This study investigated the prevalence of inducible clindamycin resistance (MLSBi) and constitutive resistance (MLSBc) and the presence of erm A and erm C genes among MLSBi Staphylococcus aureus isolates at a tertiary care hospital in India over 18 months. The study found that 10.8% of isolates showed MLSBi resistance and 11.6% showed MLSBc resistance. The erm A and erm C genes were detected in MLSBi isolates, conferring resistance to macrolides, lincosamides, and streptogramin B antibiotics. A high percentage of resistant isolates were found to be methicillin-resistant Staphylococcus aureus. The study concludes that