Quantified Self and the Self-tracking Patient (Zeo)
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This document discusses sleep management and the benefits of good sleep. It contains the following key points: 1) Short sleep is linked to greater risks of health issues like diabetes, cardiovascular disease, and depression. 2) Products like Zeo, a sleep tracker, allow users to measure and improve their sleep quality over time by providing data on sleep stages and lifestyle factors that impact sleep. 3) Users of Zeo reported getting deeper, more restorative sleep and feeling more motivated to maintain good sleep habits after using the sleep tracker.
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There is a global shortage of 4.4 million health workers according to the WHO. This document discusses how mobile phones can help address this issue in developing areas of the world where mobile phone access is growing rapidly. It describes a system developed by Nadim Mahmud called FrontlineHealth that uses text messages to connect community health workers to clinics to help coordinate care for patients in remote areas. In initial trials, this system helped save money on transportation costs, staff time, and increased enrollment in tuberculosis treatment programs.
High-Tech meets Low-Resource: Applying Innovation in a Global Health Context ...
- Water in Kibera slums of Nairobi, Kenya is scarce, costly, and often contaminated, with residents spending significant time and money searching for water.
- While mobile phone access is widespread, consistent access to clean water is lacking.
- The M-Maji project aims to use ubiquitous mobile phones to improve access to clean water by connecting water buyers with verified vendors through a USSD-based platform. A pilot program will test the impact on water prices, search times, and clean water uptake.
Cancer Thriving and Surviving
The document summarizes an online self-management program called Cancer: Thriving and Surviving for cancer survivors. The 6-week program is peer-led and aims to help survivors better manage their condition through goal setting, problem solving, and stress management. An evaluation found that participants experienced reductions in depression, insomnia, fatigue, and stress levels after 6 months, as well as improvements in role function and communication with physicians. The program is now being disseminated nationally to help more cancer survivors.
The Impact of Social Media in Physician Continuing Medical Education
Social media can impact formal medical education by allowing physicians to learn from experts and peers online. Closed social networks allow anonymous discussion of specific patients and admittance of mistakes, while open networks risk this information becoming public. Sites like Sermo and QuantiaMD have thousands of physician members discussing treatment challenges, controversies, and new areas needing education. Social media also allows ongoing, longitudinal learning outside of traditional CME formats.
Using mobile technology to change the world for kids with asthma
The document proposes using a mobile game called Azmo the Dragon to help children with asthma better manage their condition. The game would use an inexpensive portable spirometer as input to track lung function over time. Playing the game and using the spirometer daily would reward players with special abilities and loot in Azmo, encouraging adherence to asthma treatment plans. The goal is to make asthma management for kids more enjoyable, convenient and valuable through emerging mobile technologies.
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The document describes ILKUM, an interactive learning objective catalogue developed by the University Medical Center Mainz to improve learning for dental and medical students. ILKUM provides a reliable structured learning catalogue with open interfaces that is interactive. It includes features like a searchable catalogue of topics, subjects and clinical cases, electronic media like e-books and tests, and communication tools. ILKUM also allows for lecture and video recording and storage, as well as interactive tools for students. As of 2011, over 90 administrators from 36 clinics were participating in ILKUM, and student feedback has been positive.
Boyle dennis closing remarks_tempfile
IDEO is a design firm that uses an approach called "design thinking" to help organizations innovate. Design thinking is a human-centered process that involves empathizing with people to understand their needs on multiple levels. It uses techniques like prototyping ideas early and telling stories to spread concepts. IDEO has used this approach to help clients like the American Red Cross, Kaiser Permanente, and Palo Alto Medical Foundation improve experiences for donors, nurses, and patients.
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Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
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Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Quantified Self and the Self-tracking Patient (Zeo)
- 1. The Sleep Management Company 1
- 3. You Can Manage Your Sleep
- 5. People Don’t Care About This
- 6. Succeed at Work 100% Increased alertness after a 20-30 minute power nap.
- 7. Win on the Courts 42% Tennis players get a boost in hitting accuracy during depth drills from sleep extension.
- 8. Look Good Naked Per year by sleeping one extra hour instead of watching TV 14.3lbs
- 9. There’s Hope “I can manage what I can measure” ©2010 Zeo Inc. All Rights Reserved
- 10. Your Sleeping Brain Scientifically validated to show you Deep and REM Sleep ©2010 Zeo Inc. All Rights Reserved
- 11. 10
- 12. Only Zeo shows how lifestyle impacts sleep phases Explore other factors… Diet Stress Bedtime Alcohol Disruptions And more…. 11
- 13. Time to Z: 28m -> 4m Deep: 60m -> 85m 12
- 14. 13 People are already connecting the dots “It turns out that my sleep was not so simple. My sleep was always better whenI had exercised: I slept more, I got more restorative sleep and a higher ZQ on days I ran. However, when I ran 10+ miles, my sleep was almost the same as the nights when I didn’t exercise at all. Running less than 5 miles led to my best sleep. 5-10 miles had decreasing benefits for my sleep.” -Julie Penner
- 15. 14 Zeo users reported improved sleep quality Zeo users got more Deep or REM sleep of Zeo users reported getting an average of one hour more sleep Zeo is Motivating Behavioral Change
- 16. Ready for Zeo Mobile Sleep Manager? 15
- 17. The Sleep Management Company 16