- Booking.com uses MySQL extensively with thousands of servers, most of which replicate data. Protecting MySQL network traffic with TLS encryption is important for security and privacy reasons. - Configuring TLS involves generating certificates, enabling TLS on MySQL servers and clients, and verifying connections are encrypted. While TLS adds security, it also introduces overhead that can impact performance. - Proper TLS configuration, monitoring, and maintenance are required to ensure security and high availability of MySQL deployments using encryption.