Daniel K. Lesniewski has over 15 years of experience in organic synthesis, analytical chemistry, and process development. He holds an M.Sc. in Organic Chemistry from Colorado State University-Pueblo and a B.Sc. in Chemistry from the same institution. His experience includes positions at Corden Pharma, Avista Pharma Solutions, General Air, Amgen, Lexmark International, and Colorado State University, where he has experience in multi-step organic synthesis, analytical instrumentation, scale-up reactions, method development, and research.

1. Daniel K. Lesniewski
201 Wright ST. Unit 205 Cell: 720-841-0826
Lakewood, CO 80228 email: dk.lesniewski@yahoo.com
EDUCATION: M.Sc. Organic Chemistry (emphasis: Fluoro-Organic Chemistry)
December 2009 Colorado State University – Pueblo, Colorado
B.Sc. Chemistry-Physical Organic Emphasis May 2006 (ACS certified)
Colorado State University-Pueblo, Colorado
SCIENTIFIC
INTRUMENTATION: GC-MS (5890 HP, Agilent), NMR (Varian INOVA 300 MHz, 500 MHz) and 60MHz Anasazi,
IR (Nicolet FTIR), UV-Vis, LCMS, HPLC, GC-FID (HP6890 GC), ICP-OES, Fluorescence,
GC-TCD (GOW-MAC 580 & 400), GC-DID (GOW-MAC 580), Rotary Evaporation, USP
Analysis, NF Analysis
EXPERIENCE:
01/04/2016 to current Process Development Chemist-Organic Synthesis (small molecule)
Corden Pharma, Boulder CO
• cGLP and cGMP development and manufacturing environment
• Designed and executed multi-step Organic synthesis reactions
• Performed pre-scale up front run and screen reactions
• Scale-up synthesis between 2-20 kg
• Weekly technical team meeting with customer to discuss progress and results
09/2015 to 12/21/2015 Process Development Chemist-Organic Synthesis (small molecule)
Avista Pharma Solutions, Longmont CO
• Worked in a cGLP and cGMP research laboratory environment
• Designed and executed multi-step Organic Synthesis reactions
• Monitored reactions, and molecular structure determination using HPLC, LCMS and 1H NMR
• Proof of concept and total multi-step synthesis of reference standard for phase-2 clinical program,
for cancer drug
• Scale-up synthesis between 50-100 g to make 40g of final compound in a 4-step synthesis
• Performed flash-column chromatography to isolate pure product
• Wrote weekly research reports and discussed results with the Director of Process Chemistry
• Regular collaboration with senior Process Chemists
• Weekly training seminars to discuss chemistry and work through mechanisms with the Director
of Process Chemistry
11/2014 to 09/2015 Research and Development Chemist
General Air, Commerce City CO
• Analytical method development for GC analysis of atmospheric and cryogenic gasses
• Followed FDA protocols and SOPs
• Thermodynamic calculations
• NF and USP analysis of medical, research and instrumental grade gasses (N, O, Ar, Ne, blood
gasses, lung diffusions, and specialty mixes.)
• Used GC-TCD, GC-DID and GC-PED to perform gas analysis (EZ-chrome software)
• Followed NF and USP analysis protocols
• General lab maintenance and instrument care
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2. • Regular collaboration with industry consultants and vendors
12/2013 to 6/2014 NREL BioEnergy Sciences Research Associate-Organic Retro-Synthesis
BioEnergy Sciences Center, National Renewable Energy Laboratory, Golden CO
• Worked on the development of Cellulose and Hemi-cellulose extraction from Bio-
material through chemical reactions and mechanical processes run in bioreactors.
• Assisted experienced scientists with deacetylation reactions and enzymatic hydrolysis
to release the component sugars from the biomass backbone for fermentation.
• Conducted acid impregnation reactions that helped breakup the lignin
• Operated large and small high pressure (50-300 psig) Bio- reactors.
• Operated lab equipment such as mills, fermentors, centrifuges, evaporators, pumps, and
filtration devices.
• Installed mechanical equipment and systems and calibrated sensors (temperature,
pressure, flow meters, pH meters.).
• Prepared chemical solutions and chemical reactor and bioreactor vessels for
experiments.
• Performed preventative equipment maintenance.
• Collected, prepared, and performed routine analyses of solid and liquid chemical
samples (moisture content, glucose concentration).
• Input experimental data into spreadsheets, and presented results to supervisor
• Kept lab area clean and maintained safe working conditions.
05/2013 to 11/2013 Manufacturing Associate II- Biotechnology/Drug Production
Amgen, Boulder Co
• Skilled operations in manufacturing plant. Manufacturing areas include Cell Culture,
Harvest, Media, Purification, Buffer Prep, and Dispensing. Hands on operations
including set-up, clean in-place (CIP), pressure test (PT), steam in-place (SIP), and
operation of large scale production equipment.
• Also monitored critical processes, execute validation protocols, and equipment
troubleshooting.
• Drafted and revised documents such as Manufacturing Procedures and SOPs. Assisted
in the review of documentation for assigned functions (e.g. equipment logs, routine area
audits, batch records) and completed tasks while complying with SOPs, cGMPs and
Amgen regulations.
09/2012 to 11/2012 Chemical Process Operator-Anodizing Department
Lexmark International, Contract through Bolder Staffing, Broomfield Co 80021
• Development and manufacturing of photoconductors for Lexmark electrophotography
technology.
• This position involved a variety of technical tasks in an automated manufacturing
environment where aluminum cylinders are coated with light-sensitive materials.
• Initiated and monitored automated processes
• Responded to system messages
• Set-up, tore-down, cleaned up, and installed complex process hardware
• Formulated solutions and mixtures of chemicals
• Measured the properties of liquids, dispersions, and coated cylinders using basic
laboratory equipment - Reviewed and classified defects in coated drums
• Interpreted test data and adjusted process conditions as needed
• Ensured compliance with procedures covering safety and environmental regulations
• Worked alone and with others to develop and modify operating procedures
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3. 01/2011 to 04/2011 Research and Development Polymer Chemist
Septodont, Louisville CO; Supervisor Dr. Marianela Trujillo
• Responsible for the design, synthesis, purification and characterization of molecules &
intermediates in methacrylate based polymers.
• Utilized analytical and chromatographic techniques for instance FT-IR, TLC, GC-
MS, flash chromatography, and NMR (500 MHz).
• Developed synthetic routes to help route realization and selection of processes for scale
up. Evaluated new synthesized materials.
05/2002 to 12/2009 Research Assistant-FluoroOrganic Chemistry
Colorado State University; Pueblo, Dept. of Chemistry, Research Advisor: Dr. Melvin Druelinger
Responsibilities:
• Responsible for a project studying the fluorination of alkenyl alcohols and five-membered
heteroaromatic compounds via electrophilic fluorination.
• Worked in a group setting on the discovery process of a synthetic methodology to
synthesize compounds which are potentially biologically active for medicinal purposes.
• Responsible for conducting all chemical synthesis, monitoring the reaction process via
N.M.R and GC-MS studies, analysis of results, and isolation of final products via column
chromatography.
• Responsible for interpreting, and communicating research results to the research group on a
routine basis.
Achievements:
• Contributed to the development of a synthetic method that produces potential bio-active
molecules via electrophilic fluorination. This new reaction process could lead to a new
class of pharmaceutical ingredients.
• Research accepted by the American Chemical Society for presentation of, “Monofluorination
of Alkenyl Alcohols using Electrophilic Fluorine as a synthetic route to Fluoroethers”,
Division of Chemical Education (Organic), Atlanta GA, March-26, 2006, and “Cyclic
Fluoroethers via the Electrophilic Fluorination of Alkenyl Alcohols”, at the ACS national
meeting, Division of Organic Chemistry (New reactions & Methodology, Heterocycles &
Aeromatics”), Anaheim CA, March 28, 2004.
• Contributed as lead student investigator to the development of a new synthetic method for
selectively placing fluorine in a molecule which may increase biological activity
• Publication of research in ACS journal pending.
01/1999 to 12/1999 Undergraduate Research Assistant-Atmospheric Studies
University of Colorado; Boulder, CO, Dept. of Chemistry, Research Advisor: Dr. Veronica Vaida
• Performed Atmospheric Processing Research and instructed peers on the proper techniques
of using and applying data modeling software for conducting research. These experiments
examined the effects of aerosols on the earth’s upper atmosphere
• Awarded the Camile and Henry Dreyfus Environmental Fellowship. This fellowship
involved chemical research at the interface between chemistry and environmental science
The specific project entailed spectroscopic studies of the organic radicals at interfaces to
provide the fundamental data base needed to model atmospheric organic aerosols
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4. ACS PRESENTATIONS: - 231st
ACS National Meeting, Division of Chemical Education, March 26-30, 2006
Atlanta, GA
- 227th
ACS National Meeting, Division of Organic Chemistry, March 28-April 1, 2004
Anaheim, CA
PUBLICATIONS: W. Brown, B. Wallin, DK. Lesniewski, D. Gooding and J. Martin; “The Experimental
Determination of On-Off Keying Laser Communications Probability Models and a Comparison
with Theory”, submitted for pear review on November 30, 2005 in the Journal of Applied
Optics.
HONORS: - Sigma Xi Research Honor Society Associate level member (2008)
- Dean’s List (2003)
- Camile and Henry Dreyfus Scientific Research Fellowship (1999)
COMPUTERS: ChemDraw, PC-Spartan, Sci-Finder Scholar, Word, Excel, Access, Power Point, IDL, Hitran, Acrobat,
Outlook, CorelDraw
LANGUAGES: Polish fluent
OTHER: Chemistry Tutor, ACS Member
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5. REFERENCES:
Weidong Liu, Ph.D
Director of Process Chemistry
AVISTA Pharma Solutions
T: 303-386-1271
M: 303-667-7086
weidong.liu@avistapharma.com
Todd Eary, Ph.D.
Executive Director Process Chemistry and Pharmaceutics
AVISTA Pharma Solutions
T: 303-386-1101
M: 720-935-2983
teary@avistapharma.com
Marianela Trujillo, Ph.D.
Research and Development Polymer Chemist
Research and Development Manager
Septodont, Louisville CO
303-516-9075 ext 26
marianelatrujillo@yahoo.com
marianelatrujillolemon@gmail.com
Melvin Druelinger, Ph.D.
Dean of Graduate Studies and Research
Director of Research and Sponsored Programs
Professor of Chemistry
Research Advisor
Colorado State University-Pueblo
2200 Bonforte Blvd
Pueblo, CO 81001-4901
Office: 719-549-2166
e-mail: mel.druelinger@colostate-pueblo.edu
David Dillon, Ph.D.
Professor of Chemistry
Colorado State University-Pueblo
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6. 2200 Bonforte Blvd
Pueblo, CO 81001-4901
Office: 719-549-2678
e-mail: david.dillon@colostate-pueblo.edu
Bill Brown, Ph.D
Professor of Physics
Colorado State University-Pueblo
2200 Bomforte Blvd
Pueblo, CO 81001
Office: 719-549-2683
e-mail: William.brown@colostate-pueblo.edu
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7. 2200 Bonforte Blvd
Pueblo, CO 81001-4901
Office: 719-549-2678
e-mail: david.dillon@colostate-pueblo.edu
Bill Brown, Ph.D
Professor of Physics
Colorado State University-Pueblo
2200 Bomforte Blvd
Pueblo, CO 81001
Office: 719-549-2683
e-mail: William.brown@colostate-pueblo.edu
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