SlideShare a Scribd company logo
By- SWIKRITI
JAIN
Roll No.- 87
Guide- Dr.
Gaurav kapil
sir
ALEXANDER FLEMING &
DISCOVERY OF
PENICILLIN
 Prior to the discovery of penicillin patients often died from
trivial injuries or infections.
 Physicians had little ability to help patients suffering from
infections.
 Physicians could only watch and wait hoping a patient’s
immune system could topple an infection or not.
PRIOR TO PENICILLIN
Discovery of Lysozyme
 In 1922 Fleming described
lysozyme when he noted that
lysozyme-containing material
would interfere with the growth of
bacterial cultures
 Fleming found that a culture of his
own nasal mucous inhibited the
growth of staph cultured from that
same mucous
 Fleming’s background with
lysozyme research prepared him
for his next major discovery
STORY BEGINS
 Fleming had a very disorganized lab.
 In 1928 after returning to his lab
following a two week vacation, Fleming
encountered the place in its usual
disarray.
 Fleming had inoculated a number of
petri dishes with staphylococci prior to
leaving on vacation.
 He hadn’t placed them in an incubator
because he knew that the staph would
sufficiently multiply over the long
vacation.
 Little did he know that penicillium mold
grows well at room temperature.
DISORGANIZATION LEADS TO DISCOVERY
 Fleming returned to his lab to find many of
his culture plates contaminated with
fungus.
 He immediately started preparing to clean
all his plates but it happened that a former
member of his lab was visiting that day.
 Fleming took some of the contaminated
cultures to show his visitor and that’s when
he noticed the inhibition zone around the
fungus.
 Fleming was not very knowledgeable about
fungi but knew that the mold in his dish
was a species of penicillium.
 Which eventually determined to be
Penicillium notatum.
FLEMING’S OBSERVATION
 Fleming’s observation was made under
some accidental circumstances but
clearly made sense in light of Fleming’s
research background
 Fleming had the sophistication to realize
that anti-bacterial agents existed – this
view was really fueled by his background
in lysozyme research
 In 1929 Fleming published a paper
detailing his discovery
 This was also a crucial moment because
his ideas reached a large audience
ACCIDENTAL?
 Penicillin Production began in Britain on a small scale in 1941
 During WWI the death rate from pneumonia in the US Army totaled
18% but during WWII the death rate fell to
less than 1% , all credit goes to penicillin.
MASS PRODUCTION
 Although the discovery of penicillin is arguably one the
greatest discoveries of humankind, penicillin resistance poses
an enormous problem today.
DRUG RESISTANCE
THANK YOU

More Related Content

Similar to Pharma ppt

Project Antibiotics(by:harkiran)
Project Antibiotics(by:harkiran)Project Antibiotics(by:harkiran)
Project Antibiotics(by:harkiran)
guest08f61f
 
Penicillin
PenicillinPenicillin
Penicillin
priya_d
 
Pptinglese
PptinglesePptinglese
Pptinglese
lorebad
 
Pptinglese
PptinglesePptinglese
Pptinglese
lorebad
 
Alexander Fleming
Alexander FlemingAlexander Fleming
Alexander Fleming
SvetlanaHambardzumyan
 
Alexander fleming
Alexander flemingAlexander fleming
Alexander fleming
evelynarias02
 
Running head ALEXANDER FLEMING7ALEXANDER FLEMINGALEXAND.docx
Running head ALEXANDER FLEMING7ALEXANDER FLEMINGALEXAND.docxRunning head ALEXANDER FLEMING7ALEXANDER FLEMINGALEXAND.docx
Running head ALEXANDER FLEMING7ALEXANDER FLEMINGALEXAND.docx
joellemurphey
 
Presentation1 Penicillin
Presentation1 PenicillinPresentation1 Penicillin
Presentation1 Penicillin
angela evans sproat
 
Antibiotics
AntibioticsAntibiotics
Antibiotics
Cindy Clark
 
Sir Alexander Fleming
Sir Alexander FlemingSir Alexander Fleming
Sir Alexander Fleming
11jonesbrit
 
CfE2-S-74-Alexander-Fleming-PowerPoint-English_ver_2.ppt
CfE2-S-74-Alexander-Fleming-PowerPoint-English_ver_2.pptCfE2-S-74-Alexander-Fleming-PowerPoint-English_ver_2.ppt
CfE2-S-74-Alexander-Fleming-PowerPoint-English_ver_2.ppt
kapr2
 
antimicrobial.pdf notes pdf for biotechonlogy
antimicrobial.pdf  notes pdf for biotechonlogyantimicrobial.pdf  notes pdf for biotechonlogy
antimicrobial.pdf notes pdf for biotechonlogy
MianIqbal7
 
History of Bacteria
History of BacteriaHistory of Bacteria
History of Bacteria
Pharmacy Universe
 
Jigsaw reading
Jigsaw readingJigsaw reading
Jigsaw reading
Maria José Ballestero
 
Ppt alexander fleming
Ppt alexander flemingPpt alexander fleming
Ppt alexander fleming
Dennise Cruz
 
Florey brochure
Florey brochureFlorey brochure
Florey brochure
VanessaChen40
 
Sir alexander fleming
Sir alexander flemingSir alexander fleming
Sir alexander fleming
GaryKuekyDoo
 
Penicillin
Penicillin Penicillin
Physicians that changed our world
Physicians that changed our worldPhysicians that changed our world
Physicians that changed our world
lolaceituno
 
Alexander fleming
Alexander flemingAlexander fleming
Alexander fleming
Lesya Hurchyna
 

Similar to Pharma ppt (20)

Project Antibiotics(by:harkiran)
Project Antibiotics(by:harkiran)Project Antibiotics(by:harkiran)
Project Antibiotics(by:harkiran)
 
Penicillin
PenicillinPenicillin
Penicillin
 
Pptinglese
PptinglesePptinglese
Pptinglese
 
Pptinglese
PptinglesePptinglese
Pptinglese
 
Alexander Fleming
Alexander FlemingAlexander Fleming
Alexander Fleming
 
Alexander fleming
Alexander flemingAlexander fleming
Alexander fleming
 
Running head ALEXANDER FLEMING7ALEXANDER FLEMINGALEXAND.docx
Running head ALEXANDER FLEMING7ALEXANDER FLEMINGALEXAND.docxRunning head ALEXANDER FLEMING7ALEXANDER FLEMINGALEXAND.docx
Running head ALEXANDER FLEMING7ALEXANDER FLEMINGALEXAND.docx
 
Presentation1 Penicillin
Presentation1 PenicillinPresentation1 Penicillin
Presentation1 Penicillin
 
Antibiotics
AntibioticsAntibiotics
Antibiotics
 
Sir Alexander Fleming
Sir Alexander FlemingSir Alexander Fleming
Sir Alexander Fleming
 
CfE2-S-74-Alexander-Fleming-PowerPoint-English_ver_2.ppt
CfE2-S-74-Alexander-Fleming-PowerPoint-English_ver_2.pptCfE2-S-74-Alexander-Fleming-PowerPoint-English_ver_2.ppt
CfE2-S-74-Alexander-Fleming-PowerPoint-English_ver_2.ppt
 
antimicrobial.pdf notes pdf for biotechonlogy
antimicrobial.pdf  notes pdf for biotechonlogyantimicrobial.pdf  notes pdf for biotechonlogy
antimicrobial.pdf notes pdf for biotechonlogy
 
History of Bacteria
History of BacteriaHistory of Bacteria
History of Bacteria
 
Jigsaw reading
Jigsaw readingJigsaw reading
Jigsaw reading
 
Ppt alexander fleming
Ppt alexander flemingPpt alexander fleming
Ppt alexander fleming
 
Florey brochure
Florey brochureFlorey brochure
Florey brochure
 
Sir alexander fleming
Sir alexander flemingSir alexander fleming
Sir alexander fleming
 
Penicillin
Penicillin Penicillin
Penicillin
 
Physicians that changed our world
Physicians that changed our worldPhysicians that changed our world
Physicians that changed our world
 
Alexander fleming
Alexander flemingAlexander fleming
Alexander fleming
 

Recently uploaded

Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdfOsteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
Jim Jacob Roy
 
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
FFragrant
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
Holistified Wellness
 
pathology MCQS introduction to pathology general pathology
pathology MCQS introduction to pathology general pathologypathology MCQS introduction to pathology general pathology
pathology MCQS introduction to pathology general pathology
ZayedKhan38
 
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptxshare - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
Tina Purnat
 
The Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of RespirationThe Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of Respiration
MedicoseAcademics
 
How to choose the best dermatologists in Indore.
How to choose the best dermatologists in Indore.How to choose the best dermatologists in Indore.
How to choose the best dermatologists in Indore.
Gokuldas Hospital
 
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
rishi2789
 
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdfMedical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Jim Jacob Roy
 
CLEAR ALIGNER THERAPY IN ORTHODONTICS .pptx
CLEAR ALIGNER THERAPY IN ORTHODONTICS .pptxCLEAR ALIGNER THERAPY IN ORTHODONTICS .pptx
CLEAR ALIGNER THERAPY IN ORTHODONTICS .pptx
Government Dental College & Hospital Srinagar
 
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
rishi2789
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
Dr. Jyothirmai Paindla
 
Pharmacology of 5-hydroxytryptamine and Antagonist
Pharmacology of 5-hydroxytryptamine and AntagonistPharmacology of 5-hydroxytryptamine and Antagonist
Pharmacology of 5-hydroxytryptamine and Antagonist
Dr. Nikhilkumar Sakle
 
DECLARATION OF HELSINKI - History and principles
DECLARATION OF HELSINKI - History and principlesDECLARATION OF HELSINKI - History and principles
DECLARATION OF HELSINKI - History and principles
anaghabharat01
 
Cosmetology and Trichology Courses at Kosmoderma Academy PRP (Hair), DR Growt...
Cosmetology and Trichology Courses at Kosmoderma Academy PRP (Hair), DR Growt...Cosmetology and Trichology Courses at Kosmoderma Academy PRP (Hair), DR Growt...
Cosmetology and Trichology Courses at Kosmoderma Academy PRP (Hair), DR Growt...
Kosmoderma Academy Of Aesthetic Medicine
 
Outbreak management including quarantine, isolation, contact.pptx
Outbreak management including quarantine, isolation, contact.pptxOutbreak management including quarantine, isolation, contact.pptx
Outbreak management including quarantine, isolation, contact.pptx
Pratik328635
 
Cell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune DiseaseCell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune Disease
Health Advances
 
NARCOTICS- POLICY AND PROCEDURES FOR ITS USE
NARCOTICS- POLICY AND PROCEDURES FOR ITS USENARCOTICS- POLICY AND PROCEDURES FOR ITS USE
NARCOTICS- POLICY AND PROCEDURES FOR ITS USE
Dr. Ahana Haroon
 
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
19various
 

Recently uploaded (20)

Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdfOsteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
 
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
Demystifying Fallopian Tube Blockage- Grading the Differences and Implication...
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
 
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
 
pathology MCQS introduction to pathology general pathology
pathology MCQS introduction to pathology general pathologypathology MCQS introduction to pathology general pathology
pathology MCQS introduction to pathology general pathology
 
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptxshare - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
 
The Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of RespirationThe Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of Respiration
 
How to choose the best dermatologists in Indore.
How to choose the best dermatologists in Indore.How to choose the best dermatologists in Indore.
How to choose the best dermatologists in Indore.
 
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
 
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdfMedical Quiz ( Online Quiz for API Meet 2024 ).pdf
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
 
CLEAR ALIGNER THERAPY IN ORTHODONTICS .pptx
CLEAR ALIGNER THERAPY IN ORTHODONTICS .pptxCLEAR ALIGNER THERAPY IN ORTHODONTICS .pptx
CLEAR ALIGNER THERAPY IN ORTHODONTICS .pptx
 
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
 
Efficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in AyurvedaEfficacy of Avartana Sneha in Ayurveda
Efficacy of Avartana Sneha in Ayurveda
 
Pharmacology of 5-hydroxytryptamine and Antagonist
Pharmacology of 5-hydroxytryptamine and AntagonistPharmacology of 5-hydroxytryptamine and Antagonist
Pharmacology of 5-hydroxytryptamine and Antagonist
 
DECLARATION OF HELSINKI - History and principles
DECLARATION OF HELSINKI - History and principlesDECLARATION OF HELSINKI - History and principles
DECLARATION OF HELSINKI - History and principles
 
Cosmetology and Trichology Courses at Kosmoderma Academy PRP (Hair), DR Growt...
Cosmetology and Trichology Courses at Kosmoderma Academy PRP (Hair), DR Growt...Cosmetology and Trichology Courses at Kosmoderma Academy PRP (Hair), DR Growt...
Cosmetology and Trichology Courses at Kosmoderma Academy PRP (Hair), DR Growt...
 
Outbreak management including quarantine, isolation, contact.pptx
Outbreak management including quarantine, isolation, contact.pptxOutbreak management including quarantine, isolation, contact.pptx
Outbreak management including quarantine, isolation, contact.pptx
 
Cell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune DiseaseCell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune Disease
 
NARCOTICS- POLICY AND PROCEDURES FOR ITS USE
NARCOTICS- POLICY AND PROCEDURES FOR ITS USENARCOTICS- POLICY AND PROCEDURES FOR ITS USE
NARCOTICS- POLICY AND PROCEDURES FOR ITS USE
 
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
 

Pharma ppt

  • 1. By- SWIKRITI JAIN Roll No.- 87 Guide- Dr. Gaurav kapil sir ALEXANDER FLEMING & DISCOVERY OF PENICILLIN
  • 2.  Prior to the discovery of penicillin patients often died from trivial injuries or infections.  Physicians had little ability to help patients suffering from infections.  Physicians could only watch and wait hoping a patient’s immune system could topple an infection or not. PRIOR TO PENICILLIN
  • 3. Discovery of Lysozyme  In 1922 Fleming described lysozyme when he noted that lysozyme-containing material would interfere with the growth of bacterial cultures  Fleming found that a culture of his own nasal mucous inhibited the growth of staph cultured from that same mucous  Fleming’s background with lysozyme research prepared him for his next major discovery STORY BEGINS
  • 4.  Fleming had a very disorganized lab.  In 1928 after returning to his lab following a two week vacation, Fleming encountered the place in its usual disarray.  Fleming had inoculated a number of petri dishes with staphylococci prior to leaving on vacation.  He hadn’t placed them in an incubator because he knew that the staph would sufficiently multiply over the long vacation.  Little did he know that penicillium mold grows well at room temperature. DISORGANIZATION LEADS TO DISCOVERY
  • 5.  Fleming returned to his lab to find many of his culture plates contaminated with fungus.  He immediately started preparing to clean all his plates but it happened that a former member of his lab was visiting that day.  Fleming took some of the contaminated cultures to show his visitor and that’s when he noticed the inhibition zone around the fungus.  Fleming was not very knowledgeable about fungi but knew that the mold in his dish was a species of penicillium.  Which eventually determined to be Penicillium notatum. FLEMING’S OBSERVATION
  • 6.  Fleming’s observation was made under some accidental circumstances but clearly made sense in light of Fleming’s research background  Fleming had the sophistication to realize that anti-bacterial agents existed – this view was really fueled by his background in lysozyme research  In 1929 Fleming published a paper detailing his discovery  This was also a crucial moment because his ideas reached a large audience ACCIDENTAL?
  • 7.  Penicillin Production began in Britain on a small scale in 1941  During WWI the death rate from pneumonia in the US Army totaled 18% but during WWII the death rate fell to less than 1% , all credit goes to penicillin. MASS PRODUCTION
  • 8.  Although the discovery of penicillin is arguably one the greatest discoveries of humankind, penicillin resistance poses an enormous problem today. DRUG RESISTANCE