Radionuclide therapy of bone metastases and non-Hodgkin’s lymphoma (radioimmu...Herbert Klein
This interactive PowerPoint, suitable for Keynote presentation software, covers types of radionuclide therapy other than I-131 for thyroid cancer. This includes alpha- and beta-ray emitters, several agents for bone metastasis and radioimmunotherapy using radioactive monoclonal antibodies to treat non-Hodgkin's lymphoma.
Radionuclide therapy of bone metastases and non-Hodgkin’s lymphoma (radioimmu...Herbert Klein
This interactive PowerPoint, suitable for Keynote presentation software, covers types of radionuclide therapy other than I-131 for thyroid cancer. This includes alpha- and beta-ray emitters, several agents for bone metastasis and radioimmunotherapy using radioactive monoclonal antibodies to treat non-Hodgkin's lymphoma.
A refresher course on imaging in peripheral arterial disease (PAD). The session also includes talk on clinical exam in PAD, MRA in PAD and interventional radiology treatment of PAD.
CT and MRI of Aortic Valve Disease: Clinical Update Sam Watermeier
This article from Current Radiology Reports explores new improvements in CT and MR imaging techniques, which yield valuable information for patients with a variety of aortic valve and root pathology.
Review course covering high resolution imaging of the arteries of the abdomen, pelvis, and legs. This new CT technique replaces the need for catheterization in most patients.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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100
200
300
400
0 8 16 24 32 40 48 56 64 72 80
0
2
4
6
8
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INPUT
intravenous
injection rate
(mL/s)
OUTPUT
arterial
enhancement
(ΔHU)
Phase I
(surge phase)
Phase II
(continuing phase)
Biphasic Injection for Peripheral CTA
0
100
200
300
400
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2
4
6
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Fleischmann D. Eur. J. Radiol. 2003 Mar 1;45 Suppl 1:S88–93.
1) Hittmair & Fleischmann, JCAT 2001
usually
unknown
weight Biphasic Injection
<55kg 20 mL (4.0mL/s) + 96 mL (3.2mL/s)
<65kg 23 mL (4.5mL/s) + 108 mL (3.6mL/s)
75kg 25 mL (5.0mL/s) + 120 mL (4.0mL/s)
>85kg 28 mL (5.5mL/s) + 132 mL (4.4mL/s)
>95kg 30 mL (6.0mL/s) + 144 mL (4.8mL/s)
5 sec FAST + 30 sec SLOWER
6.
weight Biphasic Injection
<55 kg 20 mL (4.0mL/s) + 96 mL (3.2mL/s)
555-95 kg 25 mL (5.0mL/s) + 120 mL (4.0mL/s)
>95 kg 30 mL (6.0mL/s) + 144 mL (4.8mL/s)
Gurm HS, et al. J Am Coll Cardiol 2011; 58:907-14
7.
** Low concentration CM (300 mgI-/mL)
Courtesy:D.Fleischmann,MD
Chapter 3: Contrast Medium Injection Technique. In: Schoepf and
Meinel, eds. Multidetector-Row CT of the Thorax (2016)
9. 1 Meyer BC Eur Radiol (2010) 20:497-505
2 Ouwendijk R. Radiology (2006) 241, 603-608
Itoga NK et al. J Vasc Surg 2017, 835-43.
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Met R et al. JAMA 2009;301:415-424
Napoli A. Radiology. 2011 Dec 1;261(3):976–86.
Schernthaner R, et al. AJR 2007; 189:1215-1222
11.
Fotiadis N, et al. Clinical Radiology 2011; 66: 945-52
Napoli A. Radiology. 2011 Dec 1;261(3):976–86.
12. Willmann JK, et al. Radiology 2003; 229: 465-474.
1 Li X, et al. Eur J Radiol 2010; 98-103
2 Strotzer, Invest. Radiol. 2001:36(11)