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First Quarter 2008
Earnings Teleconference




             April 17, 2008
First Quarter 2008
               Earnings Teleconference


Introduction




                                        Amal Naj

                             Senior Vice President,
               WW Investor Development & Strategy
Forward-Looking Statements and
Non-GAAP Financial Information

  Our discussions during this conference call will include forward-
  looking statements. Actual results could differ materially from
  those projected in the forward-looking statements. The factors
  that could cause actual results to differ are discussed in Pfizer’s
  2007 Annual Report on Form 10-K and in our reports on Form
  10-Q and Form 8-K.

  Also, the discussions during this conference call will include
  certain financial measures that were not prepared in accordance
  with generally accepted accounting principles. Reconciliations of
  those non-GAAP financial measures to the most directly
  comparable GAAP financial measures can be found in Pfizer’s
  Current Report on Form 8-K dated April 17, 2008.

  These reports are available on our website at www.pfizer.com in
  the quot;Investors—SEC Filingsquot; section.


                                                                        3
First Quarter 2008
           Earnings Teleconference


Opening Remarks




                                 Jeff Kindler

             Chairman & Chief Executive Officer
First Quarter 2008
            Earnings Teleconference


Financial Review




                          Frank D’Amelio

                     Senior Vice President &
                      Chief Financial Officer
First-Quarter 2008

Income Statement Highlights
($ Millions, Except Per-Share Amounts)


                                                                                  First Quarter

                                                                 2008                   2007                  Change

 Reported Revenues                                             $11,848                $12,474                   (5%)

 Reported Net Income                                              2,784                  3,392                (18%)

 Reported Diluted EPS                                               0.41                   0.48               (15%)

                                                                  4,099                  4,804                (15%)
 Adjusted Income(1)

 Adjusted Diluted EPS(1)                                            0.61                   0.68               (10%)


                        Decline in Results Primarily Driven by
                     Norvasc and Zyrtec Loss of Exclusivity (LOE)
(1) Adjusted Income and its components and Adjusted Diluted EPS are defined as Reported Net Income and its components and
    Reported Diluted EPS, excluding Purchase Accounting Adjustments, Acquisition-Related Costs, Discontinued Operations and
    Certain Significant Items. Adjusted total costs represents primarily the total of Adjusted Cost of Sales, Adjusted SI&A
    expenses and Adjusted R&D expenses.
                                                                                                                              6
First-Quarter 2008

Certain Significant Items
($ Millions, on a Pre-Tax Basis)


                                               First Quarter

                                        2008                   2007

  Restructuring Charges                 $177                   $795

  Implementation Costs                  357                    174

  Cost-Reduction Initiatives           $534                $969

  Other                                   7                     10

  Total Certain Significant Items      $541                $979




 Lower Expenses Related to Our Total Cost-Reduction Initiatives,
    Primarily Our Site and U.S. Sales Force Rationalizations


                                                                      7
First-Quarter 2008

Quarterly Adjusted Income(1) Components
($ Millions, Except per-Share Amounts)


                                                   First Quarter

                                           2008       2007         Change

     Revenues(1)                         $11,796    $12,431         (5%)

     Cost of Sales(1)                      1,800      1,744         3%

     SI&A Expenses(1)                      3,409      3,313         3%

     R&D Expenses(1)                       1,638      1,628         1%

     Provision for Income Taxes(1)         1,150      1,331        (14%)

     Adjusted Income(1)                  $4,099     $4,804         (15%)

     Adjusted Diluted EPS(1)              $0.61       $0.68        (10%)

      Adjusted Diluted EPS(1) Decline Primarily Related to Norvasc
       and Zyrtec LOE, Partially Offset by Foreign Exchange and
                      Continued Cost Reductions
(1) See Slide 6 for definition.
                                                                            8
First-Quarter 2008

Quarterly Select Product Highlights
($ Millions)

                                            Worldwide                              U.S.             International
                                          2008    Change                 2008             Change   2008      Change
      In-LineProducts(1)
       Lipitor                           $3,137           (7%)           $1,751           (18%)    $1,386    13%
       Viagra                               460            6%               223            (1%)       237    13%
       Celebrex                             611            2%               464            (2%)       147    20%
       Lyrica                               582           47%               351            45%        231    51%
       Xalatan/Xalacom                      405           13%               135             7%        270    16%
       Detrol/Detrol LA                     313            3%               222              -         91    13%
       Geodon/Zeldox                        241           12%               200            10%         41    21%
      New Products(2)
       Chantix/Champix                      277           71%               193            33%        84    392%
       Sutent                               190           86%                66            25%       124    150%
      LOE Products(3)
       Norvasc                              513          (52%)               (5)          (101%)     518     (7%)
       Zyrtec/Zyrtec D                      117          (75%)              117            (75%)       –       –
       Camptosar                            192          (16%)               83            (36%)     109     10%



              New and In-Line Products Continue to Perform Well

    Represents revenues for major pharmaceutical products not included in (2) and (3).
(1)
    Represents revenues for pharmaceutical products launched in the U.S. since 1/1/06.
(2)
(3) Represents revenues for pharmaceutical products that lost U.S. exclusivity in 2007 and 2008.
                                                                                                                      9
First-Quarter 2008

2008 Financial Guidance

                                                                                        Guidance(3)

           Revenues                                                                 $47.0 to $49.0 Billion

                                                                        Decrease of at least $1.5–$2 Billion versus
           Adjusted Total Costs(1)
                                                                          2006 on a constant currency basis (2)

           Adjusted Cost of Sales(1) as a
                                                                                       14.5% to 15.5%
           Percentage of Revenue
           Adjusted R&D Expenses(1)                                                  $7.3 to $7.6 Billion

           Adjusted SI&A Expenses(1)                                                $14.4 to $14.9 Billion

           Reported Diluted EPS(5)                                                      $1.73 to $1.88

           Adjusted Diluted EPS(1)                                                      $2.35 to $2.45

           Effective Tax Rate(4)                                                       22.0% to 22.5%

           Cash Flows from Operations                                               $17.0 to $18.0 Billion



                                Reaffirming 2008 Financial Guidance
      See Slide 6 for definition. (2) At 2006 Exchange Rates. (3) Except as noted, at April 2008 Exchange Rates.
(1)
      On Adjusted Income.(1) (5) Excludes effects of business development transactions not completed as of March 30, 2008.
(4)

                                                                                                                             10
First-Quarter 2008

Key Takeaways

             Reaffirmed 2008 guidance
             New products(1) continue to perform well – particularly
             Chantix and Sutent
             Steady growth from several in-line products(2) – including
             Lyrica, Geodon, Viagra and Xalatan
             As anticipated, year-over-year results were negatively
             impacted by Norvasc, Zyrtec and, to a much lesser extent,
             Camptosar
             Continuing to execute on our plan to reduce costs
               – Absolute cost reduction of $1.5 to $2.0 billion vs. 2006
               – Savings will continue in 2008


      See Slide 9 for definition.         See Slide 9 for definition.
(1)                                 (2)

                                                                            11
First Quarter 2008
              Earnings Teleconference


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Pfizer Quarterly Corporate Performance - First Quarter 2008

  • 1. First Quarter 2008 Earnings Teleconference April 17, 2008
  • 2. First Quarter 2008 Earnings Teleconference Introduction Amal Naj Senior Vice President, WW Investor Development & Strategy
  • 3. Forward-Looking Statements and Non-GAAP Financial Information Our discussions during this conference call will include forward- looking statements. Actual results could differ materially from those projected in the forward-looking statements. The factors that could cause actual results to differ are discussed in Pfizer’s 2007 Annual Report on Form 10-K and in our reports on Form 10-Q and Form 8-K. Also, the discussions during this conference call will include certain financial measures that were not prepared in accordance with generally accepted accounting principles. Reconciliations of those non-GAAP financial measures to the most directly comparable GAAP financial measures can be found in Pfizer’s Current Report on Form 8-K dated April 17, 2008. These reports are available on our website at www.pfizer.com in the quot;Investors—SEC Filingsquot; section. 3
  • 4. First Quarter 2008 Earnings Teleconference Opening Remarks Jeff Kindler Chairman & Chief Executive Officer
  • 5. First Quarter 2008 Earnings Teleconference Financial Review Frank D’Amelio Senior Vice President & Chief Financial Officer
  • 6. First-Quarter 2008 Income Statement Highlights ($ Millions, Except Per-Share Amounts) First Quarter 2008 2007 Change Reported Revenues $11,848 $12,474 (5%) Reported Net Income 2,784 3,392 (18%) Reported Diluted EPS 0.41 0.48 (15%) 4,099 4,804 (15%) Adjusted Income(1) Adjusted Diluted EPS(1) 0.61 0.68 (10%) Decline in Results Primarily Driven by Norvasc and Zyrtec Loss of Exclusivity (LOE) (1) Adjusted Income and its components and Adjusted Diluted EPS are defined as Reported Net Income and its components and Reported Diluted EPS, excluding Purchase Accounting Adjustments, Acquisition-Related Costs, Discontinued Operations and Certain Significant Items. Adjusted total costs represents primarily the total of Adjusted Cost of Sales, Adjusted SI&A expenses and Adjusted R&D expenses. 6
  • 7. First-Quarter 2008 Certain Significant Items ($ Millions, on a Pre-Tax Basis) First Quarter 2008 2007 Restructuring Charges $177 $795 Implementation Costs 357 174 Cost-Reduction Initiatives $534 $969 Other 7 10 Total Certain Significant Items $541 $979 Lower Expenses Related to Our Total Cost-Reduction Initiatives, Primarily Our Site and U.S. Sales Force Rationalizations 7
  • 8. First-Quarter 2008 Quarterly Adjusted Income(1) Components ($ Millions, Except per-Share Amounts) First Quarter 2008 2007 Change Revenues(1) $11,796 $12,431 (5%) Cost of Sales(1) 1,800 1,744 3% SI&A Expenses(1) 3,409 3,313 3% R&D Expenses(1) 1,638 1,628 1% Provision for Income Taxes(1) 1,150 1,331 (14%) Adjusted Income(1) $4,099 $4,804 (15%) Adjusted Diluted EPS(1) $0.61 $0.68 (10%) Adjusted Diluted EPS(1) Decline Primarily Related to Norvasc and Zyrtec LOE, Partially Offset by Foreign Exchange and Continued Cost Reductions (1) See Slide 6 for definition. 8
  • 9. First-Quarter 2008 Quarterly Select Product Highlights ($ Millions) Worldwide U.S. International 2008 Change 2008 Change 2008 Change In-LineProducts(1) Lipitor $3,137 (7%) $1,751 (18%) $1,386 13% Viagra 460 6% 223 (1%) 237 13% Celebrex 611 2% 464 (2%) 147 20% Lyrica 582 47% 351 45% 231 51% Xalatan/Xalacom 405 13% 135 7% 270 16% Detrol/Detrol LA 313 3% 222 - 91 13% Geodon/Zeldox 241 12% 200 10% 41 21% New Products(2) Chantix/Champix 277 71% 193 33% 84 392% Sutent 190 86% 66 25% 124 150% LOE Products(3) Norvasc 513 (52%) (5) (101%) 518 (7%) Zyrtec/Zyrtec D 117 (75%) 117 (75%) – – Camptosar 192 (16%) 83 (36%) 109 10% New and In-Line Products Continue to Perform Well Represents revenues for major pharmaceutical products not included in (2) and (3). (1) Represents revenues for pharmaceutical products launched in the U.S. since 1/1/06. (2) (3) Represents revenues for pharmaceutical products that lost U.S. exclusivity in 2007 and 2008. 9
  • 10. First-Quarter 2008 2008 Financial Guidance Guidance(3) Revenues $47.0 to $49.0 Billion Decrease of at least $1.5–$2 Billion versus Adjusted Total Costs(1) 2006 on a constant currency basis (2) Adjusted Cost of Sales(1) as a 14.5% to 15.5% Percentage of Revenue Adjusted R&D Expenses(1) $7.3 to $7.6 Billion Adjusted SI&A Expenses(1) $14.4 to $14.9 Billion Reported Diluted EPS(5) $1.73 to $1.88 Adjusted Diluted EPS(1) $2.35 to $2.45 Effective Tax Rate(4) 22.0% to 22.5% Cash Flows from Operations $17.0 to $18.0 Billion Reaffirming 2008 Financial Guidance See Slide 6 for definition. (2) At 2006 Exchange Rates. (3) Except as noted, at April 2008 Exchange Rates. (1) On Adjusted Income.(1) (5) Excludes effects of business development transactions not completed as of March 30, 2008. (4) 10
  • 11. First-Quarter 2008 Key Takeaways Reaffirmed 2008 guidance New products(1) continue to perform well – particularly Chantix and Sutent Steady growth from several in-line products(2) – including Lyrica, Geodon, Viagra and Xalatan As anticipated, year-over-year results were negatively impacted by Norvasc, Zyrtec and, to a much lesser extent, Camptosar Continuing to execute on our plan to reduce costs – Absolute cost reduction of $1.5 to $2.0 billion vs. 2006 – Savings will continue in 2008 See Slide 9 for definition. See Slide 9 for definition. (1) (2) 11
  • 12. First Quarter 2008 Earnings Teleconference Q&A Session