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This document discusses research into cardiovascular risk factors in women with polycystic ovary syndrome (PCOS). The study found that PCOS women have higher rates of subclinical atherosclerosis, as measured by increased carotid intima-media thickness (CAI), compared to age-matched controls, especially in women over 40. Regression analysis showed that age, BMI, diastolic blood pressure, and higher LDL cholesterol levels are predictors of increased CAI. Having PCOS status further increased CAI levels after accounting for these risk factors. The implications are that interventions to lower LDLc and control weight in younger PCOS women may help reduce their future cardiovascular disease risk.
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Polycystic Ovary Syndrome (PCOS) is a common cause of irregular periods and infertility in women of reproductive age, affecting 5-10% of women. It is associated with increased levels of androgens and insulin resistance. Women with PCOS have an increased risk of health issues like endometrial cancer, diabetes, cardiovascular disease, and metabolic syndrome. The syndrome is diagnosed based on symptoms of excess androgen levels and irregular periods in addition to the presence of cysts in the ovaries. Lifestyle changes like diet and exercise as well as medications that improve insulin sensitivity can help treat PCOS and its symptoms.
Ovary Hyperstimulation 1
Polycystic Ovary Syndrome (PCOS) is a common cause of irregular periods and infertility in women of reproductive age, affecting 5-10% of women. It is associated with increased levels of androgens and insulin resistance. Women with PCOS have an increased risk of health issues like endometrial cancer and cardiovascular disease. The syndrome was first described in 1935 and involves bilateral polycystic ovaries seen on imaging. Hyperinsulinism correlates with increased androgen levels in women with PCOS.
不孕症 超音波 6
Polycystic Ovary Syndrome (PCOS) is a common cause of irregular periods and infertility in women of reproductive age, affecting 5-10% of women. It is associated with increased levels of androgens and insulin resistance. Women with PCOS have an increased risk of health issues like endometrial cancer, diabetes, cardiovascular disease, and metabolic syndrome. Diagnosis involves evaluating symptoms, family history, ultrasound of ovaries, and hormone levels. Treatment focuses on lifestyle changes, oral contraceptives, and medications to improve insulin sensitivity and reduce androgen levels.
CVD Egypt Clinical Diabetes Reprint Summer 2010
This document summarizes a study on screening Egyptian patients for diabetes and cardiovascular risk factors. The study found:
- 22.9% of patients had diabetes, 30.7% had hypertension, 33.4% had dyslipidemia, and 43% were smokers.
- Cardiovascular risk factors were more prevalent in females (57.7%) and urban populations (72.2%).
- Obesity affected 29% of patients and was correlated with higher blood pressure. Family history of diabetes was associated with higher BMI, waist circumference, blood sugar, and triglycerides.
- The high prevalence of risk factors indicates a need for national prevention programs in Egypt targeting obesity, diabetes, hypertension
B0430913
This study evaluated the impact of diabetes mellitus and obesity on male infertility in Iraqi patients. It found that:
1) Serum levels of HbA1C, a marker of long-term blood sugar control, were higher in diabetic patients regardless of BMI compared to healthy controls. HbA1C was also higher in normo-BMI diabetic patients compared to obese diabetic patients.
2) Serum free testosterone levels, important for male fertility, were significantly lower in obese diabetic patients compared to overweight diabetic and healthy patients.
3) There was a significant negative correlation between serum free testosterone levels and HbA1C in obese diabetic patients, suggesting poorer blood sugar control is associated with lower testosterone.
finalthesis!
This document summarizes research on interventions for polycystic ovarian syndrome (PCOS) in non-obese women. It finds that metformin, clomiphene citrate, and oral contraceptives are effective first-line treatments. Metformin increases ovulation and menstrual regularity by decreasing insulin resistance and androgen production. Studies show metformin is more effective than clomiphene citrate at restoring fertility and reducing hyperandrogenism in non-obese women with PCOS. While clomiphene citrate acts faster, combining it with metformin increases its effectiveness. Baseline BMI, insulin resistance, and androgen levels can predict treatment success, with lower levels associated with ovulation.
Sitagliptina e proteção em ca diferenciado da tireóide.x
This document discusses whether anti-diabetic medications play a specific role in differentiated thyroid cancer compared to other cancer types. It reviews the prevalence of thyroid carcinoma in obese individuals, people with intermediate hyperglycemia, and diabetic patients compared to other cancers. It suggests that the over-expression of dipeptidyl peptidase IV (DPP-IV) in thyroid tumors, which is not seen in other cancer types, may be a potential reason for the unique relationship between thyroid cancer and diabetes.
Pcos lifecycle
This document summarizes a review article about the lifecycle of polycystic ovary syndrome (PCOS) from early life through menopause. It finds that:
1) Daughters of women with PCOS show signs of an increased follicle count and mild metabolic abnormalities from infancy, suggesting early genetic and environmental influences.
2) PCOS is often diagnosed in puberty with the onset of hyperandrogenism and menstrual irregularities.
3) During the reproductive years, features of PCOS such as androgen levels and ovarian volume decrease over time, though cardiovascular risks persist after menopause for women who had PCOS.
PCOS
This document discusses polycystic ovary syndrome (PCOS) in a 22-year-old woman presenting with irregular periods, weight gain, acne, and excess hair growth. PCOS is characterized by irregular periods, polycystic ovaries, and signs of excess androgens. It is associated with insulin resistance and increased risk of diabetes and heart disease. Treatment involves lifestyle changes, birth control pills to regulate periods and excess hair, and fertility medications like clomiphene to induce ovulation. Women with PCOS require screening for metabolic and endocrine conditions.
Pcos
This document discusses polycystic ovary syndrome (PCOS) in a 22-year-old woman presenting with irregular periods, weight gain, and signs of hyperandrogenism. PCOS is characterized by ovulatory dysfunction, hyperandrogenism, and polycystic ovaries. It increases the risk of metabolic syndrome, diabetes, and cardiovascular disease. Treatment involves lifestyle changes, oral contraceptives, clomiphene or letrozole for ovulation induction, and antiandrogens depending on the patient's symptoms and fertility goals. Screening for metabolic and endocrine abnormalities is also recommended.
Hrt journal club
The WISDOM trial studied the risks and benefits of hormone replacement therapy for postmenopausal women aged 50-69. It found that for women starting HRT an average of 15 years after menopause, combined estrogen and progestogen therapy significantly increased rates of cardiovascular events and venous thromboembolism. Estrogen-only therapy showed a non-significant trend towards similar increased risks. The results supported findings from the Women's Health Initiative that combined HRT should not be used for disease prevention in older postmenopausal women.
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Pcos 2
- 1. Coagulation / Fibrinolytic Factors in PCOS
- 3. Carotid IMT in PCOS Click for larger picture
- 4. Hemodynamic Measures in PCOS Click for larger picture
- 5. Correlation of Various Subclinical CHD Measures Click for larger picture
- 6. Interaction of PCOS and Age in IMT Click for larger picture
- 7. Lancet 1997; 350 (suppl I):15 Click for larger picture
- 8. Lancet 1997;350:21 Click for larger picture
- 14. Selected Clinical and Lifestyle Factors in PCOS Cases and Controls- Preliminary Data VARIABLES (1993-94 Data) CASES (n=46) CONTROLS (n=59) * p .05 ** p .001
- 15. Selected Lipid and Hormone Levels in PCOS Cases and Controls- Preliminary Data VARIABLES (1993-4 Data) CASES (n=46) CONTROLS (n=59) * p .05 ** p .001
- 16. Differences in CAI in PCOS Cases vs. Controls by Age * p = 0.004 ** p = 0.021
- 18. Regression - Fixed Model Predictors P-value of Predictors Model Adjusted R 2 Model Significance Forced entry of CVD risk factors: Dependent variable = CAI
- 19. Regression - Lipids and Insulin Predictors P-value of Predictors Model Adjusted R 2 Model Significance Individual entry of lipids and insulin to CVD fixed model: Dependent Variable = CAI
- 20. Regression - PCOS Status Predictors P-value of Predictors Model Adjusted R 2 Model Significance Entry of PCOS status to CVD fixed model including LDL: Dependent variable = CAI
- 24. Evelyn O. Talbott A544 Crabtree Hall Pittsburg, PA (412) 624-3074