The document discusses prefixes, base words, and suffixes in words. It provides examples of how prefixes like "un-" and "mis-" can be added to the beginning of base words like "helpful" and "use" to form new words with changed meanings, like "unhelpful" and "misuse." Similarly, suffixes like "-ful" and "-less" can be added to the end of base words or words with prefixes to create new words. The document then lists some of the most common prefixes like "un-", "im-", "in-", and "re-" as well as common suffixes like "-ly", "-ty", "-er", and "-able".