Parkinson's disease
•Download as PPTX, PDF•
0 likes•50 views
Parkinson's disease is the second most common age-related neurodegenerative disease. It typically has an onset around age 60 and is more common in men than women. Risk factors include certain environmental exposures as well as genetic factors. The disease is characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta and formation of intraneuronal inclusions called Lewy bodies. This leads to decreased dopamine levels in the striatum and impaired function of the basal ganglia, resulting in the motor symptoms of Parkinson's such as tremors and impaired movement.
Report
Share
Report
Share
Recommended
parkinson's disease (updated).pptx
1.) Provides understanding of clinical knowledge of neurodegenerative disorders (parkinson's disease).
2.) To help health professionals to be to identify parkinson's disease
3.) Gives an understanding of the development of parkinson's disease and it's effects as well as treatment.
4.) Also help health professionals in research to gain more understanding of parkinson's disease.
Related Genes in Parkinson's Disease
This document provides information on Parkinson's disease (PD), including its causes, genetics, and symptoms. Key points:
- PD is a neurodegenerative disorder caused by the death of dopamine-producing neurons in the substantia nigra. Symptoms include tremors, rigidity, and impaired movement.
- Most cases are sporadic, but about 15% of patients have a family history linked to mutations in the LRRK2, PARK2, PARK7, PINK1, or SNCA genes. These are considered "causal" genes.
- Other genes like GBA and SNCAIP are associated with increased PD risk but are not solely causative. Their mutations are described as "associated
Parkinson's disease ppt SlideShare
Parkinson's disease is a brain disorder that causes shaking, stiffness, and difficulty with movement. It results from the death of dopaminergic neurons in the substantia nigra, which leads to a decrease in dopamine levels. Common symptoms include tremors, rigid muscles, slow movement, and impaired balance. While the exact causes are unknown, genetic and environmental factors may play a role. There is no cure for Parkinson's disease, but treatments like L-Dopa and Carbidopa can help manage symptoms.
Rehabilitation_Management_of_Parkinsons_Disease.ppt
This document provides an overview of rehabilitation management for Parkinson's disease. Some key points:
- Parkinson's is the second most common neurodegenerative disorder after Alzheimer's, affecting over 1 million Americans. It is characterized by motor symptoms like tremors, rigidity, bradykinesia, and non-motor symptoms.
- The pathology of Parkinson's involves degeneration of dopaminergic neurons in the substantia nigra, leading to depletion of dopamine in the striatum. Lewy bodies composed of aggregated proteins are also present.
- Treatment focuses on managing both motor and non-motor symptoms. Motor symptoms are often treated with medications like levodopa and dopamine agonists. Non-motor issues
PARKINSON’S DISEASE PPT.pptx
This document provides information on Parkinson's disease, including:
1) Its cardinal features were first described by James Parkinson in 1817 and it is characterized by resting tremor, rigidity, bradykinesia, and gait dysfunction.
2) It is caused by degeneration of dopaminergic neurons in the substantia nigra resulting in Lewy bodies and reduced striatal dopamine.
3) Treatment includes dopamine precursors like levodopa, dopamine agonists such as ropinirole and pramipexole, and MAO-B inhibitors like selegiline and rasagiline.
Parkinson disease
This document provides an overview of Parkinson's disease, including its symptoms, stages of progression, causes, risk factors, diagnosis, and treatment options. Parkinson's is a progressive neurological disorder that results from the loss of dopamine-producing cells in the brain. Its primary symptoms are tremors, rigidity, bradykinesia, and postural instability. While there is no cure, treatments can help manage symptoms and maintain quality of life, such as medication to increase dopamine levels, surgery, physiotherapy, and deep brain stimulation.
Title- Parkinson's Disease- Current Breakthroughs and Insights .pptx
Welcome to today's presentation on "Parkinson's Disease: Current Breakthroughs and Insights." In the next 20 slides, we'll delve into the world of Parkinson's disease, a complex neurodegenerative disorder that impacts millions of lives worldwide. We will explore the latest advancements in understanding its underlying causes, diagnosing the condition, and developing innovative treatments. As we navigate through this presentation, you'll gain valuable insights into the ongoing research and breakthroughs that are shaping the landscape of Parkinson's disease management. Let's embark on this journey to uncover the significant progress being made in the fight against Parkinson's disease.
Parkinson's disease
Parkinson's disease is a progressive nervous system disorder that affects movement. It results from loss of dopamine-producing neurons in the brain. The main symptoms are tremors, rigidity, slow movement, and impaired balance. While the exact causes are unknown, both genetic and environmental factors likely play a role. There is no cure for Parkinson's, but treatment aims to reduce symptoms and delay disability progression. The disease places a significant economic burden due to medical costs, lost wages, and caregiving expenses.
Recommended
parkinson's disease (updated).pptx
1.) Provides understanding of clinical knowledge of neurodegenerative disorders (parkinson's disease).
2.) To help health professionals to be to identify parkinson's disease
3.) Gives an understanding of the development of parkinson's disease and it's effects as well as treatment.
4.) Also help health professionals in research to gain more understanding of parkinson's disease.
Related Genes in Parkinson's Disease
This document provides information on Parkinson's disease (PD), including its causes, genetics, and symptoms. Key points:
- PD is a neurodegenerative disorder caused by the death of dopamine-producing neurons in the substantia nigra. Symptoms include tremors, rigidity, and impaired movement.
- Most cases are sporadic, but about 15% of patients have a family history linked to mutations in the LRRK2, PARK2, PARK7, PINK1, or SNCA genes. These are considered "causal" genes.
- Other genes like GBA and SNCAIP are associated with increased PD risk but are not solely causative. Their mutations are described as "associated
Parkinson's disease ppt SlideShare
Parkinson's disease is a brain disorder that causes shaking, stiffness, and difficulty with movement. It results from the death of dopaminergic neurons in the substantia nigra, which leads to a decrease in dopamine levels. Common symptoms include tremors, rigid muscles, slow movement, and impaired balance. While the exact causes are unknown, genetic and environmental factors may play a role. There is no cure for Parkinson's disease, but treatments like L-Dopa and Carbidopa can help manage symptoms.
Rehabilitation_Management_of_Parkinsons_Disease.ppt
This document provides an overview of rehabilitation management for Parkinson's disease. Some key points:
- Parkinson's is the second most common neurodegenerative disorder after Alzheimer's, affecting over 1 million Americans. It is characterized by motor symptoms like tremors, rigidity, bradykinesia, and non-motor symptoms.
- The pathology of Parkinson's involves degeneration of dopaminergic neurons in the substantia nigra, leading to depletion of dopamine in the striatum. Lewy bodies composed of aggregated proteins are also present.
- Treatment focuses on managing both motor and non-motor symptoms. Motor symptoms are often treated with medications like levodopa and dopamine agonists. Non-motor issues
PARKINSON’S DISEASE PPT.pptx
This document provides information on Parkinson's disease, including:
1) Its cardinal features were first described by James Parkinson in 1817 and it is characterized by resting tremor, rigidity, bradykinesia, and gait dysfunction.
2) It is caused by degeneration of dopaminergic neurons in the substantia nigra resulting in Lewy bodies and reduced striatal dopamine.
3) Treatment includes dopamine precursors like levodopa, dopamine agonists such as ropinirole and pramipexole, and MAO-B inhibitors like selegiline and rasagiline.
Parkinson disease
This document provides an overview of Parkinson's disease, including its symptoms, stages of progression, causes, risk factors, diagnosis, and treatment options. Parkinson's is a progressive neurological disorder that results from the loss of dopamine-producing cells in the brain. Its primary symptoms are tremors, rigidity, bradykinesia, and postural instability. While there is no cure, treatments can help manage symptoms and maintain quality of life, such as medication to increase dopamine levels, surgery, physiotherapy, and deep brain stimulation.
Title- Parkinson's Disease- Current Breakthroughs and Insights .pptx
Welcome to today's presentation on "Parkinson's Disease: Current Breakthroughs and Insights." In the next 20 slides, we'll delve into the world of Parkinson's disease, a complex neurodegenerative disorder that impacts millions of lives worldwide. We will explore the latest advancements in understanding its underlying causes, diagnosing the condition, and developing innovative treatments. As we navigate through this presentation, you'll gain valuable insights into the ongoing research and breakthroughs that are shaping the landscape of Parkinson's disease management. Let's embark on this journey to uncover the significant progress being made in the fight against Parkinson's disease.
Parkinson's disease
Parkinson's disease is a progressive nervous system disorder that affects movement. It results from loss of dopamine-producing neurons in the brain. The main symptoms are tremors, rigidity, slow movement, and impaired balance. While the exact causes are unknown, both genetic and environmental factors likely play a role. There is no cure for Parkinson's, but treatment aims to reduce symptoms and delay disability progression. The disease places a significant economic burden due to medical costs, lost wages, and caregiving expenses.
Dissertation work ppt
Parkinson's disease is a degenerative disorder of the central nervous system that mainly affects movement. It results from the loss of dopamine-producing neurons in the brain. The main symptoms are tremors at rest, slow movement, stiffness, and impaired balance and coordination. While the causes are mostly unknown, both genetic and environmental factors can play a role. There is no cure for Parkinson's disease but treatments can help manage the motor and non-motor symptoms.
Parkinsons disease
Parkinson's disease is a neurodegenerative disorder that occurs when dopamine-producing neurons in the substantia nigra are damaged over time. Common symptoms include tremors, slow movement, rigidity, and impaired balance and coordination. While the majority of cases are idiopathic, some genetic and environmental factors are also implicated in the disease. Diagnosis involves PET scans and neurological exams, while treatment focuses on increasing dopamine signaling through medications like levodopa and dopamine agonists or surgical procedures like deep brain stimulation.
Parkinsons disease
Parkinson's disease is the second most common degenerative disease of the central nervous system. It typically occurs in older adults around age 60 and is more common in males. The disease is characterized by degeneration of dopamine-producing neurons in the brain and presence of Lewy bodies. The main symptoms include bradykinesia, resting tremor, and rigidity. Levodopa is the most effective treatment for motor symptoms, but its long term use can cause dyskinesia and other side effects. Deep brain stimulation is an effective surgical treatment for some patients. Overall, Parkinson's disease is a progressive neurodegenerative disorder involving the extrapyramidal system.
Snigdha Sama Sigma Xi Presentation
This document summarizes a study that investigated a novel therapeutic approach for treating Parkinson's disease by targeting Lewy body aggregation and dopaminergic neuronal death in Drosophila melanogaster (fruit flies). The study examined the effects of administering the drugs ambroxol and ruthenium red, alone and in combination, to wild-type fruit flies and those with alpha-synuclein transgenes or rotenone-induced parkinsonism. Assays were conducted to measure glucocerebrosidase activity, ATP production, and motor function. The results showed that both drugs conferred neuroprotective effects and improved motor function in the fruit flies, and their combination was more effective than either drug alone. This supported the hypothesis that
Parkinson disease
Parkinson's disease is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Key motor symptoms include tremors, rigidity, bradykinesia, and postural instability. The disease results from the loss of dopamine-producing neurons in the substantia nigra. Treatment involves dopamine replacement therapy using levodopa and other drugs like dopamine agonists, COMT inhibitors, and MAO-B inhibitors to manage motor symptoms and fluctuations. As the disease progresses, additional treatment options are considered to minimize dyskinesia and reduce off-time periods.
Parkinsonism & Azheimers
Both Alzheimer’s disease and Parkinson’s disease are diseases of the brain. Both may cause forgetfulness. However, the similarities end there. In fact, researchers believe that even the memory disorder that results from Parkinson’s is distinct from the memory disorder that Alzheimer’s causes.
One main difference between the diseases is how they affect the body:
Alzheimer’s disease primarily affects memory. In advanced stages, the disease also impairs motor functions.
Parkinson’s disease primarily affects movement and coordination. In advanced stages, it may impair memory and other cognitive functions.
Non coding RNA & diseases
1. Non-coding RNAs play important roles in various biological processes and diseases. They are not translated into proteins but instead regulate gene expression.
2. Mutations or imbalances in non-coding RNAs can lead to diseases such as cancer, Prader-Willi syndrome, autism, cartilage-hair hypoplasia, Alzheimer's disease, and autoimmune diseases.
3. Prader-Willi syndrome is caused by the deletion of snoRNA gene clusters and is characterized by over-eating and learning difficulties. Autism has been linked to duplications of the SNORD115 gene cluster and changes in the expression of circular RNAs and microRNAs.
PTM responsible for Parkinsons disease ppt by meera qaiser
Parkinson's disease is a neurodegenerative disorder that affects over 1 million people in the US. It is characterized by tremors, rigidity, bradykinesia, and postural instability. The disease is caused by degeneration of dopamine-producing neurons in the substantia nigra. Mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are linked to the disease. S-nitrosylation of parkin compromises its neuroprotective functions and contributes to Lewy body formation. While there is no cure, medications like levodopa and dopamine agonists can help manage motor symptoms.
PARKINSONS PHARM PAPER
This document discusses Parkinson's disease and its treatment. Parkinson's is a neurodegenerative disorder caused by low levels of dopamine in the brain. It affects movement and is characterized by tremors, rigidity, and impaired balance and coordination. While the cause is unknown, several drugs are used to manage symptoms, including MAO-B inhibitors, dopamine modulators, COMT inhibitors, ergot derivatives, nonergot derivatives, and dopamine replacements like levodopa. These drugs each have specific indications, side effects, contraindications, and dosing protocols. Therapies can help delay disease progression, but Parkinson's dementia is still a risk as the condition advances.
Parkinson's
Parkinson's disease is a neurodegenerative disorder caused by the loss of dopamine-producing neurons in the substantia nigra. The main symptoms are motor symptoms like tremors and rigidity, as well as non-motor symptoms like depression and sleep disorders. Diagnosis is based on the presence of cardinal motor features and there are no definitive medical tests. Current treatments aim to replace dopamine or stimulate dopamine receptors through drugs. Emerging treatments include gene therapy, stem cell therapy, deep brain stimulation surgery, and alternative therapies like acupuncture. Researchers are developing new drug formulations and therapies to better treat Parkinson's symptoms like bradykinesia and tremors that remain problematic.
Parkinson’s disease ( shobs )
Parkinson's disease is characterized by tremors, rigidity, bradykinesia and postural instability. It is caused by degeneration of dopaminergic neurons in the substantia nigra, reducing striatal dopamine. The basal ganglia circuitry is disrupted, affecting movement planning and execution. Levodopa is the most effective treatment but has long term side effects; it is often combined with carbidopa to reduce peripheral effects and dosage. Differential diagnoses include conditions with similar parkinsonian symptoms but different causes or presentations.
Presentation1
The document discusses several factors that may contribute to the vulnerability of dopamine neurons in the substantia nigra pars compacta (SNc) in Parkinson's disease. These include dopamine metabolism, the interaction between dopamine and alpha-synuclein, neuromelanin content, calcium buffering capacity, and reliance on L-type calcium channels. Neurodegeneration may begin in both the SNc and supplementary motor cortex. Over time, Lewy bodies spread from the brainstem to the neocortex in a caudorostral gradient, contributing to non-dopaminergic symptoms and eventual dementia. Both neuronal cell loss and Lewy body accumulation appear to drive disease progression.
PARKINSON’S DISEASE
This document discusses Parkinson's disease. Some key points:
- Parkinson's disease is the second most common neurodegenerative disease. It affects around 1 million people in the US.
- Risk factors include age, family history, exposure to certain environmental toxins.
- Pathophysiology involves degeneration of dopamine neurons in the substantia nigra leading to impaired movement control.
- Common symptoms are resting tremor, bradykinesia, and muscle rigidity which worsen over time.
Presentation1.pptx
Parkinson disease is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. It is caused by the loss of dopamine-producing neurons in the brain and affects millions worldwide. The symptoms were first described in 1817 and include tremors, stiffness, slow movement, and impaired balance and coordination. While its progression cannot be stopped, symptoms can be effectively treated with dopamine replacement therapy such as levodopa. Advanced disease brings new challenges of managing motor fluctuations between periods of good control and poor control.
Week 1 Parkinson's disease (1) (1).pptx
Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopamine-producing neurons in the substantia nigra. Common symptoms include tremors, rigidity, and bradykinesia. Current treatments aim to replace lost dopamine, such as with L-DOPA, but long-term use can cause dyskinesia. Researchers are studying new targets like NMDA receptors and spreading of toxic alpha-synuclein aggregates to develop disease-modifying therapies that could slow progression.
PEDIATRIC POISONING IN CHILDREN(part 01).pptx
Poisoning is a really concern to our society and hence a health practitioner must have the need to understand and have the knowledge of what poisoning, what are it's causes, it's effects and how should he/she approach a poisoned patient. This slides provides the definition/causes/approach to poisoning.
burns(edited).pptx
slide helps a medical student and physician understand the basics of burns( definition, types, causes, assessment, stages, zones, complications and basic principles of management).
ABORTIONS/MISCARRIAGES(part 01).pptx
This document defines abortion and miscarriage as pregnancy loss before 28 weeks or a fetal weight of 1000 grams. It classifies abortions as either induced, which are intentional terminations, or spontaneous, which occur despite the willingness to continue the pregnancy. The main causes of spontaneous abortions discussed are genetic abnormalities, endocrine/metabolic factors, mechanical issues, infections, immunological conditions, drug/alcohol use, and sometimes unknown causes. Clinical presentations vary based on factors like bleeding, pain, cervical dilation, and ultrasound findings. Complications can include hemorrhage, injury, infection, and infertility.
PAEDIATRIC Urinary tract infections.pptx
This slides gives a basic understanding of urinary tract infections to a general physician, it's definition,epidemiology, causes, risk factors, clinical features, investigations, treatment and prevention.
It also helps a physician to have the ability on to mange urinary tract infections in paediatric patients.
THYROTOXICOSIS AND GRAVES DISEASE(part 01).pptx
Thyrotoxicosis is an essential endocrine topic that each physician must have adequate knowledge. This slide explains the defition of thyrotoxicosis and graves disease as well as the causes, pathogenesis, clinical features and approach.
burns.pptx
Burns are a one of the problems to to the human body hence knowledge is needed on this topic
This slide explains the definition/causes/classification/assessment/classification/management of burns.
HEART FAILURE.pptx
Heart failure is a structural and functional complex condition that needs to be understood by a physician hence adequate knowledge is needed. This slides provides understanding of heart failure, it's definition, classification/types,risk and precipitating factors, pathophysiology, clinical features (symptoms and signs), diagnosis/investigations, complications and management (both non pharmacological and pharmacological).
More Related Content
Similar to Parkinson's disease
Dissertation work ppt
Parkinson's disease is a degenerative disorder of the central nervous system that mainly affects movement. It results from the loss of dopamine-producing neurons in the brain. The main symptoms are tremors at rest, slow movement, stiffness, and impaired balance and coordination. While the causes are mostly unknown, both genetic and environmental factors can play a role. There is no cure for Parkinson's disease but treatments can help manage the motor and non-motor symptoms.
Parkinsons disease
Parkinson's disease is a neurodegenerative disorder that occurs when dopamine-producing neurons in the substantia nigra are damaged over time. Common symptoms include tremors, slow movement, rigidity, and impaired balance and coordination. While the majority of cases are idiopathic, some genetic and environmental factors are also implicated in the disease. Diagnosis involves PET scans and neurological exams, while treatment focuses on increasing dopamine signaling through medications like levodopa and dopamine agonists or surgical procedures like deep brain stimulation.
Parkinsons disease
Parkinson's disease is the second most common degenerative disease of the central nervous system. It typically occurs in older adults around age 60 and is more common in males. The disease is characterized by degeneration of dopamine-producing neurons in the brain and presence of Lewy bodies. The main symptoms include bradykinesia, resting tremor, and rigidity. Levodopa is the most effective treatment for motor symptoms, but its long term use can cause dyskinesia and other side effects. Deep brain stimulation is an effective surgical treatment for some patients. Overall, Parkinson's disease is a progressive neurodegenerative disorder involving the extrapyramidal system.
Snigdha Sama Sigma Xi Presentation
This document summarizes a study that investigated a novel therapeutic approach for treating Parkinson's disease by targeting Lewy body aggregation and dopaminergic neuronal death in Drosophila melanogaster (fruit flies). The study examined the effects of administering the drugs ambroxol and ruthenium red, alone and in combination, to wild-type fruit flies and those with alpha-synuclein transgenes or rotenone-induced parkinsonism. Assays were conducted to measure glucocerebrosidase activity, ATP production, and motor function. The results showed that both drugs conferred neuroprotective effects and improved motor function in the fruit flies, and their combination was more effective than either drug alone. This supported the hypothesis that
Parkinson disease
Parkinson's disease is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Key motor symptoms include tremors, rigidity, bradykinesia, and postural instability. The disease results from the loss of dopamine-producing neurons in the substantia nigra. Treatment involves dopamine replacement therapy using levodopa and other drugs like dopamine agonists, COMT inhibitors, and MAO-B inhibitors to manage motor symptoms and fluctuations. As the disease progresses, additional treatment options are considered to minimize dyskinesia and reduce off-time periods.
Parkinsonism & Azheimers
Both Alzheimer’s disease and Parkinson’s disease are diseases of the brain. Both may cause forgetfulness. However, the similarities end there. In fact, researchers believe that even the memory disorder that results from Parkinson’s is distinct from the memory disorder that Alzheimer’s causes.
One main difference between the diseases is how they affect the body:
Alzheimer’s disease primarily affects memory. In advanced stages, the disease also impairs motor functions.
Parkinson’s disease primarily affects movement and coordination. In advanced stages, it may impair memory and other cognitive functions.
Non coding RNA & diseases
1. Non-coding RNAs play important roles in various biological processes and diseases. They are not translated into proteins but instead regulate gene expression.
2. Mutations or imbalances in non-coding RNAs can lead to diseases such as cancer, Prader-Willi syndrome, autism, cartilage-hair hypoplasia, Alzheimer's disease, and autoimmune diseases.
3. Prader-Willi syndrome is caused by the deletion of snoRNA gene clusters and is characterized by over-eating and learning difficulties. Autism has been linked to duplications of the SNORD115 gene cluster and changes in the expression of circular RNAs and microRNAs.
PTM responsible for Parkinsons disease ppt by meera qaiser
Parkinson's disease is a neurodegenerative disorder that affects over 1 million people in the US. It is characterized by tremors, rigidity, bradykinesia, and postural instability. The disease is caused by degeneration of dopamine-producing neurons in the substantia nigra. Mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are linked to the disease. S-nitrosylation of parkin compromises its neuroprotective functions and contributes to Lewy body formation. While there is no cure, medications like levodopa and dopamine agonists can help manage motor symptoms.
PARKINSONS PHARM PAPER
This document discusses Parkinson's disease and its treatment. Parkinson's is a neurodegenerative disorder caused by low levels of dopamine in the brain. It affects movement and is characterized by tremors, rigidity, and impaired balance and coordination. While the cause is unknown, several drugs are used to manage symptoms, including MAO-B inhibitors, dopamine modulators, COMT inhibitors, ergot derivatives, nonergot derivatives, and dopamine replacements like levodopa. These drugs each have specific indications, side effects, contraindications, and dosing protocols. Therapies can help delay disease progression, but Parkinson's dementia is still a risk as the condition advances.
Parkinson's
Parkinson's disease is a neurodegenerative disorder caused by the loss of dopamine-producing neurons in the substantia nigra. The main symptoms are motor symptoms like tremors and rigidity, as well as non-motor symptoms like depression and sleep disorders. Diagnosis is based on the presence of cardinal motor features and there are no definitive medical tests. Current treatments aim to replace dopamine or stimulate dopamine receptors through drugs. Emerging treatments include gene therapy, stem cell therapy, deep brain stimulation surgery, and alternative therapies like acupuncture. Researchers are developing new drug formulations and therapies to better treat Parkinson's symptoms like bradykinesia and tremors that remain problematic.
Parkinson’s disease ( shobs )
Parkinson's disease is characterized by tremors, rigidity, bradykinesia and postural instability. It is caused by degeneration of dopaminergic neurons in the substantia nigra, reducing striatal dopamine. The basal ganglia circuitry is disrupted, affecting movement planning and execution. Levodopa is the most effective treatment but has long term side effects; it is often combined with carbidopa to reduce peripheral effects and dosage. Differential diagnoses include conditions with similar parkinsonian symptoms but different causes or presentations.
Presentation1
The document discusses several factors that may contribute to the vulnerability of dopamine neurons in the substantia nigra pars compacta (SNc) in Parkinson's disease. These include dopamine metabolism, the interaction between dopamine and alpha-synuclein, neuromelanin content, calcium buffering capacity, and reliance on L-type calcium channels. Neurodegeneration may begin in both the SNc and supplementary motor cortex. Over time, Lewy bodies spread from the brainstem to the neocortex in a caudorostral gradient, contributing to non-dopaminergic symptoms and eventual dementia. Both neuronal cell loss and Lewy body accumulation appear to drive disease progression.
PARKINSON’S DISEASE
This document discusses Parkinson's disease. Some key points:
- Parkinson's disease is the second most common neurodegenerative disease. It affects around 1 million people in the US.
- Risk factors include age, family history, exposure to certain environmental toxins.
- Pathophysiology involves degeneration of dopamine neurons in the substantia nigra leading to impaired movement control.
- Common symptoms are resting tremor, bradykinesia, and muscle rigidity which worsen over time.
Presentation1.pptx
Parkinson disease is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. It is caused by the loss of dopamine-producing neurons in the brain and affects millions worldwide. The symptoms were first described in 1817 and include tremors, stiffness, slow movement, and impaired balance and coordination. While its progression cannot be stopped, symptoms can be effectively treated with dopamine replacement therapy such as levodopa. Advanced disease brings new challenges of managing motor fluctuations between periods of good control and poor control.
Week 1 Parkinson's disease (1) (1).pptx
Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopamine-producing neurons in the substantia nigra. Common symptoms include tremors, rigidity, and bradykinesia. Current treatments aim to replace lost dopamine, such as with L-DOPA, but long-term use can cause dyskinesia. Researchers are studying new targets like NMDA receptors and spreading of toxic alpha-synuclein aggregates to develop disease-modifying therapies that could slow progression.
Similar to Parkinson's disease (15)
PTM responsible for Parkinsons disease ppt by meera qaiser
PTM responsible for Parkinsons disease ppt by meera qaiser
More from MeekSusiku
PEDIATRIC POISONING IN CHILDREN(part 01).pptx
Poisoning is a really concern to our society and hence a health practitioner must have the need to understand and have the knowledge of what poisoning, what are it's causes, it's effects and how should he/she approach a poisoned patient. This slides provides the definition/causes/approach to poisoning.
burns(edited).pptx
slide helps a medical student and physician understand the basics of burns( definition, types, causes, assessment, stages, zones, complications and basic principles of management).
ABORTIONS/MISCARRIAGES(part 01).pptx
This document defines abortion and miscarriage as pregnancy loss before 28 weeks or a fetal weight of 1000 grams. It classifies abortions as either induced, which are intentional terminations, or spontaneous, which occur despite the willingness to continue the pregnancy. The main causes of spontaneous abortions discussed are genetic abnormalities, endocrine/metabolic factors, mechanical issues, infections, immunological conditions, drug/alcohol use, and sometimes unknown causes. Clinical presentations vary based on factors like bleeding, pain, cervical dilation, and ultrasound findings. Complications can include hemorrhage, injury, infection, and infertility.
PAEDIATRIC Urinary tract infections.pptx
This slides gives a basic understanding of urinary tract infections to a general physician, it's definition,epidemiology, causes, risk factors, clinical features, investigations, treatment and prevention.
It also helps a physician to have the ability on to mange urinary tract infections in paediatric patients.
THYROTOXICOSIS AND GRAVES DISEASE(part 01).pptx
Thyrotoxicosis is an essential endocrine topic that each physician must have adequate knowledge. This slide explains the defition of thyrotoxicosis and graves disease as well as the causes, pathogenesis, clinical features and approach.
burns.pptx
Burns are a one of the problems to to the human body hence knowledge is needed on this topic
This slide explains the definition/causes/classification/assessment/classification/management of burns.
HEART FAILURE.pptx
Heart failure is a structural and functional complex condition that needs to be understood by a physician hence adequate knowledge is needed. This slides provides understanding of heart failure, it's definition, classification/types,risk and precipitating factors, pathophysiology, clinical features (symptoms and signs), diagnosis/investigations, complications and management (both non pharmacological and pharmacological).
SHOCK.pptx
Shock is a life threatening emergency which all physicians must know.
This slide helps in the understanding of shock, it's definition/classification/pathophysiology/clinical features/investigations and assessment of shock..
Ectopic pregnancy
To help in understanding the clinical knowledge of ectopic pregnancy(definition/risk factors/history and examination/investigations and management).
More from MeekSusiku (9)
Recently uploaded
Adhd Medication Shortage Uk - trinexpharmacy.com
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.Efficacy of Avartana Sneha in Ayurveda
Avartana Sneha is a unique method of Preparation of Sneha Kalpana in Ayurveda, mainly it is indicated for the Vataja rogas.
Travel Clinic Cardiff: Health Advice for International Travelers
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
How to choose the best dermatologists in Indore.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
Artificial Intelligence Symposium (THAIS)
Artificial Intelligence Symposium (THAIS). Parc Taulí. Sabadell
10 Benefits an EPCR Software should Bring to EMS Organizations
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Recently uploaded (20)
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
Travel Clinic Cardiff: Health Advice for International Travelers
Travel Clinic Cardiff: Health Advice for International Travelers
10 Benefits an EPCR Software should Bring to EMS Organizations
10 Benefits an EPCR Software should Bring to EMS Organizations
Tests for analysis of different pharmaceutical.pptx
Tests for analysis of different pharmaceutical.pptx
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Outbreak management including quarantine, isolation, contact.pptx
Outbreak management including quarantine, isolation, contact.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Parkinson's disease
- 1. PARKINSONS DISEASE BY NAWA .M.S
- 2. • INTRODUCTION • 2nd Most common age related neurodegenerative disease • Mean age of onset ~60 yrs • Frequency increases with age • Lifetime risk:~3% for Men and ~2% for Women • risk factors • 1.) ENVIRONMENTAL FACTORS • exposue to MPTP pesticide exposure • rural living • farming • drinking well water
- 3. • PROTECTIVE FACTORS • caffeine • cigarette • nsaids • use of calcium channel blockers • 2.) GENETIC FACTORS • HLA 6 • mutations in: • SNCA • GBA • LRRK 2
- 4. • SNCA • leads to: • early age of onset • faster progression of symptoms • patients are responsive to levo dopa • prominent cognitive impairment • maybe a prion • GBA • imports protein glucocerebrosidase • if decreased, it leads to impaired lysosomal function • leads to increased activity of SNCA
- 5. • LRRK2 • tremor is more, typically leg tremor • incomplete penetrance • better prognosis • SPINK1/PARKIN • responsible for early onset and juvenile parkinsons disease
- 6. • PHYSIOLOGY OF BASAL GANGLIA
- 9. • PATHOGENESIS • Dopamine denervation • ↑(INCRESED) firing of neurons in STN & GPi • ↑(INCREASED) inhibition of thalamus • ↓(DECREASED) activation of cortical motor system • Development of Parkinsonian features
- 12. • PATHOLOGY • HALL MARK FEATURES INCLUDE: • Degeneration of dopaminergic neurons in SNPC • Reduced striatal (Caudate nu. + Putamen) dopamine • Intraneuronal inclusions stain for alpha-synuclein (Lewy Bodies)
- 14. • PARKISONS DISEASE TREATMENT (DRUGS USED IN PARKISONS)
- 20. REFERENCES • HARRISON’S MANUAL OF MEDICINE(20TH EDITION) BY FAUCI, E’TAL.. • KUMAR AND CLARK’S CLINICAL MEDICINE(10TH EDITION) BY PROFESSOR DAME PARVEEN J KUMAR, E’TAL.. • STEP UP TO MEDICINE(5TH EDITION) BY STEVEN AGABEGI • NEUROLOGY PART 3 BY DR SHUBHAM UPADHYAY • PATHOMA-FUNDAMENTALS OF PATHOLOGY(1ST EDITION) BY HUSAIN A. SATTAR
- 21. • I KNOW YOU ARE TIRED KAH • DO NOT WORRY, YOU WILL ONLY REST IF YOU ARE ABLE TO LICK YOUR ELBOW WITH YOUR TONGUE, OTHERWISE LOVE THE MEDICINE. • THANK YOU...