The document describes a novel biomedical composite material combining hydroxyapatite bioceramic and collagen-based natural polymers, exhibiting remarkable biocompatibility and osteoconductivity for bone tissue reconstruction. This innovative material is produced from pig bones, offering a cost-effective and environmentally friendly method while avoiding hazardous waste. The collagen/hydroxyapatite composites demonstrate potential as scaffolds for hard tissue engineering and controlled antibiotic release devices.

1. Faculty of Chemical Engineering and Technology
CRACOW UNIVERSITY OF TECHNOLOGY
24 Warszawska St., 31-155 Cracow, Poland
*e-mail: asobczak@chemia.pk.edu.pl
BIOMEDICAL COMPOSITES BASED ON
INVENTION
HYDROXYAPATITE BIOCERAMIC MATERIAL
AND POLYMER MATRIX WITH COLLAGEN
INVENTORS
AGNIESZKA SOBCZAK-KUPIEC
BOŻENA TYLISZCZAK
DAGMARA MALINA
KATARZYNA BIALIK -
WĄS

2. Faculty of Chemical Engineering and Technology
CRACOW UNIVERSITY OF TECHNOLOGY
24 Warszawska St., 31-155 Cracow, Poland
*e-mail: asobczak@chemia.pk.edu.pl
The invention is a ccoommppoossiittee bbiioommaatteerriiaall
containing hhyyddrrooxxyyaappaattiittee bbiioocceerraammiicc mmaatteerriiaall
and nnaattuurraall bbiiooppoollyymmeerr also called hydrocolloid.
Due to unique ccoommbbiinnaattiioonn ooff aa ppoollyymmeerr mmaattrriixx
wwiitthh hhyyddrrooxxyyaappaattiittee the obtained biomaterial
exhibits bbiiooaaccttiivviittyy,, bbiiooccoommppaattiibbiilliittyy,, ccaappaacciittyy ttoo
ssttiimmuullaattiinngg ooff bboonnee ttiissssuuee rreeccoonnssttrruuccttiioonn,,
ssttaabbiilliittyy aanndd fflleexxiibbiilliittyy.

3. Faculty of Chemical Engineering and Technology
CRACOW UNIVERSITY OF TECHNOLOGY
24 Warszawska St., 31-155 Cracow, Poland
*e-mail: asobczak@chemia.pk.edu.pl
Due to the high biocompatibility, osteoconductivity aanndd tthhee
aabbiilliittyy ttoo ccrreeaattee cchheemmiiccaall ccoonnnneeccttiioonnss wwiitthh lliivviinngg ttiissssuuee
hydroxyapatite ceramic materials are considered to be one of
the leading materials in bone surgery.
Hydroxyapatite used in the composites have been obtained with
aa nnoovveell mmeetthhoodd using pig bones, which allows a significant cost
reduction in obtaining this type of material in comparison with
traditional methods and produces a material with given
parameters. This method is iinnnnoovvaattiivvee oonn aa gglloobbaall ssccaallee iinn
eeccoollooggiiccaall aassppeeccttss. It eliminates aggressive hydrolyzing agents,
which generate significant quantities of hazardous waste that
need to disposed of in a special way.

4. Faculty of Chemical Engineering and Technology
CRACOW UNIVERSITY OF TECHNOLOGY
24 Warszawska St., 31-155 Cracow, Poland
*e-mail: asobczak@chemia.pk.edu.pl
Natural polymers also called hhyyddrrooccoollllooiiddss are
macromolecular compounds composed of
multiple repeating units. They are natural
components of cell building blocks of living
organisms. Hydrocolloids are soluble compounds
or dispersible in water with thickening, stabilizing
and gelling properties.
One of them is ccoollllaaggeenn, the main component of
skin and tendons, it also create an organic phase
of skeletal providing elasticity and flexibility of
rigid bones. Improved cellular responses of the
collagen/hydroxyapatite porous composites have
high potential for use as hard tissue scaffolds.

5. Faculty of Chemical Engineering and Technology
CRACOW UNIVERSITY OF TECHNOLOGY
24 Warszawska St., 31-155 Cracow, Poland
*e-mail: asobczak@chemia.pk.edu.pl
Other studies have confirmed the
excellent biocompatibility in the bone
remodeling metabolism of these
composites. These cceerraammiicc//hhyyddrrooccoollllooiidd
ssttrruuccttuurreess may be designed as effective
devices for the controlled release of
antibiotic agents. Moreover, implanted
materials with polymer phase can be used
in computer tomography or magnetic
resonance imaging without being
hindered by artifacts.