It is unclear where plate boundary thrusts generate giant rather than great earthquakes. Along the Himalayas, the source
sizes and recurrence times of large seismic events are particularly uncertain, since no surface signatures were found for those
that shook the range in the twentieth century. Here we challenge the consensus that these events remained blind and did not
rupture the surface.We use geomorphological mapping of fluvial deposits, palaeo-seismological logging of river-cut cliffs and
trench walls, and modelling of calibrated 14C ages, to show that the Mw 8.2 Bihar–Nepal earthquake on 15 January 1934 did
break the surface: traces of the rupture are clear along at least 150 km of the Main Frontal Thrust fault in Nepal, between
85 500 and 87 200 E. Furthermore, we date collapse wedges in the Sir Valley and find that the 7 June AD 1255 earthquake,
an event that devastated Kathmandu and mortally wounded the Nepalese King Abhaya Malla, also ruptured the surface along
this stretch of the mega-thrust. Thus, in the past 1,000 years, two great earthquakes, 679 years apart, rather than one giant
eleventh-century AD event, contributed to the frontal uplift of young river terraces in eastern Nepal. The rare surface expression
of these earthquakes implies that surface ruptures of other reputedly blind great Himalayan events might exist.
The aim of the study:- investigate the subsurface geological and hydrogeological conditions in
this area, Using Terrameter SAS A300 and made Schlumerger array to measure the apparent resistivity to get a 2D Electric Cross Section and determine the aquifer layer depth.
An Integrated Study of Gravity and Magnetic Data to Determine Subsurface Stru...iosrjce
:The present study wascarried out to delineate the location, extension, trend and depth of subsurface
structures of Alamein area. To achieve this aim, the gravity and aeromagnetic data have been subjected to
different analytical techniques. The Fast Fourier Transform technique was used to separatethe residual
components from the regional ones. The resulted maps showed that the area was affected mainly bytheENE, EW,
WNWand NWtectonic trends. In addition, spectral analysis technique was applied on magnetic anomalies to
estimate the depth to basement surface, which varies from 3.03 in southern part to 7.24 Km in northern part.3DEulerdeconvloution
and tilt angle derivative techniques were carried out to detect the edges of magnetic sources
and to determine their depths.Correlation between them shows acoincidence between Euler solution and zero
lines of tilt angle map. A tentative basement structure map is constructed from the integration of these results
and geological information. This map shows alternative uplifted and downfaulted structure trending in the ENE,
NE and E-W directions. In addition, the NNW to NW strike-slip faults intersected them in later events. Finally,
2-D modeling technique was run on three gravity and magnetic profiles in the same location. Different drilled
wells and the constructed basement structure map support these modeled profiles. Theyshow an acidic basement
rocks. A general decreasing of Conrad discontinuity depths from about 20.5 km at southern part to 17.9 km at
northern part can be noticed. Moreover, the crustal thickness (depth to Moho discontinuity), varies between
31.5 and 28.5 km revealing visibly crustal stretching and thinning northerly
The aim of the study:- investigate the subsurface geological and hydrogeological conditions in
this area, Using Terrameter SAS A300 and made Schlumerger array to measure the apparent resistivity to get a 2D Electric Cross Section and determine the aquifer layer depth.
An Integrated Study of Gravity and Magnetic Data to Determine Subsurface Stru...iosrjce
:The present study wascarried out to delineate the location, extension, trend and depth of subsurface
structures of Alamein area. To achieve this aim, the gravity and aeromagnetic data have been subjected to
different analytical techniques. The Fast Fourier Transform technique was used to separatethe residual
components from the regional ones. The resulted maps showed that the area was affected mainly bytheENE, EW,
WNWand NWtectonic trends. In addition, spectral analysis technique was applied on magnetic anomalies to
estimate the depth to basement surface, which varies from 3.03 in southern part to 7.24 Km in northern part.3DEulerdeconvloution
and tilt angle derivative techniques were carried out to detect the edges of magnetic sources
and to determine their depths.Correlation between them shows acoincidence between Euler solution and zero
lines of tilt angle map. A tentative basement structure map is constructed from the integration of these results
and geological information. This map shows alternative uplifted and downfaulted structure trending in the ENE,
NE and E-W directions. In addition, the NNW to NW strike-slip faults intersected them in later events. Finally,
2-D modeling technique was run on three gravity and magnetic profiles in the same location. Different drilled
wells and the constructed basement structure map support these modeled profiles. Theyshow an acidic basement
rocks. A general decreasing of Conrad discontinuity depths from about 20.5 km at southern part to 17.9 km at
northern part can be noticed. Moreover, the crustal thickness (depth to Moho discontinuity), varies between
31.5 and 28.5 km revealing visibly crustal stretching and thinning northerly
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
Mechanisms of white matter changes induced by meditationLoki Stormbringer
Using diffusion tensor imaging, several recent studies have shown that training results in changes in white matter efficiency as measured by fractional anisotropy (FA). In our work, we found that a form of mindfulness meditation, integrative body–mind training (IBMT), improved FA in areas surrounding the anterior cingulate cortex after 4-wk training more than controls given relaxation training. Reductions in radial diffusivity (RD) have been interpreted as improved myelin but reductions in axial diffusivity (AD) involve other mechanisms, such as axonal density. We now report that after 4-wk training with IBMT, both RD and AD decrease accompanied by increased FA, indicating improved efficiency of white matter involves increased myelin as well as other axonal changes. However, 2-wk IBMT reduced AD, but not RD or FA, and improved moods. Our results demonstrate the time-course of white matter neuroplasticity in short-term meditation. This dynamic pattern of white matter change involving the anterior cingulate cortex, a part of the brain network related to self-regulation, could provide a means for intervention to improve or prevent mental disorders.
Matrix rigidity controls endothelial differentiation and morphogenesis of car...Loki Stormbringer
Tissue development and regeneration involve tightly coordinated and integrated processes: selective proliferation of resident stem and precursor cells, differentiation into target somatic cell type, and spatial morphological organization. The role of the mechanical environment in the coordination of these processes is poorly understood. We show that multipotent cells derived from native cardiac tissue continually monitored cell substratum rigidity and showed enhanced proliferation, endothelial differentiation, and morphogenesis when the cell substratum rigidity closely matched that of myocardium. Mechanoregulation of these diverse processes required p190RhoGAP, a guanosine triphosphatase–activating protein for RhoA, acting through RhoA-dependent and -independent mechanisms. Natural or induced decreases in the abundance of p190RhoGAP triggered a series of developmental events by coupling cell-cell and cell-substratum interactions to genetic circuits controlling differentiation.
Primary surface ruptures of the great Himalayan earthquakes in 1934 and 1255Loki Stormbringer
It is unclear where plate boundary thrusts generate giant rather than great earthquakes. Along the Himalayas, the source
sizes and recurrence times of large seismic events are particularly uncertain, since no surface signatures were found for those
that shook the range in the twentieth century. Here we challenge the consensus that these events remained blind and did not
rupture the surface.We use geomorphological mapping of fluvial deposits, palaeo-seismological logging of river-cut cliffs and
trench walls, and modelling of calibrated 14C ages, to show that the Mw 8.2 Bihar–Nepal earthquake on 15 January 1934 did
break the surface: traces of the rupture are clear along at least 150 km of the Main Frontal Thrust fault in Nepal, between
85 500 and 87 200 E. Furthermore, we date collapse wedges in the Sir Valley and find that the 7 June AD 1255 earthquake,
an event that devastated Kathmandu and mortally wounded the Nepalese King Abhaya Malla, also ruptured the surface along
this stretch of the mega-thrust. Thus, in the past 1,000 years, two great earthquakes, 679 years apart, rather than one giant
eleventh-century AD event, contributed to the frontal uplift of young river terraces in eastern Nepal. The rare surface expression
of these earthquakes implies that surface ruptures of other reputedly blind great Himalayan events might exist.
Metal protein attenuating compounds for the treatment of alzheimer's dementiaLoki Stormbringer
The protein amyloid-β (Aß) is strongly implicated in the development of Alzheimer's dementia, where it aggregates in clumps causing damage and death of brain cells. This clumping is encouraged by copper and zinc (metal ions) in the brain. Metal protein attenuating compounds (MPACS) bind strongly to copper and zinc (this is known as chelation), both preventing the clumping together of Aß and promoting processes which may cause it to dissolve and so be cleared from brain cells. Therefore MPACS may be a potential therapy for Alzheimer's dementia. Two different types of MPAC have been used in clinical trials and the drugs are known as PBT1 and PBT2. The trial of PBT1 compared with placebo (in 36 patients) showed no statistically significant difference in cognition or memory between the active treatment and placebo groups at 36 weeks. We therefore conclude that there is no current evidence that treatment with clioquinol (PBT1) has any significant effect on cognition and in particular memory (as measured by the ADAS-Cog scale) in patients with Alzheimer's dementia. This drug has now been withdrawn from development. The trial of PBT2 showed it was safe after 12 weeks of treatment but demonstrated no overall significant effect on cognition or memory.
Appeal from the united states district court for the eastern district of wisc...Loki Stormbringer
This is a case about how a court may dispose of a copyright infringement action based on the fair use affirmative defense while avoiding the burdens of discovery and trial. This case also poses the interesting question of whether the incorporation-byreference doctrine applies to audio-visual works.
"We noted during oral argument that such a broad discovery request, surely entailing expensive e-discovery of emails or other internal communications, gives Brownmark the appearance of a “copyright troll.” We are confident that the district court would have refused to grant such expansive demands."
Meta analysis of genome-wide association studies for personalityLoki Stormbringer
Personality can be thought of as a set of characteristics that influence people’s thoughts,
feelings and behavior across a variety of settings. Variation in personality is predictive of many
outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide
association (GWA) data for personality in 10 discovery samples (17 375 adults) and five
in silico replication samples (3294 adults).
Anatomical plasticity of adult brain is titrated by nogo receptor 1 (06 March...Loki Stormbringer
Experience rearranges anatomical connectivity in the brain, but such plasticity is suppressed in adulthood. We examined the turnover of dendritic spines and axonal varicosities in the somatosensory cortex of mice lacking Nogo Receptor 1 (NgR1). Through adolescence, the anatomy and plasticity of ngr1 null mice are indistinguishable from control, but suppression of turnover after age 26 days fails to occur in ngr1−/− mice. Adolescent anatomical plasticity can be restored to 1-year-old mice by conditional deletion of ngr1. Suppression of anatomical dynamics by NgR1 is cell autonomous and is phenocopied by deletion of Nogo-A ligand. Whisker removal deprives the somatosensory cortex of experience-dependent input and reduces dendritic spine turnover in adult ngr1−/− mice to control levels, while an acutely enriched environment increases dendritic spine dynamics in control mice to the level of ngr1−/− mice in a standard environment. Thus, NgR1 determines the low set point for synaptic turnover in adult cerebral cortex.
The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and ...Loki Stormbringer
For some, glioma biomarkers have been expected to solve common diagnostic problems in routine neuropathology service caused by insufficient material, technical shortcomings or lack of experience. Further, biomarkers should predict patient outcome and direct optimal therapy for the individual patient. Unfortunately, current biomarkers still fall somewhat short of these grand expectations. While there has been some progress, it has generally been slow and in small steps. In this review, the newest set of glioma biomarkers: O(6) -methylguanine-DNA methyltransferase (MGMT) methylation, BRAF fusion and IDH1 mutation are discussed. MGMT methylation is well established as a prognostic/predictive marker for glioblastoma; however, technical questions regarding testing remain, it is not currently utilized widely in guiding patient management, and it has proven to be of no assistance in diagnostics. In contrast, BRAF fusion and IDH1 mutation analyses promise to be very helpful for classifying and grading gliomas, while their potential predictive value has yet to be established.
Interventions to Improve Cognitive Functioning After TBILoki Stormbringer
Traumatic injury to the brain can affect the core of what makes us
human—our cognition and emotion. The injuries are acute but may result
in chronic burdens for individuals and families as well as society. Effective
approaches to improving functioning are needed, and the benefits may
be far-reaching. We discuss some basic principles to guide current prac-
tice, as well as major directions for continuing advancement of ways to
improve functioning after injury. Interventions are more likely to be effec-
tive when we take into account multiple levels of brain functioning, from
neurons to pharmacological systems to social networks. Training of cogni-
tive functions is of special importance, and benefits may synergize with
pharmacologic and other approaches that modify biology. The combina-
tion of physical and experiential trauma deserves special consideration,
with effects on cognition, emotion, and other substrates of behavior.
Directing further research toward key frontiers that bridge neuroscience
and rehabilitation will advance the development of clinically effective
interventions.
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
Mechanisms of white matter changes induced by meditationLoki Stormbringer
Using diffusion tensor imaging, several recent studies have shown that training results in changes in white matter efficiency as measured by fractional anisotropy (FA). In our work, we found that a form of mindfulness meditation, integrative body–mind training (IBMT), improved FA in areas surrounding the anterior cingulate cortex after 4-wk training more than controls given relaxation training. Reductions in radial diffusivity (RD) have been interpreted as improved myelin but reductions in axial diffusivity (AD) involve other mechanisms, such as axonal density. We now report that after 4-wk training with IBMT, both RD and AD decrease accompanied by increased FA, indicating improved efficiency of white matter involves increased myelin as well as other axonal changes. However, 2-wk IBMT reduced AD, but not RD or FA, and improved moods. Our results demonstrate the time-course of white matter neuroplasticity in short-term meditation. This dynamic pattern of white matter change involving the anterior cingulate cortex, a part of the brain network related to self-regulation, could provide a means for intervention to improve or prevent mental disorders.
Matrix rigidity controls endothelial differentiation and morphogenesis of car...Loki Stormbringer
Tissue development and regeneration involve tightly coordinated and integrated processes: selective proliferation of resident stem and precursor cells, differentiation into target somatic cell type, and spatial morphological organization. The role of the mechanical environment in the coordination of these processes is poorly understood. We show that multipotent cells derived from native cardiac tissue continually monitored cell substratum rigidity and showed enhanced proliferation, endothelial differentiation, and morphogenesis when the cell substratum rigidity closely matched that of myocardium. Mechanoregulation of these diverse processes required p190RhoGAP, a guanosine triphosphatase–activating protein for RhoA, acting through RhoA-dependent and -independent mechanisms. Natural or induced decreases in the abundance of p190RhoGAP triggered a series of developmental events by coupling cell-cell and cell-substratum interactions to genetic circuits controlling differentiation.
Primary surface ruptures of the great Himalayan earthquakes in 1934 and 1255Loki Stormbringer
It is unclear where plate boundary thrusts generate giant rather than great earthquakes. Along the Himalayas, the source
sizes and recurrence times of large seismic events are particularly uncertain, since no surface signatures were found for those
that shook the range in the twentieth century. Here we challenge the consensus that these events remained blind and did not
rupture the surface.We use geomorphological mapping of fluvial deposits, palaeo-seismological logging of river-cut cliffs and
trench walls, and modelling of calibrated 14C ages, to show that the Mw 8.2 Bihar–Nepal earthquake on 15 January 1934 did
break the surface: traces of the rupture are clear along at least 150 km of the Main Frontal Thrust fault in Nepal, between
85 500 and 87 200 E. Furthermore, we date collapse wedges in the Sir Valley and find that the 7 June AD 1255 earthquake,
an event that devastated Kathmandu and mortally wounded the Nepalese King Abhaya Malla, also ruptured the surface along
this stretch of the mega-thrust. Thus, in the past 1,000 years, two great earthquakes, 679 years apart, rather than one giant
eleventh-century AD event, contributed to the frontal uplift of young river terraces in eastern Nepal. The rare surface expression
of these earthquakes implies that surface ruptures of other reputedly blind great Himalayan events might exist.
Metal protein attenuating compounds for the treatment of alzheimer's dementiaLoki Stormbringer
The protein amyloid-β (Aß) is strongly implicated in the development of Alzheimer's dementia, where it aggregates in clumps causing damage and death of brain cells. This clumping is encouraged by copper and zinc (metal ions) in the brain. Metal protein attenuating compounds (MPACS) bind strongly to copper and zinc (this is known as chelation), both preventing the clumping together of Aß and promoting processes which may cause it to dissolve and so be cleared from brain cells. Therefore MPACS may be a potential therapy for Alzheimer's dementia. Two different types of MPAC have been used in clinical trials and the drugs are known as PBT1 and PBT2. The trial of PBT1 compared with placebo (in 36 patients) showed no statistically significant difference in cognition or memory between the active treatment and placebo groups at 36 weeks. We therefore conclude that there is no current evidence that treatment with clioquinol (PBT1) has any significant effect on cognition and in particular memory (as measured by the ADAS-Cog scale) in patients with Alzheimer's dementia. This drug has now been withdrawn from development. The trial of PBT2 showed it was safe after 12 weeks of treatment but demonstrated no overall significant effect on cognition or memory.
Appeal from the united states district court for the eastern district of wisc...Loki Stormbringer
This is a case about how a court may dispose of a copyright infringement action based on the fair use affirmative defense while avoiding the burdens of discovery and trial. This case also poses the interesting question of whether the incorporation-byreference doctrine applies to audio-visual works.
"We noted during oral argument that such a broad discovery request, surely entailing expensive e-discovery of emails or other internal communications, gives Brownmark the appearance of a “copyright troll.” We are confident that the district court would have refused to grant such expansive demands."
Meta analysis of genome-wide association studies for personalityLoki Stormbringer
Personality can be thought of as a set of characteristics that influence people’s thoughts,
feelings and behavior across a variety of settings. Variation in personality is predictive of many
outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide
association (GWA) data for personality in 10 discovery samples (17 375 adults) and five
in silico replication samples (3294 adults).
Anatomical plasticity of adult brain is titrated by nogo receptor 1 (06 March...Loki Stormbringer
Experience rearranges anatomical connectivity in the brain, but such plasticity is suppressed in adulthood. We examined the turnover of dendritic spines and axonal varicosities in the somatosensory cortex of mice lacking Nogo Receptor 1 (NgR1). Through adolescence, the anatomy and plasticity of ngr1 null mice are indistinguishable from control, but suppression of turnover after age 26 days fails to occur in ngr1−/− mice. Adolescent anatomical plasticity can be restored to 1-year-old mice by conditional deletion of ngr1. Suppression of anatomical dynamics by NgR1 is cell autonomous and is phenocopied by deletion of Nogo-A ligand. Whisker removal deprives the somatosensory cortex of experience-dependent input and reduces dendritic spine turnover in adult ngr1−/− mice to control levels, while an acutely enriched environment increases dendritic spine dynamics in control mice to the level of ngr1−/− mice in a standard environment. Thus, NgR1 determines the low set point for synaptic turnover in adult cerebral cortex.
The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and ...Loki Stormbringer
For some, glioma biomarkers have been expected to solve common diagnostic problems in routine neuropathology service caused by insufficient material, technical shortcomings or lack of experience. Further, biomarkers should predict patient outcome and direct optimal therapy for the individual patient. Unfortunately, current biomarkers still fall somewhat short of these grand expectations. While there has been some progress, it has generally been slow and in small steps. In this review, the newest set of glioma biomarkers: O(6) -methylguanine-DNA methyltransferase (MGMT) methylation, BRAF fusion and IDH1 mutation are discussed. MGMT methylation is well established as a prognostic/predictive marker for glioblastoma; however, technical questions regarding testing remain, it is not currently utilized widely in guiding patient management, and it has proven to be of no assistance in diagnostics. In contrast, BRAF fusion and IDH1 mutation analyses promise to be very helpful for classifying and grading gliomas, while their potential predictive value has yet to be established.
Interventions to Improve Cognitive Functioning After TBILoki Stormbringer
Traumatic injury to the brain can affect the core of what makes us
human—our cognition and emotion. The injuries are acute but may result
in chronic burdens for individuals and families as well as society. Effective
approaches to improving functioning are needed, and the benefits may
be far-reaching. We discuss some basic principles to guide current prac-
tice, as well as major directions for continuing advancement of ways to
improve functioning after injury. Interventions are more likely to be effec-
tive when we take into account multiple levels of brain functioning, from
neurons to pharmacological systems to social networks. Training of cogni-
tive functions is of special importance, and benefits may synergize with
pharmacologic and other approaches that modify biology. The combina-
tion of physical and experiential trauma deserves special consideration,
with effects on cognition, emotion, and other substrates of behavior.
Directing further research toward key frontiers that bridge neuroscience
and rehabilitation will advance the development of clinically effective
interventions.
The Final Seminar of the Project for Assessment of Earthquake Disaster Risk for the Kathmandu Valley in Nepal was held on 14 February 2018.
The public seminar was held three times during the project.
The Final Seminar, “ Understanding Disaster Risks and Moving Towards DRR and Resilience”, presented on the activities and accomplishment of the project, construction of robust and resilient society against natural disaster risk.
Thank you all for your support and enthusiastic participation in this seminar.
Presentation: Overview of Hazard Assessment Results
Recent north magnetic pole acceleration towards Siberia caused by flux lobe e...Sérgio Sacani
The wandering of Earth’s north magnetic pole, the location where the magnetic field points vertically downwards, has long been
a topic of scientific fascination. Since the first in situ measurements in 1831 of its location in the Canadian arctic, the pole has
drifted inexorably towards Siberia, accelerating between 1990 and 2005 from its historic speed of 0–15 km yr−1
to its present
speed of 50–60 km yr−1
. In late October 2017 the north magnetic pole crossed the international date line, passing within 390 km
of the geographic pole, and is now moving southwards. Here we show that over the last two decades the position of the north
magnetic pole has been largely determined by two large-scale lobes of negative magnetic flux on the core–mantle boundary
under Canada and Siberia. Localized modelling shows that elongation of the Canadian lobe, probably caused by an alteration
in the pattern of core flow between 1970 and 1999, substantially weakened its signature on Earth’s surface, causing the pole
to accelerate towards Siberia. A range of simple models that capture this process indicate that over the next decade the north
magnetic pole will continue on its current trajectory, travelling a further 390–660 km towards Siberia.
Modern water at low latitudes on Mars: Potential evidence from dune surfacesSérgio Sacani
Landforms on the Martian surface are critical to understanding the nature of surface processes in the recent
past. However, modern hydroclimatic conditions on Mars remain enigmatic, as explanations for the formation
of observed landforms are ambiguous. We report crusts, cracks, aggregates, and bright polygonal ridges on the
surfaces of hydrated salt-rich dunes of southern Utopia Planitia (~25°N) from in situ exploration by the Zhurong
rover. These surface features were inferred to form after 1.4 to 0.4 million years ago. Wind and CO2 frost processes can be ruled out as potential mechanisms. Instead, involvement of saline water from thawed frost/snow is
the most likely cause. This discovery sheds light on more humid conditions of the modern Martian climate and
provides critical clues to future exploration missions searching for signs of extant life, particularly at low latitudes with comparatively warmer, more amenable surface temperatures.