This document provides a partial bibliography for a lecture on May 26, 2021 about a genetic experiment on how children respond. It includes 18 references to articles mentioned in the lecture on topics like: anatomical and physiological differences between children and adults relevant to brain injuries; differences in blood flow in the brain and heart depending on age; toxicity and immunogenicity of lipid nanoparticles and PEGylated systems; factors that predict the severity of COVID-19 infections; and the relationship between GGT enzyme levels and conditions like diabetes and heart disease.

1. ‫רשימה‬
‫ביב‬
‫ליוגרפי‬
‫ת‬
)‫(חלקית‬
‫להרצאה‬
‫מיום‬
26.5.2021
:
‫א‬ ‫על‬ ‫"ניסוי‬
‫הגנטי‬ ‫לתרכיב‬ ‫הילדים‬ ‫יגיבו‬ ‫איך‬ :‫וטומט‬
?
"
‫מאמרים‬
‫נבחרים‬
‫בהרצאה‬ ‫שהוזכרו‬
‫לעיונכם‬
‫נלווה‬ ‫טקסט‬ ‫בצירוף‬ ,
:
‫שקפים‬
4
-
3
:
‫הבדלים‬
‫וטרא‬ ‫לפגיעות‬ ‫רלוונטיים‬ ‫אשר‬ ‫למבוגרים‬ ‫ילדים‬ ‫מח‬ ‫בין‬ ‫ופיזיולוגיים‬ ‫אנטומיים‬
‫ומה‬
:
1. Figaji A. A. et al. (2017) "Anatomical and Physiological Differences
between Children and Adults Relevant to Traumatic Brain Injury and the
Implications for Clinical Assessment and Care". Frontiers in Neurology,
8:685.
:‫ילדים‬ ‫של‬ ‫אנטומיה‬
‫ה‬
‫ב‬ ‫בדלים‬
‫כבד‬
‫לוואי‬ ‫לתופעות‬ ‫והקשר‬
‫מבוגרים‬ ‫לעומת‬ ‫ילדים‬ ,
‫בה‬
‫למשל‬ ‫קשר‬
‫אפילפסיה‬ ‫של‬ ‫תרופות‬ ‫של‬
2. Anderson G.D. et al. (2002) "Children versus adults: pharmacokinetic and
adverse-effect differences". Epilepsia (2002) 43 Suppl 3:53-9.
‫בין‬ ‫ומבוגרים‬ ‫ילדים‬ ‫אצל‬ ‫ובלב‬ ‫במח‬ ‫דם‬ ‫בזרימת‬ ‫גיל‬ ‫תלויי‬ ‫הבדלים‬ :‫ילדים‬ ‫של‬ ‫אנטומיה‬
) 3-4 ‫(שקפים‬ :‫שנים‬ 61-‫ל‬ ‫חודשים‬ 7 ‫גילאי‬
3. Wu, C., Honarmand, A. R., et al. (2016). "Age-Related Changes of Normal
Cerebral and Cardiac Blood Flow in Children and Adults Aged 7 Months to
61 Years". Journal of the American Heart Association, 5(1), e002657.
‫שקף‬
5
–
‫עיגודלי‬
:‫מרנ"א‬ ‫של‬ ‫ם‬
,‫הטכנולוגיה‬ ‫על‬
,‫העיגולד‬ ‫בניית‬
‫והסכנות‬ ‫הרעילות‬
4. Whitehead K. "Lipid Nanoparticles for mRNA vaccine delivery", youtube,
"The technology behind the new COVID-19 mRNA vaccines" 18/2/21
https://www.youtube.com/watch?v=lJO51Sguyaw
Hongtao Ly. Shubjao Zhang et al. (2006) "Toxicity of Cationic lipids and
cationic polymers in gene delivery" ACS Nano Review, Controlled Release Vol:
114, 100−109.
5. Morille M., Passirani C., et al. (2008) "Progress in Developing Cationic
Vectors for Non-viral Systemic Gene Therapy against Cancer", Biomaterials,
29, 3477−3496
6. Juszkiewicz K., Sikorski A. et al. (2020) "Building Blocks to Design
Liposomal Delivery Systems", Int. J. Mol. Sci. 2020, 21(24), 9559
‫שקף‬
6
:
‫ל‬
-
70
‫מהאוכלוסיה‬ ‫אחוז‬
‫יש‬
‫כנג‬ ‫נוגדנים‬
‫ד‬
PEG
(
‫בסביבת‬ ‫יותר‬ ‫מאוחר‬ ‫גם‬ ‫מופיע‬ ‫הנושא‬
‫ש‬
‫קף‬
20
)
7. Hoang T. Thi, Pilkington E.H. et al. "The Importance of Poly(ethylene glycol)
Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and
Bioconjugation"

2. 8. Zhang P, Sun F, et al. (2016). "Anti-PEG antibodies in the clinic: Current
issues and beyond PEGylation". J Control Release (2016) 244(Pt B):184-193.
9. Mohamed M., Abu Lila Amr S. et al. (2019) "PEGylated liposomes:
immunological responses", Sci Technol Adv Mater. 2019; 20(1): 710–724.
10. Abu Lila Amr S, Kiwada H. et al. (2013) "The accelerated blood clearance
(ABC) phenomenon: Clinical challenge and approaches to manage", Journal
of Controlled Release, Vol 172(1):38-47
‫וקוגין‬ ‫פגני‬ ‫בשם‬ ‫תרופה‬ ,‫חריפה‬ ‫כלילית‬ ‫תסמונת‬
‫שק‬
‫פים‬
8
-
7
‫לאן‬
‫ה‬
?‫בגוף‬ ‫מגיע‬ ‫חומר‬
‫מדו"ח‬ ‫ציטטות‬
EMA
11. EMA, Assessment report /707383/2020. p. 47.
EMA/707383/2020 Corr, Committee for Medicinal Products for Human Use
(CHMP), Assessment report Comirnaty Common name: COVID-19 mRNA
vaccine (nucleoside-modified) Procedure No. EMEA/H/C/005735/0000 ,
page no. 46 of 140
12. EMA, EMA/707383/2020 Corr, Committee for Medicinal Products for
Human Use, (CHMP) Assessment report Comirnaty Common name: COVID-
19 mRNA vaccine (nucleoside-modified) Procedure No.
EMEA/H/C/005735/0000, (study 185350), page no. 47 of 140
‫שקף‬
11
:
‫בין‬ ‫הקשר‬
GGT
‫לסכרת‬
‫מסוג‬
2
-
‫ו‬
‫לגלוקוז‬ ‫סבילות‬ ‫אי‬
13. Haghighi S, Amini M, et al. (2011) "Relationship between gamma-glutamyl
transferase and glucose intolerance in first degree relatives of type 2
diabetics patients". J Res Med Sci, 16(2):123-9.
14. Ortega E., Koska J. et al. (2006) "Serum γ-Glutamyl Transpeptidase Is a
Determinant of Insulin Resistance Independently of Adiposity in Pima Indian
Children", The Journal of Clinical Endocrinology & Metabolism, 91(4): 1419–
1422
19 ‫קוביד‬ ‫עם‬ ‫מבוגרים‬ ‫אצל‬ ‫יותר‬ ‫ארוכה‬ ‫שהיה‬ ‫מנבא‬ GGT :11 ‫שקף‬
15. Shao T, Tong Y, et al. (2020),"γ-Glutamyltransferase Elevations Are Frequent
in Patients With COVID-19: A Clinical Epidemiologic Study". Hepatology
Communications, 4(12):1744–50.
‫שקף‬
11
:
‫קוביד‬ ‫עם‬ ‫זיהום‬ ‫חומרת‬ ‫שמנבאים‬ ‫פקטורים‬
-
19
–
‫אנזים‬
GGT
‫התפתחות‬ ‫ניבא‬
‫מחלה‬
‫יותר‬ ‫קשה‬
16. Sánchez R., Lepe-Balsalobre R., et al. (2021) "Prognostic factors for the
severity of SARS-CoV-2 infection" Advances in Laboratory Medicine (Avances
en Medicina de Laboratorio), Published Ahead of Print / Just Accepted
‫שקף‬
11
:
‫אנזים‬
GGT
‫ילדים‬ ‫במיון‬ ‫ילדים‬ ‫של‬ ‫פרוגנוזה‬ ‫מנבא‬
:
17. Aygun F., Kirkoc R., Aygun D, et al. (2018) "Gamma Glutamyl Transferase
and Uric Acid Levels Can Be Associated with the Prognosis of Patients in
the Pediatric Intensive Care Unit." Children (Basel) 30; 5(11):147

3. ‫שקף‬
11
:
GGT
‫כללית‬ ‫אוכלוסייה‬ ‫מבוסס‬ ‫מחקר‬ ‫לפי‬
–
‫הרב‬
‫עון‬
‫מנבא‬ ‫שלו‬ ‫העליון‬
‫בהשתלת‬ ‫צורך‬
‫להחלפתה‬ ‫התחלתי‬ ‫טיפול‬ ‫או‬/‫ו‬ ‫כליה‬
18. Lee, D.Y., Han, K., et al. (2020) "Gamma-glutamyl transferase variability can
predict the development of end-stage of renal disease: a nationwide
population-based study". Sci Rep, 10, 11668.
‫שקף‬
12
:
‫אנזים‬
GGT
-
‫קשור‬
‫בסי‬
‫לאתרוס‬ ‫כון‬
‫(גרמניה‬ ‫כלילית‬ ‫לב‬ ‫ומחלת‬ ‫קלרוזה‬
2018
)
–
‫התרשים‬
‫מכאן‬ ‫במצגת‬ ‫שתרגמתי‬
19. Ndrepepa G., Colleran R., et al. (2018) "Gamma-glutamyl transferase and the
risk of atherosclerosis and coronary heart disease." Clin Chim Acta (2018)
476:130-138.
‫רעיל‬ ‫מכימיקל‬ ‫מסונתז‬ ‫פג‬ :17 ‫שקף‬
20. D'souza AA, Shegokar R. (2016)"Polyethylene glycol (PEG): a versatile
polymer for pharmaceutical applications". Expert Opin Drug Deliv.
13:1257‐1275
21. Hussein S.Z., Belkind G. J. et al. "Probable neuropsychiatric toxicity of
polyethylene glycol: roles of media, internet and the caregivers", GastroHep,
‫שקפים‬
16
-
13
:
‫שעס‬ ‫מהמאמרים‬ ‫מקצת‬
‫ב‬ ‫קו‬
‫רעילות‬
‫ו‬
‫של‬ ‫אימונוגניות‬
‫נשיאה‬ ‫מערכות‬
-
‫מיצלות‬
-
‫פגילציה‬ ‫שעברו‬
‫תופעת‬ ‫ועל‬
ABC
‫על‬ ‫מדברת‬ ‫אבל‬ ‫במצגת‬ ‫עליה‬ ‫פירטתי‬ ‫(שפחות‬
‫הצט‬
‫ברות‬
‫רעילה‬
)‫מהדם‬ ‫מהיר‬ ‫פינוי‬ ‫בגלל‬
22. Shiraishi K, Yokoyama M. et al. (2019) "Toxicity and immunogenicity
concerns related to PEGylated-micelle carrier systems: a review"
Sci Technol Adv Mater. 2019; 20(1): 324–336.
23. The accelerated blood clearance (ABC) phenomenon: Clinical challenge and
approaches to
24. Onoue S., Yamada S. wt al. (2014) "Nanodrugs: pharmacokinetics and
safety", Int J Nanomedicine. 2014; 9: 1025–1037
‫שקפים‬
31
-
17
:
25. Rose, J. PhD, MSc, BSc. "Potential dangers associated with COVID-19
injectable products", a letter to Dr. Simone Gold, May 8, 2021
https://www.slideshare.net/enave2609/letter-for-simone-goldjessica-rose
26. Rose J. "VAERS report for VCC", 4/5/21
https://www.youtube.com/watch?v=CfeiZzXcjNw
27. Blétry O, Piette AM. (1997) "Recurrent fetal loss and antiphospholipid
antibodies: clinical and therapeutic aspects". Infect Dis Obstet Gynecol,
5(2):183-191
28. A Study of the Potential for Polyethylene Glycol (Miralax) to Metabolize
into Toxic Oxalate
- ‫דם‬ ‫וקרישי‬ ‫תרומבוטיים‬ ‫אירועים‬ – ‫גוצקו‬ ‫ג'וש‬ ‫ד"ר‬ ‫מצגות‬
29. https://drive.google.com/file/d/1wLCnMibfoEcX9GDBN_rHNRodK5E5cr
Oe/view?usp=sharing

4. 30. https://www.slideshare.net/enave2609/reports-of-blood-clot-related-
adverse-events-may-23-josh-g
31. https://www.slideshare.net/enave2609/reports-of-blood-clot-related-
adverse-events-ipc-may-23
‫שקפי‬
20
:+
‫מוד‬ ‫(בחיסון‬ ‫בדם‬ ‫משוטטות‬ ‫הספייק‬ ‫של‬ ‫חתיכות‬
‫רנ‬
‫ה‬
:)
32. Ogata A.F., Cheng C.A., et al. (2021)"Circulating SARS-CoV-2 Vaccine
Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients", Clinical
Infectious Diseases (2021)
‫חלבון‬
S
1
‫מג‬
:‫למח‬ ‫יע‬
33. Rhea, E.M., Logsdon, A.F., Hansen, K.M. et al. The S1 protein of SARS-CoV-
2 crosses the blood–brain barrier in mice. Nat Neurosci (2021) 24, 368–378
‫מ‬ ‫שעבר‬ ‫מרנ"א‬ ‫תרכיבי‬ ‫של‬ ‫רעילות‬
‫ודיפיקציה‬
34. Jeonghwan K., Eygeris Y. et al. (2021) "Self assembled mRNA vaccines",
Adv Drug Deliv Rev., 170: 83–112
35. Andries O., Mc Cafferty S. et al. (2015) "N(1)-methylpseudouridine-
incorporated mRNA outperforms pseudouridine-incorporated mRNA by
providing enhanced protein expression and reduced immunogenicity in
mammalian cell lines and mice", J. Control Release 10;217:337-44
36. McKenzie R., W. Fried M., et al. (1995) "Hepatic Failure and Lactic
Acidosis Due to Fialuridine (FIAU), an Investigational Nucleoside
Analogue for Chronic Hepatitis B", N Engl J Med 1995; 333:1099-1105
:‫מחדש‬ ‫החיסון‬ ‫מערכת‬ ‫תכנות‬
37. Research suggests that Pfizer-Biontech Covid-19 vaccined reporograms
innate immune responses
: ‫וגינליים‬ ‫דימומים‬
38. Thrombosis after covid-19 vaccination BMJ 2021; 373 (Published 14 April
2021)Cite this as: BMJ 2021;373:n958
https://www.bmj.com/content/373/bmj.n958/rr-2
‫ועמיתים‬ ‫יאנג‬
2016
‫ששמו‬ ‫אחר‬ ‫ממחקר‬ ‫כציטוט‬ ‫לקחנו‬
:
The Importance of Poly(ethylene glycol) Alternatives
for Overcoming PEG Immunogenicity in Drug
Delivery and Bioconjugation
Thai Thanh Hoang Thi 1
,
Emily H. Pilkington 2
,
Dai Hai Nguyen 3,4 , Jung Seok Lee 5
,
Ki Dong Park 6
and Nghia P. Truong 2
,
*