This document discusses a project aimed at integrating a multidisciplinary approach to studying Prader-Willi and Angelman syndromes in Romania. The project has 8 partners and general objectives including implementing new genetic/epigenetic analysis methods, collaborating with patient associations, and establishing international partnerships. Specific objectives are to develop a clinical evaluation algorithm to rapidly diagnose cases, identify genetic and environmental factors influencing imprinting, and create a national registry of clinical and genetic data on these rare diseases. The project aims to establish expertise centers and help approach rare diseases in Romania through collaboration between medical institutions.