This PPT includes the pharmacodynamics in detail for pharmacology 2nd yr 4th semester

1. PHARMACODYNAMICS
ASIYABI.M
ASSISTANT PROFESSOR
DEPARTMENTOF PHARMACOLOGY

2. DEFINITION

9. TRANSPORT
OROCESS
ENZYMES
ION
CHANNELS
RECEPTORS

11. SYMPORTERS: A symporter one ion across
the plasma membrane in the same direction
by using the electrochemical gradient of
another ion. Example: Ca channels.
ANTIPORTER: Antiporters use
electrochemical gradient of one ion to drive
another ion across the membrane in the
opposite direction.

13.  Stimulation: Generally drugs which are actually
foreign substance are unable to stimulate enzymes.
Stimulation of enzyme relates to endogenous
several mediators and modulators in nature.
 Inhibition: A common mode of action of drugs is by
inhibition of enzymes.Enzyme inhibition may be
classified as
 Non-specific inhibition: Denaturation of protein is
adequately carried out by drugs. Drugs can cause
an inhibition of enzyme with which it comes in
contact by altering its tertiary strcture.

14.  Specific inhibition: Many drugs possess the ability
of inhibiting a specific enzyme in such a manner
that the other enzyme involved in that particular
Pathway are not affected at all.
 Competitive: The drug competes with the normal
substance or the coenzymes.
 Non-competitive: Inhibitors that do not react with
the catalytic site instead react with an adjacent site,
is termed as non-competitive inhibitors.

17. THANK YOU