Rabies virus is a bullet-shaped, enveloped virus classified under the family Rhabdoviridae and genus Lyssavirus, with a single-stranded, negative sense RNA genome. It primarily affects the central nervous system and initial symptoms can include malaise, fever, and anxiety, leading to severe neurological manifestations. Treatment involves wound washing, application of disinfectants, and administration of rabies immunoglobulin.

1. RABIES VIRUS

2. Rhabdoviruses areRod or bullet shaped, enveloped viruses.
Have nucleocapsid with helical symmetry.
Genome is single stranded, unsegmented, negative sense RNA.
(Rhabdos = rod).

3. Classification of Virus:
Group: Group V ((-)ssRNA)
Order: Mononegavirales
Family: Rhabdoviridae
Genus: Lyssavirus
Species: Rabies virus

4.  Pathogensis of rabies virus

5.  Replication of rabies:
 Attachement of the viral G glycoproteins to host receptors
 Fusion of virus membrane with the vesicle membrane
 Sequential transcription
 Replication presumably starts when enough nucleoprotein is present
 The ribonucleocapsid binds to the matrix protein.

6.  Viral diseases:
Rabies is a viral disease that affects the central nervous system (CNS).
The genus lyssavirus contains more than 80 viruses. Classic rabies.

7.  Symptoms may include the following:
Malaise.
Anorexia.
Headaches.
Fever.
Chills.
Pharyngitis.
Nausea.
Emesis.
Diarrhea.
Anxiety.
Agitation.
Insomnia.
Depression.

8.  Treatments:
Washing the wound with copious amounts of soap and water.
Apply 1% quaternary ammonium compounds after all traces of soap have been
removed.
Apply antirabies serum ( human rabies immunoglobulin)(HRIG) into the wound and by
infiltration around the wound.

9. By:
Selina Al-Halayqa.
Duha Sider.