How to defeat hyperphosphatemia for hemodialysis patients without the risk of protein energy malnutrition: quality matters.
by dr Nilly Shams
Clinical Nutrition and Public Health Consultant
Cardiovascular disease - more common in diabetic patients than in the general population
Dyslipidemia – common in patients with both types of diabetes.
Aggressive lipid treatment goals have been recommended for patients with type 2 diabetes
Diabetic Dyslipidemia is highly prevalent in the Indian diabetic population
Dyslipidemia in diabetes differs significantly with hypertriglyceridemia and small dense LDL-C
Cardiovascular disease - more common in diabetic patients than in the general population
Dyslipidemia – common in patients with both types of diabetes.
Aggressive lipid treatment goals have been recommended for patients with type 2 diabetes
Diabetic Dyslipidemia is highly prevalent in the Indian diabetic population
Dyslipidemia in diabetes differs significantly with hypertriglyceridemia and small dense LDL-C
India has a large pool of diabetic patients
ICMR-INDIAB study – extrapolated estimations suggest 62.4 million people with diabetes and 77.2 million are prediabetic
Estimates show ~ 85.5% men and 97.8% women who are diabetic in India have concomitant dyslipidemia
Presentation given to our fellowship program about diabetic kidney disease.
2022 update discussing SGLT2i, MRA (e.g. finerenone), health economics and beyond
Dr. John Buse prepared useful practice aids pertaining to type 2 diabetes for this CME activity titled "An Update on SGLT2 Inhibition for the Prevention and Treatment of Kidney Disease in Patients With Type 2 Diabetes." For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2Wm2VJw. CME credit will be available until June 12, 2020.
This presentation deals with the various approaches of medical nutrition therapy in Diabetes, comparison of the ADA, RSSDI and ICMR guidelines. It also talks about the various calorie counting apps as well.
Prediabetes means that your blood sugar level is higher than normal but not yet high enough to be classified as type 2 diabetes. Without intervention, prediabetes is likely to become type 2 diabetes in 10 years or less.
this is a brief study on prediabetes , in present scenario many of them are prediabetic ......
please comment
thank you
Silvio E. Inzucchi, MD, prepared useful Practice Aids pertaining to type 2 diabetes management for this CME activity titled "The Role of SGLT2 Inhibitors in Type 2 Diabetes: CV, Metabolic, and Renal Considerations." For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2l4h3Ss. CME credit will be available until June 27, 2019.
India has a large pool of diabetic patients
ICMR-INDIAB study – extrapolated estimations suggest 62.4 million people with diabetes and 77.2 million are prediabetic
Estimates show ~ 85.5% men and 97.8% women who are diabetic in India have concomitant dyslipidemia
Presentation given to our fellowship program about diabetic kidney disease.
2022 update discussing SGLT2i, MRA (e.g. finerenone), health economics and beyond
Dr. John Buse prepared useful practice aids pertaining to type 2 diabetes for this CME activity titled "An Update on SGLT2 Inhibition for the Prevention and Treatment of Kidney Disease in Patients With Type 2 Diabetes." For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2Wm2VJw. CME credit will be available until June 12, 2020.
This presentation deals with the various approaches of medical nutrition therapy in Diabetes, comparison of the ADA, RSSDI and ICMR guidelines. It also talks about the various calorie counting apps as well.
Prediabetes means that your blood sugar level is higher than normal but not yet high enough to be classified as type 2 diabetes. Without intervention, prediabetes is likely to become type 2 diabetes in 10 years or less.
this is a brief study on prediabetes , in present scenario many of them are prediabetic ......
please comment
thank you
Silvio E. Inzucchi, MD, prepared useful Practice Aids pertaining to type 2 diabetes management for this CME activity titled "The Role of SGLT2 Inhibitors in Type 2 Diabetes: CV, Metabolic, and Renal Considerations." For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2l4h3Ss. CME credit will be available until June 27, 2019.
Hyperphosphatemia in CKD patients; The Magnitude of The Problem - Prof. Alaa ...MNDU net
Hyperphosphatemia in CKD patients; The Magnitude of The Problem
Prof. Alaa Sabry - Professor of Nephrology
Mansoura Nephrology and Dialysis Unit (MNDU) Course
Nuts, Beans and Bucking the Trend: The changing paradigm for patients with CKDKeryx Biopharmaceuticals
Not all phosphorous is created equal! This white paper highlights, then debunks, the traditional wisdom surrounding the Chronic Kidney Disease diet. Authors Joan Brookhyser Hogan and Kathe LeBeau explain why (and how) CKD patients can enjoy a healthy diet that incorporates legumes, leafy greens and other "high phosphorous" foods previously perceived as inaccessible to this population. Finally, the authors propose ways to safely and creatively incorporate these healthy foods into the renal diet - adding a wealth of options to a diet CKD patients have historically considered an "empty plate.”
Small Linear/ Cyclic Bioactive/Synthetic peptides for the treatment of Iron Deficiency Anaemia. Softwares used were licenced versions. Method is specific for laboratory scale only, for fine crystals, Glycine / Alanine are better starting materials.
Hey Sugar: An Ecstacy Appeal with Monster impactNilly Shams
Anecstacy Appeal of Sugar
The sweet danger of sugar
Attention deficit hyperactivity disorder
in children & adolescents
Cognitive Dysfunction
Obesity
Immunity
Asthma
Recommendations
The Well Being of Breast Cancer PatientCan Nutrition Help? by Nilly ShamsNilly Shams
Good nutrition is important for cancer patients.
Understanding Malnutrition and Cancer, why should we care?
Anorexia and cachexia.
Nutrition and breast cancer management.
Diet and Lifestyle in Women with Breast Cancer: is their a link?
Breast cancer and diet/physical activity.
Dietary intake and breast cancer chemoprevention.
Special Diets for Breast Cancer, do they wok?
Support with nutrition for women receiving chemotherapy for breast cancer.
Can Nutrition Lower the Risk of Recurrence in Breast Cancer?
Nutrition Goals of prevention and treating cancer.
Side Effects of Cancer and Cancer Treatment, How to Deal with?
If it is that simple so why it does not work??
Take Home Messages.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Phosphorus and Hemodialysis: a Predator that can be Tamed.
1. Phosphorus and Hemodialysis
A Predator that can be tamed
Dr.Nilly Shams
Public Health and Nutrition Consultant
Certified Health Coach, Institute of Integrative Nutrition, USA
President of Egyptian Nutrition and Health Coaching Association, ENHCA
NephroAelx 2019, 25- 27 July 2019. Tolip, Alexandria. Egypt
2. Talk Outline
• Phosphorus: The Devil’ Element.
• Management of Hyperphosphatemia: Phosphate-Lowering Therapies.
Dialysis.
Phosphorus Binding Agents.
Dietary Phosphorus Restriction.
• Management of Hyperphosphatemia: New Concepts and Applications.
Phosphorus-to-Protein Ratio.
Bioavailability.
Phophorus Food Pyramid.
Health Literacy.
• Role of Renal Dietitians.
• Take Home Message.
3. Talk Outline
• Phosphorus: The Devil’ Element.
• Management of Hyperphosphatemia: Phosphate-Lowering Therapies.
Dialysis.
Phosphorus Binding Agents.
Dietary Phosphorus Restriction.
• Management of Hyperphosphatemia: New Concepts and Applications.
Phosphorus-to-Protein Ratio.
Bioavailability.
Phophorus Food Pyramid.
Health Literacy.
• Role of Renal Dietitians.
• Take Home Message.
4. Phosphorus: The Devil’ Element
• Hyperphosphatemia is a universal complication of end stage renal disease that is
widely recognized as one of the most essential and most challenging clinical
targets to meet in the care of dialysis patients.
Renal Nutrition Forum. 2015; 34: 265-70
5. Phosphorus: The Devil’ Element
USA: Elsevier; 2017. p.429-36.
Phosphorus Balance in Normal Physiology
6. Phosphorus: The Devil’ Element
USA: Elsevier; 2017. p.429-36.
Phosphate homeostasis is determinants
intestinal uptake of
dietary phosphate
7. Phosphorus: The Devil’ Element
USA: Elsevier; 2017. p.429-36.
Phosphate homeostasis is determinants
intestinal uptake of
dietary phosphate
renal phosphate reabsorption
of filtered phosphate
8. Phosphorus: The Devil’ Element
USA: Elsevier; 2017. p.429-36.
Phosphate homeostasis is determinants
intestinal uptake of
dietary phosphate
renal phosphate reabsorption
of filtered phosphate
the shift of intracellular
phosphate between
extracellular and bone
storage pools.
9. Phosphorus: The Devil’ Element
USA: Elsevier; 2017. p.429-36.
Urinary phosphorus excretion matches the net absorption of phosphorus from the
gastrointestinal tract.
10. Phosphorus: The Devil’ Element
Am Soc Nutr Adv Nutr. 2014; 5:98-103
Fasting serum phosphorus is maintained within a tight range despite wide fluctuations in
dietary phosphorus intake through variations in the urinary phosphorus excretion.
11. Phosphorus: The Devil’ Element
Am J Physiol Renal Physiol. 2010; 299(2):F285-96.
Absence of renal phosphate excretion is a leading factor that impedes
phosphate control in ESRD patients, especially among those without residual renal function
12. Phosphorus: The Devil’ Element
DOPPS: American Journal of Kidney Diseases. 2008;52(3):519-30.
• Hyperphosphatemia is associated with greater all-cause mortality and increased
morbidities in dialysis patients.
13. Phosphorus: The Devil’ Element
DOPPS: American Journal of Kidney Diseases. 2008;52(3):519-30.
• Hyperphosphatemia is associated with greater all-cause mortality and increased
morbidities in dialysis patients.
14. Phosphorus: The Devil’ Element
N Engl J Med. 2010; 362:1312-24.
Presumptive Mechanisms Linking Hyperphosphatemia
and Cardiovascular Disease
15. Talk Outline
• Phosphorus: The Devil’ Element.
• Management of Hyperphosphatemia: Phosphate-Lowering Therapies.
Dialysis.
Phosphorus Binding Agents.
Dietary Phosphorus Restriction.
• Management of Hyperphosphatemia: New Concepts and Applications.
Phosphorus-to-Protein Ratio.
Bioavailability.
Phophorus Food Pyramid.
Health Literacy.
• Role of Renal Dietitians.
• Take Home Message.
16. Management of Hyperphosphatemia
Kidney Int. 2017; 92(1):26-36.
Phosphate-Lowering Therapies
• Management of hyperphosphatemia in patients with ESRD often necessitates a
multimodal approach.
18. Management of Hyperphosphatemia
Nephrol Dial Transplant. 2013; 28(12):2961-8.
Effect of various dialysis modalities on phosphate removal
Dialysis modality Schedule Phosphate removal
Conventional
hemodialysis
4–5 h
three times a week
600–1200 mg/session
1800–3600 mg/week
Peritoneal dialysis Continuous
300–360 mg/day
2100–2520 mg/week
Nocturnal hemodialysis
6–10 h,
5–7 nights per week
600–1200 mg/day
3000–8400 mg/week
Short daily dialysis
1.5–3 h,
5–7 days per week
Variable
19. Management of Hyperphosphatemia
Nutrients. 2013; 5(3):1002-23.
If patients adhere to a daily phosphorus limit of 1,000 mg
phosphorus accumulates
If 70% of the phosphorus in the diet is absorbed this is 4,500 to 5,000 mg in a week
A 4-hours HD session will remove only 3,600 mg for patients undergoing dialysis 3 times per week
far less than phosphorus absorption
20. Management of Hyperphosphatemia
Clin J Am Soc Nephrol. 2011; 6(12):2854-60.
Effect of various dialysis modalities on phosphate removal
Conventional hemodialysis alone is insufficient for phosphorus
control due to insufficient phosphate removal; phosphate resides in the intracellular
compartment and thus is challenging to access during dialysis.
23. Management of Hyperphosphatemia
Cleve Clin J Med. 2018; 85(8):629-38.
Phosphorus binding agents
• Oral phosphate binders are used in over 90% of ESRD patients.
• Absorption of phosphorus is normally about 60% of that ingested, but
could be as low as 40% in the presence of phosphate binders.
• They are much more effective when taken with meals.
• Phosphate binder dosage is dependent upon the patient’s serum
phosphorus and the size of meals consumed.
24. Cleve Clin J Med. 2018; 85(8):629-38.
Phosphorus Binding Agents
Phosphorus
binder
Dose
PBED of 1
tablet to 1 g of
calcium
carbonate
Average
number
of pills to reach
PBED 6 g
Formulation Advantages Disadvantages
Calcium
carbonate
750–3,500 mg 0.75 8
Swallowed and
chewable
tablets
Low cost, over
the counter
Calcium burden
Calcium acetate 667–6,000 mg 0.67 9
Swallowed
tablet
Less calcium
than calcium
carbonate
Needs
prescription
Lanthanum 500–3,750 mg 1.0 3
Chewable and
swallowed
tablet (can be
crushed)
Lower pill
burden than
many other
binders
Expensive
Sevelamer 800–8,000 mg 0.60 10
Swallowed
tablet and
granule packets
Lowers low-
density
lipoprotein
cholesterol
High pill
burden
Sucroferric
oxyhydroxide
500–3,000 mg 1.6 3.75 Chewable tablet
Lower pill
burden
Cost and
gastrointestinal
side effects
Ferric citrate 210–2,500 mg 2.0 9
Swallowed
tablet
Improves iron
parameters
Expensive
25. Cleve Clin J Med. 2018; 85(8):629-38.
Phosphorus Binding Agents
Phosphorus
binder
Dose
PBED of 1
tablet to 1 g of
calcium
carbonate
Average
number
of pills to reach
PBED 6 g
Formulation Advantages Disadvantages
Calcium
carbonate
750–3,500 mg 0.75 8
Swallowed and
chewable
tablets
Low cost, over
the counter
Calcium burden
Calcium acetate 667–6,000 mg 0.67 9
Swallowed
tablet
Less calcium
than calcium
carbonate
Needs
prescription
Lanthanum 500–3,750 mg 1.0 3
Chewable and
swallowed
tablet (can be
crushed)
Lower pill
burden than
many other
binders
Expensive
Sevelamer 800–8,000 mg 0.60 10
Swallowed
tablet and
granule packets
Lowers low-
density
lipoprotein
cholesterol
High pill
burden
Sucroferric
oxyhydroxide
500–3,000 mg 1.6 3.75 Chewable tablet
Lower pill
burden
Cost and
gastrointestinal
side effects
Ferric citrate 210–2,500 mg 2.0 9
Swallowed
tablet
Improves iron
parameters
Expensive
26. Management of Hyperphosphatemia
Cleve Clin J Med. 2018; 85(8):629-38.
Barriers diminishing phosphorus binders effectiveness
• In ESRD patients taking phosphate binders, a transient upregulation of NPT2b,
increasing total phosphate absorption and could blunt binder effectiveness.
• Phosphorus Binding Capacities: the limited ability of phosphate binders to bind
phosphorus as there is a maximum limit of phosphorus that can be bound to a
unit of binder.
“In a typical anuric ESRD patient receiving standard three times weekly dialysis, nearly 300–500 mg
of absorbed dietary phosphorus will need to be bound daily by phosphate binders limited
binding capacity of existing phosphate binder regimens may hinder phosphate control.
27. Management of Hyperphosphatemia
Cleve Clin J Med. 2018; 85(8):629-38.
Barriers diminishing phosphorus binders effectiveness
• In ESRD patients taking phosphate binders, a transient upregulation of NPT2b,
increasing total phosphate absorption and could blunt binder effectiveness.
• Phosphorus Binding Capacities: the limited ability of phosphate binders to bind
phosphorus as there is a maximum limit of phosphorus that can be bound to a
unit of binder.
(Nearly 300–500 mg of absorbed dietary phosphorus will need to be bound daily by phosphate
binders limited binding capacity of existing phosphate binder regimens may hinder phosphate
control).
28. Management of Hyperphosphatemia
Cleve Clin J Med. 2018; 85(8):629-38.
Barriers diminishing phosphorus binders effectiveness
• In ESRD patients taking phosphate binders, a transient upregulation of NPT2b,
increasing total phosphate absorption and could blunt binder effectiveness.
• Phosphorus Binding Capacities: the limited ability of phosphate binders to bind
phosphorus as there is a maximum limit of phosphorus that can be bound to a
unit of binder.
(Nearly 300–500 mg of absorbed dietary phosphorus will need to be bound daily by phosphate
binders limited binding capacity of existing phosphate binder regimens may hinder phosphate
control).
29. Management of Hyperphosphatemia
Cleve Clin J Med. 2018; 85(8):629-38.
Barriers diminishing phosphorus binders effectiveness
• Poor adherence to treatment regimen in the ESRD population due to high pill
burden.
• The high prevalence of side effects associated with binders, like diarrhea,
nausea or chalky taste in the mouth, and the variable individual meal patterns
contribute to poor adherence.
30. Management of Hyperphosphatemia
Cleve Clin J Med. 2018; 85(8):629-38.
Barriers diminishing phosphorus binders effectiveness
• Poor adherence to treatment regimen in the ESRD population due to high pill
burden.
• The high prevalence of side effects associated with binders, like diarrhea,
nausea or chalky taste in the mouth, and the variable individual meal patterns
contribute to poor adherence.
35. Management of Hyperphosphatemia
Nephrol Dial Transplant. 2013; 28(12):2961-8.
3. Dietary Phosphorus Restriction
Because of the delicate balance between ensuring adequate protein intake
and simultaneously restricting phosphorus intake
Impact on survival.
36. Management of Hyperphosphatemia
Kidney Int Suppl. 2017; 7:1-59.
3. Dietary Phosphorus Restriction
Lets have a look at management of Hyperphosphatemia from another perspective
New Concepts and Applications
37. Talk Outline
• Phosphorus: The Devil’ Element.
• Management of Hyperphosphatemia: Phosphate-Lowering Therapies.
Dialysis.
Phosphorus Binding Agents.
Dietary Phosphorus Restriction.
• Management of Hyperphosphatemia: New Concepts and Applications.
Phosphorus-to-Protein Ratio.
Bioavailability.
Phophorus Food Pyramid.
Health Literacy.
• Role of Renal Dietitians.
• Meal Plans.
38. 3. Dietary Phosphorus Restriction
Clin J Am Soc Nephrol. 2010; 5(3):519-30.
In patients on HD
Increase Protein intake to 1.1 g/kg/day
limit phosphorus intake to about 800 to 1,000 mg/ day
Tailoring dietary recommendations to leverage the existence of foods with naturally
high protein but low in phosphorus
39. 3. Dietary Phosphorus Restriction
Clin J Am Soc Nephrol. 2010; 5(3):519-30.
Phosphorus-to-Protein Ratio
In patients on HD
Increase Protein intake to 1.1 mg/kg/day
limit phosphorus intake to about 800 to 1,000 mg/ day
Tailoring dietary recommendations to leverage the existence of foods with naturally
high protein but low in phosphorus
40. Phosphorus-to-Protein Ratio
Cleve Clin J Med. 2018; 85(8):629-38.
Ratio of phosphorus to protein in food is not constant
Control dietary phosphorus intake accurately purely by reducing the amount of
protein in the diet is difficult
41. Phosphorus-to-Protein Ratio
Kidney Int Suppl. 2013; 3(5):462-8.
Ratio of phosphorus to protein in food is not constant
Control dietary phosphorus intake accurately purely by reducing the amount of
protein in the diet is difficult
A phosphorus-to-protein ratio of less than 10 mg/g helps to balance adequate
protein intake while preventing hyperphosphatemia
42. Phosphorus-to-Protein Ratio
Cleve Clin J Med. 2018; 85(8):629-38.
High phosphate-to-protein ratio
Egg yolk
Beans, lentils, and dried peas
Cheese
Milk
Nuts and seeds
Organ meats and certain seafoods like shrimp, crab, and oysters
Low phosphate-to-protein ratio
Egg white
White bread, pasta, crackers
Soups that are water-based or broth-based
Seafoods like sea bass
43. 3. Dietary Phosphorus Restriction
Kidney Int Suppl. 2017; 7:1-59.
Sources of dietary phosphate
Natural phosphates
(as cellular and protein constituents)
contained in raw or unprocessed foods
(Organic and Inorganic)
Added phosphates
(added during processing)
Phosphates in Dietary Supplements/
Medications
46. Sources and types of dietary phosphate
Proportion of a nutrient intake that is capable of being absorbed through the intestine and
made available either for metabolic use or storage.
It determines the efficiency with which a dietary component is used systematically
through normal metabolic pathways.
Expressed as a percentage of intakes and is known to be influenced by dietary factors.
Bioavailability
Patient Prefer Adherence. 2018; 12:1175-91.
49. Sources and types of dietary phosphate
After all, many of the foods that are traditionally labeled as high phosphorus may
be more acceptable with the knowledge that the phosphorus is absorbed more
slowly and not as efficiently.
Inorganic phosphate is more readily absorbed, and its presence is likely to be
underreported in nutrient.
Bioavailability
Kidney Int Suppl. 2017; 7:1-59.
50. Sources and types of dietary phosphate
Foods which contain phosphate additives have a phosphorus content nearly 70%
higher than those that do not contain additives.
Phosphate contents between unprocessed and processed meat or poultry may
differ by more than 60%, and thus the absorbable phosphate may even be 2 to 3
times higher per weight in processed food.
Bioavailability
J Ren Nutr. 2011; 21(4):303-8.
54. Management of Hyperphosphatemia
Lebanon. Nutr Res Pract. 2014; 8(1):103-11.
Health Literacy
The degree to which an individual has the capacity to obtain, communicate,
process, and understand basic health information and services in order to make
appropriate health decisions
low health literacy among the dialysis population
It might be difficult for patients to comprehend the importance of complex
regimens
55. Talk Outline
• Phosphorus: The Devil’ Element.
• Management of Hyperphosphatemia: Phosphate-Lowering Therapies.
Dialysis.
Phosphorus Binding Agents.
Dietary Phosphorus Restriction.
• Management of Hyperphosphatemia: New Concepts and Applications.
Phosphorus-to-Protein Ratio.
Bioavailability.
Phophorus Food Pyramid.
Health Literacy.
• Role of Renal Dietitians.
• Take Home Message.
57. Management of Hyperphosphatemia
Kidney Int Suppl. 2017; 7:1-59.
Role of Renal Dietitians
Renal dietitians can directly apply the updated clinical
recommendations in the evaluation of:
Diet composition
Food additives
Adherence challenges
Phosphate binder type and use
Change in dietary habits and phosphorus-additive containing foods
58. Talk Outline
• Phosphorus: The Devil’ Element.
• Management of Hyperphosphatemia: Phosphate-Lowering Therapies.
Dialysis.
Phosphorus Binding Agents.
Dietary Phosphorus Restriction.
• Management of Hyperphosphatemia: New Concepts and Applications.
Phosphorus-to-Protein Ratio.
Bioavailability.
Phophorus Food Pyramid.
Health Literacy.
• Role of Renal Dietitians.
• Take Home Message.
59. Take Home Messages
Conventional hemodialysis alone is insufficient for phosphorus control due to
the kinetics of dialytic phosphorus removal.
The limited binding capacity of existing phosphate binder regimens, poor
adherence and side effects may hinder phosphate control in a large number of
dialysis patients.
Messing with the saver may drown the ship
60. Take Home Messages
Renal professionals should be mindful of the potential risks of protein over-
restriction and could consider tailoring dietary recommendations to leverage
the existence of foods with naturally high protein but low in phosphorus.
Sensitize patients to follow a diet with a low load of phosphorus, a mixed
composition of food from plant and food from animal origin should be
encouraged, while the intake of processed foods should be limited.
Strategies to improve compliance are necessary to decrease the incidence of
hyperphosphatemia in HD patients as Education, Counseling to defeat low
Health Literacy.
More detailed information of the phosphate content of foods, described by
manufacturers, can lead to better control of phosphorus intake with the HD
patients’ diet