This document discusses the prevention of ingestion injuries in children. It provides an overview of the burden of ingestion injuries, including the high risk for children under 5 years old. Common agents that cause ingestion injuries include coins, inappropriate food items, caustic substances, batteries, and magnets. Ingestion injuries can cause complications like chemical burns, esophageal strictures, gastrointestinal obstruction, and fistula formation. Prevention strategies should use a multifaceted approach involving education, environmental modifications, technology, legislation, and community participation. The health impact pyramid and Haddon matrix can be used as frameworks for injury prevention.
Childhood Poisoning: Safeguarding Young Children from Addictive SubstancesCenter on Addiction
Based on a recent report by Center on Addiction, this presentation summarizes the available research on the nature, extent, and consequences of young children’s exposure to a range of addictive substances based on data collected by the American Association of Poison Control Centers (AAPCC), as well as other research reports and data sources. It explains why and how such exposures occur, and what the barriers are to preventing them. Finally, it provides a comprehensive approach to addressing the problem of childhood exposures and poisonings.
Children are curious and tend to explore their surroundings. While doing so they may run, ingest, or inhale potentially harmful substances. Tens of thousands of cases of childhood poisoning are reported annually and some are associated with major morbidity and mortality.
This document discusses how environmental factors are contributing to increases in chronic diseases in children. It outlines how children are more vulnerable than adults to toxic chemicals due to greater exposure and developing bodies. While many chemicals children encounter have not been tested for toxicity, evidence links exposures to neurodevelopmental disorders, asthma, and cancer. Preventing disease requires testing chemicals, researching causes, patient care, and education. Studies like the National Children's Study aim to identify preventable environmental causes of conditions like autism and obesity. Reducing exposures at home, in communities, and through policy can lower health risks to children from a toxic world.
This document discusses pediatric environmental hazards. It notes that children are more vulnerable than adults to environmental contaminants due to their developing bodies and behaviors. Key exposures include contaminants in drinking water like lead and arsenic, foodborne pathogens like E. coli and Listeria, and chemicals that can leach from plastics into food and water like BPA. The document provides details on how certain contaminants can disrupt normal development and cause higher exposures in children through their behaviors and metabolisms. It outlines commonly identified hazards in areas like water, food, and indoor environments.
Innovation: managing risk, not avoiding itbis_foresight
The document discusses managing risks associated with innovation. It argues that innovation is essential for economic growth and well-being but always carries risks. It advocates for framing risks rigorously to make decisions more robust, and acknowledges that context matters as science is not the only lens for assessing risks. Well-informed regulation and decision-making requires considering these factors and sustaining strong institutions for scientific advice.
The document discusses the precautionary principle, which holds that actions should not be taken if their consequences are uncertain and potentially dangerous. It notes that the principle can be interpreted in different ways, such as "guilty until proven innocent," where industry must prove no harm before proceeding, or "innocent until proven guilty," where industry can proceed unless specific harms are identified. The document provides examples of how the precautionary principle is applied to issues like the environment, energy, food safety, chemicals, health, and technology. It also lists government agencies and departments that utilize the principle.
EMPHNET-PHE course: Module03 ethical issues in surveillance, screening and ou...Dr Ghaiath Hussein
This is a series of presentations I gave in the Eastern Mediterranean Public Health Network (EMPHNET)'s Public Health Ethics (PHE) that was held in Amman in June 2014.
This presentation outlines the ethical issues related to surveillance, screening, and outbreak investigation.
- Preventive dentistry aims to prevent dental diseases before they occur through various levels of prevention including primordial, primary, secondary, and tertiary.
- Primary prevention removes the possibility of disease by targeting the entire population or high-risk groups through health promotion, education, environmental modifications, and specific protective measures like water fluoridation or dental sealants.
- Secondary prevention halts disease progression through early diagnosis and prompt treatment while tertiary prevention focuses on rehabilitation and reducing impairments from existing conditions.
Childhood Poisoning: Safeguarding Young Children from Addictive SubstancesCenter on Addiction
Based on a recent report by Center on Addiction, this presentation summarizes the available research on the nature, extent, and consequences of young children’s exposure to a range of addictive substances based on data collected by the American Association of Poison Control Centers (AAPCC), as well as other research reports and data sources. It explains why and how such exposures occur, and what the barriers are to preventing them. Finally, it provides a comprehensive approach to addressing the problem of childhood exposures and poisonings.
Children are curious and tend to explore their surroundings. While doing so they may run, ingest, or inhale potentially harmful substances. Tens of thousands of cases of childhood poisoning are reported annually and some are associated with major morbidity and mortality.
This document discusses how environmental factors are contributing to increases in chronic diseases in children. It outlines how children are more vulnerable than adults to toxic chemicals due to greater exposure and developing bodies. While many chemicals children encounter have not been tested for toxicity, evidence links exposures to neurodevelopmental disorders, asthma, and cancer. Preventing disease requires testing chemicals, researching causes, patient care, and education. Studies like the National Children's Study aim to identify preventable environmental causes of conditions like autism and obesity. Reducing exposures at home, in communities, and through policy can lower health risks to children from a toxic world.
This document discusses pediatric environmental hazards. It notes that children are more vulnerable than adults to environmental contaminants due to their developing bodies and behaviors. Key exposures include contaminants in drinking water like lead and arsenic, foodborne pathogens like E. coli and Listeria, and chemicals that can leach from plastics into food and water like BPA. The document provides details on how certain contaminants can disrupt normal development and cause higher exposures in children through their behaviors and metabolisms. It outlines commonly identified hazards in areas like water, food, and indoor environments.
Innovation: managing risk, not avoiding itbis_foresight
The document discusses managing risks associated with innovation. It argues that innovation is essential for economic growth and well-being but always carries risks. It advocates for framing risks rigorously to make decisions more robust, and acknowledges that context matters as science is not the only lens for assessing risks. Well-informed regulation and decision-making requires considering these factors and sustaining strong institutions for scientific advice.
The document discusses the precautionary principle, which holds that actions should not be taken if their consequences are uncertain and potentially dangerous. It notes that the principle can be interpreted in different ways, such as "guilty until proven innocent," where industry must prove no harm before proceeding, or "innocent until proven guilty," where industry can proceed unless specific harms are identified. The document provides examples of how the precautionary principle is applied to issues like the environment, energy, food safety, chemicals, health, and technology. It also lists government agencies and departments that utilize the principle.
EMPHNET-PHE course: Module03 ethical issues in surveillance, screening and ou...Dr Ghaiath Hussein
This is a series of presentations I gave in the Eastern Mediterranean Public Health Network (EMPHNET)'s Public Health Ethics (PHE) that was held in Amman in June 2014.
This presentation outlines the ethical issues related to surveillance, screening, and outbreak investigation.
- Preventive dentistry aims to prevent dental diseases before they occur through various levels of prevention including primordial, primary, secondary, and tertiary.
- Primary prevention removes the possibility of disease by targeting the entire population or high-risk groups through health promotion, education, environmental modifications, and specific protective measures like water fluoridation or dental sealants.
- Secondary prevention halts disease progression through early diagnosis and prompt treatment while tertiary prevention focuses on rehabilitation and reducing impairments from existing conditions.
NHS 5YFV Vanguards-Dr Chris Jones presentationmckenln
This document outlines the West Wakefield Health & Wellbeing initiative, which aims to improve health outcomes through an integrated model of care. Key elements of the model include:
- Establishing an information hub and integrated teams to coordinate proactive care.
- Expanding access through digital tools, extended primary care hours, and initiatives like a schools app challenge.
- Implementing programs to address local health issues like obesity and oral health.
- Facing challenges in workforce, technology, and governance while accelerating the pace of change.
This document summarizes a presentation on protecting children during the COVID-19 pandemic. It discusses the general impacts of the pandemic on children, including increased health risks, rise in abuse and neglect, and challenges with remote learning. Recommendations are provided to support children and families through social services, continue essential health services, increase online safety, and enhance parental education on positive parenting. The roles of government, non-profits, and parents are emphasized to collectively address child protection issues during this crisis.
There are many factors that can contribute to infant mortality, including biological, socioeconomic, environmental, and healthcare-related factors such as premature birth, poverty, pollution, and lack of access to care. Preventing infant mortality requires a multifaceted approach including prenatal and postnatal care, education, public health policies, and interventions that address the underlying social and economic causes. Global infant mortality rates in 2019 ranged widely, from 3 deaths per 1,000 live births in Europe to 53 deaths per 1,000 live births in Sub-Saharan Africa. Reducing infant mortality requires a comprehensive approach to prevention that ensures the health and well-being of future generations.
ROLE OF NURSE IN PROVIDING SAFE AND CLEAN.pptxBinal Joshi
The document discusses the nurse's role in providing a safe environment for patients. It covers conducting thorough patient assessments, including assessing their home environments and risk factors. It provides examples of nursing interventions to address safety risks, such as fall prevention, medication management, and health promotion. The nurse collaborates with patients, families, and other providers to develop individualized plans of care focused on safety.
Introduction, Defination, Scenario of Poisoining worldwide, Risk Factors, Ecology of Poisoining, Presenting features of common poisonings, Basic management of a poisoned patient, Emergency stabilization measures, Identification of poison, Removal of toxin, Eye/Dermai/Gut/Gastric lavage/ adsorbent administration/Catharsis, Specific antidotal therapy, Promotion of excretion of toxin, supportive therapy, prevention of poisoining, some specific poisons and antidotes-OP poisoining/Hydrocarbon poisoining/Barbiturate poisoining/Iron poisoining
PUBLIC HEALTH APPROACHES FOR ORAL DISEASE PREVENTIONAneesa K Ayoob
This document discusses public health approaches for preventing oral diseases. It outlines criteria for prioritizing health problems from a public health perspective. Oral diseases are considered public health problems due to their widespread prevalence linked to social and economic factors. Strategies for prevention can target individuals, populations, or whole populations. Effective strategies consider underlying disease determinants and use approaches like health education, regulation, and environmental changes to create lasting public health improvements. Evaluation of prevention programs is important to ensure their continued benefits and accessibility.
1. Humans face health risks from infectious diseases, chemical exposures, and lifestyle choices. Synthetic chemicals like BPA can disrupt the endocrine system.
2. The document discusses the controversy around BPA in baby bottles and food containers. While scientists study long term low-level effects of chemicals, over 90% of Americans test positive for BPA.
3. Protecting public health requires understanding pathways of disease transmission, estimating chemical exposures, and reducing risks from poverty, gender inequality, and lifestyle factors.
Presentation by Prof. George Gray, Director of the Centre for Risk Science and Public Health, George Washington University, at the Workshop on Risk Assessment in Regulatory Policy Analysis (RIA), Session 15, Mexico, 9-11 June 2014. Further information is available at http://www.oecd.org/gov/regulatory-policy/
The WHO document discusses preconception care, which aims to improve health outcomes for mothers and children through interventions before conception. Unplanned pregnancies are common, and preconception nutritional deficiencies, infections like HIV, and early childbearing increase mortality risks. The WHO's preconception care package addresses issues like nutrition, genetic conditions, and early pregnancy through evidence-based interventions. Countries can learn from successful initiatives and adapt this framework with WHO support through strategic planning and monitoring progress over time.
Zika Prevention Approaches in Jamaica UWI_Markcomm
Shaping the Caribbean's response to Zika, UWI’s Zika Task Force (www.uwi.edu/zika) is gathering and providing expert advice to develop a strategic, scientific approach for tackling the Zika virus.
substance use in children and young adultsHimanshi Walia
Substance use disorders often begin in adolescence. This narrative review examines substance use patterns, epidemiology, risk factors, and management among those under 18 in India. Literature shows over half of psychiatric disorders start before age 14. In India, 13% of substance abusers are under 20. Street children have very high rates of inhalant use. Social and psychological risk factors include adverse life events, conduct disorders, parental substance abuse, and poor parenting. Prevention strategies target schools, families, and communities to build resilience. Treatment involves comprehensive assessment and psychosocial interventions like CBT and family therapy. More research is still needed on substance use among children and adolescents in India.
Universities as One Health ‘Game Changers’: Addressing emerging health challe...Global Risk Forum GRFDavos
The document discusses how universities can be "game changers" in addressing emerging health challenges through One Health education, research, and outreach programs. It outlines how universities are developing innovative One Health approaches that include new classroom methods like case-based teaching, field-based training, multi-disciplinary partnerships, and career paths that cut across human, animal and environmental health. The goal is to improve workforce capacity for managing health threats at the human-animal-environment interface and foster closer collaboration between academic institutions and government/community needs.
The document summarizes the work of the National Patient Safety Agency in the UK to improve patient safety. It discusses how patient safety issues cost the UK health system over £1 billion per year. It then outlines the agency's seven steps for hospitals to improve safety culture, which include building an open culture, leadership support, integrated risk management, incident reporting, patient involvement, learning from incidents, and implementing solutions. Specific strategies mentioned include risk assessments, reporting systems, investigation training, and emphasizing design improvements and system changes over individual blame.
Oral cancer is a major public health problem worldwide and in India. Key risk factors include tobacco use (smoking, smokeless tobacco, betel quid), alcohol consumption, and HPV infection. Precancerous lesions include leukoplakia and erythroplakia. Prevention focuses on education about risk factors, screening of high-risk individuals, and regulatory policies like graphic health warnings and advertising bans on tobacco products.
This is a joint presentation on how Public Health, Community Safety and Fire are working on shared agendas in Hertfordshire, given to the LGA Anual Safer Communities Conference, December 2015
This document provides an overview of ethics in scientific research. It begins with definitions of key terms like research ethics and discusses important historical events that shaped modern guidelines, like the Tuskegee Syphilis Study and Nazi medical experiments. The objectives of research ethics are outlined as protecting participants, ensuring research benefits society, and examining projects for ethical soundness. Principles of research ethics like scientific honesty, care, and intellectual freedom are described. The document covers issues in the internal domain of scientific practice like publication and citation practices as well as the external domain regarding safety, new chemical substances, and sustainable development.
Challenges in increasing biosecurity in the nursery industryForest Research
The document discusses challenges in increasing biosecurity in the nursery industry. It summarizes existing industry certification schemes in the UK and overseas aimed at improving plant health and reducing biosecurity risks. It identifies issues like asymmetric information and public good characteristics that can lead to underprovision of biosecurity. The document also outlines themes discussed with industry, including the need for clear benefits to encourage participation in voluntary schemes, government support through policies, and ensuring schemes are designed to maximize coverage. Market impacts and future areas of research are also addressed.
Environmental Toxins: Practical Solutions for HealthSummit Health
Did you know that exposure to environmental toxins can happen at home, in the workplace and outside? This presentation focuses on lessening and managing exposure to pollution, including by-products of plastics, heavy metals such as mercury and lead, pesticides, bacteria, viruses, and molds, and other respirables such as tobacco smoke. Learn tips to improve air quality in your home year round so that you can protect your health and the health of your loved ones.
This document provides an agenda and speaker bios for an expert consultation hosted by the President's Task Force on Children's Environmental Health Risks and Safety Risks to Children Subcommittee on Climate Change. The agenda outlines a day-long series of sessions on various topics related to the effects of climate change on children's health. Speaker bios are provided for over 20 experts participating in the consultation. The goal of the consultation is to inform federal strategies for addressing climate change impacts on children.
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
NHS 5YFV Vanguards-Dr Chris Jones presentationmckenln
This document outlines the West Wakefield Health & Wellbeing initiative, which aims to improve health outcomes through an integrated model of care. Key elements of the model include:
- Establishing an information hub and integrated teams to coordinate proactive care.
- Expanding access through digital tools, extended primary care hours, and initiatives like a schools app challenge.
- Implementing programs to address local health issues like obesity and oral health.
- Facing challenges in workforce, technology, and governance while accelerating the pace of change.
This document summarizes a presentation on protecting children during the COVID-19 pandemic. It discusses the general impacts of the pandemic on children, including increased health risks, rise in abuse and neglect, and challenges with remote learning. Recommendations are provided to support children and families through social services, continue essential health services, increase online safety, and enhance parental education on positive parenting. The roles of government, non-profits, and parents are emphasized to collectively address child protection issues during this crisis.
There are many factors that can contribute to infant mortality, including biological, socioeconomic, environmental, and healthcare-related factors such as premature birth, poverty, pollution, and lack of access to care. Preventing infant mortality requires a multifaceted approach including prenatal and postnatal care, education, public health policies, and interventions that address the underlying social and economic causes. Global infant mortality rates in 2019 ranged widely, from 3 deaths per 1,000 live births in Europe to 53 deaths per 1,000 live births in Sub-Saharan Africa. Reducing infant mortality requires a comprehensive approach to prevention that ensures the health and well-being of future generations.
ROLE OF NURSE IN PROVIDING SAFE AND CLEAN.pptxBinal Joshi
The document discusses the nurse's role in providing a safe environment for patients. It covers conducting thorough patient assessments, including assessing their home environments and risk factors. It provides examples of nursing interventions to address safety risks, such as fall prevention, medication management, and health promotion. The nurse collaborates with patients, families, and other providers to develop individualized plans of care focused on safety.
Introduction, Defination, Scenario of Poisoining worldwide, Risk Factors, Ecology of Poisoining, Presenting features of common poisonings, Basic management of a poisoned patient, Emergency stabilization measures, Identification of poison, Removal of toxin, Eye/Dermai/Gut/Gastric lavage/ adsorbent administration/Catharsis, Specific antidotal therapy, Promotion of excretion of toxin, supportive therapy, prevention of poisoining, some specific poisons and antidotes-OP poisoining/Hydrocarbon poisoining/Barbiturate poisoining/Iron poisoining
PUBLIC HEALTH APPROACHES FOR ORAL DISEASE PREVENTIONAneesa K Ayoob
This document discusses public health approaches for preventing oral diseases. It outlines criteria for prioritizing health problems from a public health perspective. Oral diseases are considered public health problems due to their widespread prevalence linked to social and economic factors. Strategies for prevention can target individuals, populations, or whole populations. Effective strategies consider underlying disease determinants and use approaches like health education, regulation, and environmental changes to create lasting public health improvements. Evaluation of prevention programs is important to ensure their continued benefits and accessibility.
1. Humans face health risks from infectious diseases, chemical exposures, and lifestyle choices. Synthetic chemicals like BPA can disrupt the endocrine system.
2. The document discusses the controversy around BPA in baby bottles and food containers. While scientists study long term low-level effects of chemicals, over 90% of Americans test positive for BPA.
3. Protecting public health requires understanding pathways of disease transmission, estimating chemical exposures, and reducing risks from poverty, gender inequality, and lifestyle factors.
Presentation by Prof. George Gray, Director of the Centre for Risk Science and Public Health, George Washington University, at the Workshop on Risk Assessment in Regulatory Policy Analysis (RIA), Session 15, Mexico, 9-11 June 2014. Further information is available at http://www.oecd.org/gov/regulatory-policy/
The WHO document discusses preconception care, which aims to improve health outcomes for mothers and children through interventions before conception. Unplanned pregnancies are common, and preconception nutritional deficiencies, infections like HIV, and early childbearing increase mortality risks. The WHO's preconception care package addresses issues like nutrition, genetic conditions, and early pregnancy through evidence-based interventions. Countries can learn from successful initiatives and adapt this framework with WHO support through strategic planning and monitoring progress over time.
Zika Prevention Approaches in Jamaica UWI_Markcomm
Shaping the Caribbean's response to Zika, UWI’s Zika Task Force (www.uwi.edu/zika) is gathering and providing expert advice to develop a strategic, scientific approach for tackling the Zika virus.
substance use in children and young adultsHimanshi Walia
Substance use disorders often begin in adolescence. This narrative review examines substance use patterns, epidemiology, risk factors, and management among those under 18 in India. Literature shows over half of psychiatric disorders start before age 14. In India, 13% of substance abusers are under 20. Street children have very high rates of inhalant use. Social and psychological risk factors include adverse life events, conduct disorders, parental substance abuse, and poor parenting. Prevention strategies target schools, families, and communities to build resilience. Treatment involves comprehensive assessment and psychosocial interventions like CBT and family therapy. More research is still needed on substance use among children and adolescents in India.
Universities as One Health ‘Game Changers’: Addressing emerging health challe...Global Risk Forum GRFDavos
The document discusses how universities can be "game changers" in addressing emerging health challenges through One Health education, research, and outreach programs. It outlines how universities are developing innovative One Health approaches that include new classroom methods like case-based teaching, field-based training, multi-disciplinary partnerships, and career paths that cut across human, animal and environmental health. The goal is to improve workforce capacity for managing health threats at the human-animal-environment interface and foster closer collaboration between academic institutions and government/community needs.
The document summarizes the work of the National Patient Safety Agency in the UK to improve patient safety. It discusses how patient safety issues cost the UK health system over £1 billion per year. It then outlines the agency's seven steps for hospitals to improve safety culture, which include building an open culture, leadership support, integrated risk management, incident reporting, patient involvement, learning from incidents, and implementing solutions. Specific strategies mentioned include risk assessments, reporting systems, investigation training, and emphasizing design improvements and system changes over individual blame.
Oral cancer is a major public health problem worldwide and in India. Key risk factors include tobacco use (smoking, smokeless tobacco, betel quid), alcohol consumption, and HPV infection. Precancerous lesions include leukoplakia and erythroplakia. Prevention focuses on education about risk factors, screening of high-risk individuals, and regulatory policies like graphic health warnings and advertising bans on tobacco products.
This is a joint presentation on how Public Health, Community Safety and Fire are working on shared agendas in Hertfordshire, given to the LGA Anual Safer Communities Conference, December 2015
This document provides an overview of ethics in scientific research. It begins with definitions of key terms like research ethics and discusses important historical events that shaped modern guidelines, like the Tuskegee Syphilis Study and Nazi medical experiments. The objectives of research ethics are outlined as protecting participants, ensuring research benefits society, and examining projects for ethical soundness. Principles of research ethics like scientific honesty, care, and intellectual freedom are described. The document covers issues in the internal domain of scientific practice like publication and citation practices as well as the external domain regarding safety, new chemical substances, and sustainable development.
Challenges in increasing biosecurity in the nursery industryForest Research
The document discusses challenges in increasing biosecurity in the nursery industry. It summarizes existing industry certification schemes in the UK and overseas aimed at improving plant health and reducing biosecurity risks. It identifies issues like asymmetric information and public good characteristics that can lead to underprovision of biosecurity. The document also outlines themes discussed with industry, including the need for clear benefits to encourage participation in voluntary schemes, government support through policies, and ensuring schemes are designed to maximize coverage. Market impacts and future areas of research are also addressed.
Environmental Toxins: Practical Solutions for HealthSummit Health
Did you know that exposure to environmental toxins can happen at home, in the workplace and outside? This presentation focuses on lessening and managing exposure to pollution, including by-products of plastics, heavy metals such as mercury and lead, pesticides, bacteria, viruses, and molds, and other respirables such as tobacco smoke. Learn tips to improve air quality in your home year round so that you can protect your health and the health of your loved ones.
This document provides an agenda and speaker bios for an expert consultation hosted by the President's Task Force on Children's Environmental Health Risks and Safety Risks to Children Subcommittee on Climate Change. The agenda outlines a day-long series of sessions on various topics related to the effects of climate change on children's health. Speaker bios are provided for over 20 experts participating in the consultation. The goal of the consultation is to inform federal strategies for addressing climate change impacts on children.
Similar to prevention of childhood ingestion injuries.pptx (20)
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2. Overview
• The Burden of ingestion Injury
• A clinical perspective
• Agents
• Presentation
• complications
• A public health perspective
• Epidemiology of Childhood injuries
• Childhood Ingestion Injuries
• The aetiology of Injury
• Risk factors
• Prevention
3. Ingestion Injuries
• children under- 5 have the highest risk
• peak incidence at 3 years of age
• A Healthcare Burden:
• increased emergency room visits
• long term consequences and
morbidity
• Preventable !
4. Agents
• Coin ingestion
• Choking on age-inappropriate food items
• Caustic: sodium hydroxide and potassium
permanganate, hair relaxer, swimming
pool products, and toilet bowl cleaners
• Corrosive: hydrochloric acid, battery acid
• Button batteries
• Magnets
5. Presentation
• A history of ingestion may be absent
• Ingestion is witnessed in as few as a
quarter of all cases
• These external signs do not reliably
predict oesophageal penetration
• Caustic Ingestion
• volatile agents (e.g. paraffin,
hydrocarbons).
• Household cleaning agents
6. Complications
• Chemical Burns: strong alkali (pH ≥11.5), strong acid
(pH ≤2)
• Oesophageal stricture formation
• Sharp objects penetrate GIT
• Blunt objects cause GIT obstruction and pressure
necrosis
• ≥2 magnets : entero-enteric fistula
• Electric Disk cells:
• focal oesophageal burns
• perforation with mediastinitis
• trachea-oesophageal fistula formation
• oesophago-aortic fistulas due to erosion
• long-term oesophageal stricture formation
12. The
Child
• Vulnerable to different injuries at
different stages of their lives
• Toddlers
• Infants:
• Children <9years
• ADHD
13. The
Environment
• The backdrop to injury patterns
• Physical and Psychological
• SES factors
• Emotional stress
• Social and cultural
14. Prevention
• Change the environment, behaviour
and societal concern
• Multifacited approach:
• Community
• professionals of many disciplines
• government.
• Healthworkers: inform the public and
motivate for change
• Educators and media: educate, increase
safety and awareness
• Community participation
• Identify local priorities
• Find accepted and effective
solutions
15. The 4
E’s
• Education
• Environmental Modification
• Technological Engineering
• Legislation and Enforcement
16. • Research
• Advocacy
• inform legislation
• contribute to the development of state
policies and programmes
• submissions to new legislation
• make recommendations for legislation and
specifications on products designed to be used
by children.
• Education
• Programmes: Safe travel to school, home
safety, walk this way
17. Organisations promoting education
campaigns:
• Parrafin Safety Association of SA
• MRC- UNISA Crime Violence and Injury Lead Programme
• The Department of Transport and Emergency Services
20. Legislation
and
Enforcement
in SA
• Child-proof bottle tops
• Limitation on pH of detergents
• Toy sizing
• Secure battery compartments
• Package labelling requirements
• warning on packaging of
aspiration or swallowing risk.
• Dangerous product recall
21. Unresolved Challenges to Primary Prevention
• Ongoing household use of strong industrial-strength caustic agents
• Marketing, using brightly coloured packaging
22. References
• A. Gill, DrP Nancy R Kelly ‘Pediatric injury prevention: Epidemiology,
history, and application’ `UpToDate. June 2020
• M. Kibel, H. Saloojee, T Westwood ‘Child Health for All’ Fifth Edition
2012
• M Arnold,A B van As, A Numanoglu ‘Prevention of ingestion injuries in
children’ S Afr Med J 2017;107(3):183-187.
• T. Friedman ‘A Framework for Public Health Action: The Health Impact
Pyramid’ Am J Public Health. 2010 April; 100(4): 590–595.
Editor's Notes
children under- 5 have the highest risk of injury from ingested foreign bodies and caustic substances
with a peak incidence at 3 years of age
Curiosity, exploration of the developing oral phase,
the child’s inexperience and limited understanding of the environment
inadequate caregiver supervision
A burden to society: increased emergency room visits, long term consequences and morbidity, they are preventable
Coin ingestion alone has been reported in as many as 4% of children, with 15% of their parents seeking healthcare.
choking on age-inappropriate food items (typically hard sweets or large chunks of meat) or bones (especially fish bones, and accidental medication ingestion).
Caustic ingestion affects 5 - 518/100 000 people per year, largely in less industrialised nations.
Accidental ingestion of caustic agents continues to be a major concern for pediatric emergency department clinicians.
Caustic ingestions can cause severe acute injury and long-term complications, especially the development of esophageal strictures
Most ingestions by children are accidental and the amounts ingested tend to be small. The opposite is the case in adolescents and adults,
Caustic Ingestion: peri-oral inflammation, dysphagia, drooling, cough, stridor, hoarseness, vomiting or signs of peritonitis.
volatile agents (e.g. paraffin, hydrocarbons) cause respiratory distress, which may require temporary oxygen support.
Household cleaning agents: peroxide or chloride bleach: superficial redness and mild oedema
Foreign body perforation and/or obstruction of the gastrointestinal tract (GIT) typically occurs proximal to normal anatomical narrowing, i.e.
the cricopharynx, which is the narrowest part of the child’s upper GIT
the upper third of the oesophagus, where the left main bronchus and aortic arch cross anteriorly with the vertebral bodies posteriorly
(iii) the oesophagogastric junction (lower oesophageal sphincter)
(iv) the pylorus
(v) the duodenum at the ligament of Treitz
(vi) the ileocaecal valve.
The number of under-5 deaths, as well as under-5 mortality rates in SA, have declined in the past decade.
Under-5 mortality is estimated at 37 - 40 deaths per 1 000 live births for 2015
Neonatal mortality accounts for approximately one-third of all under-5 deaths.
UN and VR figures both suggest that, outside of the new-born period, pneumonia, diarrhoea and non-natural deaths are the leading causes of death.
Declines in the number of deaths and case fatality rates associated with diarrhoea, pneumonia and severe acute malnutrition have contributed substantially to the decline in under-5 mortality.
Mortality statistics are only the tip of the iceberg, viewed in isolation they do not reflect the full picture.
Although accurate data is not available, non-fatal injury also results in a huge short term cost, both human and financial and carries a significant risk of long term complications or permanent disability.
Complex interacting causes of injury
The Agent: Inflicts the Injury directly
Some agents are inherently dangerous whilst others become dangerous in specific situations
The Child
The Environment
Vulnerable to different injuries at different stages of their lives
Toddlers are inquisitive and active, lack physical coordination and cannot perceive danger
susceptible to ingestion injuries, poisoning, drowning and burns.
Infants: vulnerable to chocking as they instinctively feed objects into their mouth
Children <9years lack the physical and cognitive maturity to assess dangers in their environment, in particular traffic situation.
ADHD
The backdrop to injury patterns
Physical and Psychological
SES factors determine:
type and quality of hazards
the space available for safe play
the quality of adult supervision
the access to healthcare
Emotional stress within the family unit:
makes the child more vulnerable
distracts the caregiver from providing adequate supervision
Substance abuse is important in this regard
Social and cultural: many people have a fatalistic attitude to life and believe that injuries are beyond their control.
Education is more effective when targeted at specific groups,
may not show immediate benefits,
Can be on an individual basis or campaigns
Environmental modification especially to uplift low SES
Environmental modificatiom, engineering and legislation can bring about more immediate change
A model for conceptualizing the potential impact of paediatric injury prevention interventions is the Health Impact Pyramid. In this model, the lower tier interventions (at the base of the pyramid) have greater population impact and require less individual effort; the higher tier interventions have less population impact and require more individual effort:
●Tier 1 – Socioeconomic factors (e.g., poverty reduction, improved education)
●Tier 2 – Changing the environmental context to encourage healthy decisions (e.g., improved road and vehicle safety)
●Tier 3 – Long-lasting protective interventions (e.g., car seat loaner programs, smoke detector installation programs)
●Tier 4 – Clinical interventions (e.g., clinic-based car seat or bicycle helmet inspection for proper fit and use)
●Tier 5 – Counselling and education (e.g., counselling to wear seat belts, provision of patient education handouts, such as "The Injury Prevention Program" handouts from the American Academy of Paediatrics) (see 'Injury prevention resources' below)
Child-proof bottle tops
Limitation on pH of detergents
Restriction of toys marketed for children ≤3 years old to a minimum of 3 cm in diameter.
Secure battery compartments
Package labelling requirements
LABELS: regarding content of chemicals in household use, associated health risks with ingestion, and first-aid advice, including poison centre contact details
warning on packaging of any smaller object to prevent access by children <3 years because of aspiration or swallowing risk.
Dangerous product recall
Ongoing household use of strong industrial-strength caustic agents, often illegally sold or decanted and stored in nondescript containers or recycled cold-drink containers, is of great concern. Thirsty children may seek these out or be given these by unsuspecting older siblings, particularly in hot weather, with devastating consequences.
Marketing, using brightly coloured packaging, has brought new risks to the fore in the past few decades, e.g. automated dishwasher detergent pods, which have caused an upsurge in associated caustic oesophageal injuries in developed countries, although fortunately significant injury occurs in <5% of cases.