Pain relief;
A basic human right

               Yousf M. Tak
                    Consultant of Anesthesia
            Security Forces Hospital Dammam KSA
Regards from Kashmir; a paradise on earth
Pain relief; A basic human right


 Pain is leading cause of ER visits and hospitalizations
 Pain is a common mode of presentation in patients with
  sickle cell disease (SCD) but there is considerable
  variability in the way SCD pain is managed
Pain relief; A basic human right


 Pain is common undertreated entity
 One of the factors contributing to poor pain management is
  conflicting perceptions between patients, their families and
  healthcare professionals about pain that is reported and
  analgesia that is required (Stinson & Naser, 2003).
Pain relief; A basic human right




The most reliable indicator of the existence pain and its intensity
is the patient’s description
Pain relief; A basic human right


 The aim of the wise is not to secure pleasure, but to
  avoid pain. Aristotle




 Pain is a worst lord of mankind than death itself.
Pain relief; A basic human right


    Tachycardia And elevated blood pressure
    Decreased Limb movement; increased risk of DVT
   Respiratory effects; shallow breathing , tachypnea, cough suppression
. due to increased risk of pneumonia & atelectasis

    Decreased GI Motility
    Increased catabolic demands
Pain relief; A basic human right

 Psychological effects of Pain
    Negative emotions: anxiety, depression
    Sleep deprivation
    Existential suffering: may lead to patients
     seeking active end of life
 Immunologic Effects of pain
    Decrease natural killer cell counts
    Effects on other lymphocytes not yet defined
Pain relief; A basic human right




 5TH Vital Sign


 Basic human Right; Human rights watch
Pain relief; A basic human right



 Effective control of pain


         Lack of awareness among public


         Minimal knowledge among health providers
Pain relief; A basic human right




Pain Clinic
Modified WHO Analgesic Ladder
                                Quality of Life
                                 Invasive treatments
     Proposed 4th Step          Opioid Delivery

                            Pain persisting or increasing

                                       Step 3
                         Opioid for moderate to severe pain
                               Nonopioid Adjuvant
                             Pain persisting or increasing
                                      Step 2
                         Opioid for mild to moderate pain
  The WHO                    Nonopioid  Adjuvant

   Ladder                  Pain persisting or increasing
                                      Step 1
                                    Nonopioid
                                     Adjuvant


                                      Pain
Deer, et al., 1999
Pain relief; A basic human right
Pain relief; A basic human right
Pain relief; A basic human right
Pain relief; A basic human right




              Pain relief; A basic human right
Pain relief; A basic human right




 Paediatric Scales
Pain relief; A basic human right

  Table: Severity of pain (Using a simple pain score)
  .

  0
        Mafee alam                No Pain
  1
        Shoa alam                 Mild Pain
  2
        Nus nus alam              Moderate pain
  3
        Kateer alam)              Severe Pain
Acute Pain in Sickle Cell Disease


Somatic pain
   – Deep structures
   – Focal or referred

Visceral pain
   – Spleen, liver, lungs

   – Vague, poorly localized, referred, diffuse, dull-aching   in character
   – Nausea, vomiting, sweating
   – Associated with muscle spasms, tenderness, hyperaesthesia
Comprehensive Regimen for the sickle cell disease pain
      Maintenance therapy with opioid analgesic
      Non opioid analgesic
      Rescue therapy for breakthrough pain
      Adjuvant therapy
      Anxiolytics/muscle relaxants
      Laxatives
      Non-pharmacologic therapy
      Incentive spirometry
      Hydration (1-1.5x maintenance)
      Physical: Heating pads, massage, TENS, acupuncture, physical therapy
      Behavioral: Relaxation, deep breathing, behavior modification, biofeedback
    •Psychological: cognitive therapies, distraction, social support, hypnotherapy
Pain relief; A basic human right




 WHO Pain Ladder
Meperidine
       Shorter duration of action (1-2 hours only )


       Seizures on repeated administration


       Dermal and sub dermal fibrosis on I.M injection

Pethidine
     Narrow therapeutic index


     Norpethidine > Antagonistic


     Seizures on repeated administration
Pain relief; A basic human right
Pain relief; A basic human right
S.No   Severity of pain   Regimen
1      Mild               Paracetomol 0.5g to 1g every 8H /
                          Lornoxicam4-8 mg Every 12-24 H

2      Moderate           Paracetomol 0.5g to 1g every 8H /
                          Lornoxicam4-8 mg Every 12-24 H
                                    +
                          Tramadol50-100mgs Q 8H

3      Severe             Paracetomol 0.5g to 1g every 8H /
                          Lornoxicam4-8 mg Every 12-24 H
                                        +
                          Morphine 5-mgs Q 8 H
Pain relief; A basic human right

PRN Schedule Illogical


Pain Cycle (Basal + Incident + Breakthrough Pain


Start (1Hr)} Asses} Reassess} Adjust


Tapering and not abrupt withdrawl
Pain relief; A basic human right


NSAIDS
    Bone Pain
    Opiod Sparing
    Ceiling Effect
Opiods
    Potent analgesics
    Safety Profile
Pain relief; A basic human right



Addiction
      Nightmare for physician


      Curse for the patient
Pain relief; A basic human right


 When asked, 59% of the patients desired that oral non-
  opioid analgesics be prescribed while 31% were not
  bothered about what analgesic was given. Only 8%
  requested opioids.
 A total of 65% of the patients did not require hospital
  admission but were observed in the day-care unit and
  allowed home within 24 h. Only 17% required hospital
  admission for more than a week.
Pain relief; A basic human right

 Prevention of Pain
 Triggers of pain: viral illness,
 infection/sepsis, stress, extreme exercise,
 change in temperature, change in altitude
 Fluids (2 glasses of water q 2 hours)
 Avoiding extreme temperatures, activities (e.g. swimming in cold
  water)
 Regular moderate exercise
 Penicillin prophylaxis to prevent infection
STAY
PAINFREE

Pain relief in sickle cell disese

  • 1.
    Pain relief; A basichuman right Yousf M. Tak Consultant of Anesthesia Security Forces Hospital Dammam KSA
  • 2.
    Regards from Kashmir;a paradise on earth
  • 3.
    Pain relief; Abasic human right  Pain is leading cause of ER visits and hospitalizations  Pain is a common mode of presentation in patients with sickle cell disease (SCD) but there is considerable variability in the way SCD pain is managed
  • 4.
    Pain relief; Abasic human right  Pain is common undertreated entity  One of the factors contributing to poor pain management is conflicting perceptions between patients, their families and healthcare professionals about pain that is reported and analgesia that is required (Stinson & Naser, 2003).
  • 6.
    Pain relief; Abasic human right The most reliable indicator of the existence pain and its intensity is the patient’s description
  • 7.
    Pain relief; Abasic human right  The aim of the wise is not to secure pleasure, but to avoid pain. Aristotle  Pain is a worst lord of mankind than death itself.
  • 8.
    Pain relief; Abasic human right  Tachycardia And elevated blood pressure  Decreased Limb movement; increased risk of DVT  Respiratory effects; shallow breathing , tachypnea, cough suppression . due to increased risk of pneumonia & atelectasis  Decreased GI Motility  Increased catabolic demands
  • 9.
    Pain relief; Abasic human right  Psychological effects of Pain  Negative emotions: anxiety, depression  Sleep deprivation  Existential suffering: may lead to patients seeking active end of life  Immunologic Effects of pain  Decrease natural killer cell counts  Effects on other lymphocytes not yet defined
  • 10.
    Pain relief; Abasic human right  5TH Vital Sign  Basic human Right; Human rights watch
  • 11.
    Pain relief; Abasic human right  Effective control of pain  Lack of awareness among public  Minimal knowledge among health providers
  • 12.
    Pain relief; Abasic human right Pain Clinic
  • 13.
    Modified WHO AnalgesicLadder Quality of Life Invasive treatments Proposed 4th Step Opioid Delivery Pain persisting or increasing Step 3 Opioid for moderate to severe pain Nonopioid Adjuvant Pain persisting or increasing Step 2 Opioid for mild to moderate pain The WHO Nonopioid  Adjuvant Ladder Pain persisting or increasing Step 1 Nonopioid  Adjuvant Pain Deer, et al., 1999
  • 14.
    Pain relief; Abasic human right
  • 15.
    Pain relief; Abasic human right
  • 16.
    Pain relief; Abasic human right
  • 17.
    Pain relief; Abasic human right Pain relief; A basic human right
  • 18.
    Pain relief; Abasic human right  Paediatric Scales
  • 19.
    Pain relief; Abasic human right Table: Severity of pain (Using a simple pain score) . 0 Mafee alam No Pain 1 Shoa alam Mild Pain 2 Nus nus alam Moderate pain 3 Kateer alam) Severe Pain
  • 20.
    Acute Pain inSickle Cell Disease Somatic pain  – Deep structures  – Focal or referred Visceral pain  – Spleen, liver, lungs  – Vague, poorly localized, referred, diffuse, dull-aching in character  – Nausea, vomiting, sweating  – Associated with muscle spasms, tenderness, hyperaesthesia
  • 21.
    Comprehensive Regimen forthe sickle cell disease pain  Maintenance therapy with opioid analgesic  Non opioid analgesic  Rescue therapy for breakthrough pain  Adjuvant therapy  Anxiolytics/muscle relaxants  Laxatives  Non-pharmacologic therapy  Incentive spirometry  Hydration (1-1.5x maintenance)  Physical: Heating pads, massage, TENS, acupuncture, physical therapy  Behavioral: Relaxation, deep breathing, behavior modification, biofeedback  •Psychological: cognitive therapies, distraction, social support, hypnotherapy
  • 22.
    Pain relief; Abasic human right  WHO Pain Ladder
  • 23.
    Meperidine  Shorter duration of action (1-2 hours only )  Seizures on repeated administration  Dermal and sub dermal fibrosis on I.M injection Pethidine  Narrow therapeutic index  Norpethidine > Antagonistic  Seizures on repeated administration
  • 24.
    Pain relief; Abasic human right
  • 25.
    Pain relief; Abasic human right S.No Severity of pain Regimen 1 Mild Paracetomol 0.5g to 1g every 8H / Lornoxicam4-8 mg Every 12-24 H 2 Moderate Paracetomol 0.5g to 1g every 8H / Lornoxicam4-8 mg Every 12-24 H + Tramadol50-100mgs Q 8H 3 Severe Paracetomol 0.5g to 1g every 8H / Lornoxicam4-8 mg Every 12-24 H + Morphine 5-mgs Q 8 H
  • 26.
    Pain relief; Abasic human right PRN Schedule Illogical Pain Cycle (Basal + Incident + Breakthrough Pain Start (1Hr)} Asses} Reassess} Adjust Tapering and not abrupt withdrawl
  • 27.
    Pain relief; Abasic human right NSAIDS  Bone Pain  Opiod Sparing  Ceiling Effect Opiods  Potent analgesics  Safety Profile
  • 28.
    Pain relief; Abasic human right Addiction Nightmare for physician Curse for the patient
  • 29.
    Pain relief; Abasic human right  When asked, 59% of the patients desired that oral non- opioid analgesics be prescribed while 31% were not bothered about what analgesic was given. Only 8% requested opioids.  A total of 65% of the patients did not require hospital admission but were observed in the day-care unit and allowed home within 24 h. Only 17% required hospital admission for more than a week.
  • 30.
    Pain relief; Abasic human right  Prevention of Pain  Triggers of pain: viral illness,  infection/sepsis, stress, extreme exercise,  change in temperature, change in altitude  Fluids (2 glasses of water q 2 hours)  Avoiding extreme temperatures, activities (e.g. swimming in cold water)  Regular moderate exercise  Penicillin prophylaxis to prevent infection
  • 31.