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EXPERIMENT 6
PHYSIOLOGY OF THE SKIN
PROCEDURE
RESULTS
Table 1. Skin color determination
Group No.

Skin color before
compression

Skin color in
compressed area

1

Pinkish

Pale pink, white,
blue

2

Pinkish

White

3

Pinkish

White, pale pink
DISCUSSION
PINK

Normal
blood
circulation

WHITE

Disruption of
blood flow

BLUE

Lack of
oxygen
APPLICATIONS
Healthy skin
o Pinkish skin
o slightly flushed with blood and
full of oxygen
o suggests a strong heart and lungs
o
o

JAUNDICE

o
o

skin yellowing
caused by the build up of
bilirubin due to malfunction of
the liver
eating too many carrots
“carotenemia”
tanning pills “canthaxanthin”
o

HYPOCHROMIC
ANEMIA

greenish skin or pallor

o

hemoglobin levels are
too low leading to undersized red blood cells
o

ARGYRIA &
CYANOSIS

Paul Karason consumed
colloidal silver to treat a bad
case of dermatitis on his face

o

and turned blue
Caused by inadequate
amount of oxygen in the
blood
APPLICATIONS
predicts your
future from the
fate lines in the
palm and tell
about your health
and character
from the palm
colour

PALMISTRY
YELLOW

PINK

o selfishness
in your
character
o short
temper

RED
o aggressive

BLUE
o sluggish

o cheerful
o optimistic
ATTRACTIVENESS
o women rated male faces
with a greater amount of
golden color in their skin
as more attractive
SYMPTOM OF
HORMONAL
IMBALANCE
o Addison’s disease is caused by
low cortisol and aldosterone
o Bronzing (hyperpigmentation)
o Cushing syndrome caused by
exposure to high levels of
cortisol
o Purple marks (striae) and
bruised skin
PLOTTING THE DISTRIBUTION OF SWEAT GLANDS
ECCRINE SWEAT GLAND
APOCRINE SWEAT GLAND
o produce sweat that is mostly salt,
o secrete urea,
electrolytes and water (e.g. a thick sweat packed with
uric acid, ammonia,fatty acids and proteins
amino acids,
o
glucose, lactic acid)located deep into the skin and opens
to protect the
o cools the body & help hair
skin from bacteriao larger than eccrine
and pathogens
o causes body odor
o no body odor
o secreted starting
o do not extend as deep into the skin from puberty
and they excrete through pores
o smaller than apocrine
PLOTTING THE DISTRIBUTION OF SWEAT GLANDS
Eccrine sweat glands
Apocrine sweat glands
o Distributed over the
Occur mainly in arm
entire body of nipples
pits, areola except lip
margins, nail beds,
& perineum
o nipples, inner surface
Also found in ear and
of prepuce, labia
eyelid
minora, glans penis
& glans clitoris
o Heavily concentrated
on soles, palms,
armpits, forehead &
cheeks
o Low in trunk and
extremeties
o Sweating occurs in
response to external heat
stimuli which alters skin
temperature
o Cools the skin through
evaporative cooling
which makes use of the
high latent heat of
vaporization of water

Thermoregulation
PROCEDURE

Sweat Gland Mapping
RESULTS
SWEAT GLAND MAPPING
Group 1

ARM

PALM

Group 2
Group 3

ARM

PALM
DISCUSSION
Amylopectin + Amylose
Iodine trapped in amylose
DISCUSSION
• According to Henry Gray's
estimates, the palm has
around 370 sweat glands per
cm2 while forearm have 155
per cm
• Palms contain eccrine
glands since it does not have
hairs and needs to cool more
• Eccrine glands are smaller
than apocrine glands of the
arm so more glands can fit
into the palm
APPLICATIONS
o over-active thyroid causes
an increase in your
metabolic rate
o burn more calories (weight
loss) and sweat more as
your body temperature
increases.

HYPERHIDROSIS &
HYPERTHYROIDISM
EXPERIMENT 7
PHYSIOLOGY OF THE SKELETAL SYSTEM
o bones support the
body
o protect vital
organs
o allow movement
o store minerals
o produce red blood
cells

FUNCTION

• ..FUNCTION
Canaliculi

Osteon

Osteocytes in lacunae
Volkmann’s canal

Lamellae

Haversian canal

TYPES OF OSSEOUS TISSUES

Osteon:
SPONGY BONE
Lamellaeo functionaltubes of
concentric unit
is bone spicule
bone matrix
called trabeculae
o less dense canalHaversian
o site of metabolic
passageway for
activity e.g.
exchange of
blood vessels and
calcium ions
nerves
Volkmann’s
canals- connect the
blood and nerve
COMPACT BONE
o functionalthe is
supply of unit
the osteon or
periosteum to
Haversian systems
o matrix is solidly filled
Haversian canal
with organic ground
substance and
Canaliculi- hairinorganic salts
like channels
connecting
osteocytes and
central canal
BONE CELLS

o Osteoclastslarge cells that
dissolve the
bone
o Osteoblastscells that form
new bones
o Osteocytesmature
osteoblasts
found in lacunae
o Osteoid- new
bone made up of
collagen and
ground
substance
BONE REMODELLING
EFFECT OF MECHANICAL STRESS
TO BONE STRENGTH
PROCEDURE
Removal of
inorganic
components
o Fresh chicken
leg was soaked
in 10% nitric
acid overnight
o Gently apply
pressure

Skin color
ACID DECALCIFICATION
Migrates

Calcium in
bone

Acid solution

“Ionic exchange”
RESULTS
o make up 65% of bone
by mass
o Hydroxyapatite(Ca10(PO4)6(OH)2 )
a mineral salt giving
the bone compressive
strength and hardness
o Osteocalcium
phosphate (brushite)

soft rubbery
consiste
nt
BRITTLEness
HARDness

Removal of INORGANIC
DISCUSSION
COMPONENTS
PROCEDURE
Removal of Organic
Components
RESULTS
OXIDATION OF ORGANIC
COMPONENTS OF BONE

Collagen
Oxygen

Carbon
dioxide

Water
o BONE CELLS
(osteoblasts,
osteocytes, and
osteoclasts)
o OSTEOID
(ground substance
and collagen
fibers)

RESILIENC
E FLEXIBILI
TY
BRITTLE
HARD

• collagen
• 90% of organic component
• primarily type I collagen
• provides tensile strength
• proteoglycans
• responsible for compressive strength
• inhibit mineralization
• matrix proteins
• includes noncollagenous proteins
• function to promote mineralization and bone
formation
1. Osteocalcin
2. Osteonectin
3. Osteopontin
4. Cytokine and growth factors

DISCUSSION
ORGANIC COMPONENTS
APPLICATIONS
OSTEOMALACIA AND
RICKETS

o softening of the bones due to a
lack of vitamin D or a problem
with the body's ability to break
down and use this vitamin
o Rickets is osteomalacia in
growing bones of children
Ehlers-Danlos
syndrome

o result of abnormal genes that
produce abnormal proteins that
confer an inherited frailty of
collagen
o typical features are stretchy
skin, loose joints and
fragile body tissues
Stephen ID et al (2009). Facial skin coloration affects perceived health of human
faces. International Journal of Primatology DOI 10.1007/s10764009-9380-z.
Shanghai Daily March 31, 2009) <http://www.china.org.cn/health/200903/31/content_17530186_2.htm>
Rachael Rettner (2012) A Man's Golden Skin Puts a Gleam in a Woman's Eye.
Retrieved from < http://www.livescience.com/36145-skin-tone-healthattractiveness.html>
Susan T. McClure (2010) About Addison's Disease and Skin Pigment. Retrieved
from <http://www.livestrong.com/article/162213-about-addisonsdisease-and-skin-pigment/#ixzz2mm2B6ET3>
Kevin Berman (2011) Hyperhidrosis. Retrieved from
<http://www.nlm.nih.gov/medlineplus/ency/article/007259.htm>
Tracy Jones (2013) Bone Matrix. Retrieved from
<http://www.orthobullets.com/basic-science/9003/bone-matrix>

REFERENCES
Cleveland clinic (2010) Osteomalacia. Retrieved from
<http://classes.midlandstech.edu/carterp/Courses/bio210/chap06/lectur
e1.html>
Shiel, William Jr. (2013) Ehlers-Danlos Syndrome. Retrieved from
<http://www.medicinenet.com/ehlers-danlos_syndrome/article.htm>
Akpan, Nsikan (2013) A Half-Red Baby And 3 Other Ways Biology Can Change
Skin Color. Retrieved from http://www.medicaldaily.com/half-red-baby-and-3other-ways-biology-can-change-skin-color-graphic-photos-247995

REFERENCES

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Physiology of Skin and Skeletal system

  • 3. RESULTS Table 1. Skin color determination Group No. Skin color before compression Skin color in compressed area 1 Pinkish Pale pink, white, blue 2 Pinkish White 3 Pinkish White, pale pink
  • 5. APPLICATIONS Healthy skin o Pinkish skin o slightly flushed with blood and full of oxygen o suggests a strong heart and lungs
  • 6. o o JAUNDICE o o skin yellowing caused by the build up of bilirubin due to malfunction of the liver eating too many carrots “carotenemia” tanning pills “canthaxanthin”
  • 7. o HYPOCHROMIC ANEMIA greenish skin or pallor o hemoglobin levels are too low leading to undersized red blood cells
  • 8. o ARGYRIA & CYANOSIS Paul Karason consumed colloidal silver to treat a bad case of dermatitis on his face o and turned blue Caused by inadequate amount of oxygen in the blood
  • 10. predicts your future from the fate lines in the palm and tell about your health and character from the palm colour PALMISTRY
  • 11. YELLOW PINK o selfishness in your character o short temper RED o aggressive BLUE o sluggish o cheerful o optimistic
  • 12. ATTRACTIVENESS o women rated male faces with a greater amount of golden color in their skin as more attractive
  • 13. SYMPTOM OF HORMONAL IMBALANCE o Addison’s disease is caused by low cortisol and aldosterone o Bronzing (hyperpigmentation) o Cushing syndrome caused by exposure to high levels of cortisol o Purple marks (striae) and bruised skin
  • 14. PLOTTING THE DISTRIBUTION OF SWEAT GLANDS ECCRINE SWEAT GLAND APOCRINE SWEAT GLAND o produce sweat that is mostly salt, o secrete urea, electrolytes and water (e.g. a thick sweat packed with uric acid, ammonia,fatty acids and proteins amino acids, o glucose, lactic acid)located deep into the skin and opens to protect the o cools the body & help hair skin from bacteriao larger than eccrine and pathogens o causes body odor o no body odor o secreted starting o do not extend as deep into the skin from puberty and they excrete through pores o smaller than apocrine
  • 15. PLOTTING THE DISTRIBUTION OF SWEAT GLANDS Eccrine sweat glands Apocrine sweat glands o Distributed over the Occur mainly in arm entire body of nipples pits, areola except lip margins, nail beds, & perineum o nipples, inner surface Also found in ear and of prepuce, labia eyelid minora, glans penis & glans clitoris o Heavily concentrated on soles, palms, armpits, forehead & cheeks o Low in trunk and extremeties
  • 16. o Sweating occurs in response to external heat stimuli which alters skin temperature o Cools the skin through evaporative cooling which makes use of the high latent heat of vaporization of water Thermoregulation
  • 22. DISCUSSION • According to Henry Gray's estimates, the palm has around 370 sweat glands per cm2 while forearm have 155 per cm • Palms contain eccrine glands since it does not have hairs and needs to cool more • Eccrine glands are smaller than apocrine glands of the arm so more glands can fit into the palm
  • 24. o over-active thyroid causes an increase in your metabolic rate o burn more calories (weight loss) and sweat more as your body temperature increases. HYPERHIDROSIS & HYPERTHYROIDISM
  • 25. EXPERIMENT 7 PHYSIOLOGY OF THE SKELETAL SYSTEM
  • 26. o bones support the body o protect vital organs o allow movement o store minerals o produce red blood cells FUNCTION • ..FUNCTION
  • 27. Canaliculi Osteon Osteocytes in lacunae Volkmann’s canal Lamellae Haversian canal TYPES OF OSSEOUS TISSUES Osteon: SPONGY BONE Lamellaeo functionaltubes of concentric unit is bone spicule bone matrix called trabeculae o less dense canalHaversian o site of metabolic passageway for activity e.g. exchange of blood vessels and calcium ions nerves Volkmann’s canals- connect the blood and nerve COMPACT BONE o functionalthe is supply of unit the osteon or periosteum to Haversian systems o matrix is solidly filled Haversian canal with organic ground substance and Canaliculi- hairinorganic salts like channels connecting osteocytes and central canal
  • 28. BONE CELLS o Osteoclastslarge cells that dissolve the bone o Osteoblastscells that form new bones o Osteocytesmature osteoblasts found in lacunae o Osteoid- new bone made up of collagen and ground substance
  • 30. EFFECT OF MECHANICAL STRESS TO BONE STRENGTH
  • 31. PROCEDURE Removal of inorganic components o Fresh chicken leg was soaked in 10% nitric acid overnight o Gently apply pressure Skin color
  • 32. ACID DECALCIFICATION Migrates Calcium in bone Acid solution “Ionic exchange”
  • 34. o make up 65% of bone by mass o Hydroxyapatite(Ca10(PO4)6(OH)2 ) a mineral salt giving the bone compressive strength and hardness o Osteocalcium phosphate (brushite) soft rubbery consiste nt BRITTLEness HARDness Removal of INORGANIC DISCUSSION COMPONENTS
  • 37. OXIDATION OF ORGANIC COMPONENTS OF BONE Collagen Oxygen Carbon dioxide Water
  • 38. o BONE CELLS (osteoblasts, osteocytes, and osteoclasts) o OSTEOID (ground substance and collagen fibers) RESILIENC E FLEXIBILI TY BRITTLE HARD • collagen • 90% of organic component • primarily type I collagen • provides tensile strength • proteoglycans • responsible for compressive strength • inhibit mineralization • matrix proteins • includes noncollagenous proteins • function to promote mineralization and bone formation 1. Osteocalcin 2. Osteonectin 3. Osteopontin 4. Cytokine and growth factors DISCUSSION ORGANIC COMPONENTS
  • 40. OSTEOMALACIA AND RICKETS o softening of the bones due to a lack of vitamin D or a problem with the body's ability to break down and use this vitamin o Rickets is osteomalacia in growing bones of children
  • 41. Ehlers-Danlos syndrome o result of abnormal genes that produce abnormal proteins that confer an inherited frailty of collagen o typical features are stretchy skin, loose joints and fragile body tissues
  • 42. Stephen ID et al (2009). Facial skin coloration affects perceived health of human faces. International Journal of Primatology DOI 10.1007/s10764009-9380-z. Shanghai Daily March 31, 2009) <http://www.china.org.cn/health/200903/31/content_17530186_2.htm> Rachael Rettner (2012) A Man's Golden Skin Puts a Gleam in a Woman's Eye. Retrieved from < http://www.livescience.com/36145-skin-tone-healthattractiveness.html> Susan T. McClure (2010) About Addison's Disease and Skin Pigment. Retrieved from <http://www.livestrong.com/article/162213-about-addisonsdisease-and-skin-pigment/#ixzz2mm2B6ET3> Kevin Berman (2011) Hyperhidrosis. Retrieved from <http://www.nlm.nih.gov/medlineplus/ency/article/007259.htm> Tracy Jones (2013) Bone Matrix. Retrieved from <http://www.orthobullets.com/basic-science/9003/bone-matrix> REFERENCES
  • 43. Cleveland clinic (2010) Osteomalacia. Retrieved from <http://classes.midlandstech.edu/carterp/Courses/bio210/chap06/lectur e1.html> Shiel, William Jr. (2013) Ehlers-Danlos Syndrome. Retrieved from <http://www.medicinenet.com/ehlers-danlos_syndrome/article.htm> Akpan, Nsikan (2013) A Half-Red Baby And 3 Other Ways Biology Can Change Skin Color. Retrieved from http://www.medicaldaily.com/half-red-baby-and-3other-ways-biology-can-change-skin-color-graphic-photos-247995 REFERENCES

Editor's Notes

  1. 1. Press the watch glass firmly against the plate for a few seconds2. Observe and record the color of the skin in the compressed area
  2. data
  3. Blue- if the pressure is continued for an extended period in this area
  4. The color of the palm, says Ma, reveals the general health condition, just like qise of the face. It reflects blood circulation. 
  5. Other abnormal variations in skin color Bilirubin is a yellow chemical in hemoglobin, the substance that carries oxygen in your red blood cells. As red blood cells break down, your body builds new cells to replace them. The old ones are processed by the liver. If the liver cannot handle the blood cells as they break down, bilirubin builds up in the body and your skin may look yellow.Carrots packed with a compound called carotene, which belongs to family of orange pigments called carotenoids. Our cells need carotene to make vitamin A, which is important for eye and skin health. Regular levels of carotene are easily excreted by the body by sweating or urinating, but too much consumption can lead to &apos;carotenaemia&apos; — orange skin — as the compound accumulates. The condition is typically harmless and dissipates after a few months.Tanning pills, which the Mayo Clinic and FDA deem as unsafe, contain canthaxanthin, which is a carotenoid that sometimes turns skin orange.
  6. PictureCyanosis
  7. Consuming chemical compounds with silver can turn a person blue, which is known as argyria, The most famous case of argyria arguably belongs to Paul Karason, who believed that drinking silver in his water on a daily basis could cure his skin dermatitis, even though FDA says otherwise.Blue skin can also be caused by genetic blood disorder called methemoglobinemia. People with the disease produce large amounts of methemoglobin, a type of hemoglobin, which is the protein that blood cells use to carry oxygen. Methemoglobin struggles to release the oxygen, leading to the change to smurf-dom.
  8. Yellow-less blood in your body Pink- liveliness and good healthBlue- blood movement is slow in the body
  9. Distribution of sweat glandsEccrine sweat glands develop in utero (during foetal development) and are distributed over the entire body, with the exception of the lip margins, nail beds, nipples, the inner surface of the prepuce (foreskiheavily concentrated include:Soles of the feet: 620 ± 20 per cm2;Palms of the hands: 300 ± 80 per cm2;Armpits: 360 ± 60 per cm2;Forehead: 360 ± 60 per cm2; andCheeks: 300 ± 80 per cm2.Sites which have a low concentration of eccrine glands include:Trunk: 65 ± 20 per cm2; andExtremities (arms and legs): 120 ± 30 per cm2.n), labia minora(outer folds of skin of the vulva/vagina), glans penis (head of the penis) and glans clitoris.Apocrine glands occur mainly in the arm pit, the areola of the nipples, and the perineum (region separating the anus from the genitals). They can also be found in the ear and eyelid. 
  10. Sweating is primarily a thermoregulatory response to control the body temperature. Normal thermoregulatory sweating occurs in response to external heat stimuli which alters skin temperature. However, it is thought to be primarily controlled by the body&apos;s internal temperature and particularly the temperature of the centralbrain. Thermoregulatory sweating is regulated by signals from thehypothalamus (a structure in the brain), and occurs diurnally (in the day) and nocturnally (at night).
  11. With paperPainted a region in the palm and another region in the forearm with iodine solution and allowed to dry thoroughlyPlaced 2 squares of bondpaper (1 cmx 1 cm) to the painted regions and tape it securelyand leave for 20 minutesAfter 20 minutes, removed the paper squares and count the number of blue-black dots on the square
  12. Estimated based on the intensity of the color to determine with part has the more concentration of sweat glands
  13. Generally based on the results, sweat glands are more concentrated on the palms
  14. Our palms often heat up when we are nervous or anxious, but if this is happening to you on a regular basis, your thyroid could be to blame. An over-active thyroid causes an increase in your metabolic rate. This means you burn more calories and sweat more as your body temperature increases. You may also experience unexplained weight loss, a constant feeling of nervous energy and a swelling of the thyroid gland in the throat. An overactive thyroid can be treated with medication
  15. Pic background
  16. Due to their function, it is necessary that the skeletal system is strong but flexible.
  17. How mechanical stress affects strength? Dietary factors?
  18. Procedure
  19. Acidreleases calcium from its chemical combinations with phosphates and carbonates in bone through ionic exchange
  20. Soft and bendable without breaking
  21. Structure of hydroxyapatite and osteocalcium
  22. Burn the bone completely using the alcohol lamp
  23. Application of pressure made the bones easily break into pieces
  24. What we accessed in the first experiment is the importance of the organic components of the bone and the function of the remaining organic material