Ultra-fast Outflows from Active Galactic Nuclei of Seyfert I GalaxiesAshkbiz Danehkar
High Energy Phenomena Seminar, Harvard CfA, Cambridge, USA, September 7, 2016, https://doi.org/10.6084/m9.figshare.13699048 https://youtu.be/7q_wv61ou1E
Tendex and Vortex Lines around Spinning Supermassive Black HolesAshkbiz Danehkar
Talk presented at the 30th Midwest Relativity Meeting (Virtual), University of Notre Dame, IN, USA, October 23, 2020, https://doi.org/10.6084/m9.figshare.13699531
Active Galactic Nuclei: Laboratory for Gravitational PhysicsAshkbiz Danehkar
Talk at the 29th Midwest Relativity Meeting, Grand Valley State University, Grand Rapids, MI, USA, October 4, 2019, https://doi.org/10.6084/m9.figshare.13699240
Ultra-fast Outflows from Active Galactic Nuclei of Seyfert I GalaxiesAshkbiz Danehkar
High Energy Phenomena Seminar, Harvard CfA, Cambridge, USA, September 7, 2016, https://doi.org/10.6084/m9.figshare.13699048 https://youtu.be/7q_wv61ou1E
Tendex and Vortex Lines around Spinning Supermassive Black HolesAshkbiz Danehkar
Talk presented at the 30th Midwest Relativity Meeting (Virtual), University of Notre Dame, IN, USA, October 23, 2020, https://doi.org/10.6084/m9.figshare.13699531
Active Galactic Nuclei: Laboratory for Gravitational PhysicsAshkbiz Danehkar
Talk at the 29th Midwest Relativity Meeting, Grand Valley State University, Grand Rapids, MI, USA, October 4, 2019, https://doi.org/10.6084/m9.figshare.13699240
Bayesian X-ray Spectral Analysis of the Symbiotic Star RT CruAshkbiz Danehkar
Talk presented at Chandra Data Science: Novel Methods in Computing and Statistics for X-ray Astronomy, Virtual Meeting, Chandra X-ray Center, USA, August 18, 2021
Morphologies of Wolf-Rayet Planetary Nebulae based on IFU ObservationsAshkbiz Danehkar
Talk presented at Asymmetrical Post-Main-Sequence Nebulae 8 (APN8): the Shaping of Stellar Outflows (Virtual), October 8, 2021, https://doi.org/10.6084/m9.figshare.16850317
Hard X-ray Emitting Symbiotics: Candidates for Type Ia Supernova ProgenitorsAshkbiz Danehkar
Talk presented at American Physical Society (APS) April Meeting, Session Z09: Stars, White Dwarfs, & Thermonuclear Supernovae, Abstract id.Z09.006, Virtual Meeting, USA, April 20, 2021, https://doi.org/10.6084/m9.figshare.14669499
Hydrodynamic Simulations of Starburst-driven SuperwindsAshkbiz Danehkar
Talk presented at Challenges and Innovations in Computational Astrophysics - III (ChaICA-III; Virtual), 21 June 2021, https://doi.org/10.6084/m9.figshare.14820438
Chemical Compositions of [WR] Planetary Nebulae based on IFU ObservationsAshkbiz Danehkar
Talk presented at Evolved Stars and their Circumstellar Environments (Online Workshop), SOFIA Science Center, December 15, 2021, https://doi.org/10.6084/m9.figshare.17700830
Hydrodynamic Simulations and Time-dependent Photoionization Modeling of Starb...Ashkbiz Danehkar
Talk presented at IAU Symposium 362 (IAUS362): Predictive Power of Computational Astrophysics as a Discovery Tool (Online Video-Conference), November 8, 2021, https://doi.org/10.6084/m9.figshare.17125607
Non-equilibrium Photoionization and Hydrodynamic Simulations of Starburst-dri...Ashkbiz Danehkar
Talk presented at 4th Workshop on Numerical Modeling in MHD and Plasma Physics (MHD-PP; Virtual), 13 October 2021, https://doi.org/10.6084/m9.figshare.16820926
Bayesian X-ray Spectral Analysis of the Symbiotic Star RT CruAshkbiz Danehkar
Talk presented at Chandra Data Science: Novel Methods in Computing and Statistics for X-ray Astronomy, Virtual Meeting, Chandra X-ray Center, USA, August 18, 2021
Morphologies of Wolf-Rayet Planetary Nebulae based on IFU ObservationsAshkbiz Danehkar
Talk presented at Asymmetrical Post-Main-Sequence Nebulae 8 (APN8): the Shaping of Stellar Outflows (Virtual), October 8, 2021, https://doi.org/10.6084/m9.figshare.16850317
Hard X-ray Emitting Symbiotics: Candidates for Type Ia Supernova ProgenitorsAshkbiz Danehkar
Talk presented at American Physical Society (APS) April Meeting, Session Z09: Stars, White Dwarfs, & Thermonuclear Supernovae, Abstract id.Z09.006, Virtual Meeting, USA, April 20, 2021, https://doi.org/10.6084/m9.figshare.14669499
Hydrodynamic Simulations of Starburst-driven SuperwindsAshkbiz Danehkar
Talk presented at Challenges and Innovations in Computational Astrophysics - III (ChaICA-III; Virtual), 21 June 2021, https://doi.org/10.6084/m9.figshare.14820438
Chemical Compositions of [WR] Planetary Nebulae based on IFU ObservationsAshkbiz Danehkar
Talk presented at Evolved Stars and their Circumstellar Environments (Online Workshop), SOFIA Science Center, December 15, 2021, https://doi.org/10.6084/m9.figshare.17700830
Hydrodynamic Simulations and Time-dependent Photoionization Modeling of Starb...Ashkbiz Danehkar
Talk presented at IAU Symposium 362 (IAUS362): Predictive Power of Computational Astrophysics as a Discovery Tool (Online Video-Conference), November 8, 2021, https://doi.org/10.6084/m9.figshare.17125607
Non-equilibrium Photoionization and Hydrodynamic Simulations of Starburst-dri...Ashkbiz Danehkar
Talk presented at 4th Workshop on Numerical Modeling in MHD and Plasma Physics (MHD-PP; Virtual), 13 October 2021, https://doi.org/10.6084/m9.figshare.16820926
PROBING THE SOLAR INTERIOR WITH LENSED GRAVITATIONAL WAVES FROM KNOWN PULSARSSérgio Sacani
When gravitational waves (GWs) from a spinning neutron star arrive from behind the Sun, they are
subjected to gravitational lensing that imprints a frequency-dependent modulation on the waveform.
This modulation traces the projected solar density and gravitational potential along the path as
the Sun passes in front of the neutron star. We calculate how accurately the solar density prole
can be extracted from the lensed GWs using a Fisher analysis. For this purpose, we selected three
promising candidates (the highly spinning pulsars J1022+1001, J1730-2304, and J1745-23) from the
pulsar catalog of the Australia Telescope National Facility. The lensing signature can be measured
with 3 condence when the signal-to-noise ratio (SNR) of the GW detection reaches 100 (f=300Hz)1
over a one-year observation period (where f is the GW frequency). The solar density prole can be
plotted as a function of radius when the SNR improves to & 104.
Solving the Multimessenger Puzzle of the AGN-starburst Composite Galaxy NGC 1068Sérgio Sacani
Multiwavelength observations indicate that some starburst galaxies show a dominant nonthermal contribution from
their central region. These active galactic nuclei (AGN)-starburst composites are of special interest, as both
phenomena on their own are potential sources of highly energetic cosmic rays and associated γ-ray and neutrino
emission. In this work, a homogeneous, steady-state two-zone multimessenger model of the nonthermal emission
from the AGN corona as well as the circumnuclear starburst region is developed and subsequently applied to the
case of NGC 1068, which has recently shown some first indications of high-energy neutrino emission. Here, we
show that the entire spectrum of multimessenger data—from radio to γ-rays including the neutrino constraint—can
be described very well if both, starburst and AGN corona, are taken into account. Using only a single emission
region is not sufficient.
AGN Feeding and Feedback in M84: From Kiloparsec Scales to the Bondi RadiusSérgio Sacani
We present the deepest Chandra observation to date of the galaxy M84 in the Virgo Cluster, with over 840 kiloseconds of data
provided by legacy observations and a recent 730 kilosecond campaign. The increased signal-to-noise allows us to study the
origins of the accretion flow feeding the supermassive black hole in the center of M84 from the kiloparsec scales of the X-ray
halo to the Bondi radius, 𝑅B. Temperature, metallicity, and deprojected density profiles are obtained in four sectors about M84’s
AGN, extending into the Bondi radius. Rather than being dictated by the potential of the black hole, the accretion flow is strongly
influenced by the AGN’s bipolar radio jets. Along the jet axis, the density profile is consistent with 𝑛𝑒 ∝ 𝑟
−1
; however, the
profiles flatten perpendicular to the jet. Radio jets produce a significant asymmetry in the flow, violating a key assumption of
Bondi accretion. Temperature in the inner kiloparsec is approximately constant, with only a slight increase from 0.6 to 0.7 keV
approaching 𝑅B, and there is no evidence for a temperature rise imposed by the black hole. The Bondi accretion rate 𝑀¤ B exceeds
the rate inferred from AGN luminosity and jet power by over four orders of magnitude. In sectors perpendicular to the jet, 𝑀¤ B
measurements agree; however, the accretion rate is > 4𝜎 lower in the North sector along the jet, likely due to cavities in the X-ray
gas. Our measurements provide unique insight into the fueling of AGN responsible for radio mode feedback in galaxy clusters.
The Tidal Disruption Event AT2021ehb: Evidence of Relativistic Disk Reflectio...Sérgio Sacani
We present X-ray, UV, optical, and radio observations of the nearby (≈78 Mpc) tidal disruption event
AT2021ehb/ZTF21aanxhjv during its first 430 days of evolution. AT2021ehb occurs in the nucleus of a galaxy
hosting a≈107 Me black hole (MBH inferred from host galaxy scaling relations). High-cadence Swift and Neutron
Star Interior Composition Explorer (NICER) monitoring reveals a delayed X-ray brightening. The spectrum first
undergoes a gradual soft → hard transition and then suddenly turns soft again within 3 days at δt≈272 days during
which the X-ray flux drops by a factor of 10. In the joint NICER+NuSTAR observation (δt = 264 days, harder
state), we observe a prominent nonthermal component up to 30 keV and an extremely broad emission line in the
iron K band. The bolometric luminosity of AT2021ehb reaches a maximum of -
+ 6.0 % 3.8 L 10.4
Edd when the X-ray
spectrum is the hardest. During the dramatic X-ray evolution, no radio emission is detected, the UV/optical
luminosity stays relatively constant, and the optical spectra are featureless. We propose the following
interpretations: (i) the soft → hard transition may be caused by the gradual formation of a magnetically
dominated corona; (ii) hard X-ray photons escape from the system along solid angles with low scattering optical
depth (∼a few) whereas the UV/optical emission is likely generated by reprocessing materials with much larger
column density—the system is highly aspherical; and (iii) the abrupt X-ray flux drop may be triggered by the
thermal–viscous instability in the inner accretion flow, leading to a much thinner disk.
X-RAY MEASUREMENTS OF THE PARTICLE ACCELERATION PROPERTIES AT INWARD SHOCKS I...Sérgio Sacani
We present new evidence that the bright non-thermal X-ray emission features in the interior of the Cassiopeia A
supernova remnant (SNR) are caused by inward moving shocks based on Chandra and NuSTAR observations. Several
bright inward-moving filaments were identified using monitoring data taken by Chandra in 2000–2014. These inwardmoving shock locations are nearly coincident with hard X-ray (15–40 keV) hot spots seen by NuSTAR. From proper
motion measurements, the transverse velocities were estimated to be in the range ∼2,100–3,800 km s−1
for a distance of
3.4 kpc. The shock velocities in the frame of the expanding ejecta reach values of ∼5,100–8,700 km s−1
, slightly higher
than the typical speed of the forward shock. Additionally, we find flux variations (both increasing and decreasing) on
timescales of a few years in some of the inward-moving shock filaments. The rapid variability timescales are consistent
with an amplified magnetic field of B ∼ 0.5–1 mG. The high speed and low photon cut-off energy of the inward-moving
shocks are shown to imply a particle diffusion coefficient that departs from the Bohm regime (k0 = D0/D0,Bohm ∼ 3–8)
for the few simple physical configurations we consider in this study. The maximum electron energy at these shocks is
estimated to be ∼8–11 TeV, smaller than the values of ∼15–34 TeV inferred for the forward shock. Cassiopeia A is
dynamically too young for its reverse shock to appear to be moving inward in the observer frame. We propose instead
that the inward-moving shocks are a consequence of the forward shock encountering a density jump of & 5–8 in the
surrounding material.
Multi dimensional simulations_of_the_expanding_supernova_remnant_of_sn1987_aSérgio Sacani
Artigo descreve as mais novas simulações computacionais realizadas para se poder entender o funcionamento e a origem da remanescente de supernova SN1987A.
Matter ejections behind the highs and lows of the transitional millisecond pu...Sérgio Sacani
Transitional millisecond pulsars are an emerging class of sources linking low-mass X-ray binaries to millisecond radio pulsars in
binary systems. These pulsars alternate between a radio pulsar state and an active low-luminosity X-ray disc state. During the active
state, these sources exhibit two distinct emission modes (high and low) that alternate unpredictably, abruptly, and incessantly. X-ray
to optical pulsations are observed only during the high mode. Knowledge of the root reason for this puzzling behaviour remains
elusive. This paper presents the results of the most extensive multi-wavelength campaign ever conducted on the transitional pulsar
prototype, PSR J1023+0038, covering from radio to X-rays. The campaign was carried out over two nights in June 2021, and involved
12 different telescopes and instruments including XMM-Newton, HST, VLT/FORS2 (in polarimetric mode), ALMA, VLA and FAST.
By modelling the broadband spectral energy distributions in both emission modes, we show that the mode switches are caused by
changes in the innermost region of the accretion disc. These changes trigger the emission of discrete mass ejections, which occur on
top of a compact jet, as testified by the detection of at least one short-duration millimetre flare with A
GRMHD Simulations of Neutron-star Mergers with Weak Interactions: r-process N...Sérgio Sacani
Fast neutron-rich material ejected dynamically over 10 ms during the merger of a binary neutron star (BNS) can
give rise to distinctive electromagnetic counterparts to the system’s gravitational-wave emission that serve as a
“smoking gun” to distinguish between a BNS and an NS–black hole merger. We present novel ab initio modeling
of the kilonova precursor and kilonova afterglow based on 3D general-relativistic magnetohydrodynamic
simulations of BNS mergers with nuclear, tabulated, finite-temperature equations of state (EOSs), weak
interactions, and approximate neutrino transport. We analyze dynamical mass ejection from 1.35–1.35 Me
binaries, consistent with properties of the first observed BNS merger GW170817, using three nuclear EOSs that
span the range of allowed compactness of 1.35 Me-neutron stars. Nuclear reaction network calculations yield a
robust second-to-third-peak r-process. We find few ×10−6 Me of fast (v > 0.6c) ejecta that give rise to broadband
synchrotron emission on ∼years timescales, consistent with tentative evidence for excess X-ray/radio emission
following GW170817. We find ≈2 × 10−5 Me of free neutrons that power a kilonova precursor on hours
timescale. A boost in early UV/optical brightness by a factor of a few due to previously neglected relativistic
effects, with enhancements up to 10 hr post-merger, is promising for future detection with UV/optical telescopes
like Swift or ULTRASAT. We find that a recently predicted opacity boost due to highly ionized lanthanides at
70,000 K is unlikely to affect the early kilonova based on the obtained ejecta structures. Azimuthal
inhomogeneities in dynamical ejecta composition for soft EOSs found here (“lanthanide/actinide pockets”) may
have observable consequences for both early kilonova and late-time nebular emission.
Detection of anisotropic satellite quenching in galaxy clusters up to z ∼ 1Sérgio Sacani
Satellite galaxies in the cluster environment are more likely to be quenched than galaxies in the general field. Recently, it has
been reported that satellite galaxy quenching depends on the orientation relative to their central galaxies: satellites along the
major axis of centrals are more likely to be quenched than those along the minor axis. In this paper, we report a detection
of such anisotropic quenching up to z ∼ 1 based on a large optically selected cluster catalogue constructed from the Hyper
Suprime-Cam Subaru Strategic Program. We calculate the quiescent satellite galaxy fraction as a function of orientation angle
measured from the major axis of central galaxies and find that the quiescent fractions at 0.25 < z < 1 are reasonably fitted
by sinusoidal functions with amplitudes of a few per cent. Anisotropy is clearer in inner regions (<r200m) of clusters and not
significant in cluster outskirts (>r200m). We also confirm that the observed anisotropy cannot be explained by differences in
local galaxy density or stellar mass distribution along the two axes. Quiescent fraction excesses between the two axes suggest
that the quenching efficiency contributing to the anisotropy is almost independent of stellar mass, at least down to our stellar
mass limit of M∗ = 1 × 1010 M. Finally, we argue that the physical origins of the observed anisotropy should have shorter
quenching time-scales than ∼ 1 Gyr, like ram-pressure stripping, because, for anisotropic quenching to be observed, satellites
must be quenched before their initial orientation angles are significantly changed.
Mass spectrometry, Ion motion in the commonly used mass analyzer.pdfSherif Taha
This lecture is an advanced one that presents more details on the Ion motion in the commonly used mass analyzer in mass spectrometry. It is focusing on the main used parameters to control such ionic motions. Included m/z analyzers are; Quadrupole, Orbitrap, Ion cyclotron, Time of flight, and magnetic one.
Similar to Relativistic Compact Outflows in Radio-quiet AGN (20)
Conditions for Cool Superwinds in Massive Star-forming RegionsAshkbiz Danehkar
e-Talk presented at IAU Symposium 373 (IAUS373): Resolving the Rise and Fall of Star Formation in Galaxies, Busan, Korea, August 2022
Danehkar, Ashkbiz (2024). Conditions for Cool Superwinds in Massive Star-forming Regions. figshare. Presentation. https://doi.org/10.6084/m9.figshare.25029482
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
1. Relativistic Compact Outflows
in Radio-quiet AGN
Image
Credit:
NASA/JPL-Caltech
Image
Credit:
NASA/JPL-Caltech
Ashkbiz Danehkar
Department of Astronomy, University of Michigan
danehkar@umich.edu
In collaborations with: Mike Nowak (MIT), Gerard Kriss (STSI), Julia Lee (Harvard),
In collaborations with: Mike Nowak (MIT), Gerard Kriss (STSI), Julia Lee (Harvard),
Randall Smith (SAO) and et al.
Randall Smith (SAO) and et al.
Extreme Astrophysics Group, University of Michigan, Michigan, USA, October 31st
, 2019
2. 10/31/2019 Extreme Astrophysics Group
2
Outline
Introduction
Radio-quiet AGN Class
Ultra-Fast Outflow (UFO)
X-ray Absorbers
PG 1211+143
Previous XMM-Newton Observations
Chandra X-ray and Hubble UV Observations in 2015
Photoionization Modeling (Parallelization with MPI)
Confidence MCMC Maps of Measured Parameters
Future Direction for UFO in AGN
Unified AGN Outflow Model
A Possible Angular Momentum-UFO Correlation
Summary
3. 10/31/2019 Extreme Astrophysics Group
3
AGN Classification
AGN Unified Model (radio-loud & -quiet AGN, Seyfert I & II Galaxies)
Beckmann & Shrader 2012,
Active Galactic Nuclei
Unified Models for AGNs
Antonucci, ARA&A, 1993, 31, 473
Unified Schemes for AGNs
Megan Urry & Padovani, 1995, PASP, 107, 803
(Bernie Fanaroff &
Julia Riley 1974)
AGN Unified Model
• Radio-Quiet AGN
Seyfert I (BLR+NLR,
compact outflows)
Seyfert II (NLR)
• Radio-Loud AGN
FR I (compact radio jets)
FR II (extended radio jets)
Blazar (relativistic beams)
(Carl Seyfert 1942)
4. 10/31/2019 Extreme Astrophysics Group
4
AGN Classification
Dermer & Giebles 2016
radio-loud & -quiet AGN, Seyfert I & II Galaxies
Blandford, Netzer, Woltjer 1990, Active Galactic Nuclei
5. 10/31/2019 Extreme Astrophysics Group
5
X-ray Feature of AGN
Disk
Black-
body
Hot Corona
Warm
Absorbers
K-shell Iron
Beckmann & Shrader 2012
Risaliti & Elvis 2004
(bbody + powerlaw + ∑ emis) x ∏ abs
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X-ray Absorbers
Ultra-fast Outflows (UFOs):
hard X-ray blue-shifted absorption lines
H-like & He-like Fe Ions
Velocity > 10,000 km/s (0.03c)
high velocity ~ 0.1– 0.4c
(Pounds + 2003, Cappi 2006, Braito + 2007)
Recently observed in 30% of radio-quite and -loud AGN
(Tombest + 2010,2011,2012,2014)
Warm Absorbers (WAs):
soft X-ray blue-shifted absorption lines
H-like & He-like O, Ne, Mg, Si, S Ions
Velocity < 10,000 km/s (0.03c)
Observed in 50% of Seyfert I galaxies
(Reynold & Fabian 1995, Reynold 1997, George + 1998)
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Tombesi + 2013
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PG 1211+143
A Narrow-line Quasi-Stellar Object (QSO)
In a radio-quite (Seyfert I) galaxy (z = 0.0809)
Strong soft excess
Mildly relativistic outflows – 0.06c and 0.13c (XMM-Newton)
redshifted aborbers at 0.2-0.4c: infall to the black hole
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PG 1211+143: XMM-Newton
UFOs vout
~ -0.07c (Pounds + 2003)
UFOs vout
~ -0.13c (Pounds+ 2006,2007,2009)
UFOs vout
~ -0.06c and -0.13c (Pounds + 2016)
H- and He-like O, Ne, Mg, Si, S, Ar and Fe ions
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PG 1211+143: Chandra
X-ray Chandra Observations
High Energy Transmission Grating
(HETG; PI: J.C. Lee, 2015 April)
6 observations over 9 days ~ 433 ks
H- and He-like Ne, Mg, S ions: -0.06c
PG 1211+143 Chandra Observations (PI J.C. Lee)
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Ultra-fast Outflow in AGN
Detection of relativistic outflows in X-ray
●
Seyfert I PDS 456
Ionized outflow at -0.24c and -0.48 c
Biossay-Malaquin, Danehkar + 2019
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Unified AGN Outflow Model
Absorption Measure Distribution (AMD): similar to Emission Measure Distribution (EMD)
n(r) ~ r -1.4
density profile
Behar 2009
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Unified AGN Outflow Model
Unification of UFOs and WAs
Tombesi + 2013
(Ultra-fast outflows)
(Warm Absorbers)
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Unified AGN Outflow Model
Non-Unification of UFOs and WAs
Tombesi + 2013
(Ultra-fast outflows)
(Warm Absorbers)
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Unified AGN Outflow Model
Black Hole Spin Implication for a Unified AGN Model?
Garofalo + 2010
Beckmann & Shrader 2012,
Active Galactic Nuclei
AGN Unified Model
- Radio-Quiet AGN: Seyfert I, Seyfert II
- Radio-Loud AGN: FR I, FR II (extended radio jets)
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Supermassive Black Hole Spin
Black Hole Spin Measurement (see Brenneman 2013)
●
Thermal Continuum Fitting (UV observation)
– stellar-mass black hole
– AGN (may problematic due to UV absorption lines!)
●
Inner Disk Reflection Modeling
– AGN (X-ray)
●
High Frequency Quasi-Periodic Oscillations
– AGN + stellar-mass black hole (fully not developed)
●
X-ray Polarimetry
– Need sensitive X-ray polarimter (not available now!)
●
Imaging the Event Horizon Shadow
– Need Very Long Baseline Interferometry (in development)
– Suitable only for Sgr A* and M87
a = J c / G M2
(a: BH spin, J: angular momentum, M: BH mass, G: gravitational constant, c: speed of light)
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Supermassive Black Hole Spin
Relativistically broadened Kα iron line (6.4 keV)
Compton hump (> 10keV)
Black Hole Spin Measurement from X-ray
a = - 1
a = 0
a = 1
Image credit: NASA/JPL-Caltech
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Supermassive Black Hole Mass
BH Mass from Reverberation Mapping Technique (Kaspi + 2000)
●
Variation in light curves of broad emission line region (BLR) in Seyfert I AGN
●
Time delay in variation of BLR luminosity (Hb 4861A) relative to
variation of accretion disk luminosity (continuum 5100A)
www.techfreaq.de
Bentz + 2006
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SMBH Spin Implication
Black Hole Spin Implication for a Unified AGN Model?
Danehkar +
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Theories for UFO in AGN
●
strong magnetic field in accretion flow/disk
of rotating BH
– Blandford-Znajek process (1977) for strong jets from flow
– Blandford-Payne process (1982) for slow winds from disk
●
frame dragging (gravitomagnetism indirectly)
– Penrose process (1971)
– Kerr spacetime of rotating BH
– extracting black-hole rotational energy
●
frame dragging + magnetic field
(e.g. Narayan & Quataert 2005)
●
gravitomagnetism
Frame dragging+magnetic
(Narayan & Quataert 2005)
Blandford-Znajek process
(Thorne 1995)
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Theories for UFO in AGN
For local gravitational filed, these are Einstein field equations:
For non-local gravitational fields, there are dynamical formulas from Bianchi
identities in General Relativity:
Newtonian Tidal force
Non-Newtonian effect
Gravitational waves
shear current
angular momentum
Trumper 1964, Hawking 1966, Ellis 1971
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Summary
X-ray ionized Absorbers
WAs: typically H-like & He-like O, Ne, Mg, Si & S ions, low velocity < 10,000 km/s
UFOs: typically H-like & He-like Fe, high velocity > 10,000 km/s, usually ~ 0.05– 0.45c
The Quasar PG1211+143
XMM-Newton observations: UFOs vout
~ -0.06c and -0.13c
Chandra observations together with Hubble UV, VLA radio observations in 2015
Photoionization Modeling of PG1211+143
X-ray ionized absorber: outflow velocity -0.06c
UV Lyα absorption: outflow velocity -0.06c, possible counterpart to X-ray absorber
MPI-based parallelization for supercomputers: MPI_XSTAR
Unified AGN Outflow Model
Ionization parameter-Outflow velocity correlations (Tombesi + 2013)
A possible correlation between UFO and angular momentum?
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Image
Credit:
NASA/JPL-Caltech
Image
Credit:
NASA/JPL-Caltech
Thank you for your attention
Thank you for your attention