Pharmacology for nursing semenar

1. Kurdistan Regional Government _ Iraq
Shekhan Technical College and Institute
Department of Nursing
Grade : 2"
Stage 2nd Semester
Seminar about
(Quinapyramine )
Preapared by
 Samira Muhammad
 Zina Sleman
 Zhiyan Abdulrazaq
2023-2024

2. Description
 Quinapyramine is a
pharmaceutical compound used
as an antiprotozoal agent,
primarily known for its potent
antimalarial properties and
potential effectiveness in treating
specific parasitic infections.

3. Mechanism of action
• Protozoa Targeting
Quinapyramine exerts its effect by selectively
targeting the mitochondria of protozoa,
disrupting crucial metabolic pathways essential
for their survival.
• Antimalarial Activity
It effectively hinders the growth and replication
of malarial parasites, thereby providing relief to
afflicted individuals.
• Action Against Parasites
Its mode of action extends to a broad spectrum
of parasitic organisms, making it a versatile
intervention in medical practice.

4. Side effect
• Gastrointestinal disturbances
Upset Stomach
Diarrhea
• Dizziness.
The side effects of
quinapyramine in animals can
indeed include

5. • antrycide.
• quinapyramine chloride.
• quinapyramine dimesylate.
• quinapyramine dimethyl
sulfate.
• quinapyramine disulfate.
• quinpyramine sulfate
Types of quinapyramine

6. Route of administration
quinapyramine
 Quinapyramine sulphate is
considered a drug of choice for
the treatment of trypanosomiasis
in domestic animals. Currently, it
is available in the form of powder
for reconstitution for the
administration

7. Pharmacokinetics
• Absorption
Upon oral administration, quinapyramine is
rapidly absorbed from the gastrointestinal tract,
with peak plasma concentrations achieved
within several hours.
• Distribution
It exhibits extensive tissue distribution, with
substantial concentrations observed in critical
sites of protozoal infection.
• Metabolism and Excretion
The compound undergoes hepatic metabolism
and is primarily excreted via the urinary
system, with a small fraction eliminated
through feces.

8. Indications
 Treatment of trypanosomiasis in camels,
cattle, cats, dogs, goats, horses, sheep
and swine.
Contra indications
 Hypersensitivity to quinapyramine.
Administation to animals with an impaired
renal and / or hepatic function.

9. Withdrawal times
 - For meat : 21 days.
 - For milk : 4 days.
Packaging
 Sachet of 3 g.

10. Storage of Quinapyramine Sulphate /
Quinapyramine Chloride
 Store medicines at room temperature, away from
heat and direct light.
 Do not freeze medicines unless required by
package insert.
 Keep medicines away from children and pets.
 Do not flush medications down the toilet or pour
them into drainage unless instructed to do so.
 Medication discarded in this manner may
contaminate the environment.
 Please consult your pharmacist or doctor for
more details on how to safely
discard Quinapyramine Sulphate /
Quinapyramine Chloride.

11. Reference
 https://www.interchemie.com/veterinary-
medicines/interquin.html
 Ndoutamia G, Moloo SK, Murphy NB, Peregrine AS.
Derivation and characterization of a quinapyramine-
resistant clone of Trypanosoma congolense. Antimicrobial
agents and chemotherapy. 1993 May;37(5):1163-6.
 Seebeck T, Sterk GJ, Ke H. Phosphodiesterase inhibitors
as a new generation of antiprotozoan drugs: exploiting
the benefit of enzymes that are highly conserved between
host and parasite. Future medicinal chemistry. 2011
Aug;3(10):1289-306.
 Seebeck, Thomas, Geert Jan Sterk, and Hengming Ke.
"Phosphodiesterase inhibitors as a new generation of
antiprotozoan drugs: exploiting the benefit of enzymes
that are highly conserved between host and parasite."
Future medicinal chemistry 3.10 (2011): 1289-1306.