This document provides guidance for creating easy-to-understand health communication materials. It discusses the importance of considering an audience's culture and literacy skills when designing materials. The guide outlines best practices for making messages clear, using effective text and visuals, layout and design considerations, and testing materials for readability. Appendices include checklists and resources for communication planning and calculating readability formulas. The overall goal is to transform technical health information into formats audiences can understand and relate to.