Dara Ajay (Cheers Interactive, India) Patentable Subject matter, list out the controversial inventions ineligible for patent registration. These inventions are related to genetic modification, software patents and business methods etc. which have been debated on national, international levels at various conventions. Currently, there are multiple patent litigation reported under patentable subject matter and are prosecuted with different perspectives. However, these inventions despite meeting the criteria are still been prosecuted based on patentable subject matter. The presentation would discuss some of the famous case studies in the area of genetic modification both at level of inventions and discovery. Further, more emphasis is focused toward the recent patent case on gene discovery of Myriad Patent litigations. There by address the critical question whether “patentable subject matter” is actually satisfying the current upcoming technologies assessment or acting as an impediment for future innovations. In other words, dose patentable subject matter stifle the growth of latest upcoming technologies which could emerge as future breakthrough innovations!