have recruited 1,556 participants across 45 studies, as well as performing multiple follow-up visits for participants already enrolled in legacy studies. We are delighted by these numbers and to have already surpassed our previous recruitment record set in 2016/17 of 1,500 participants with a full 6 months of the financial year remaining! There is still a lot of the year to go, but we are currently the top recruiting District General Hospital into research studies across the entire East of England region (see graph below). We hope to finish the year in this position but our colleagues in Basildon are giving us a good run for the prize with their excellent recruitment figures attained during Q2 with Southend currently residing in 7 th place out of the 14 Trusts. What is most gratifying in our recruitment numbers is that the majority of this activity has been in relation to interventional studies (55%). Interventional studies are often viewed as being of the ‘highest quality’ and the studies most likely to translate into improvements in the health of those that take part in them and most likely to quickly translate into improvements in clinical practice (i.e. new approved medicines). Again when we look at the graph below we can see that MEHT has welcomed the highest number of patients into interventional studies across all district general hospitals in the East of England…by quite some margin too. As well as delivering high quality (55% of recruitment into interventional studies), and a high quantity of research activity (1% of patients treated in the Trust consenting to take part in research), MEHT has demonstrated fantastic value for money to our main funders the NIHR when compared to other district general hospitals in the region (see graph below).
  • 5. Research, Development & Innovation Page 5 of 12 A Day In The Life Of A Research Nurse Jo Topliffe – Research Nurse The day starts with a visit to the Stroke Unit to listen to the clinical handover meeting to assess if any patients have arrived on the Unit overnight who may be eligible for a research study we have recently opened. I have been working alongside the stroke team for over 5 years now and clearly last night had been a busy night for them! The study I am recruiting to is called ‘Xilo-Fist’. The study is investigating if allopurinol (a drug normally used to treat Gout) can improve patient outcomes following a stroke; particularly with regard to cognitive decline and hypertension. The team talk about a patient who came in and it looks like they meet the strict inclusion / exclusion criteria that we have to adhere to for any study. I arrange to come back to the ward later to speak to the patient before heading off to my dermatology research clinic. My mind switches from ‘Xilo-Fist’ to ‘BADBIR’; a clinical study to monitor the long-term safety of drugs (biologics) used to treat psoriasis. Today I am performing follow up visits with 4 participants already enrolled in the study and have 1 new patient who is coming to see me to hear more about the research (informed consent). I have a general discussion about how their health has been and this gives them time to share their experiences of their treatment and how their skin affects their wellbeing. They then complete some questionnaires and I extract data from their clinical notes and record their height and weight. This information all feeds back to the register looking at long term changes in the health and safety of these new therapeutics. Before lunch I see a patient in the Research Centre who is currently on a clinical trial, he is returning for a scheduled blood test to ensure he is doing well on the new medication. His liver function results were slightly abnormal. I contact the lead research doctor for the study in the Trust (aka Principal Investigator) to make them aware of the situation and the steps we need to take to restore the participants health (closer monitoring, withdrawal of trial medication) as the safety of the participant is absolutely paramount to us. The patient also has some questions as he is new on the study, so I spend some time with him ensuring he is put at ease and has all the information he requires. I return to the Stroke Unit and check the patient’s notes again to make sure nothing has changed since this morning that may make the m unsuitable for the study. I spend time discussing the known risks and benefits of taking part in the ‘Xilo-Fist’ study with the patient and their relative and give them a ‘Patient Information Sheet’ which covers everything I have said in writing. All research studies have these and it is good practice to give the patient as much time as possible to consider their involvement and ask any questions they have before welcoming them onto the study. They agree for me to revisit them tomorrow to discuss further and I document this in their medical notes. I call into medical records to pull one set of notes that I require some extra information from to answer some data queries regarding one of our research participants. The person had a recent admission to A&E with a fall. Although unlikely to be directly related to the research, we report all safety events back to the study sponsor immediately upon knowledge. It is important that if there is any safety issues (i.e. perhaps dizziness in this instance) that these will be quickly acted upon. The safety and wellbeing of the patients is our first concern in research. I make telephone calls to patients later in the afternoon to offer them information on a study they may be eligible for. If they are interested I post the patient information sheet to them and make an agreement to call them back again in a few days once they have considered. I then make a call to a patient already on a stroke study to ask if all is ok with him. It has been 4 weeks since our previous follow up appointment. We also discuss how he is getting on with giving up smoking, as he hoped to stop. He asked me to refer him to the Smoking Cessation team. Health Promotion also plays a big part in my role. It is rewarding to be able to spend time supporting patients in this way. A new stroke study has been sent to me to look at this afternoon via email to check through its requirements and whether it is feasible to open in the hospital from a research nurse perspective. My feedback is used within the Research and Development team to ensure that we participate in high quality studies that awe can deliver in the hospital to advance patient care.
  • 6. Research, Development & Innovation Page 6 of 11 Good Clinical Practice Training Working to the principles of Good Clinical Practice (GCP) are the cornerstone for anyone involved in research. All people new to research must receive introductory training in GCP and update (refresher) training every 2 years. We run several taught and online ‘Introductory’ and ‘Refresher’ training courses to support you in understanding and applying the principles of GCP into practice. Our forthcoming classroom courses are on:- ‘Introduction to GCP’ Friday 3 rd November 2017, 9.30am-4.00pm, Olga Rippon Room, MAU. 6 CPD points Thursday 25 th January 2018, 9.30am-4.00pm, Lecture Theatre 1, MAU ‘Refresher GCP Training’ Friday 26 th January 2018, 2.00-5.00pm, Olga Rippon Room, MAU 4 CPD points If none of the dates are convenient for you, we are happy to schedule further events. For further information, or to register for online training contact Paul Roberts on ext. 6454 or at paul.roberts2@meht.nhs.uk “I have been to several GCP courses/refreshers over the years and this is, hands down, the best!” Consultant Anaesthetist, MEHT Principal Investigator Oversight Master Class Training Events Regional Renal & Urology Research Symposium – Chelmsford, 30th January 2018 The Clinical Research Network for North Thames are holding their first ‘Renal & Urology Research Symposium’ at Broomfield Hospital on Tuesday 30 th January (9am to 5pm in the Medical Academic Unit). Broomfield Hospital was selected to host the event due to the Trust being the highest recruiting NHS organisation into renal and urology studies within the region during 2017 thus far. Sessions on the day will include:  Key Note lecture from Prof John Feehally (Leicester) on the ‘UK Renal Research Strategy’  Prof Martin Wilkie (Sheffield) speaking about the UKPDOPPS study  The Mid Essex Research Team  Patient experience and story  EXPEC, SIMPLIFIED trial case studies  Future studies This event is open to all investigators and their research teams working in the CRN North Thames area. Further details about the programme & how to register can be found on the link below:- https://www.eventbrite.co.uk/e/crn-north-thames-renal-urology-symposium-tickets-36655271905?aff=es2 We are pleased to announce a new training course to research staff across the region. This course has been designed for experienced Principal Investigators (PIs), to offer practical solutions to enhance effective study oversight and management. The master class applies an evidence-based adult learning approach, which enables PIs to utilise their existing knowledge, learn from others and consider how they can apply what they are learning directly to their practice. Our next course (8 spaces, 3 CPD points) will be held on:- Friday 3 rd November, 2.00pm-4.30pm. For further information, or to register, contact Paul Roberts on ext. 6454 or at paul.roberts2@meht.nhs.uk
  • 7. Research, Development & Innovation Page 7 of 11 Known Research Publications Authored by Trust Staff in Q2 2017/18 (July 2017 –September 2017) Names of MEHT authors highlighted below 1. Abbott T.E.F.; Lee A.M.; Pearse R.M.; Ackland G.L.; Minto G.; King A.; Pollak C.; Williams C.; Patrick A.; West C.; Vickers E.; Green R.; Clark M.; Whittle J.; Paredes L.G.; Stephens R.C.M.; Jones A.; Otto J.; Lach A.; Del Arroyo A.G.; Toner A.; Williams A.; Owen T.; Pradhu P.; Hull D.; Montague L.; MacDonald N.; Parnell W.; Niebrzegowska E.; Gallego L.; McAlees E.; Januszewska M.; Smith A.; Gillies M.; Antonelli J.; Beattie C.; McCulloch C.; Young N.; Cameron D.; McKeown D.; Walsh T.; Wilson E.; Hope D.; Hay A.; Beatty M.; Parks R.; Lynn K.; Blunt M.; Young P.; Moondi P.; Gibson J.; Carter J.; Watson B.; Hobbinger H.; Abdy S.; Pretorius R.; Shafeek S.; Wong K.; Gent E.; Wolf R.; Wijewardena G.; Young B.; Irvine M.; Elliot S.; Griffiths K.; Beardow Z.; Breen A.; Howell S.; Birch S.; Berridge J.; Mohr O.; Reynolds T.; Fawcett E.; Baytug B.; Hester N.; Sothisrihari S.; Cronin J.; Mullenheim J.; Clarkson R.; Dark P.; Kershaw M.; Stubbs C.; Walsh A.; Baldwin J.; Rice L.; Tricklebank S.; Smith J.; Lei K.; Sanderson B.; Pearce A.; Ostermann M.; Wan R.; McKenzie C.; Berry W.; Kirk-Bayley J.; Clements D.; Dickinson M.; Shankar S.; Carvalho P.; Kelliher L.; Jones C.; Maddison B.; Wright C.; McNeela F.; Swan K.; Topliffe J.; Williams S.; Smolen S. et al. (2017) ‘Elevated preoperative heart rate is associated with cardiopulmonary and autonomic impairment in high-risk surgical patients.’ British Journal of Anaesthesia’ 119: 87-94. 2. Albert, V., Mndolo, S., Harrison, E. M., O'Sullivan, E., Wilson, I. H., Walker, I. A. (2017) ‘Lifebox pulse oximeter implementation in Malawi: evaluation of educational outcomes and impact on oxygen desaturation episodes during anaesthesia’ Anaesthesia 72: 686-693. 3. Allori, A.C., Kelley, T., Meara, J.G., Albert, A., Bonanthaya, K., Kuchhal, R., Chapman, K., Cunningham, M., Daskalogiannakis, J., Long, R.E., De Gier, H., Heggie, A.A., Hernandez, C., Jackson, O., Taylor, J.A., Jones, Y., Williams, C., Kangesu, L., Thorburn, G., Koudstaal, M.J., Lohmander, A., Magee, L., Monson, L., Wirthlin, J.O., Rose, E., Sitzman, T.J., Van Eeden, S., Wong K.W. (2017) ‘A standard set of outcome measures for the comprehensive appraisal of cleft care’ Cleft Palate-Craniofacial Journal 54: 540-554. 4. Bache, S.E., Fitzgerald O’Connor, E., Theodorakopoulou, E., Frew, Q., Philp, B., Dziewulski, P. (2017) ‘The Hand Burn Severity (HABS) score: A simple tool for stratifying severity of hand burns.’ Burns 43: 93-99. 5. Battersby, C., Michaelides, S., Upton, M., Rennie, J.M., Babirecki, M., Harry, L., Rackham, O., Wickham, T., Hamdan, S., Gupta, A., Wigfield, R., Wong, L., Mittal, A., Nycyk, J., Simmons, P., Singh, A., Seal, S., Hassan, A. et al. (2017) ‘Term admissions to neonatal units in England: A role for transitional care? A retrospective cohort study’ BMJ Open 7: (no. 5). 6. Bouras, T., Fennema, P., Burke, S., Bosman, H. (2017) ‘Stenotic intercondylar notch type is correlated with anterior cruciate ligament injury in female patients using magnetic resonance imaging.’ Knee Surg Sports Traumatol Arthrosc. [Epub ahead of print] 7. Charalabopoulos, A., Lorenzi. B., Kordzadeh, A., Tang, C.B., Kadirkamanathan, S., Jayanthi, N.V. (2017) ‘Role of 3D in minimally invasive esophagectomy.’ Langenbeck's Archives of Surgery 402: 555-561. 8. Cheong, R.C., Bowles, P., Moore, A., Watts, S. (2017) ‘Peri-operative management of high-risk paediatric adenotonsillectomy patients: A survey of 35 UK tertiary referral centres.’ Int J Pediatr Otorhinolaryngol. [epub ahead of print]. 9. Cobb, M., Little, M., Liggins, S. (2017) ‘Mediastinal abscess and empyema complicating an odontogenic infratemporal fossa abscess.’ The British Journal of Oral & Maxillofacial Surgery’ 55: 339-340. 10. Das D.; Nair R. (2017). ‘Bilateral trans-muscular quadratus lumborum blocks, unilateral PECS blocks and serratus plane block for analgesia after DIEP flap breast reconstruction surgery’ Anaesthesia 72: 76. 11. Datta, M., Anderson, J., Brewis, A.J. (2017) ‘Rapid response to unexpected death; A service improved, a countywide approach’ Archives of Disease in Childhood [epub ahead of print]. 12. Donker, T., Grundmann, H., Reuter, S., Torok, M.E., Peacock, S.J., Bentley, S.D., Holden, M.T.G., Parkhill, J., Scriberras, J., Feil, E.J., Reynolds, R., Brown, N.M., James, R., Aenensen, D.M., Spratt, B.G., Cherian, B., Elston, T., Kent, R., Hayward, J., Teare, L., Foweraker, J., Enoch, D., Elhag, N., Singh, P., Tilley, R. (2017). ‘Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns. Microbial Genomics 3: 7. 13. Emile, J.F., Julié, C., Le Malicot, K., Lepage, C., Tabernero, J., Mini, E., Folprecht, G., Van Laethem, J.L., Dimet, S., Boulagnon-Rombi, C., Allard, M.A., Penault-Llorca, F., Bennouna, J., Laurent-Puig, P., Taieb, J, Tahir, S. et al. (2017) ‘Prospective validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients treated with adjuvant FOLFOX’ European Journal of Cancer 82: 16-24. 14. Farhangmehr, N., Ahmed, N., Jayanthi, N.V. (2017) ‘Laparoscopic retrocolic roux-en-y biliary bypass for the management of a retained 5 cm common bile duct stone’ Surgical Endoscopy and Other Interventional Techniques 31: (no. 2). 15. Farhangmehr, N., Tang, C.B., Lorenzi, B., Charalabopoulos, A., Kadirkamanathan, S., Siriwardana, P., Mansour, S., Jayanthi, N.V. (2017) ‘Thoracoscopic hand-sewn anastomosis for minimal access Ivor-lewis oesophagectomy’ Surgical Endoscopy and Other Interventional Techniques 31: (no. 2). 16. Giesen, T., Calcagni, M., Elliot, D. (2017) ‘Primary Flexor Tendon Repair with Early Active Motion: Experience in Europe.’ Hand Clin. 33: 465-472. 17. Giesen, T., Klein, H.J., Franchi, A., Medina, J.A., Elliot, D. (2017). ‘Thumb carpometacarpal joint denervation for primary osteoarthritis: A prospective study of 31 thumbs.’ Hand surgery & rehabilitation 36: 192-197. 18. Gill, I., Brezina, L., Siddiqi, J. (2017) ‘Unexpected case of sclerosing mucoepidermoid carcinoma of the submandibular salivary gland’ British Journal of Oral and Maxillofacial Surgery 55: 646-647. 19. Gopal, A., Redman, M., Cox, D., Foreman, D., Elsey, E., Fleming, S. (2017) ‘Academic poster design at a national conference: a need for standardised guidance?’ The Clinical Teacher 14: 360-364. 20. Gorur, V., Burgess, A., Zachariah, G. (2017) ‘P1-4 - Thrombolysis in extremes of age-Two case reports pushing the boundaries of convention.’ Journal of Stroke & Cerebrovascular Diseases 26: 898-898. 21. Govind, G., Siriwardana, H.P.P., Sdralis, E., Ram, M., Lee, P.,1, Charalabopoulos, A. (2017) ‘Chronic ileitis with transmural migration of ingested foreign body treated by laparoscopy.’ Acta chirurgica Belgica 1: 1-5. 22. Gravante, G., Stephenson, J.A., Elshaer, M., Osman, A., Vasanthan, S., Mullineux, J.H., Gani, M.A.D., Sharpe, D., Yeung, J., Norwood, M., Miller, A., Boyle, K., Hemingway, D. (2017) ‘Analysis of outcomes achieved with squamous cell carcinomas of the anus in a single university hospital over the last two decades: Clinical response rate, relapse and survival of 190 patients.’ Journal of Surgical Oncology (epub ahead of print). 23. Henderson, J.R., Thilagarajah, R. (2017) ‘Impact of national guidance on service delivery; potential pitfalls of reacting too swiftly’ Journal of One-Day Surgery 27: 4-8. 24. Hendra, H., Gorur, V., Nagi, W. (2017) ‘Audit on management of high international normalized ratio (INR) in warfarinised inpatients’ Haematologica 102: 402. 25. Heptinstall, L., Carroll, C., Siddiqi, J., Kamel, D., Petkar, M. (2017) ‘Sclerosing Mucoepidermoid Carcinoma of the Submandibular Gland Presenting as Chronic Sialadenitis: A Case Report and Review of Literature.’ Head and Neck Pathology [Epub ahead of print]. 26. Johnson, L., O'Donoghue, J.M., Lennard, A., Collis, N., McLean, N., Turton, P., Khan, A.A., Turner, S.D., Butterworth, M., Krupa, K., Gui, G., MacNeill, F.A., Bristol, J, Hurren, J., Smith, S., Grover, K., Spyrou, G., Azmy, I.A., Young, I.E., Staiano, J.J., Khalil, H. (2017). ‘Breast implant associated anaplastic large cell lymphoma: The UK experience. Recommendations on its management and implications for informed consent.’ European Journal of Surgical Oncology 43: 1393-1401. 27. Kimakhe, J., Gilleard, O., Swan, M.C., Pandya, P., Thakur, V., Ushakov, F., Regan, L., Minhas, M., Bailey, J., Hughes, J., Codling, P., Morris, P., Thorburn, G., Lees, M., McEvoy, M., Abel, F., Cochrane, L., Harding, L., Nambiar,S., Chorbachi, R., Seselgyte, R., Hay, N., Patel, B., Kangesu, L. (2017) ‘Prenatal ultrasound detection of micrognathia and its association with Robin sequence.’ Journal of Plastic, Reconstructive and Aesthetic Surgery 70: 1308-1311. 28. Kinnear, J., Wilson, N. (2017) ‘Assessing the association between thinking dispositions and clinical error.’ Postgraduate Medical Journal (epub ahead of print). 29. Kordzadeh , A., Browne, T., Panayiotopoulos, Y.P., Parsa, A.D., Askari, A. (2017) ‘The Clinical Implication of Blood Product Transfusion on Morbidity and Mortality of Ruptured Abdominal Aortic Aneurysm.’ Clinical and Applied Thrombosis/Hemostasis 23: 601-606. 30. Kordzadeh ,A., Panayiotopolous, Y. (2017) ‘S-shaped versus conventional straight skin incision: Impact on primary functional maturation, stenosis and thrombosis of autogenous radiocephalic arteriovenous fistula: Impact of incision on maturation, stenosis & failure of RCAVF. Study design: Prospective observational comparative.’ Annals of Medicine and Surgery 22: 16-21. Publications
  • 8. Research, Development & Innovation Page 8 of 11 …continued 31. Kordzadeh, A., Askari, A., Hoff, M., Smith, V., Panayiotopoulos, Y. (2017) ‘The Impact of Patient Demographics, Anatomy, Comorbidities, and Peri-operative Planning on the Primary Functional Maturation of Autogenous Radiocephalic Arteriovenous Fistula.’ European journal of vascular and endovascular surgery 53: 726- 732. 32. Kordzadeh, A., Charalabopoulos, A. (2017) ‘The little old lady's hernia.’ Surgery (epub ahead of print). 33. Kordzadeh, A., Hoff, M., Tokidis, E., King, D.H., Browne, T., Prionidis, I. (2017) ‘Novel Assessment (BlueDop) Device for Detection of Lower Limb Arterial Disease: A Prospective Comparative Study.’ J Ultrasound Med (Epub ahead of print). 34. Kordzadeh, A., Liu, M.O., Jayanthi, N.V. (2017) Male infertility following inguinal hernia repair: a systematic review and pooled analysis. Hernia 21: 1-7. 35. Kordzadeh, A., Panayiotopolous, Y.P. (2017) ‘Algorithmic salvage techniques in non-maturing radiocephalic arteriovenous fistulae with their long-term patency.’ Journal of Vascular Access 18: 443-449. 36. Kordzadeh, A., Tokidis, E., Panayiotopoulos, Y., Hoff, M., Askari, A. (2017) ‘The independent association of preoperative serum albumin on the functional maturation of radiocephalic arteriovenous fistulae’ Journal of Vascular Access 18: 148-152. 37. Laing, T.A., Sierakowski, A., Elliot, D. (2017) ‘Management of painful scar-tethered cutaneous nerves of the upper limb.’ Hand Surgery & Rehabilitation 36: 208-214. 38. Masud, D., Haram, N., Moustaki, M., Chow, W., Saour, S., Mohanna, P.N. (2017) ‘Microsurgery simulation training system and set up: An essential system to complement every training programme.’ Journal of Plastic, Reconstructive & Aesthetic Surgery 70: 893-900. 39. Mukherjee, C., Ewins, K., Green, J., Hodby, F. (2017) ‘A new approach to assessing nutrition and hydration capacity in patients with dementia.’ BGS Newsletter (British Geriatrics Society) 62:4-7. 40. Naji, S., Loh, C.Y.Y., Tare, M. (2017) ‘The exquisitely painful fingertip – subungual glomus tumours’ International Wound Journal (epub ahead of print). 41. Patel, J.,Siriwardana, H.P. P., Hammond, T.,;Hanif, M.A. (2017) ‘Successful ultrasound-guided drainage of an intra-abdominal collection in late pregnancy.’ BMJ case reports vol. 2017. 42. Pidgeon, T.E., Limb, C., Agha, R.A., Whitehurst, K., Chandrakumar, C., Wellstead, G., Fowler, A.J., Orgill, D.P. (2017) ‘The use of study registration and protocols in plastic surgery research: A systematic review’ International Journal of Surgery 44: 215-222. 43. Pournaras, D.J., Photi, E.S., Barnett, N., Challand, C.P., Chatzizacharias, N.A., Dlamini, N.P., Doulias, T., Foley, A., Hernon, J., Kumar, B., Martin, J., Nunney, I., Panagiotopoulou, I., Sengupta, N., Shivakumar, O., Sinclair, P., Stather, P., Than, M.M., Wells, A.C., Xanthis, A., Dhatariya, K. (2017) ‘Assessing the quality of primary care referrals to surgery of patients with diabetes in the East of England: A multi-centre cross-sectional cohort study.’ International Journal of Clinical Practice 71: (no. 7). 44. Raine, C., Stapleton, P.P., Merinopoulos, D., Maw, W.W., Achilleos, K., Gayford, D., Mapplebeck, S., Mackerness, C., Schofield, P., Dasgupta, B. (2017) ‘A 26-week feasibility study comparing the efficacy and safety of modified-release prednisone with immediate-release prednisolone in newly diagnosed cases of giant cell arteritis.’ Int J Rheum Dis (Epub ahead of print). 45. Rashid, M.S., Aziz, S., Haydar, S., Datta, A., Fleming, S.S. (2017) ‘Intra-operative fluoroscopic radiation exposure in orthopaedic trauma theatre.’ European Journal of Orthopaedic Surgery and Traumatology 1: 1-6. 46. Roshdy, A. (2017) ‘Intensive care medicine: Navigation into the future!’ Trends in Anaesthesia and Critical Care [epub ahead of print]. 47. Roshdy, A. (2017) ‘Suprasternal Doppler as a haemodynamic tool in emergency care.’ Emergency Medicine Australasia 29: 476-476. 48. Saddington, F., Maddison, B., Wang, C. (2017) ‘Human factors in a maternal cardiac arrest secondary to massive obstetric haemorrhage-utilising people and resources’ Anaesthesia 72: 68. 49. Saour, S., Libondi, G., Ramakrishnan, V. (2017) ‘Microsurgical refinements with the use of internal mammary (IM) perforators as recipient vessels in transverse upper gracilis (TUG) autologous breast reconstruction.’ Gland Surgery 6: 375-379. 50. Sdralis, E.K., Rashid, F., Lorenzi, B., Charalabopoulos, A., Petousis, S. (2017) ‘Epidemiology, diagnosis, and management of esophageal perforations: systematic review.’ Diseases of the Esophagus 30: 1-6 51. Sherring, K., Waites, C., Kadri, M., Petkar, M. (2017) ‘Lymphoepithelioma-like carcinoma of the skin: A rare primary cutaneous carcinoma presenting as a metastatic cervical lymph node.’ British Journal of Dermatology; 177: 138. 52. Sinha, K., Petkar, M., Sinclair, C., Altamura, D., Dziewulski, P. (2017) ‘Clinicopathological features of melanoma in children and young adults - Not as easy as ABC: A 10-year tertiary-referral-centre experience.’ British Journal of Dermatology 177: 59. 53. Soblet, J., Mendola, A., Helaers, R., Uebelhoer, M., Limaye, N., Boon, L.M., Vikkula, M., Kangas, J., Natynki, M., Kaakinen, M., Eklund, L., Cordisco, M., Lanoel, A., Dompmartin, A., Enjolras, O., Holden, S., Irvine, A.D., McAleer, M.A., Watson, R., Kangesu, L., Leaute-Labreze, C., Lokmic, Z., Penington, A., Maas, S., Rieu, P., Syed, S., van der Vleuten, C., Fishman S.J., Mulliken, J.B. (2017) ‘Blue Rubber Bleb Nevus (BRBN) Syndrome Is Caused by Somatic TEK (TIE2) Mutations’ Journal of Investigative Dermatology 137: 207-216. 54. Sothisrihari, S.R., Wright, C., Hammond, T. (2017) ‘Should preoperative optimization of colorectal cancer patients supersede the demands of the 62-day pathway?’ Colorectal Disease 19: 617-620. 55. Staruch, R.M., Beverly, A., Lewis, D., Wilson, Y., Martin, N. (2017) ‘Should early amputation impact initial fluid therapy algorithms in burns resuscitation? A retrospective analysis using 3D modelling’ Journal of the Royal Army Medical Corps 163: 58-64. 56. Steinack, C., Franzen, D., Lenherr R., Hendra, H. (2017) ‘The use of life-saving extracorporeal membrane oxygenation (ECMO) for pregnant woman with status asthmaticus’ Journal of Asthma 54: 84-88. 57. Tang, S.S., Kaptanis, S., Haddow, J.B., Mondani, G., Elsberger, B., Tasoulis, M.K., Obondo, C., Johns, N., Ismail, W., Syed, A., Kissias, P., Venn, M., Sundaramoorthy, S., Irwin, G., Sami, A.S., Elfadl, D., Baggaley, A., Remoundos, D.D., Langlands, F., Charalampoudis, P., Barber, Z., Hamilton-Burke, W.L.S., Khan, A., Sirianni, C., Merker, L.A.G., Saha, S. et al. (2017) ‘Current margin practice and effect on re-excision rates following the publication of the SSO-ASTRO consensus and ABS consensus guidelines: a national prospective study of 2858 women undergoing breast-conserving therapy in the UK and Ireland.’ European Journal of Cancer 84: 315- 324. 58. Thaler, J., Greil, R., Gaenzer, J., Eisterer, W., Tschmelitsch, J., Keil, F., Samonigg, H., Zabernigg, A., Schmid, F., Steger, G., Steinacher, R., Andel, J., Jagdt, B., Lang, A., Fridrik, M., Fugger, R., Hofbauer, F., Woell, E., Geissler, D., Lenauer, A., Prager, M., Demolin, G., Kerger, J., Deboever, G., Ghillebert, G., Polus, M., Van Cutsem, E., Kalantari, H.R., Delaunoit, T., Goeminne, J.C., Peeters, M., Vergauwe, P., Houbiers, G., Humblet, Y., Janssens, J., Schrijvers, D., Tahir, S. et al. (2017) ‘Prospective validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients treated with adjuvant FOLFOX.’ European Journal of Cancer 82: 16-24. 59. Thomas R.J., Creasy, H., Dheansa, B. (2017) ‘Community over-the-counter management of burns wounds: Is there an education gap?’ Burns (epub ahead of print). 60. Toscani, L., Aya, H.D., Antonakaki, D., Bastoni, D., Watson, X., Arulkumaran, N., Rhodes, A., Cecconi, M. (2017) ‘What is the impact of the fluid challenge technique on diagnosis of fluid responsiveness? A systematic review and meta-analysis.’ Critical Care 21: (no. 1). 61. Trinh, S., Siddiqi, O., Zachariah, G., Mathews, A. (2017) ‘Prehospital times and their influence on stroke to needle times’ European Stroke Journal; 2: 413-414. 62. Upadhyaya, K., Hampanna, H., Brayshaw, S. (2017). ‘ Labour epidural monitoring: a quality improvement project at Mid Essex Hospital Services NHS Trust.’ Anaesthesia 72: 105. 63. Waites C.; Kadri M.; Sherring K.; Petkar M. (2017) ‘Atypical fibroxanthoma: Histological and immunohistochemical review of 98 cases from a single centre.’ British Journal of Dermatology; 177: 134. 64. Waites, C., Sherring, K., Kadri, M., Kempalingaiah, A., Petkar, M. (2017) ‘Clear cell atypical fibroxanthoma: Report of three cases of an uncommon variant of atypical fibroxanthoma.’ British Journal of Dermatology 177: 134. 65. Witoelar, A., Wang, Y., Djurovic, S., Bettella, F., Andreassen, O.A., Jansen, I.E., Heutink, P., Blauwendraat, C., Hernandez, D.G., Gasser, T., Sharma, M., Simon- Sanchez, J., Berg, D., Brockmann, K., Wurster, I., Matzler, W., Desikan, R.S., Schork, A.J., McEvoy, L.K., Dale, A.M., Gibbs, J.R., Singleton, A.B., Nalls, M.A., Arepalli, S., Brooks, J., Majounie, E., Chong, S., Cookson, M.R., Dillman, A., Moore, M., Traynor, B.J., Van Der Brug, M., Thompson, W.K,. Lie, B.A., Ellinghaus, D., Franke, A., Karlsen, T.H., Lesage, S., Brice, A., Morris, H.R., Mudanohwo, E., Wood, N.W., Hardy, J., Sheerin, U.-M., Bras, J.M., Charlesworth, G., Gardner, M., Guerreiro, R., Ryten, M., Trabzuni, D., Hardy, J.A., Schulte, C., Plagnol, V., Saad, M., Martinez, M., Corvol, J.C., Durr, A., Sveinbjornsdottir S. et al. (2017) ‘Genome-wide pleiotropy between Parkinson disease and autoimmune diseases’ JAMA Neurology 74: 780-792. 66. Wormald, J.C.R., Jain, A., Lloyd-Hughes, H., Gardiner, S., Gardiner, M.D. (2017) ‘A systematic review of the influence of burying or not burying Kirschner wires on infection rates following fixation of upper extremity fractures’ Journal of Plastic, Reconstructive and Aesthetic Surgery 70: 1298-1301.
  • 9. Research, Development & Innovation Page 9 of 11 Funding£ National Research Grant Funding Opportunities & Deadlines Below are some of the currently open nationally competitive research funding calls that are applicable to the Trust. The list below is by no means an exhaustive list of opportunities; just the main (NIHR badged) ones. You are encouraged to contact the R&D office if seeking funding to support your research idea at the earliest opportunity. Especially if your proposed study is likely to need the services of a Clinical Trials Unit. We are here to help search for the most appropriate funding opportunities that are available both nationally and internationally to you. NIHR ‘RESEARCH FOR PATIENT BENEFIT’ (UP TO £350,000) Researcher-led call. All specialities. 2 stage application process.  Purpose is to realise, through evidence, the huge potential for improving, expanding and strengthening the way that healthcare is delivered for patients, the public and the NHS.  Current Competition 34: deadline 22 nd November 2017  Current Competition 35: deadline TBA (likely mid-March 2018) http://www.nihr.ac.uk/funding-and-support/funding-for-research-studies/how-to-apply/research-programmes/research- for-patient-benefit/ NIHR ‘PUBLIC HEALTH RESEARCH PROGRAMME’ Commissioned call for proposals that address specific topics, identified by the PHRP 17/103 - Prevention of unintentional injury in the home in children under 5 years: deadline 20 th March https://www.nihr.ac.uk/funding-and-support/funding-opportunities/17103-prevention-of-unintentional-injury-in-the- home-in-children-under-5-years/6870?diaryentryid=26095 NIHR ‘HEALTH TECHNOLOGY ASSESSMENT PROGRAMME’ Commissioned call for proposals that address specific topics, identified by the HTA 17/89 - Interventions for babies born late preterm and early term: deadline 25th January 2018. 17/88 - Fluid resuscitation regimens for burn injuries: deadline 25 th January 2018. 17/95 - Treatments for women with stress urinary incontinence after failed primary surgery: deadline 25 th January 2018. https://www.nihr.ac.uk/funding-and-support/current-funding-opportunities/?&start=21&custom_in_Programme=5239 NIHR ‘HEALTH SERVICES AND DELIVERY RESEARCH PROGRAMME Research-led (evidence synthesis) call. Deadline for applications: 11 th January 2018 http://www.nihr.ac.uk/funding-and-support/funding-opportunities/1745-health-services-and-delivery-research- programme-researcher-led-evidence-synthesis/6146?diaryentryid=22806 BRITISH HEART FOUNDATION – PROJECT GRANTS (<£300,000) No deadline, submit application when ready https://www.bhf.org.uk/research/information-for-researchers/what-we-fund/project-grants THE STROKE ASSOCIATION – PROJECT GRANT AWARD (UP TO £210,000) Researcher-led call. Deadline for applications: February 2018. https://www.stroke.org.uk/research/looking-funding/project-grants-0 JOINT STROKE ASSOCIATION / BRITISH HEART FOUNDATION – ‘CLINICAL STUDY IN STROKE AWARD’ (UP TO £1,500,000) Researcher-led call. Deadline for applications: February 2018. https://www.stroke.org.uk/research/looking-funding/joint-stroke-association-british-heart-foundation-clinical-study-stroke-0 For further information and support in writing an application for any of the above, or to learn about other funding avenues, please contact Paul Roberts (Home-Grown Research Project Manager) on paul.roberts2@meht.nhs.uk or ext. 6454 at the earliest convenience.
  • 10. nnrnrnynyr MedTech Accelerator Programme – ‘Call 3’ Funding Deadline Approaching Following the success of ‘Calls 1 & 2’, Health Enterprise East are pleased to announce ‘Call 3’ of the MedTech Accelerator Programme; a new proof of concept financial awards scheme to progress medical device, diagnostics, software and e-health ideas developed primarily from within the NHS. With a funding pot of £1.5 million, awards on offer range from £15K-£125K. The MedTech Accelerator will support and finance technology ideas at a very early stage in their development in order to maximise the potential for success in bringing new life enhancing technologies to patients. Awards are aimed at supporting early proof of concept work; which typically includes:- Market Research > IP Protection > Product and Market Validation > Prototype Development & Testing They hope that through their support, new technology ideas in the NHS can be supported and eventually spun out into being new commercial companies in a similar way to how Universities have been so successful over the past few decades. Time to bring your innovations forward and be fully supported in turning your ideas into a commercial reality! The deadline for ‘Call 3’ applications is Friday 1 st December 2017, with short-listed applicants invited to present to the awards panel on the 11 th January in Cambridge. For more information please contact the R&D office at the earliest opportunity so that we can work up your application with you or visit the MedTech Accelerator website. ‘Clinical Entrepreneurs Forum – Developing Your Business Case’ 27th October, Girton College, Cambridge With the aim of creating networks and communities of clinical entrepreneurs who are better placed to overcome barriers to innovation in healthcare, Health Enterprise East are pleased to announce details of their latest Clinical Entrepreneurs Forum. This forum (9am-1pm) is free to attend and open to all aspiring clinical and allied health professional entrepreneurs, and other NHS innovators operating in the eastern region. To view the programme and book please visit:- https://www.eventbrite.co.uk/e/clinical-entrepreneurs-forum-developing-your-business-case-tickets-37454704028 Innovations Health Enterprise East Innovation Award Winners 2017 Now in its 11th year, the competition challenges NHS staff and small/medium size businesses across the East of England, East Midlands and London to come forward with innovative ideas for products and services that address unmet needs in the NHS and improve patient services. Hosted by the science broadcaster Vivienne Parry, the awards at this year’s ceremony at Sturmer Hall, Haverhill on the 20 th September went to:- Medical Technology – ‘Novel urinary catheter’, Cambridge University Hospital Service Improvement – ‘IV plastic training arm’, Cambridge University Hospital Primary Care – ‘C the signs - early cancer diagnosis’, Herts Valley CCG SME Innovation - ‘Training aid for vascular surgeons’, Oxford Heartbeat Ltd Diabetes – ‘EGGS: a new breed of antenatal care’ Basildon Hospital Clinical Entrepreneur – KLIPS, Queen Elizabeth Hospital, Kings Lynn https://www.hee.org.uk/news/2017/09/health-enterprise-east-announce- winners-in-nhs-innovation-competition-2017 Application Deadline – Friday 1st December 2017
  • 11. New ‘Research Governance Framework for Health & Social Care Published Transparency, public involvement, safety and proportionality must be at the centre of UK health research, a new position statement published by the Health Research Authority on the 16 th October has demanded. The new guidelines replace separate ‘Research Governance Frameworks’ in each UK country with a single, modern set of principles for the whole UK. The document sets out ‘19 principles of good practice in research’ for those who manage and conduct health and social research in the UK. This is the key regulatory document that the R&D department in the Trust needs to ensure we are fully compliant with. Since the previous frameworks were issued (back in 2001 & 2005), the environment for health research has changed considerably; with technological developments and shifts in societal attitudes meaning a number of new areas needed to be addressed. These include:-  Patients, service users & public being involved in the design, management and conduct of research.  Registering research and making it publicly available.  Ensuring researchers pass the research findings on to the people who take part in their studies.  Research regulation should be proportionate to the level of risk the participants are exposed to.  R&D offices should share good practice with the wider community and publish a statement of their research capacity. We welcome the publication of this document. The Trust is already compliant with the framework and working towards greater patient involvement in the design of research studies for patient benefit. Full document can be accessed via link below. http://beta.hra.nhs.uk/planning-and-improving-research/policies-standards-legislation/uk-policy-framework-health-social-care-research/ and finally…    Research, Development & Innovation C254 West Wing, Broomfield Hospital, Court Road, Chelmsford, Essex, CM1 7ET  Telephone: (01245) 515136  E-mail: research@meht.nhs.uk  Website: www.meht.nhs.uk/research  Twitter: @MEHTresearch The NIHR Research Design Service – Free guidance in support of grant applications The NIHR Research Design Service (RDS) provides support to clinicians and researchers who intend applying to national peer-reviewed funding programmes to undertake applied health or social care research. RDS advisers offer a unique breadth of experience in helping both novice and more experienced researchers to develop competitive research applications. Advice is confidential and free of charge. If you are developing a research proposal to attract nationally competitive funding, please contact Paul Roberts in the R&D department (paul.roberts2@meht.nhs.uk ext. 6454) in the first instance. Paul will support you in writing your bid and will liaise with the RDS to set up an initial meeting to talk through your research ideas and provide ongoing support to enhance the bid. The RDS holds regular ‘bid development workshops’ and also offers ‘pre-submission’ review panels. Bid Development Panel – 16 th November 2017 Cambridge, Cambridgeshire (Submit proposals by 9 November 2017). Pre-submission panel – 9 th January 2018 (Submit proposals by 19 th December 2017 To learn more about the RDS, please visit their website www.rds-eoe.nihr.ac.uk