This document discusses otic preparations, which are medications used in the ear. It describes the different types of otic preparations including solutions, suspensions, drops, and their main uses for removing earwax and treating ear infections, inflammation, and pain. It provides examples of active and inactive ingredients used in common otic preparations and how they are formulated, packaged, and administered in the ear.
Gaseous dosage forms are packed in a container which gets released upon applying pressure. The gas inside contains therapeutically active medicaments. The containers have valve systems with continuous or limited delivery. They are used for topical application on skin and as local application into nose and mouth.
Sprays
Vaporizer
Aerosols
Nebulizer or atomizer
Inhalers
Gaseous dosage forms are packed in a container which gets released upon applying pressure. The gas inside contains therapeutically active medicaments. The containers have valve systems with continuous or limited delivery. They are used for topical application on skin and as local application into nose and mouth.
Sprays
Vaporizer
Aerosols
Nebulizer or atomizer
Inhalers
Pharmaceutical Aerosols: Definition, propellants, containers, valves, types of aerosol systems; formulation and manufacture of aerosols; Evaluation of aerosols; Quality control and stability studies
Suspension is made of two phase system, consisting of a finely divided solid particles (Dispersed phase) distributed in a particular manner throughout another medium (Continuous phase).
Intranasal drug delivery system - Introduction, Nasal enzymes and nasal ph, cross sectional view of nose, factors affecting nasal absorption, general formulations of intranasal drugs, Intranasal dosage forms, nasal sprays, spray pump devices, nasal aerosols, compressed air nebulizers, nasal powder, nasal gels, applications of intranasal drug delivery system, delivery of intranasal vaccines, intranasal anaesthesia, Evaluation of intranasal formulation, ussing chamber, Advantages and disadvantages of intranasal drug delivery system
Pharmaceutical Aerosols: Definition, propellants, containers, valves, types of aerosol systems; formulation and manufacture of aerosols; Evaluation of aerosols; Quality control and stability studies
Suspension is made of two phase system, consisting of a finely divided solid particles (Dispersed phase) distributed in a particular manner throughout another medium (Continuous phase).
Intranasal drug delivery system - Introduction, Nasal enzymes and nasal ph, cross sectional view of nose, factors affecting nasal absorption, general formulations of intranasal drugs, Intranasal dosage forms, nasal sprays, spray pump devices, nasal aerosols, compressed air nebulizers, nasal powder, nasal gels, applications of intranasal drug delivery system, delivery of intranasal vaccines, intranasal anaesthesia, Evaluation of intranasal formulation, ussing chamber, Advantages and disadvantages of intranasal drug delivery system
How to Choose the Right Nasal irrigation Syringe For Babies
Nasal irrigation has proven to be a safe and effective method for alleviating nasal congestion in little ones. By flushing out mucus and reducing inflammation, it provides much-needed relief for your baby. However, with a myriad of nasal irrigation products available in the market, choosing the most suitable one can be overwhelming for parents.
Introduction
History
Bleaching agent
Classification of Bleaching technique.
Vital bleaching technique
Effect of vital bleaching on tooth structure
Effect of vital bleaching on tetracycline stain
Effect of vital bleaching on Fluorosis stain
Effect of vital bleaching on restorative material
Conclusion
References
Topical fluorides for home use, Professionally applied fluoride products, Planning a preventive programmes in the practice, Dental fluorosis, Fluoride toxicity,
To prepare relatively stable and homogeneous mixtures of two immiscible liquids.
Permits administration of a liquid drug in the form of minute globules rather than in bulk.
Palatable administration of an otherwise distasteful oil by dispersing it in a sweetened, flavored aqueous vehicle.
Biphasic system
emulsions
Classification of emulsion
Theories of emulsification
The HLB system
Stability of Emulsion
Emulsion Manufacturing
Test for emulsions
Pharmaceutical applications of emulsions
Packaging of emulsions
Notes made by PU student:
INTRODUCTION TO DRUG AND DIFFERENT DOSAGE FORMS
Drug
Pharmaceutical Preparations Manufactured by Pharmaceutical Industry
Pharmaceutical Preparations Compounded Individually
SOLID DOSAGE FORMS
LIQUID DOSAGE FORMS
SEMI-SOLID DOSAGE FORM
NEW DRUG DELIVERY SYSTEMS
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
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http://sandymillin.wordpress.com/iateflwebinar2024
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Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
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The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
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Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
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He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
4. • The waxy material of the ear is called
cerumen, or commonly known as ear wax
• Cerumen is formed from the combination
of the oily secretions from the exocrine
glands with fatty fluid from the apocrine
glands in the external auditory canal.
Ear Wax
5. • Otic prepartions sometimes referred to as
ear or aural preparations
• Solutions are most frequently used in the
ear, with suspensions and ointments also
finding some applications.
• Ear preparations are usually placed in the
ear canal by drops in small amount for
removal of excessive cerumen or for
treatment of ear infection, inflammations or
pain.
Otic Preparations
6. • Excessive accumulation of cerumen in the
ear may cause itching, pain, and impaired
hearing.
• Through the years, light mineral oil,
vegetable oils, hydrogen peroxide have
been used to soften the impacted cerumen
for its removal.
• Recently, solutions of synthetic surfactants
have been developed for their ability to
remove earwax.
Cerumen Removing Preparation
7. • Anhydrous Glycerin, Propylene glycol
are used as main solvents.
• Being anhydrous/ hygroscopic in nature
they absorb the moisture from the
inflamed area thus relieve the
inflammations.
• Propylene glycol emulsifies the cerumen
thus facilitate its explusion.
Solvents
8. Cerumen removal usually involves placing
the otic solutions in the ear canal with the
patient’s head tilled at a 45° angle, inserting
a cotton plug to retain the medication in the
ear for 15 to 30 minutues, followed for
gentle fushing of the ear canal with
lukewarm water using a soft rubber ear
cyringe.
Cerumen removing method
9. • Propane glycol is used to emulsify the
cerumen to facilitate its removal.
• Carbamide peroxide in glycerin or
propylene glycol release oxygen on contact
with cerumen which disrupts the integrity
of impacted wax allowing its easy removal.
Examples of Otic Solutions
11. Subtle difference in the formulation of otic
suspension may be bothersome to the patient.
This is so especially as it relates to difference in
inactive or inert ingredients that are considered
equivalent on the basis of active ingredients and
strength. E.g Several suspension and
combinations of polymyxin B sulfate, neomycin
sulfate, and hydrocortisone have been shown to
be more acidic at Ph 3.0 to 3.5 than the standard
product, Cortisporin TC otic, whose Ph 4.8 TO 5.1
Otic suspensions
12. Consequently there is a risk that when drops
are legally substituted, a burning and
stinging sensation can occur when the drops
are introduced into the ear of young
children, especially those with
tympanostomies. It has been demonstrated
that with time, the pH of these formulations,
including Cortisporin, becomes more acidic,
possibly pH 3.0 canal on later use.
13. PedOtic suspension
• Manufacturer ; Glaxo wellcome
• Active ingredient; Polymyxin B sulfate, neomycin
sulfate, hydrocortisone
• Vehicle; Mineral oil, propylene glycol, water for
injection
• Use; Superficial bacterial infection
Example
15. Some eardrops by virtue of their low pH may
cause stinging upon administration. Parents
and children should be
forewarned,especially if a child has
tympanostomy tubes in the ear. The patient
should also understand how long to use the
product. For antibiotic eardrops it is not
necessary to finish the entire bottle, because
therapy could last 20 to 30 days, depending
upon the dosage regimen.
Otic Drops
16. • Patient should be instructed to continue
using the drops for 3 days after symptoms
disappear. Product for otitis externa may take
up to 7 to 10 days to demonstrate efficay.
• If a child prone to develope ear infection as a
result of swimming and showering, it might
be advisible to recommend the parents to
consult a physician for prophylactic
medication to use during swimming and
consider using ear plugs that fit snugly in the
ear when swimming or shovering.
17. Debrox drops
• Active ingredients; Carbamide peroxide
• Vehicle; Anhydrous glycerin
• Use; Earwax removal
Example
19. Anti infective preparation
Topical use of anti infective agents such as
Chloramphenicol, Colistin sulfate, neomycin,
polymyxin B sulfate in ear preparation.
These agents are formulated as ear drops in
anhydrous glycerin, propylene glycol.
Nystatin [ awell known antifungal agent] is
also formulated to suppress ear fungal
infection, in the form of ear drops.
Anti infective, anti inflammation,
and analgesic Ear Preparations
20. Analgesic preparation
When pain is associated with ear infection,
certain commerical products are available in
combination with anti infective and
analgesics.
Examples ; Antipyine (analgesic),
Lidocaine, Benzocaine (local anesthetic)
21. Anti inflammatory preparation
Liquid ear preparation of anti inflammatory
agents hydrocortisone and dexamethasone
sodium phosphate are prescribed for their
effects against the swelling and inflammation
that frequently accompany allergic and
irritative manifestations of the ear.
22. Extemporaneous preparation
Pharmacist may also be called on
extempraneous preparation of a solution of
acetic acid 2% to 2.5% in rubbing alcohol
(70% isopropyl alcohol or ethanol ),
propylene glycol, or anhydrous glycerin. The
source of acetic acid can be glacial acetic
acid, USP, or Acetic acid NF, Boric acid 2%
to 5% dissolvedin either ethanol or
propylene glycol has also recommanded.
23. Some otic preparations require
preservatives. The commonly used
preservatives;
Chlorobutanol (0.5%)
Thimerosal (0.01%)
And various combinations of parabeans.
Preservatives
24. Otic preparations are mostly packed in
small glass or plastic containers with
dropper.
Packaging
25. • Ear preparation are usually placed in the
ear canal to remove Cerumen.
• They are also used for the treatment of ear
infection, inflammation or pain.
• They are categorized as;
– Cerumenolytic preparations
– Anti infective preparations
– Anti inflammatory
– Analgesic
Uses