The Pipeliner Manifesto outlines the company's mission to prioritize people by providing a CRM solution that empowers individuals and enhances their experience. It emphasizes the creation of 1 million new sales jobs globally by 2020 and introduces the concept of the 'salespreneur' who is self-responsible and adaptable to a buyer-driven market. The manifesto advocates for a new network selling approach that promotes economic freedom and wealth through trade.