In this presentation. I explain the definition, epidemiology, symptoms, and treatment of osteosarcopenia.

1. Dr. Mohammad Hassan Jokar

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8. Braithwaite RS, Col NF, Wong J (2003) Estimating hip fracture
morbidity, mortality and costs. J Am Geriatr
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*Braithwaite RS, Col NF, Wong J (2003) Estimating hip fracture morbidity, mortality and costs. J Am Geriatr

9. Osteopenia/osteoporosis + sarcopenia
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• In 1989, Rosenberg came up with the
term sarcopenia
• In 2009, Binkley and Buehring coined
the term Sarco-osteopenia

11. Osteopenia/osteoporosis & sarcopenia:
• Are associated with aging
• Have similar risk factors
• Have Similar biological pathways
• They closely interact with each other
• Similar negative outcomes (falls, fractures, loss of
function and …)
• Somewhat similar treatment

16. • Osteosarcopenia is a recent terminology, so
there are relatively few studies assessing its
epidemiology
• Prevalence
o Men
 14.3% (60– 64 years)
 59.4% (≥75 years)
o Women
 20.3% (60–64 years)
 48.3% (≥75 years),
Nielsen BR, Abdulla J, Andersen HE, Schwarz P, Suetta C. Sarcopenia and osteoporosis in older people: a systematic review and meta-analysis. Eur Geriatr Med 2018;9:419–434

20. • Sarx: flesh
• A muscle disease (muscle failure) rooted in
adverse muscle changes that accrue across a
lifetime.
• It is associated with increased: falls, functional
decline, disability, and mortality
• in 2016: Recognition of sarcopenia as an
independent condition with an ICD-10 code.

22. Categories of sarcopenia
• Primary sarcopenia
• Secondary sarcopenia
 Acute sarcopenia < 6 months
 chronic sarcopenia> 6 months
 Sarcopenic obesity

23. Epidemiology
• The target population for screening comprised people who are
65 (or 60) years old or older

30. Screening (SARC-F questionnaire)

31. European Working Group on Sarcopenia in Older People 2 (EWGSOP2)

32. Handgrip strength
Dynamometer

33. Chair stand test
The test measures the time needed for a patient to rise five
times from a seated position without using their arms

34. • SMM (skeletal muscle mass)
• ASM (Appendicular skeletal muscle mass): the total
muscle weight of the upper and lower limbs
• SMI (Skeletal muscle mass index): ASM/height2
(kg/m2)

35. •DXA

36. • Bioelectrical impedance analysis (BIA)

37. An objectively measured whole-body function related
to locomotion
• Timed up and go test
• Gait speed
• Short physical performance battery
• Stair climb power test
The 4-m usual walking speed test (without
acceleration and deceleration) is commonly
used

40. To date, few sarcopenia pharmacotherapies
have been attempted after phase 2 trials.

42. • Creatine
• SARMs (selective androgen receptor modulators ):
o LDG-4033
o BMS-564929
o Enobasarm

43. THANK YOU!