This ppt is made by Mr. arkab khan pathan under guidance of Mrs. RAKHI GOAR. this ppt contain the detail and all the lecture notes of HEG.
THANK YOU.
Arkab khan
This ppt is made by Mr. arkab khan pathan under guidance of Mrs. RAKHI GOAR. this ppt contain the detail and all the lecture notes of HEG.
THANK YOU.
Arkab khan
Adult learning theory principles and practiceDianne Rees
Obtain an overview of adult learning theory (andragogy) and learn how Gagne's nine events of instruction can be modified with adult learning theory in mind. Some critiques of the theory are also presented.
complcations of third stage of labour, includes PPH, Inversion of uterus, retained placenta, placenta accreta, increta, percreta, amniotic fluid embolism
Obstetric emergency which can kill instantly !! - PPH presenting to ED, so what is the role of Emergency Dept ? The most basic presentation of Obstetric emergency and how to tackle it? Being an emergency physician, obstetrics is always challenging! Keep yourself updated with Obstetric emergency.
Abortions and Maternal Termination of Pregnancy pptMichael Kino
Abortion means spontaneous or induced expulsion of products of conception before the period of viability( 28 weeks).
In medical practice, the abortion occurs in 1st trimester, miscarriage in the 2nd trimester and premature labor in the 3rd trimester.
legally all the above terms are synonymous.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
1. Post Partum Hemorrhage (PPH)
class for undergradutes
Dr. Debraj Mondal
MBBS, MS, DNB, MRCOG (1)-UK
Asst. Professor, Dept. of OBGY
GIMSH, Durgapur, WB, India
2. Clinical Definition
Any bleeding from or into the
genital tract following birth of
the baby up to the end of
puerperium which adversely
affects the general condition of
the patient evidenced by rise in
pulse rate and falling blood pressure
is called “Post Partum Hemorrhage
(PPH)”.
3. End of puerperium
Previously it was considered as 6
wk.
Now it has extended up to 12 wk
following birth of the child.
4. Quantitative definition
Blood loss >500 ml following
vaginal birth of the baby
Or >1000 ml after CS (WHO).
ACOG: Either a 10% drop of
Hematocrit of need for Packed RBC
transfusion following birth of the
baby.
5. How much time do we have ?
It is estimated that, if untreated,
Death occurs on average in:
2 hours from Postpartum Hemorrhage
12 hours from Antepartum Hemorrhage
2 days from Obstructed Labor
6 days from Infection
6. Types
Primary PPH
Within 1st 24 hour of
delivery of baby. Two
types:
1. Third stage
bleeding: bleeding
during separation of
placenta.
2. True primary PPH:
After delivery of the
placenta.
Secondary PPH
Beyond first 24 hours
and upto 12 wk (or
some say 6 wk).
7. Causes of PPH
4 ‘T’s
Tonicity- Atonic PPH- most
common (75-90%).
Trauma- Traumatic PPH (10-20%)
Tissue- Retained tissues related
PPH (Placenta, membranes).
Thromboplastin- Coagulation
defect related PPH.
8. Atonic PPH- Risk Factors
1. Over distended uterus: Multiple
pregnancy, hydramnios.
2. Mismanaged third stage of labour.
3. Multi parity
4. Anemia & malnutrition
5. Prolonged labour, precipitate labour
6. APH
7. Abnormal Uterine anatomy- malformation,
fibroids.
8. Obesity
9. Drugs- Halothane, tocolytics
10. Prior history of atonic PPH.
9. Traumatic PPH
1. Laceration of the cervix, vagina,
perineum and peri-urethral tear-
mostly in instrumental delivery,
complicated vaginal delivery.
2. Ruptured uterus
3. Extension of the cesarean
section incision- Uterine artery tear.
4. Broad ligament hematoma.
5. Uterine inversion.
11. Prevention
1. Regular antenatal care
2. Correction of anemia & malnutrition
3. Identify at risk women and deliver them
in a hospital where emergency Obstetric
care (EmOC) facility available.
4. Emergency referral facility to a tertiary
care hospital should be available.
&
5. Routine AMTSL
12. Active Management of Third Stage of
Labour (AMTSL)
It is recommended by WHO that
AMTSL should be done in all cases.
Because:
1. It minimizes the blood loss
2. Cut short the third stage of labour.
13. WHO Recommendations for Active
Management of the Third Stage of Labour
(AMTSL), 2012
1. Check the uterus for presence of twin.
2. Uterotonic immediately after the
delivery of the baby in all births.
3. Delayed cord clamping.
4. Controlled Cord traction (CCT): is not
mandatory. Perform CCT, if required.
5. Postpartum vigilance for uterine
tonus.
14. Uterotonic immediately after the
delivery of the baby in all births
The use of uterotonics for the
prevention of postpartum haemorrhage
(PPH) during the third stage of labour is
recommended for all births.
Oxytocin (10 IU, IV/IM) is the
recommended uterotonic drug for the
prevention of PPH.
Other option is misoprostol.
Ensure a continuous supply of high-quality
Oxytocin by maintaining the cool chain.
15. Delayed cord clamping
Delay clamping the cord for at least
1-3 minutes to reduce rates of
infant anaemia.
The only indication for Early cord
clamping in modern day obstetrics:
Asphyxiated baby who needs
immediate neonatal resuscitation.
16. CCT: is not mandatory.
Perform CCT, if required
In settings where skilled birth
attendants (SBA) are available,
controlled cord traction (CCT) is
recommended for vaginal births
In settings where SBA are
unavailable, CCT is not
recommended.
CCT is the recommended method for
removal of the placenta in
caesarean section.
17. Postpartum vigilance for uterine
tonus
Immediately assess uterine tone to
ensure a contracted uterus; continue to
check every 15 minutes for 2 hours.
If there is uterine atony, perform fundal
massage and monitor more frequently.
But sustained uterine massage is not
recommended as an intervention to prevent
PPH in women who have received prophylactic
oxytocin
21. H= Help-ask for help
Whenever there is PPH the 1st thing
to do is to shout for help.
It is a team effort not a one man’s
job.
22. A= Asses (Vitals, Blood loss) &
resuscitate
Monitor Vitals:
Pulse,
BP,
Temp,
Respiration & oxygen saturation
Put the patient on multi-parameter
monitor.
23. Resuscitate
Make two intra-venous channel with
large bore cannula (18G) in both
hands.
IV fluids: Crystalloids (RL) and
colloids (to be given till the blood is
available).
Moist O2 @ 10-15 Lit/min.
Catheterize to monitor urine output.
24. E= Establish the etiology
Asses the uterus tone- Atonic?
Local examination to exclude
Trauma?
Examination of placenta &
membranes to exclude retained
bits?
Investigations: Complete
hemogram, Coagulation profile,
electrolytes, blood grouping.
25. Ensure availability of blood.
Immediately send blood for
grouping and cross-matching and
arrange for at least two units of
WHOLE BLOOD.
26. Oxytocics
Start oxytocin infusion: 10 units in
500 ml NS @ 15-30 drops/min.
Methergine (Methyle ergometrine):
0.2 mg may be given IV
27. Oxytocics
Drug Dosage Cant be given
Oxytocin
infusion
10 units in 500 ml NS @ 15-30
drops/min
If pt has heart
failure
Methergine
(Methyle
ergometrine)
0.2 mg may be given IV
Repeat after 15 min, Max 4
doses.
If pt has
hypertension
Carboprost
(PGF2α)
250 micro-gram IM
Repeat after 15 min, max 8
doses.
If pt has
asthma
Misoprostol Tablets 200 micro-gram
sublingual or Per-rectal. Usual
dose 600 micro-gram.
Nothing
significant
Tranexamic acid IV injections 500-1000 mg can
be repeated after 4 hr.
Nothing
significant
28. S= Shift to OT
While shifting the patient the
following things may be done:
Bimanual compression of the
uterus,
NASG: Non-pneumatic anti-shock
garments.
32. T= Trauma, Temponade
If any trauma is noted it should be
immediately repaired.
Temponade:
Bakri baloon
Sengstaken-Blakemore tube
Rusch balloon
Foley's catheter.
Or uterus can be packed with
Gauge.
43. I= Intervention radiology
Selective
uterine artery or
Internal iliac (Hypogastric) artery
embolization with the help of
angiographycally guided techniques.
45. S= Subtotal Hysterectomy
Last resort, if everything fails.
Sometimes total hysterectomy is
also done
Ovaries must be preserved at any
cost.
46. Golden Hour
The 1st hour of PPH is taken as the
golden hour, coz if management
started within 1st hour of onset of
PPH, then the patient has the best
chance of survival.
Chance of survival decrease sharply
after the 1st hour.
47. Rule of 30
1. SBP drops by 30mmHg
2. Heart rate falls by 30 bpm
3. Resp rate becomes >30/ min
4. Hematocrit/ Hb drops by 30%
5. Urine output becomes <30 ml/hr
It means that the pt has lost >30%
of her blood and is in moderate
shock.