Alexander Fleming discovered penicillin in 1928 almost by accident. Upon returning from vacation, Fleming noticed a mold growing in one of his culture plates that contained staphylococci bacteria. He observed a clear zone around the mold where no bacteria was growing, indicating that the mold was secreting a substance that was killing the bacteria. The mold was later identified as penicillium mold. This was a seminal discovery as it showed that microbes could be used to kill other microbes. However, it took over a decade for penicillin to be mass produced and used widely to treat bacterial infections during World War II, saving many lives. While penicillin revolutionized medicine, drug resistance has since emerged as a major challenge.