This document analyzes factors that contribute to differences in per capita income between U.S. states using Indiana as a case study. It finds that Indiana's per capita income ranking has declined from 21st in 1950 to 40th currently, diverging from the national average. While standards of living have doubled in Indiana over 50 years, growth has lagged the national rate. The document examines components of personal income for Indiana over time and identifies socioeconomic factors, human capital levels, inequality, and migration as influences on income differences worth further policy consideration to potentially impact long-term economic development.