Tools for personalised medicine in clinical trials. The implementation of clinical trials in personalized medicine is a different way of doing clinical research, compared to the standard way of large clinical trials aiming for statistical significance. Personalized medicine uses a medical model that separates people into different groups with medical decisions, practices, drugs, interventions being tailored to the individual patient based on their predicted response. Basis for this approach is the progress of the study of the human genome and its variation over the last two decades. Especially advancements in automated DNA sequencing, PCR technologies and the use of expressed sequence tags (ESTs), cDNAs, antisense molecules, small interfering RNAs (siRNAs). But the adoption of personalized medicine requires an active and flexible and highly integrated infrastructure, which must allow the joining of many different competences and technologies. We asked the question: can the tools developed for personalized medicine in the p-pedicine project be employed effectively in a clinical trials network to support personalised clinical trials? We conducted an analysis of tool integration and the evaluation of tool usage requirements. Based on the survey results, the tendency for the clinical trial network ECRIN is to use software as a service in the form of SaaS or ASP. ECRIN data centres will (probably) not install and employ p-medicine tools in one of their data centres. A robust business model for the provision of services and the implementation and employment of tools does not yet exist. How can the personalized medicine infrastructure p-medicine and the clinical trials network ECRIN gain from each other to allow the conduct of personalized clinical trials? We suggest a business model, in which personalized medicine infrastructures and clinical trials networks exchange their services to gain jointly from each other. An integration of networks by reciprocal exchange of services may be the solution. Not only software as a service will be exchanged, but also knowledge, personnel and staff trainings.