The Philippine Trench is located east of the Philippine Islands and is over 10,000 meters deep, subjecting humans to pressures over 1,000 atmospheres. The three body systems most affected by the extreme pressure are the circulatory, respiratory, and digestive systems. The circulatory system experiences irregular blood flow and heart overload due to uneven pressure distribution. The respiratory system causes fatigue from resistance in breathing and pressure changes. Digestive issues like irregular peptic glands and taste/food changes result from muscle fatigue and stress. Special clothing and equipment like waterproof suits with leaded accessories and gas mixtures are needed to survive in these environments.