This document summarizes an experiment on the physiology of the skin. It describes procedures where a person's skin color was observed before and after compression. The results showed skin colors of pink, pale pink, white and blue. The discussion explains that pink indicates normal blood circulation, white is a disruption of blood flow, and blue is a lack of oxygen. The document discusses several applications of skin color including health indicators, medical conditions that impact skin color, and mapping the distribution of sweat glands.
1. The document outlines different types of glands found in the skin, including simple and compound tubular and saccular glands.
2. Examples of simple tubular glands given are sweat glands and ceruminous glands, while mammary glands are identified as compound tubular glands.
3. The skin of mammals is described as the most complex, with two main layers - the epidermis and dermis, along with associated structures like hair, claws/nails, and glands.
D anatomy and physiology of the hair and skinErica P
The document discusses the anatomy and physiology of the hair and skin, including the three main layers of the skin - epidermis, dermis, and subcutis. It describes the structure and functions of hair follicles, sebaceous glands, sweat glands, and melanocytes. Additionally, it outlines the three stages of hair growth - anagen, catagen, and telogen - and lists the major functions of the skin like protection, temperature regulation, secretion, and absorption.
This document provides an overview of burn injuries, including the assessment and management of thermal burns. It discusses the pathophysiology and stages of thermal burns. Assessment involves determining the extent and depth of the burn using methods like the Rule of Nines. Management of minor burns includes local cooling, but moderate to severe burns require sterile dressings and consideration of fluid resuscitation using formulas like the Parkland formula to prevent shock. Complications like infection and organ failure are also addressed.
The skin has three main layers - the epidermis, dermis, and subcutaneous layer. The epidermis is made of epithelial tissue in 5 layers (stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, stratum corneum) and contains four main cell types. The dermis is made of connective tissue and contains hair follicles, sebaceous glands, sweat glands, and nerves. The skin provides protection from external factors, regulates body temperature, and serves important sensory functions.
The document describes the three main layers of the skin:
1. The dermis is the true skin and consists of two layers - the papillary layer containing blood vessels and nerve endings, and the reticular layer made of collagen, elastin and reticulin tissues.
2. Below the dermis is the subcutaneous tissue, a fatty layer that stores energy and protects underlying structures.
3. The deepest layer is the subcutaneous layer, which provides insulation and warmth for the body.
The skin is the largest organ of the body and has three main layers - the epidermis, dermis, and subcutaneous tissue. The epidermis is made of stratified squamous epithelium and contains keratinocytes, melanocytes, Langerhans cells, and Merkel cells. The dermis lies below the epidermis and contains collagen, elastic fibers, hair follicles, sweat and sebaceous glands. The skin acts as a protective, sensory, synthetic and temperature regulating organ.
The skin is composed of three layers: the epidermis, dermis, and hypodermis. The epidermis is the outermost layer and consists of four sublayers including the stratum corneum. The dermis lies below the epidermis and consists of collagen, elastic, and reticular fibers that modify the structure and function of the epidermis. The hypodermis is the deepest layer and consists of connective tissue, elastic fibers, and fat that act as an energy reserve, insulator, and determine body contour. The skin has important functions such as protection, thermoregulation, and vitamin D synthesis.
1. The document outlines different types of glands found in the skin, including simple and compound tubular and saccular glands.
2. Examples of simple tubular glands given are sweat glands and ceruminous glands, while mammary glands are identified as compound tubular glands.
3. The skin of mammals is described as the most complex, with two main layers - the epidermis and dermis, along with associated structures like hair, claws/nails, and glands.
D anatomy and physiology of the hair and skinErica P
The document discusses the anatomy and physiology of the hair and skin, including the three main layers of the skin - epidermis, dermis, and subcutis. It describes the structure and functions of hair follicles, sebaceous glands, sweat glands, and melanocytes. Additionally, it outlines the three stages of hair growth - anagen, catagen, and telogen - and lists the major functions of the skin like protection, temperature regulation, secretion, and absorption.
This document provides an overview of burn injuries, including the assessment and management of thermal burns. It discusses the pathophysiology and stages of thermal burns. Assessment involves determining the extent and depth of the burn using methods like the Rule of Nines. Management of minor burns includes local cooling, but moderate to severe burns require sterile dressings and consideration of fluid resuscitation using formulas like the Parkland formula to prevent shock. Complications like infection and organ failure are also addressed.
The skin has three main layers - the epidermis, dermis, and subcutaneous layer. The epidermis is made of epithelial tissue in 5 layers (stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, stratum corneum) and contains four main cell types. The dermis is made of connective tissue and contains hair follicles, sebaceous glands, sweat glands, and nerves. The skin provides protection from external factors, regulates body temperature, and serves important sensory functions.
The document describes the three main layers of the skin:
1. The dermis is the true skin and consists of two layers - the papillary layer containing blood vessels and nerve endings, and the reticular layer made of collagen, elastin and reticulin tissues.
2. Below the dermis is the subcutaneous tissue, a fatty layer that stores energy and protects underlying structures.
3. The deepest layer is the subcutaneous layer, which provides insulation and warmth for the body.
The skin is the largest organ of the body and has three main layers - the epidermis, dermis, and subcutaneous tissue. The epidermis is made of stratified squamous epithelium and contains keratinocytes, melanocytes, Langerhans cells, and Merkel cells. The dermis lies below the epidermis and contains collagen, elastic fibers, hair follicles, sweat and sebaceous glands. The skin acts as a protective, sensory, synthetic and temperature regulating organ.
The skin is composed of three layers: the epidermis, dermis, and hypodermis. The epidermis is the outermost layer and consists of four sublayers including the stratum corneum. The dermis lies below the epidermis and consists of collagen, elastic, and reticular fibers that modify the structure and function of the epidermis. The hypodermis is the deepest layer and consists of connective tissue, elastic fibers, and fat that act as an energy reserve, insulator, and determine body contour. The skin has important functions such as protection, thermoregulation, and vitamin D synthesis.
This presentation gives a brief about the Enagic's Kangen Water Devices and the science behind the Kangen Water. More details about Kangen Water Ionizers & Kangen Water Ionizer Doorstep demonstration call: +917675951155
The document discusses clinical diagnosis of dehydration and electrolyte disorders. It covers:
- Types of dehydration including water loss and salt/water loss dehydration.
- Symptoms and signs of dehydration seen on physical exam including decreased skin turgor and dry mucous membranes.
- Laboratory tests that can help diagnose dehydration including hematocrit, BUN, and urine specific gravity.
- Electrolyte disorders involving sodium, potassium, calcium, magnesium, and chloride are described. Imbalances of these electrolytes can cause neurological or muscular symptoms. Laboratory tests are important to diagnose electrolyte levels.
The document discusses the importance of drinking ionized, alkaline water for health and disease prevention. It states that most beverages are acidic and can lead to acidosis, which is linked to many diseases. The solution proposed is drinking alkaline Tyent Water, which has benefits like powerful antioxidants, increased hydration, and an alkaline pH that supports optimal health. The document advertises the Tyent Water ionizer and its ability to produce ionized, alkaline water with purported health benefits.
C:\documents and settings\administrator\桌面\11 fluid therapySumit Prajapati
This document discusses fluid therapy for acute diarrhea and dehydration in children. It describes the assessment of dehydration severity based on clinical signs. For mild to moderate dehydration, oral rehydration solution (ORS) is recommended. For severe dehydration, intravenous fluids are needed. The document provides formulas for ORS and intravenous fluids and guidelines for calculating fluid volumes based on the degree of dehydration.
The document discusses fluid therapy for acute diarrhea and dehydration in children. It covers the pathophysiology of dehydration, clinical signs, diagnosis, electrolyte disturbances, and treatment approaches including oral rehydration solutions and intravenous fluid therapy. Treatment involves correcting water and electrolyte deficits in a stepwise manner, first expanding blood volume and then replenishing and maintaining fluids based on the degree of dehydration.
This document provides an overview of saliva, including its composition, functions, and role in oral health and disease. It discusses the major and minor salivary glands, how saliva is formed, and clinical considerations like dry mouth. Saliva helps maintain oral health by washing away food debris, neutralizing acids, and enhancing remineralization. The document also explores using saliva as a diagnostic tool by analyzing biomarkers for conditions like periodontal disease. Reduced saliva flow can increase risks of dental caries, gingivitis, and other oral issues by impairing cleansing and buffering in the mouth.
This document summarizes different types of sweat glands and disorders that can affect them. It discusses the three main types of sweat glands - eccrine, apocrine, and apoeccrine. The major disorder types covered are hyperhidrosis (excessive sweating) and hypohidrosis/anhidrosis (reduced or absent sweating). Treatment options are provided for different forms of hyperhidrosis that range from topical therapies to procedures like botulinum toxin injections or thoracic sympathectomy. Sweat retention syndromes like miliaria that cause skin eruptions are also summarized.
This document discusses different types of insecticides including organophosphorus compounds, halogenated hydrocarbons, and miscellaneous preparations. It provides details on the absorption, metabolism, mode of action, symptoms of poisoning, treatment, and postmortem findings of organophosphorus compounds and halogenated hydrocarbons like DDT. Specific insecticides discussed in depth include parathion, malathion, DDT, aldrin, and dieldrin.
This document discusses functional components found in salmon and krill. It describes collagen, omega-3 fatty acids, protein hydrolysates, and chitin that can be extracted from these seafood using supercritical fluid extraction. The extracted components have various health benefits and can be incorporated into foods like red wine and milk through emulsification. Strict regulations regarding food labeling and claims must be followed when adding these functional ingredients to products.
Calcarea carb is prepared from oyster shell and is suited for fair, fatty, flabby patients who are chilly and sensitive to cold. It is used for bone and glandular affections, respiratory troubles, and abdominal disorders. Key indications include delayed development, profuse sweating, sour discharges, craving for eggs and indigestible items, and aggravation from cold. It is useful for bronchial asthma, tuberculosis, soft and weak bones with delayed ossification, and pathological fractures.
Alkalize or Die
Need of Alkalizing our bodies in todays World, as we are surrounded and consuming a lot of food, water, air, which is acidifying our body and causes damages which need to be tackled fast.
The document presents a case study of a 21-year-old female patient diagnosed with autoimmune hemolytic anemia. Key findings include low hemoglobin and hematocrit levels, elevated reticulocytes, and positive direct Coombs test. She was treated with prednisolone, folic acid, calcium, vitamin D, risedronate, and levothyroxine. Her bilateral knee pain and weakness improved over the course of her treatment.
Fluid and electrolyte balance Dr Reshma Gafoorreshm007
FLUID AND ELECTROLYTE BALANCE IN ORAL AND MAXILLOFACIAL SURGERY
BRIEF DISCUSSION OF FLUID REPLACEMENT THERAPY
END PARAMETERS AND GOALS OF FLUID REPLACEMENT
https://userupload.net/8mky0eijld91
An understanding of the physiology of body fluids is essential when considering appropriate fluid resuscitation and fluid replacement therapy in critically-ill patients. In healthy humans, the body is composed of approximately 60% water, distributed between intracellular and an extracellular compartments. The extracellular compartment is divided into intravascular, interstitial and transcellular compartments. The movement of fluids between the intravascular and interstitial compartments, is classically described as being governed by Starling forces, leading to a small net efflux of fluid from the intravascular to the interstitial compartment. More recent evidence suggests that a model incorporating the effect of the endothelial glycoclayx layer, a web of glycoproteins and proteoglycans that are bound on the luminal side of the vascular endothelium, better explains the observed distribution of fluids. The movement of fluid to and from the intracellular compartment and the interstitial fluid compartment, is governed by the relative osmolarities of the two compartments. Body fluid status is governed by the difference between fluid inputs and outputs; fluid input is regulated by the thirst mechanism, with fluid outputs consisting of gastrointestinal, renal, and insensible losses. The regulation of intracellular fluid status is largely governed by the regulation of the interstitial fluid osmolarity, which is regulated by the secretion of antidiuretic hormone from the posterior pituitary gland. The regulation of extracellular volume status is regulated by a complex neuro-endocrine mechanism, designed to regulate sodium in the extracellular fluid.
This document provides information about Enagic and kangen water ionizers. It begins with an overview of Enagic as a 41-year old privately held company that is a top industry leader. It then discusses the health benefits of kangen water, which is high in antioxidants, highly alkaline, and micro-clustered. Testimonials are provided about how kangen water has helped with various health conditions like cancer, skin diseases, and diabetes. Product information and pricing for Enagic's kangen water ionizers is also presented.
intravenous fluid and electrolytes are important topics in medical science. potassium is one of the vital electrolytes of the human body. this presentation has a discussion on several iv fluids and potassium balance and also how to manage the potassium imbalance.
Water is vital to every bodily function and makes up about 65% of our body weight. It contributes to chemical reactions, tissue structure, temperature regulation, and digestion. The body obtains water through drinking, food, and metabolic processes. Water balance is important and is regulated by fluid distribution between intracellular and extracellular compartments and water intake and output. Electrolytes like sodium, potassium, and chloride are also essential and their balances are maintained by organ systems like the kidneys and hormones. Imbalances can impair cellular functions and cause health issues.
water and electrolyte (2).pptx Body is composed of about 60-70% water Distr...Shivangi sharma
URINE
Major route of water loss
Normal urine 1-2L/day.
Water loss through kidneys well regulated to meet body demands.
Urine production cannot be completely shut down, despite there being no water intake
due to the fact that some amount of water (about 500ml/day) is essential as the medium to eliminate the waste products from the body.
Rational use of intravenous fluids by Dr. KetorKetor Edem
This document discusses rational use of intravenous fluids. It begins by describing fluid compartments in the body and factors that can cause fluid and electrolyte losses. It then covers physiology of water balance, electrolytes, and daily fluid and electrolyte requirements. Different types of intravenous fluids are outlined including crystalloids, colloids, and special solutions. Guidelines for fluid therapy in conditions like dehydration, shock, and maintenance are provided. Considerations for fluid management in renal and liver disorders are also mentioned.
Kosmoderma Academy, a leading institution in the field of dermatology and aesthetics, offers comprehensive courses in cosmetology and trichology. Our specialized courses on PRP (Hair), DR+Growth Factor, GFC, and Qr678 are designed to equip practitioners with advanced skills and knowledge to excel in hair restoration and growth treatments.
This presentation gives a brief about the Enagic's Kangen Water Devices and the science behind the Kangen Water. More details about Kangen Water Ionizers & Kangen Water Ionizer Doorstep demonstration call: +917675951155
The document discusses clinical diagnosis of dehydration and electrolyte disorders. It covers:
- Types of dehydration including water loss and salt/water loss dehydration.
- Symptoms and signs of dehydration seen on physical exam including decreased skin turgor and dry mucous membranes.
- Laboratory tests that can help diagnose dehydration including hematocrit, BUN, and urine specific gravity.
- Electrolyte disorders involving sodium, potassium, calcium, magnesium, and chloride are described. Imbalances of these electrolytes can cause neurological or muscular symptoms. Laboratory tests are important to diagnose electrolyte levels.
The document discusses the importance of drinking ionized, alkaline water for health and disease prevention. It states that most beverages are acidic and can lead to acidosis, which is linked to many diseases. The solution proposed is drinking alkaline Tyent Water, which has benefits like powerful antioxidants, increased hydration, and an alkaline pH that supports optimal health. The document advertises the Tyent Water ionizer and its ability to produce ionized, alkaline water with purported health benefits.
C:\documents and settings\administrator\桌面\11 fluid therapySumit Prajapati
This document discusses fluid therapy for acute diarrhea and dehydration in children. It describes the assessment of dehydration severity based on clinical signs. For mild to moderate dehydration, oral rehydration solution (ORS) is recommended. For severe dehydration, intravenous fluids are needed. The document provides formulas for ORS and intravenous fluids and guidelines for calculating fluid volumes based on the degree of dehydration.
The document discusses fluid therapy for acute diarrhea and dehydration in children. It covers the pathophysiology of dehydration, clinical signs, diagnosis, electrolyte disturbances, and treatment approaches including oral rehydration solutions and intravenous fluid therapy. Treatment involves correcting water and electrolyte deficits in a stepwise manner, first expanding blood volume and then replenishing and maintaining fluids based on the degree of dehydration.
This document provides an overview of saliva, including its composition, functions, and role in oral health and disease. It discusses the major and minor salivary glands, how saliva is formed, and clinical considerations like dry mouth. Saliva helps maintain oral health by washing away food debris, neutralizing acids, and enhancing remineralization. The document also explores using saliva as a diagnostic tool by analyzing biomarkers for conditions like periodontal disease. Reduced saliva flow can increase risks of dental caries, gingivitis, and other oral issues by impairing cleansing and buffering in the mouth.
This document summarizes different types of sweat glands and disorders that can affect them. It discusses the three main types of sweat glands - eccrine, apocrine, and apoeccrine. The major disorder types covered are hyperhidrosis (excessive sweating) and hypohidrosis/anhidrosis (reduced or absent sweating). Treatment options are provided for different forms of hyperhidrosis that range from topical therapies to procedures like botulinum toxin injections or thoracic sympathectomy. Sweat retention syndromes like miliaria that cause skin eruptions are also summarized.
This document discusses different types of insecticides including organophosphorus compounds, halogenated hydrocarbons, and miscellaneous preparations. It provides details on the absorption, metabolism, mode of action, symptoms of poisoning, treatment, and postmortem findings of organophosphorus compounds and halogenated hydrocarbons like DDT. Specific insecticides discussed in depth include parathion, malathion, DDT, aldrin, and dieldrin.
This document discusses functional components found in salmon and krill. It describes collagen, omega-3 fatty acids, protein hydrolysates, and chitin that can be extracted from these seafood using supercritical fluid extraction. The extracted components have various health benefits and can be incorporated into foods like red wine and milk through emulsification. Strict regulations regarding food labeling and claims must be followed when adding these functional ingredients to products.
Calcarea carb is prepared from oyster shell and is suited for fair, fatty, flabby patients who are chilly and sensitive to cold. It is used for bone and glandular affections, respiratory troubles, and abdominal disorders. Key indications include delayed development, profuse sweating, sour discharges, craving for eggs and indigestible items, and aggravation from cold. It is useful for bronchial asthma, tuberculosis, soft and weak bones with delayed ossification, and pathological fractures.
Alkalize or Die
Need of Alkalizing our bodies in todays World, as we are surrounded and consuming a lot of food, water, air, which is acidifying our body and causes damages which need to be tackled fast.
The document presents a case study of a 21-year-old female patient diagnosed with autoimmune hemolytic anemia. Key findings include low hemoglobin and hematocrit levels, elevated reticulocytes, and positive direct Coombs test. She was treated with prednisolone, folic acid, calcium, vitamin D, risedronate, and levothyroxine. Her bilateral knee pain and weakness improved over the course of her treatment.
Fluid and electrolyte balance Dr Reshma Gafoorreshm007
FLUID AND ELECTROLYTE BALANCE IN ORAL AND MAXILLOFACIAL SURGERY
BRIEF DISCUSSION OF FLUID REPLACEMENT THERAPY
END PARAMETERS AND GOALS OF FLUID REPLACEMENT
https://userupload.net/8mky0eijld91
An understanding of the physiology of body fluids is essential when considering appropriate fluid resuscitation and fluid replacement therapy in critically-ill patients. In healthy humans, the body is composed of approximately 60% water, distributed between intracellular and an extracellular compartments. The extracellular compartment is divided into intravascular, interstitial and transcellular compartments. The movement of fluids between the intravascular and interstitial compartments, is classically described as being governed by Starling forces, leading to a small net efflux of fluid from the intravascular to the interstitial compartment. More recent evidence suggests that a model incorporating the effect of the endothelial glycoclayx layer, a web of glycoproteins and proteoglycans that are bound on the luminal side of the vascular endothelium, better explains the observed distribution of fluids. The movement of fluid to and from the intracellular compartment and the interstitial fluid compartment, is governed by the relative osmolarities of the two compartments. Body fluid status is governed by the difference between fluid inputs and outputs; fluid input is regulated by the thirst mechanism, with fluid outputs consisting of gastrointestinal, renal, and insensible losses. The regulation of intracellular fluid status is largely governed by the regulation of the interstitial fluid osmolarity, which is regulated by the secretion of antidiuretic hormone from the posterior pituitary gland. The regulation of extracellular volume status is regulated by a complex neuro-endocrine mechanism, designed to regulate sodium in the extracellular fluid.
This document provides information about Enagic and kangen water ionizers. It begins with an overview of Enagic as a 41-year old privately held company that is a top industry leader. It then discusses the health benefits of kangen water, which is high in antioxidants, highly alkaline, and micro-clustered. Testimonials are provided about how kangen water has helped with various health conditions like cancer, skin diseases, and diabetes. Product information and pricing for Enagic's kangen water ionizers is also presented.
intravenous fluid and electrolytes are important topics in medical science. potassium is one of the vital electrolytes of the human body. this presentation has a discussion on several iv fluids and potassium balance and also how to manage the potassium imbalance.
Water is vital to every bodily function and makes up about 65% of our body weight. It contributes to chemical reactions, tissue structure, temperature regulation, and digestion. The body obtains water through drinking, food, and metabolic processes. Water balance is important and is regulated by fluid distribution between intracellular and extracellular compartments and water intake and output. Electrolytes like sodium, potassium, and chloride are also essential and their balances are maintained by organ systems like the kidneys and hormones. Imbalances can impair cellular functions and cause health issues.
water and electrolyte (2).pptx Body is composed of about 60-70% water Distr...Shivangi sharma
URINE
Major route of water loss
Normal urine 1-2L/day.
Water loss through kidneys well regulated to meet body demands.
Urine production cannot be completely shut down, despite there being no water intake
due to the fact that some amount of water (about 500ml/day) is essential as the medium to eliminate the waste products from the body.
Rational use of intravenous fluids by Dr. KetorKetor Edem
This document discusses rational use of intravenous fluids. It begins by describing fluid compartments in the body and factors that can cause fluid and electrolyte losses. It then covers physiology of water balance, electrolytes, and daily fluid and electrolyte requirements. Different types of intravenous fluids are outlined including crystalloids, colloids, and special solutions. Guidelines for fluid therapy in conditions like dehydration, shock, and maintenance are provided. Considerations for fluid management in renal and liver disorders are also mentioned.
Similar to Physiology of Skin and Skeletal system (20)
Kosmoderma Academy, a leading institution in the field of dermatology and aesthetics, offers comprehensive courses in cosmetology and trichology. Our specialized courses on PRP (Hair), DR+Growth Factor, GFC, and Qr678 are designed to equip practitioners with advanced skills and knowledge to excel in hair restoration and growth treatments.
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdfrightmanforbloodline
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
low birth weight presentation. Low birth weight (LBW) infant is defined as the one whose birth weight is less than 2500g irrespective of their gestational age. Premature birth and low birth weight(LBW) is still a serious problem in newborn. Causing high morbidity and mortality rate worldwide. The nursing care provide to low birth weight babies is crucial in promoting their overall health and development. Through careful assessment, diagnosis,, planning, and evaluation plays a vital role in ensuring these vulnerable infants receive the specialize care they need. In India every third of the infant weight less than 2500g.
Birth period, socioeconomical status, nutritional and intrauterine environment are the factors influencing low birth weight
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
DECLARATION OF HELSINKI - History and principlesanaghabharat01
This SlideShare presentation provides a comprehensive overview of the Declaration of Helsinki, a foundational document outlining ethical guidelines for conducting medical research involving human subjects.
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
3. RESULTS
Table 1. Skin color determination
Group No.
Skin color before
compression
Skin color in
compressed area
1
Pinkish
Pale pink, white,
blue
2
Pinkish
White
3
Pinkish
White, pale pink
6. o
o
JAUNDICE
o
o
skin yellowing
caused by the build up of
bilirubin due to malfunction of
the liver
eating too many carrots
“carotenemia”
tanning pills “canthaxanthin”
8. o
ARGYRIA &
CYANOSIS
Paul Karason consumed
colloidal silver to treat a bad
case of dermatitis on his face
o
and turned blue
Caused by inadequate
amount of oxygen in the
blood
13. SYMPTOM OF
HORMONAL
IMBALANCE
o Addison’s disease is caused by
low cortisol and aldosterone
o Bronzing (hyperpigmentation)
o Cushing syndrome caused by
exposure to high levels of
cortisol
o Purple marks (striae) and
bruised skin
14. PLOTTING THE DISTRIBUTION OF SWEAT GLANDS
ECCRINE SWEAT GLAND
APOCRINE SWEAT GLAND
o produce sweat that is mostly salt,
o secrete urea,
electrolytes and water (e.g. a thick sweat packed with
uric acid, ammonia,fatty acids and proteins
amino acids,
o
glucose, lactic acid)located deep into the skin and opens
to protect the
o cools the body & help hair
skin from bacteriao larger than eccrine
and pathogens
o causes body odor
o no body odor
o secreted starting
o do not extend as deep into the skin from puberty
and they excrete through pores
o smaller than apocrine
15. PLOTTING THE DISTRIBUTION OF SWEAT GLANDS
Eccrine sweat glands
Apocrine sweat glands
o Distributed over the
Occur mainly in arm
entire body of nipples
pits, areola except lip
margins, nail beds,
& perineum
o nipples, inner surface
Also found in ear and
of prepuce, labia
eyelid
minora, glans penis
& glans clitoris
o Heavily concentrated
on soles, palms,
armpits, forehead &
cheeks
o Low in trunk and
extremeties
16. o Sweating occurs in
response to external heat
stimuli which alters skin
temperature
o Cools the skin through
evaporative cooling
which makes use of the
high latent heat of
vaporization of water
Thermoregulation
22. DISCUSSION
• According to Henry Gray's
estimates, the palm has
around 370 sweat glands per
cm2 while forearm have 155
per cm
• Palms contain eccrine
glands since it does not have
hairs and needs to cool more
• Eccrine glands are smaller
than apocrine glands of the
arm so more glands can fit
into the palm
24. o over-active thyroid causes
an increase in your
metabolic rate
o burn more calories (weight
loss) and sweat more as
your body temperature
increases.
HYPERHIDROSIS &
HYPERTHYROIDISM
26. o bones support the
body
o protect vital
organs
o allow movement
o store minerals
o produce red blood
cells
FUNCTION
• ..FUNCTION
27. Canaliculi
Osteon
Osteocytes in lacunae
Volkmann’s canal
Lamellae
Haversian canal
TYPES OF OSSEOUS TISSUES
Osteon:
SPONGY BONE
Lamellaeo functionaltubes of
concentric unit
is bone spicule
bone matrix
called trabeculae
o less dense canalHaversian
o site of metabolic
passageway for
activity e.g.
exchange of
blood vessels and
calcium ions
nerves
Volkmann’s
canals- connect the
blood and nerve
COMPACT BONE
o functionalthe is
supply of unit
the osteon or
periosteum to
Haversian systems
o matrix is solidly filled
Haversian canal
with organic ground
substance and
Canaliculi- hairinorganic salts
like channels
connecting
osteocytes and
central canal
28. BONE CELLS
o Osteoclastslarge cells that
dissolve the
bone
o Osteoblastscells that form
new bones
o Osteocytesmature
osteoblasts
found in lacunae
o Osteoid- new
bone made up of
collagen and
ground
substance
34. o make up 65% of bone
by mass
o Hydroxyapatite(Ca10(PO4)6(OH)2 )
a mineral salt giving
the bone compressive
strength and hardness
o Osteocalcium
phosphate (brushite)
soft rubbery
consiste
nt
BRITTLEness
HARDness
Removal of INORGANIC
DISCUSSION
COMPONENTS
38. o BONE CELLS
(osteoblasts,
osteocytes, and
osteoclasts)
o OSTEOID
(ground substance
and collagen
fibers)
RESILIENC
E FLEXIBILI
TY
BRITTLE
HARD
• collagen
• 90% of organic component
• primarily type I collagen
• provides tensile strength
• proteoglycans
• responsible for compressive strength
• inhibit mineralization
• matrix proteins
• includes noncollagenous proteins
• function to promote mineralization and bone
formation
1. Osteocalcin
2. Osteonectin
3. Osteopontin
4. Cytokine and growth factors
DISCUSSION
ORGANIC COMPONENTS
40. OSTEOMALACIA AND
RICKETS
o softening of the bones due to a
lack of vitamin D or a problem
with the body's ability to break
down and use this vitamin
o Rickets is osteomalacia in
growing bones of children
41. Ehlers-Danlos
syndrome
o result of abnormal genes that
produce abnormal proteins that
confer an inherited frailty of
collagen
o typical features are stretchy
skin, loose joints and
fragile body tissues
42. Stephen ID et al (2009). Facial skin coloration affects perceived health of human
faces. International Journal of Primatology DOI 10.1007/s10764009-9380-z.
Shanghai Daily March 31, 2009) <http://www.china.org.cn/health/200903/31/content_17530186_2.htm>
Rachael Rettner (2012) A Man's Golden Skin Puts a Gleam in a Woman's Eye.
Retrieved from < http://www.livescience.com/36145-skin-tone-healthattractiveness.html>
Susan T. McClure (2010) About Addison's Disease and Skin Pigment. Retrieved
from <http://www.livestrong.com/article/162213-about-addisonsdisease-and-skin-pigment/#ixzz2mm2B6ET3>
Kevin Berman (2011) Hyperhidrosis. Retrieved from
<http://www.nlm.nih.gov/medlineplus/ency/article/007259.htm>
Tracy Jones (2013) Bone Matrix. Retrieved from
<http://www.orthobullets.com/basic-science/9003/bone-matrix>
REFERENCES
43. Cleveland clinic (2010) Osteomalacia. Retrieved from
<http://classes.midlandstech.edu/carterp/Courses/bio210/chap06/lectur
e1.html>
Shiel, William Jr. (2013) Ehlers-Danlos Syndrome. Retrieved from
<http://www.medicinenet.com/ehlers-danlos_syndrome/article.htm>
Akpan, Nsikan (2013) A Half-Red Baby And 3 Other Ways Biology Can Change
Skin Color. Retrieved from http://www.medicaldaily.com/half-red-baby-and-3other-ways-biology-can-change-skin-color-graphic-photos-247995
REFERENCES
Editor's Notes
1. Press the watch glass firmly against the plate for a few seconds2. Observe and record the color of the skin in the compressed area
data
Blue- if the pressure is continued for an extended period in this area
The color of the palm, says Ma, reveals the general health condition, just like qise of the face. It reflects blood circulation.
Other abnormal variations in skin color Bilirubin is a yellow chemical in hemoglobin, the substance that carries oxygen in your red blood cells. As red blood cells break down, your body builds new cells to replace them. The old ones are processed by the liver. If the liver cannot handle the blood cells as they break down, bilirubin builds up in the body and your skin may look yellow.Carrots packed with a compound called carotene, which belongs to family of orange pigments called carotenoids. Our cells need carotene to make vitamin A, which is important for eye and skin health. Regular levels of carotene are easily excreted by the body by sweating or urinating, but too much consumption can lead to 'carotenaemia' — orange skin — as the compound accumulates. The condition is typically harmless and dissipates after a few months.Tanning pills, which the Mayo Clinic and FDA deem as unsafe, contain canthaxanthin, which is a carotenoid that sometimes turns skin orange.
PictureCyanosis
Consuming chemical compounds with silver can turn a person blue, which is known as argyria, The most famous case of argyria arguably belongs to Paul Karason, who believed that drinking silver in his water on a daily basis could cure his skin dermatitis, even though FDA says otherwise.Blue skin can also be caused by genetic blood disorder called methemoglobinemia. People with the disease produce large amounts of methemoglobin, a type of hemoglobin, which is the protein that blood cells use to carry oxygen. Methemoglobin struggles to release the oxygen, leading to the change to smurf-dom.
Yellow-less blood in your body Pink- liveliness and good healthBlue- blood movement is slow in the body
Distribution of sweat glandsEccrine sweat glands develop in utero (during foetal development) and are distributed over the entire body, with the exception of the lip margins, nail beds, nipples, the inner surface of the prepuce (foreskiheavily concentrated include:Soles of the feet: 620 ± 20 per cm2;Palms of the hands: 300 ± 80 per cm2;Armpits: 360 ± 60 per cm2;Forehead: 360 ± 60 per cm2; andCheeks: 300 ± 80 per cm2.Sites which have a low concentration of eccrine glands include:Trunk: 65 ± 20 per cm2; andExtremities (arms and legs): 120 ± 30 per cm2.n), labia minora(outer folds of skin of the vulva/vagina), glans penis (head of the penis) and glans clitoris.Apocrine glands occur mainly in the arm pit, the areola of the nipples, and the perineum (region separating the anus from the genitals). They can also be found in the ear and eyelid.
Sweating is primarily a thermoregulatory response to control the body temperature. Normal thermoregulatory sweating occurs in response to external heat stimuli which alters skin temperature. However, it is thought to be primarily controlled by the body's internal temperature and particularly the temperature of the centralbrain. Thermoregulatory sweating is regulated by signals from thehypothalamus (a structure in the brain), and occurs diurnally (in the day) and nocturnally (at night).
With paperPainted a region in the palm and another region in the forearm with iodine solution and allowed to dry thoroughlyPlaced 2 squares of bondpaper (1 cmx 1 cm) to the painted regions and tape it securelyand leave for 20 minutesAfter 20 minutes, removed the paper squares and count the number of blue-black dots on the square
Estimated based on the intensity of the color to determine with part has the more concentration of sweat glands
Generally based on the results, sweat glands are more concentrated on the palms
Our palms often heat up when we are nervous or anxious, but if this is happening to you on a regular basis, your thyroid could be to blame. An over-active thyroid causes an increase in your metabolic rate. This means you burn more calories and sweat more as your body temperature increases. You may also experience unexplained weight loss, a constant feeling of nervous energy and a swelling of the thyroid gland in the throat. An overactive thyroid can be treated with medication
Pic background
Due to their function, it is necessary that the skeletal system is strong but flexible.
How mechanical stress affects strength? Dietary factors?
Procedure
Acidreleases calcium from its chemical combinations with phosphates and carbonates in bone through ionic exchange
Soft and bendable without breaking
Structure of hydroxyapatite and osteocalcium
Burn the bone completely using the alcohol lamp
Application of pressure made the bones easily break into pieces
What we accessed in the first experiment is the importance of the organic components of the bone and the function of the remaining organic material