Please answer question 4b only 4- The image below (on Endomembrane Sys.docx

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Briefly describe how the following structures work together: (Letters: A, C, L, and O). A vesicle containing hydrolytic enzymes fuses with a lysosome, releasing the enzymes inside the lysosome. The lysosome then digests materials in the cell and transports them to the Golgi body for secretion outside the cell through transport vesicles that fuse with the cell membrane.

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Please answer question 4b only
4. The image below (on Endomembrane System) has been labeled. Refer to the key as you
answer the two questions ( 4 a and 4 b ) that follow. Key for Image > A. Vesicle B. Hydrolytic
enzymes C. Lysosome D. Transport vesicle E. Lipids F. Smooth ER G. Ribosome H. Nucleus I.
Rough ER J. Transport vesicle K. Proteins L. Golgi body M. Cytoplasm N. Secretory vesicle O.
Cell membrane Follow-up questions corresponding to image above. 4a. Briefly describe how the
following structures work together: (Letters: G, I, J, L, N, and O). 4b. Briefly describe how the
following structures work together: (Letters: A, C, L, and O).

Please answer all questions. Will upvote! Profitability ratios help in the analysis of the combined impact of liquidity ratios, asset management ratios, and debt management ratios on the operating performance of a firm. Your boss has asked you to calculate the profitability ratios of Randall and Arts Inc. and make comments on its second-year performance as compared with its first-year performance. The following shows Randall and Arts Inc.'s income statement for the last two years. The company had assets of $10 , 575 million in the first year and $16 , 916 million in the second year. Common equity was equal to $5 , 625 million in the first year, and the company distributed 100% of its earnings out as dividends during the first and the second years. In addition, the firm did not issue new stock during either year. Randall and Arts Inc. Income Statement For the Year Ending on December 31 (Millions of dollars) Calculate the profitability ratios of Randall and Arts Inc. in the following table. Convert all calculations to a percentage rounded to two decimal places. Decision makers and analysts look deeply into profitability ratios to identify trends in a company's profitability. Profitability ratios give insights into both the survivability of a company and the benefits that shareholders receive. Identify which of the following statements are true about profitability ratios. Check all that apply. A higher operating margin than the industry average indicates either lower operating costs, higher product pricing, or both. If a company's operating margin increases but its profit margin decreases, it could mean that the company paid more in interest or taxes. An increase in the return on assets ratio implies an increase in the assets a firm owns. If a company issues new common shares but its net income does not increase, return on common equity will increase. .

picture of artery and vein to label i need a plain diagram of arteries.docx

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Please answer all questions- 1) Adaptive immunity has five distinct a.docx

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Please answer all questions. 1) Adaptive immunity has five distinct attributes: a) ___ : Adaptive immune responses are precisely tailored reactions against specific attackers. b) : Cells of adaptive immunity activate only in response to specific pathogens. c) : Once induced, cells of adaptive immunity proliferate to form many generations of nearly identical cells called clones. d) : As a rule, adaptive immunity does not act against normal body cells. e) : An adaptive immune response has immunological memory and is able to generate faster and more effective responses in subsequent encounters with a particular pathogen or toxin. 2) These characteristics of adaptive immunity involve the activities of which are a type of leukocyte (white blood cell) that acts against specific pathogens. 3) Human lymphocytes of humans form in the where blood stem cells produce all types of blood cells. 4) There are two main types of lymphocytes, and a) arise and mature in the red bone marrow of adults. b) begin in the bone marrow but mature in the thymus. 5) Adaptive immunity consists of two basic types of responses, a) immune responses and often act against intracellular pathogens. b) immune responses and often act against extracellular pathogens and toxins 6) The long-term ability of descendants of B and T cells to mount adaptive immunological responses against specific pathogens is called immunological 7) An is a protein secreted by the descendant of a B cell that recognizes and strongly binds to the specific biochemical shape. ELEMENTS OF ADAPTIVE IMMUNITY 1) The is composed of lymphatic vessels, which conduct the flow of lymph, and lymphoid and that are directly involved in specific immunity. 2) The lymphoid organs include nodes, the , the the and (MALT). .

Photoreceptors respond to the removal of light by Group of answer choi.docx

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Please answer all questions- IMMUNIZATION Immunization or vaccination.docx

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Please answer all questions. IMMUNIZATION Immunization or vaccination - what's the difference? The terms 'vaccination' and 'immunization' don't mean the same thing. Immunity is a state of protection from a particular infectious disease. Immunization is the process of producing a state of immunity in a subject. Vaccine is a preparation of immunogenic material used to induce immunity against pathogenic organisms. Vaccination is the term for the process of inducing adaptive immunity. Brief History of Immunization 1. The Chinese adopted a policy of deliberately infecting young children with particles of ground smallpox scabs from children who had survived mild cases by a procedure, called 2. developed the modern practice of vaccination when he inoculated people with cowpox virus to protect them against smallpox Active Immunization 1. The basic principle behind vaccination is to stimulate a response and a memory response that primes the immune system for future exposure to a virulent pathogen. 2. Active immunization involves different vaccine types: a. also called modified live vaccines contain weakened microorganisms; and generally provide lifelong immunity b. vaccines consist of killed bacteria or viruses which include i. , which are produced with inactivated but whole microbes. ii. which are produced with antigenic fragments of microbes. iii. For these vaccines, which cannot replicate or retain residual virulence, multiple doses must be administered to achieve immunity iv. May contain , which are chemicals added to increase their ability to stimulate active immunity. c. vaccines are chemically or thermally modified toxins that stimulate immunity against toxins rather than cellular antigens d. vaccines combine antigens from several pathogens that are administered simultaneously. e. vaccines use recombinant gene technology to remove virulence genes from microbes to create attenuated vaccines, to produce large quantities of antigens for use in immunizations, or to alter cells, viruses, or plasmids by introducing genes for antigens into them. .

Place these phases of an audit in chronological order- A- Assess the r.docx

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Petty Cash Fund Petty Cash Fund Libby Company established a petty cas.docx

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Please answer all questions. b. The in which CD95L binds to CD95 on the target cell, triggering target cell apoptosis. T cells, which function in memory responses. 4. Cytotoxic T cells may also form Antibody Immune Responses Inducement of T-Dependent Antibody Immunity with Clonal Selection Activation of T-dependent antibody immunity requires the assistance of type 2 helper T (Th2) cells. 1. In antibody immunity, an APC's MHC II protein-epitope complex activates a helper T cell (Th cell) bearing a complementary 2. APCs present epitopes on MHC molecules and form an immunological synapse with Th using the complementary TCR. 3. CD 4 MHC interaction stabilizes the synapse, and the delivers a second signal. 4. ( IL 4 ) then induces the Th cell to become a type T cell (Th2). 5. The Th_cell interacts with cells displaying epitope on MHC II and releases . Since only B cells displaying the epitope the Th2 cell recognizes are activated, this process is called selection. 6. The activated B cell proliferates rapidly and the clones differentiate into either B cells or cells. 7. cells live for only a short time but secrete large amounts of antibodies, beginning with and class switching as they get older. 8. B cells migrate to lymphoid tissues to await a subsequent encounter with the same antigen. Types of Acquired Immunity Specific immunity is characterized either naturally or artificially acquired and as either active or passive. 1. When the body mounts a specific immune response against an infectious agent, the result is called _ immunity. 2. The passing of maternal IgG to the fetus and the transmission of secretory IgA in breastmilk to a baby are examples of immunity. 3. immunity is achieved by deliberately injecting someone with antigens in vaccines to provoke an active response, as in the process of immunization. 4. immunotherapy involves the administration of preformed antibodies in antitoxins or antisera to a patient. Immune Responses 1. The first adaptive response to a particular antigen is called the As a result of this initial encounter, the adaptive immune system "remembers" the mechanism that was effective against that specific antigen. 2. If the same antigen is encountered later in life, a stronger antigen-specific adaptive immune response occurs, called the response. .

Please answer all questions- T Lymphocytes (T Cells) 1) T lymphocytes.docx

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Please answer all questions. T Lymphocytes (T Cells) 1) T lymphocytes act against antigens, producing -mediated immune responses. 2) T cells have (TCRs), which have an antigen- binding site for a specific epitope. 3) T cells mature under the influence of signals from the , and they attack cells that harbor endogenous pathogens during -mediated immune responses. 4) In cell-mediated immunity, - also called CD8 positive (CD8+ cells) because they have membrane protein CD8-act against infected or abnormal body cells, including virus-infected cells, bacteria-infected cells, some fungus- or protozoan-infected cells, some cancer cells, and foreign cells that enter the body as a result of organ transplantation. 5) Two types of - Th1 and Th2 - are characterized by a membrane protein, CD4, so they are CD4+ and direct cell-mediated and antibody immune responses, respectively. B Lymphocytes (B Cells) and Antibodies 1. , which in the red bone marrow, make immunoglobulins (Ig) of two types(BCRs) and 2. Immunoglobulins are complementary to epitopes and consist of two identical shorter chains and two identical longer chains joined via bonds to form Y shaped molecules. 3. are inserted into the cytoplasmic membranes of B cells via transmembrane polypeptides. 4. The arms of each heavy and light chain vary in amino acid sequence, and thus each is called a region. 5. The two variable regions form -binding sites. 6. Exact binding between an antigen-binding site and an epitope accounts for the of an antibody immune response. 7. Because an antigen typically has numerous , many different BCRs will recognize any particular antigen's epitopes, but each BCR recognizes only epitope. 8. When an antigenic epitope stimulates a specific B cell, the B cell begins reproducing. a. The daughter B lymphocytes are now called cells, secrete and no longer display 9. Antibodies: a. similar to BCRs in shape but are portion of BCRs. b. Antibodies carry the same cell. for an epitope as the BCR of the activated B c. The arms, or antigen-binding sites. (fragment, antigen-binding), of the antibody contain the d. The antibody stem is called the (fragment, crystallizable). e. There are five basic types of stems, and these form the five classes of antibodies: , and .

Please answer all questions- 5- When the inflammatory mediators excee (1).docx

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Please answer all questions. 5. When the inflammatory mediators exceed the body's coping mechanisms, acute shock may occur, which requires immediate treatment with epinephrine. 6. Type I hypersensitivity can be diagnosed by and can be partially prevented by avoidance of and by 7. Some type I hypersensitivities are treated with IMMUNODEFICIENCY DISEASES 1. develop when the body cannot launch or sustain an immune response and may be classified as: a. immunodeficiency diseases, which result from mutations or developmental anomalies and occur in young children, are present from birth, resulting from a genetic defect or developmental abnormality. They are generally rare and may affect B cells, T cells, natural killer (NK) cells, phagocytes, or complement components. b. immunodeficiency diseases, occur after birth, perhaps due . The most significant example of an acquired immunodeficiency is (AIDS). c. People with either type of immunodeficiency tend to have repeated infections; the types of infections often depend on which part of the immune system is affected. .

Please answer all questions- 10- Antibody Function- The binding of an.docx

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Please answer all questions. 10. Antibody Function: The binding of antibody to epitope is the central functional feature of antibody adaptive immune responses. Once bound, they function in several ways. These include: a. : Stems of antibody molecules can bind and activate complement protein 1 (C1), triggering the complement cascade. IgE antibody stems attach to mast cells and eosinophils, causing them to release inflammatory chemicals. b. which antibodies achieve by binding to critical portions, or neutralization of bacteria or viruses, when bound antibodies block attachment molecules on their surfaces. c. : whereby antibodies act as opsonins to stimulate Phagocytes have receptors for antibody stems and can phagocytize them quickly. d. which is the clumping of antigen-bound antibody molecules, and which hinders the activity of pathogens and increases the chance that they will be e. (ADCC). Similar to opsonization, the stems of antibodies interact with , which then releases perforin and granzymes, which trigger in the targeted cell. Immune Response Cytokines 1. are soluble regulatory proteins that act as intercellular signals when released by certain body cells, including those of the kidney, skin, and immune system. 2. Cytokines of the immune system include: a. : which signal among leukocytes (primarily). b. : which are antiviral proteins that also act as cytokines. The most potent is gamma interferon (IFN-p). c. which stimulate leukocyte stem cells to divide. d. which is secreted by macrophages and T cells to kill tumor cells and to regulate immune responses and inflammation. e. which signal leukocytes to move to a site of inflammation or infection, or to move within tissues. Cell-Mediated Immune Responses The body uses cell-mediated immune responses to endogenous antigens to fight intracellular pathogens such as viruses that have invaded body cells, as well as abnormal body cells such as cancer cells. 1. Once activated by cells, T cells (Tc cells) recognize abnormal molecules presented by MHC class foreign cells. 2. Activated Tc cells reproduce to form protein on the surface of infected, cancerous, or expansion. 3. T cells destroy their target cells via two pathways: a. The pathway, which kills the affected cells by secreting perforins and granzymes .

Phosphatidate is an intermediate in the formation of- a) phospholipids.docx

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phage type of 42D- Which statement(s) are true- Check All That Apply T.docx

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phage type of 42D. Which statement(s) are true? Check All That Apply The man who is suing picked up a pathogenic S . aureus from another source, perhaps even from his own normal biota. The potato salad was the source of the outbreak for all of these people. Person number 4 who ate the original potato salad did not get ill from S . aureus in that potato salad. There is no way to determine who got infected with which S. aureus. Ceck Ar That Apour phinge typed, and this is abs eone with fecil samples trom 4 of the il peogle. The 4 it people hed no potaio saisd ien. A week ister anather person, cloiming to have boughr ine potano salsd and thrown it out aftes .

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Please update the registers at the end of the program execution- Also.docx

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Please see below H10 table released by the Fed- Rates in currency unit.docx

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Please see below H 10 table released by the Fed. Rates in currency units per U.S. dollar except as noted by an asterisk ("). Asterisk indicates U.S. dollars per currency unit. Foreign Exchange Rates - H.10 Weekly (Rates in currenev unitt per U.S. dollar exceot as noted] Using the data from the above table H 10 , calculate and state the value of the exchange rate yens per South Africa rand, EY/R on February 12. .

People are perceived as being more trustworthy when they- Select one-.docx

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Please make revision to the following program so it incorporates three.docx

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Please make revision to the following program so it incorporates three different functions (other than main) without changing much of the code itself. #include <iostream> #include <fstream> #include <string> using namespace std; int main(int argc, char *argv[]) { (void) argc; string filename = argv[1]; ifstream infile; infile.open(filename); if (!infile.is_open()) { cerr << "ERROR: Error opening file - "; cerr << "please check that you specified the correct file name "; exit(EXIT_FAILURE); } if (infile.eof()) { cerr << "ERROR: Letter file is not properly formatted. "; exit(EXIT_FAILURE); } // Read the contents of the file into a string string contents; char ch; while (infile >> ch) { contents += ch; } // Calculate the frequency distribution of letters in the text int letter_count[26]; int size_of_file = contents.size(); for (int i = 0; i < 26; i++) letter_count[i] = 0; int total_letters = 0; for (int i = 0; i < size_of_file; i++) { char letter = contents[i]; if (letter >= 'a' && letter <= 'z') { letter_count[letter - 'a']++; total_letters++; } else if (letter >= 'A' && letter <= 'Z') { letter_count[letter - 'A']++; total_letters++; } } // The expected frequency distribution of English letters double expected_count[26] = {0.0812, 0.0149, 0.0271, 0.0432, 0.1202, 0.0230, 0.0203, 0.0592, 0.0731, 0.0010, 0.0069, 0.0398, 0.0261, 0.0695, 0.0768, 0.0182, 0.0011, 0.0602, 0.0628, 0.0910, 0.0288, 0.0111, 0.0209, 0.0017, 0.0211, 0.0007}; // Calculate the sum of squared errors between observed and expected // frequencies double min_error = 1e9; int shift = 0; for (int s = 0; s < 26; s++) { double error = 0.0; for (int i = 0; i < 26; i++) { int observed_count = letter_count[(i + s) % 26]; double expected = total_letters * expected_count[i]; double diff = observed_count - expected; error += diff * diff / expected; } if (error < min_error) { min_error = error; shift = s; } } // Output the shift amount cout << "The shift amount is: " << shift << endl; // Close the input file infile.close(); return 0; } .

Please make sure the program is in Java 2- A double-ended queue is a g.docx

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Please make sure the program is in Java 2- A double-ended queue is a generalization of the queue in which elements can be added or deleted from both the front and rear ends. Write java classes to implement the double-ended queue ADT with at least the following operations: constructor, IsEmpty, IsFull, AddFront, AddRear, DeleteFront, DeleteRear, CheckFront, CheckRear, and Reverse. Write the main program to test it. (7.5 marks) .

Please help- Thank you I really appreciate your help A large hospital.docx

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Please help. Thank you I really appreciate your help A large hospital needs to update its training program so that new staff members are trained in the most efficient manner possible. Which activity should be included in the planning process for this initiative? Assess the scope of the change project Begin the process improvement method Sponsor an area-specific champion Determine the corrective action A pharmacy in a rural area wants to be open 24 hours a day Monday through Saturday to decrease wait time for receiving prescriptions. What would be the first step in this change? Expanding the waiting room area Conducting user surveys from the community Creating a new schedule for the pharmacy Hiring more staff for the additional hours An urgent care facility has determined that both a software and hardware upgrade is needed for the internal information system to meet regulatory compliance. Which activity should come next in this facility's planning process? Developing a baseline project schedule Documenting the impact of requested changes Assessing the current system Analyzing how data is currently being reported .

Please make sure you write the question before answering- Please draw.docx

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Please make sure you write the question before answering. Please draw the graphs and explain. Possible points: 6 Due date: 2/20/23 1. Draw and explain a supply curve for music downloads....(2) 2. Consider the following events: the scientists reveal that eating oranges decreases the risk of diabetes, at the same time, farmers use a new fertilizer that makes the orange trees produce more oranges. Explain the effects of these changes on equilibrium price and quantity of oranges. Explain and draw graphs. (Draw at least two graphs)... (4) .

Pedigree 4- Use A to represent the allele for the ability to taste PTC.docx

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PLEASE HELP PLEASE 12) The difference between vitamins and minerals i.docx

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PLEASE HELP PLEASE 12) The difference between vitamins and minerals is that vitamins are ___ while minerals are ____. A. Organic; inorganic B. Non-GMO; conventional C. Inorganic; organic 13) Stratified epithelia are most likely to be found in which of the following locations (select all that apply) Inside the mouth Gas exchange surface of lungs Collecting duct of kidney Inside the esophagus 16) Where in the mammalian kidney do you find sodium potassium pumps? Where in the mammalian kidney do you find sodium potassium pumps? Thin ascending limp in the loop of Henle Thick ascending limp in the loop of Henle Descending limp in the loop of Henle 19) How do humans ventilate their lungs? A. Negative pressure ventilation B. Positive pressure ventilation .

Please help me- Q1) True or False- Support and explain your answers i.docx

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Pedigree 1- An individual with albinism lacks an enzyme needed to form.docx

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Pedigree 1: An individual with albinism lacks an enzyme needed to form the skin pigment melanin. This condition is controlled by a recessive allele. Use DD to represent the allele for normal skin and dd to represent the genotype for albinism. Fill in the genotypes below each individual in the pedigree below. If individuals 1&2 in generation II were to have another child, what is the chance the next child will be normal? Pedigree 2: Hemophilia is a sex-linked genetic disease caused by recessive allele ( X 2 ) which doesn"t allow the blood to clot. Female hemophiliaes are homoxygous recestive, but carrier female have only one allele and their blood clots normally. List the genotypes of each individual in the pedigree below. If individual 2 in generation III were to marry a woman that was normal for blood clotting. what is the chance that their first child will be a hemophiliac? .

Please help me make a UML for Java! Look at the code below and make a.docx

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Please help me make a UML for Java! Look at the code below and make a UML for it. Die.Java public class Die { private int number_of_Sides; private int currentSide; public Die(int numSides) { this.number_of_Sides = number_of_Sides; roll(); } public int get_Num_Sides() { return number_of_Sides; } public int get_Current_Side() { return currentSide; } public void roll() { currentSide = (int) (Math.random() * number_of_Sides) + 1; } public String toString() { return "Die with " + number_of_Sides + " sides showing " + currentSide; } } DiceCollection.Java public class DiceCollection { private Die[] dice; public DiceCollection(int[] numSidesArray) { dice = new Die[numSidesArray.length]; for (int i = 0; i < numSidesArray.length; i++) { dice[i] = new Die(numSidesArray[i]); } } public int get_Current_Sum() { int sum = 0; for (Die die : dice) { sum += die.getCurrentSide(); } return sum; } public int get_Min_Possible_Sum() { int sum = 0; for (Die die : dice) { sum += 1; } return sum; } public int get_Max_Possible_Sum() { int sum = 0; for (Die die : dice) { sum += die.get_Num_Sides(); } return sum; } public void rollAll() { for (Die die : dice) { die.roll(); } } public String toString() { StringBuilder sb = new StringBuilder(); for (Die die : dice) { sb.append(die.toString() + "\n"); } sb.append("Minimum possible roll: " + getMinPossibleSum() + "\n"); sb.append("Maximum possible roll: " + getMaxPossibleSum() + "\n"); sb.append("Current total showing on the dice: " + getCurrentSum()); return sb.toString(); } public int[] histogram(int numRolls) { int[] counters = new int[getMaxPossibleSum() - getMinPossibleSum() + 1]; for (int i = 0; i < numRolls; i++) { rollAll(); int sum = getCurrentSum(); counters[sum - getMinPossibleSum()]++; } return counters; } } Main.java public class Main { public static void main(String[] args) { Scanner scanner = new Scanner(System.in); System.out.print("Enter the no. of dice: "); int numDice = scanner.nextInt(); int[] sides = new int[numDice]; for (int i = 0; i < numDice; i++) { System.out.print("Enter the number of sides for die " + (i + 1) + ": "); sides[i] = scanner.nextInt(); } DiceCollection diceCollection = new DiceCollection(sides); System.out.println(diceCollection); while (true) { System.out.println("\nSelect an option:"); System.out.println("1. Roll once"); System.out.println("2. Roll 100,000 times"); System.out.println("3. Quit"); int choice = scanner.nextInt(); switch (choice) { case 1: diceCollection.roll(); System.out.println(diceCollection); break; case 2: System.out.print("Enter the number of rolls: "); int numRolls = scanner.nextInt(); int[] histogram = diceCollection.histogram(numRolls); System.out.println("Histogram of " + numRolls + " rolls:"); for (int i = 0; i < histogram.length; i++) { if (histogram[i] != 0) { System.out.println(i + ": " + histogram[i]); } } break; case 3: System.exit(0); default: System.out.println("Invalid option"); } } } } Please PUT your UML. Thank you!! .

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