A research project and presentation I worked on in my Medical Nutrition Therapy class, which discusses the link between moderate consumption of red wine and its effect on breast cancer

1. Cristi Ambroso
Erin Ducker
Julia Simon
Lauren Walker

2.  Hypothesis
 Introduction
 Body of Knowledge
 Polyphenols
 Estrogen
 Phytoestrogens
 Studies
 Conclusion
 Implications
 Recommendations
 Trials and Tribulations
 Quiz

3.  Moderate Consumption of Red Wine Reduces
the Risk of Breast Cancer

4.  1 in 8 women will get breast cancer during
their lifetime
 Based on this statistic, 10 people in HNF 320
will develop breast cancer in their lifetime
 1/3 of cancers are linked to diet
 3-4 million cancer cases can be prevented
each year by change in diet
 Grapes are most widely consumed fruit
worldwide
 Contain polyphenols

5.  Antioxidants found in the seeds, skins, and
stems of grapes
 Beneficial health effects including inhibiting
cancer growth
 Resveratrol is a powerful polyphenol in red
wine and prevents tumor growth

6.  Estrogen:
hormone that contributes to
normal breast and sexual development
 Estrogenstimulates cell division, meaning
excessive amounts can lead to tumor
development
 Polyphenols decrease estrogen levels
 Phytoestrogens are estrogens found in plants

7.  Commonly found in tofu, soy beans, whole
grains, fruits, and vegetables
 Diethigh in phytoestrogens can decrease
one’s risk for breast cancer
 If phytoestrogens bind to the estrogen receptor
instead of the stronger human made estrogen
less cell division will occur

8.  Objective: To determine the anti-proliferative affect
of red wine concentrate on the hormone sensitive
breast cancer cells
 Results: Low concentrations of polyphenols, and
consecutively, consumptions of wine or other
polyphenol rich foods and beverages could have a
beneficial anti-proliferative affect on breast cancer
cell growth

9.  Objective: To determine whether Resveratrol
may be considered a phytoestrogen
 Researchers found resveratrol binds to the
human estrogen competeing with human made
estrogen
 Results: Resveratrol is a phytoestrogen, meaning
Resveratrol plays a role in reducing breast
cancer risk

10.  Objective: To determine whether Resveratrol can
be a cancer chemopreventive agent
 Used a mouse mammory gland culture model of
carcinogenesis to test activity resveratrol
 Results: found to inhibit tumor initiation,
promotion, and progression

11.  Positive correlation between red wine
consumption and decrease breast cancer risk
 Hypothesis is accepted
 Polyphenols have been shown to be beneficial in
decreasing breast cancer risk
 More research is needed, especially clinical trials
involving humans

12.  Moderate consumption of red wine can be
beneficial
 Grapes contain the polyphenols, not alcohol
 Eating grapes or drinking 100% natural grape
juice can offer similar protection against breast
cancer

13.  Bothmen and women should have a diet rich
in polyphenols (antioxidants)

14.  Rewards:
 Became knowledgeable on importance of diet
with breast health
 Became more familiar with researching
 Challenges:
 Difficult to compile all of our information
 Interpreting the research articles

15.  Polyphenols are
 A. Grapes
 B. Antioxidants
 C. A type of wine
 D. Cancer causing substance
B. Antioxidant

16.  True or false
 Resveratrol is a human made estrogen